Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9B2B8_LEIMU

TriTrypDb:

LmxM.30.3170

Length:

635

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 120
NetGPI	no	yes: 0, no: 120

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	113
GO:0110165	cellular anatomical entity	1	113
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

E9B2B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2B8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	55
GO:0022857	transmembrane transporter activity	2	55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.162
CLV_NRD_NRD_1	12	14	PF00675	0.516
CLV_NRD_NRD_1	256	258	PF00675	0.259
CLV_NRD_NRD_1	459	461	PF00675	0.384
CLV_PCSK_KEX2_1	12	14	PF00082	0.478
CLV_PCSK_KEX2_1	256	258	PF00082	0.272
CLV_PCSK_KEX2_1	38	40	PF00082	0.308
CLV_PCSK_KEX2_1	459	461	PF00082	0.369
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.340
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.369
CLV_PCSK_SKI1_1	104	108	PF00082	0.244
CLV_PCSK_SKI1_1	194	198	PF00082	0.392
CLV_PCSK_SKI1_1	231	235	PF00082	0.302
CLV_PCSK_SKI1_1	256	260	PF00082	0.238
CLV_PCSK_SKI1_1	289	293	PF00082	0.326
CLV_PCSK_SKI1_1	38	42	PF00082	0.265
CLV_PCSK_SKI1_1	553	557	PF00082	0.548
DOC_MAPK_gen_1	256	265	PF00069	0.467
DOC_MAPK_gen_1	38	45	PF00069	0.454
DOC_MAPK_gen_1	459	468	PF00069	0.552
DOC_MAPK_gen_1	556	564	PF00069	0.390
DOC_MAPK_MEF2A_6	259	267	PF00069	0.342
DOC_MAPK_MEF2A_6	38	47	PF00069	0.483
DOC_MAPK_MEF2A_6	461	470	PF00069	0.550
DOC_MAPK_MEF2A_6	491	498	PF00069	0.346
DOC_MAPK_MEF2A_6	566	573	PF00069	0.293
DOC_MAPK_RevD_3	267	283	PF00069	0.447
DOC_PP1_RVXF_1	287	293	PF00149	0.266
DOC_PP2B_LxvP_1	472	475	PF13499	0.312
DOC_SPAK_OSR1_1	135	139	PF12202	0.305
DOC_USP7_MATH_1	18	22	PF00917	0.701
DOC_USP7_MATH_1	273	277	PF00917	0.351
DOC_USP7_MATH_1	325	329	PF00917	0.651
DOC_USP7_MATH_1	336	340	PF00917	0.780
DOC_USP7_MATH_1	420	424	PF00917	0.396
DOC_USP7_MATH_1	574	578	PF00917	0.411
DOC_USP7_MATH_1	611	615	PF00917	0.669
DOC_USP7_UBL2_3	241	245	PF12436	0.373
DOC_USP7_UBL2_3	553	557	PF12436	0.399
DOC_WW_Pin1_4	251	256	PF00397	0.511
DOC_WW_Pin1_4	425	430	PF00397	0.398
LIG_14-3-3_CanoR_1	19	26	PF00244	0.638
LIG_14-3-3_CanoR_1	342	351	PF00244	0.760
LIG_14-3-3_CanoR_1	352	360	PF00244	0.714
LIG_BIR_II_1	1	5	PF00653	0.625
LIG_BRCT_BRCA1_1	180	184	PF00533	0.455
LIG_deltaCOP1_diTrp_1	492	498	PF00928	0.207
LIG_EH1_1	106	114	PF00400	0.458
LIG_EH1_1	149	157	PF00400	0.304
LIG_eIF4E_1	101	107	PF01652	0.517
LIG_FHA_1	294	300	PF00498	0.369
LIG_FHA_1	316	322	PF00498	0.675
LIG_FHA_1	389	395	PF00498	0.499
LIG_FHA_1	405	411	PF00498	0.311
LIG_FHA_1	426	432	PF00498	0.344
LIG_FHA_1	467	473	PF00498	0.462
LIG_FHA_2	224	230	PF00498	0.424
LIG_FHA_2	232	238	PF00498	0.418
LIG_FHA_2	31	37	PF00498	0.627
LIG_GBD_Chelix_1	264	272	PF00786	0.298
LIG_LIR_Apic_2	99	103	PF02991	0.470
LIG_LIR_Gen_1	137	145	PF02991	0.333
LIG_LIR_Gen_1	383	394	PF02991	0.511
LIG_LIR_Gen_1	492	500	PF02991	0.292
LIG_LIR_Gen_1	56	66	PF02991	0.345
LIG_LIR_Gen_1	582	592	PF02991	0.329
LIG_LIR_Nem_3	137	142	PF02991	0.296
LIG_LIR_Nem_3	175	179	PF02991	0.342
LIG_LIR_Nem_3	181	187	PF02991	0.336
LIG_LIR_Nem_3	197	203	PF02991	0.256
LIG_LIR_Nem_3	383	389	PF02991	0.517
LIG_LIR_Nem_3	492	496	PF02991	0.346
LIG_LIR_Nem_3	56	62	PF02991	0.333
LIG_LIR_Nem_3	582	588	PF02991	0.338
LIG_NRBOX	263	269	PF00104	0.183
LIG_Pex14_1	395	399	PF04695	0.335
LIG_Pex14_2	121	125	PF04695	0.232
LIG_Pex14_2	202	206	PF04695	0.353
LIG_Pex14_2	258	262	PF04695	0.328
LIG_Pex14_2	581	585	PF04695	0.359
LIG_PTB_Apo_2	411	418	PF02174	0.307
LIG_Rb_pABgroove_1	92	100	PF01858	0.382
LIG_REV1ctd_RIR_1	189	198	PF16727	0.280
LIG_RPA_C_Fungi	337	349	PF08784	0.663
LIG_SH2_CRK	260	264	PF00017	0.383
LIG_SH2_CRK	281	285	PF00017	0.386
LIG_SH2_CRK	303	307	PF00017	0.464
LIG_SH2_CRK	48	52	PF00017	0.279
LIG_SH2_NCK_1	419	423	PF00017	0.355
LIG_SH2_PTP2	589	592	PF00017	0.327
LIG_SH2_SRC	8	11	PF00017	0.620
LIG_SH2_STAP1	228	232	PF00017	0.452
LIG_SH2_STAP1	520	524	PF00017	0.365
LIG_SH2_STAP1	551	555	PF00017	0.324
LIG_SH2_STAT5	201	204	PF00017	0.307
LIG_SH2_STAT5	232	235	PF00017	0.313
LIG_SH2_STAT5	248	251	PF00017	0.315
LIG_SH2_STAT5	303	306	PF00017	0.335
LIG_SH2_STAT5	551	554	PF00017	0.352
LIG_SH2_STAT5	57	60	PF00017	0.317
LIG_SH2_STAT5	589	592	PF00017	0.322
LIG_SH3_3	215	221	PF00018	0.293
LIG_SH3_3	249	255	PF00018	0.341
LIG_SH3_3	267	273	PF00018	0.300
LIG_SH3_3	87	93	PF00018	0.377
LIG_SUMO_SIM_anti_2	476	481	PF11976	0.295
LIG_SUMO_SIM_anti_2	483	488	PF11976	0.275
LIG_SUMO_SIM_anti_2	511	518	PF11976	0.307
LIG_TYR_ITIM	279	284	PF00017	0.336
LIG_UBA3_1	484	491	PF00899	0.384
LIG_WRC_WIRS_1	173	178	PF05994	0.348
LIG_WRC_WIRS_1	495	500	PF05994	0.394
MOD_CDC14_SPxK_1	254	257	PF00782	0.384
MOD_CDK_SPK_2	251	256	PF00069	0.430
MOD_CDK_SPxK_1	251	257	PF00069	0.384
MOD_CK1_1	388	394	PF00069	0.379
MOD_CK1_1	400	406	PF00069	0.371
MOD_CK1_1	433	439	PF00069	0.328
MOD_CK1_1	508	514	PF00069	0.369
MOD_CK1_1	532	538	PF00069	0.344
MOD_CK1_1	583	589	PF00069	0.357
MOD_CK1_1	78	84	PF00069	0.323
MOD_CK2_1	223	229	PF00069	0.270
MOD_CK2_1	231	237	PF00069	0.263
MOD_CK2_1	30	36	PF00069	0.471
MOD_CK2_1	356	362	PF00069	0.559
MOD_CK2_1	367	373	PF00069	0.498
MOD_CK2_1	381	387	PF00069	0.384
MOD_CK2_1	448	454	PF00069	0.377
MOD_Cter_Amidation	10	13	PF01082	0.616
MOD_GlcNHglycan	139	142	PF01048	0.363
MOD_GlcNHglycan	180	183	PF01048	0.315
MOD_GlcNHglycan	372	376	PF01048	0.496
MOD_GlcNHglycan	404	407	PF01048	0.319
MOD_GlcNHglycan	442	445	PF01048	0.311
MOD_GlcNHglycan	507	510	PF01048	0.290
MOD_GlcNHglycan	576	579	PF01048	0.362
MOD_GlcNHglycan	62	65	PF01048	0.300
MOD_GSK3_1	157	164	PF00069	0.338
MOD_GSK3_1	26	33	PF00069	0.581
MOD_GSK3_1	343	350	PF00069	0.617
MOD_GSK3_1	352	359	PF00069	0.675
MOD_GSK3_1	367	374	PF00069	0.557
MOD_GSK3_1	381	388	PF00069	0.450
MOD_GSK3_1	400	407	PF00069	0.378
MOD_GSK3_1	494	501	PF00069	0.374
MOD_GSK3_1	532	539	PF00069	0.317
MOD_GSK3_1	579	586	PF00069	0.365
MOD_GSK3_1	611	618	PF00069	0.534
MOD_GSK3_1	75	82	PF00069	0.313
MOD_N-GLC_1	194	199	PF02516	0.303
MOD_N-GLC_1	353	358	PF02516	0.692
MOD_N-GLC_1	70	75	PF02516	0.370
MOD_N-GLC_2	561	563	PF02516	0.434
MOD_NEK2_1	274	279	PF00069	0.321
MOD_NEK2_1	343	348	PF00069	0.508
MOD_NEK2_1	385	390	PF00069	0.400
MOD_NEK2_1	397	402	PF00069	0.303
MOD_NEK2_1	480	485	PF00069	0.288
MOD_NEK2_1	494	499	PF00069	0.294
MOD_NEK2_1	531	536	PF00069	0.285
MOD_NEK2_1	579	584	PF00069	0.310
MOD_NEK2_1	630	635	PF00069	0.690
MOD_NEK2_2	381	386	PF00069	0.476
MOD_PIKK_1	18	24	PF00454	0.650
MOD_PIKK_1	343	349	PF00454	0.521
MOD_PIKK_1	404	410	PF00454	0.350
MOD_PIKK_1	454	460	PF00454	0.409
MOD_PIKK_1	70	76	PF00454	0.289
MOD_PK_1	75	81	PF00069	0.376
MOD_PKA_1	240	246	PF00069	0.395
MOD_PKA_2	11	17	PF00069	0.639
MOD_PKA_2	134	140	PF00069	0.279
MOD_PKA_2	18	24	PF00069	0.444
MOD_PKA_2	341	347	PF00069	0.741
MOD_PKA_2	356	362	PF00069	0.578
MOD_PKA_2	611	617	PF00069	0.548
MOD_Plk_4	129	135	PF00069	0.274
MOD_Plk_4	145	151	PF00069	0.331
MOD_Plk_4	154	160	PF00069	0.327
MOD_Plk_4	172	178	PF00069	0.361
MOD_Plk_4	274	280	PF00069	0.326
MOD_Plk_4	381	387	PF00069	0.409
MOD_Plk_4	397	403	PF00069	0.354
MOD_Plk_4	430	436	PF00069	0.319
MOD_Plk_4	448	454	PF00069	0.362
MOD_Plk_4	473	479	PF00069	0.312
MOD_Plk_4	480	486	PF00069	0.302
MOD_Plk_4	508	514	PF00069	0.328
MOD_Plk_4	536	542	PF00069	0.296
MOD_Plk_4	580	586	PF00069	0.276
MOD_Plk_4	75	81	PF00069	0.381
MOD_Plk_4	82	88	PF00069	0.349
MOD_ProDKin_1	251	257	PF00069	0.373
MOD_ProDKin_1	425	431	PF00069	0.491
TRG_DiLeu_BaEn_1	327	332	PF01217	0.412
TRG_DiLeu_BaEn_1	430	435	PF01217	0.304
TRG_DiLeu_BaEn_4	463	469	PF01217	0.268
TRG_DiLeu_LyEn_5	626	631	PF01217	0.712
TRG_ENDOCYTIC_2	260	263	PF00928	0.361
TRG_ENDOCYTIC_2	281	284	PF00928	0.300
TRG_ENDOCYTIC_2	303	306	PF00928	0.299
TRG_ENDOCYTIC_2	399	402	PF00928	0.351
TRG_ENDOCYTIC_2	48	51	PF00928	0.285
TRG_ENDOCYTIC_2	528	531	PF00928	0.328
TRG_ENDOCYTIC_2	589	592	PF00928	0.381
TRG_ENDOCYTIC_2	59	62	PF00928	0.284
TRG_ENDOCYTIC_2	594	597	PF00928	0.403
TRG_ER_diArg_1	255	257	PF00400	0.301
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	75%	100%
A0A0N1HT40	Leptomonas seymouri	40%	100%
A0A0N1HZC2	Leptomonas seymouri	26%	100%
A0A0N1IKC5	Leptomonas seymouri	41%	100%
A0A0N1PB63	Leptomonas seymouri	25%	96%
A0A0N1PD04	Leptomonas seymouri	21%	99%
A0A0N1PFR4	Leptomonas seymouri	26%	96%
A0A0S4JR45	Bodo saltans	28%	100%
A0A1X0NKK0	Trypanosomatidae	28%	100%
A0A1X0NL32	Trypanosomatidae	30%	100%
A0A1X0NM09	Trypanosomatidae	25%	100%
A0A1X0NRW5	Trypanosomatidae	41%	91%
A0A1X0NV13	Trypanosomatidae	43%	98%
A0A1X0NV19	Trypanosomatidae	39%	100%
A0A1X0NV27	Trypanosomatidae	38%	100%
A0A1X0NVH8	Trypanosomatidae	39%	96%
A0A1X0NVM7	Trypanosomatidae	42%	98%
A0A1X0NWQ1	Trypanosomatidae	43%	99%
A0A1X0NZE6	Trypanosomatidae	31%	100%
A0A1X0NZU2	Trypanosomatidae	28%	98%
A0A1X0NZU5	Trypanosomatidae	32%	100%
A0A1X0NZW1	Trypanosomatidae	28%	100%
A0A1X0P0M7	Trypanosomatidae	30%	100%
A0A381MMW5	Leishmania infantum	28%	97%
A0A3Q8I7Y9	Leishmania donovani	39%	100%
A0A3Q8IEC4	Leishmania donovani	28%	98%
A0A3Q8IF95	Leishmania donovani	26%	100%
A0A3Q8IIT5	Leishmania donovani	27%	94%
A0A3Q8ISY9	Leishmania donovani	92%	100%
A0A3R7JSQ9	Trypanosoma rangeli	27%	100%
A0A3R7KKN8	Trypanosoma rangeli	29%	100%
A0A3R7MAQ7	Trypanosoma rangeli	40%	90%
A0A3R7N415	Trypanosoma rangeli	29%	100%
A0A3R7N921	Trypanosoma rangeli	29%	100%
A0A3R7R443	Trypanosoma rangeli	27%	100%
A0A3S7WRJ4	Leishmania donovani	39%	99%
A0A3S7WRJ5	Leishmania donovani	38%	91%
A0A3S7WRL4	Leishmania donovani	37%	100%
A0A3S7WRS3	Leishmania donovani	23%	100%
A0A3S7WSR4	Leishmania donovani	41%	100%
A0A3S7WWU1	Leishmania donovani	24%	96%
A0A3S7X2G0	Leishmania donovani	28%	97%
A0A3S7X2K5	Leishmania donovani	28%	100%
A0A3S7XB11	Leishmania donovani	28%	100%
A0A422MSE4	Trypanosoma rangeli	41%	100%
A0A422MSP6	Trypanosoma rangeli	30%	100%
A0A422MST9	Trypanosoma rangeli	27%	100%
A0A422MU68	Trypanosoma rangeli	25%	100%
A4H6J0	Leishmania braziliensis	40%	100%
A4H6J1	Leishmania braziliensis	39%	100%
A4H6J3	Leishmania braziliensis	37%	98%
A4H6Q5	Leishmania braziliensis	23%	100%
A4HC19	Leishmania braziliensis	25%	100%
A4HHG2	Leishmania braziliensis	27%	100%
A4HHG3	Leishmania braziliensis	27%	100%
A4HHG4	Leishmania braziliensis	26%	100%
A4HJW3	Leishmania braziliensis	82%	100%
A4HPE2	Leishmania braziliensis	28%	100%
A4HUX5	Leishmania infantum	39%	99%
A4HUX6	Leishmania infantum	38%	91%
A4HUX7	Leishmania infantum	37%	100%
A4HUX8	Leishmania infantum	38%	100%
A4HV40	Leishmania infantum	24%	100%
A4HZF5	Leishmania infantum	26%	100%
A4HZJ4	Leishmania infantum	25%	96%
A4I4L2	Leishmania infantum	27%	94%
A4I7C5	Leishmania infantum	92%	100%
A4ICI3	Leishmania infantum	28%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	93%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AE01	Leishmania major	27%	100%
E9AE09	Leishmania major	26%	99%
E9AE10	Leishmania major	26%	99%
E9AE11	Leishmania major	28%	100%
E9AGK5	Leishmania infantum	41%	100%
E9AHJ0	Leishmania infantum	28%	98%
E9AHJ1	Leishmania infantum	28%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9ANL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	97%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	99%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	99%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q1E4	Leishmania major	28%	100%
Q4Q5T8	Leishmania major	91%	100%
Q4QC27	Leishmania major	24%	100%
Q4QC28	Leishmania major	26%	98%
Q4QFY5	Leishmania major	40%	100%
Q4QGU8	Leishmania major	23%	100%
Q4QH10	Leishmania major	37%	98%
Q4QH11	Leishmania major	38%	95%
Q4QH12	Leishmania major	38%	95%
Q4QH13	Leishmania major	38%	95%
Q4QH14	Leishmania major	37%	100%
Q4QH15	Leishmania major	40%	100%
V5B647	Trypanosoma cruzi	42%	100%
V5B983	Trypanosoma cruzi	31%	100%
V5BBB1	Trypanosoma cruzi	43%	100%
V5BFV8	Trypanosoma cruzi	29%	95%
V5BQY6	Trypanosoma cruzi	38%	90%
V5BVP0	Trypanosoma cruzi	41%	100%
V5DT25	Trypanosoma cruzi	41%	100%