Autophagy_act_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagy protein 10

Species:

Leishmania mexicana

UniProt:

E9B2B0_LEIMU

TriTrypDb:

LmxM.30.3105

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2B0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.475
CLV_PCSK_FUR_1	146	150	PF00082	0.377
CLV_PCSK_FUR_1	31	35	PF00082	0.463
CLV_PCSK_KEX2_1	148	150	PF00082	0.475
CLV_PCSK_KEX2_1	33	35	PF00082	0.542
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.542
DEG_Nend_UBRbox_1	1	4	PF02207	0.510
DOC_CDC14_PxL_1	169	177	PF14671	0.436
DOC_MAPK_DCC_7	92	100	PF00069	0.418
DOC_MAPK_MEF2A_6	92	100	PF00069	0.418
DOC_MAPK_RevD_3	133	149	PF00069	0.408
DOC_PP2B_LxvP_1	174	177	PF13499	0.409
DOC_PP4_FxxP_1	73	76	PF00568	0.386
DOC_USP7_MATH_1	119	123	PF00917	0.376
DOC_USP7_MATH_2	27	33	PF00917	0.449
DOC_WW_Pin1_4	23	28	PF00397	0.451
LIG_14-3-3_CanoR_1	118	124	PF00244	0.449
LIG_14-3-3_CanoR_1	12	16	PF00244	0.393
LIG_14-3-3_CanoR_1	163	171	PF00244	0.332
LIG_BH_BH3_1	154	170	PF00452	0.386
LIG_BRCT_BRCA1_1	165	169	PF00533	0.336
LIG_FHA_1	111	117	PF00498	0.540
LIG_FHA_1	139	145	PF00498	0.354
LIG_FHA_1	3	9	PF00498	0.498
LIG_FHA_1	45	51	PF00498	0.383
LIG_FHA_1	62	68	PF00498	0.295
LIG_LIR_Apic_2	72	76	PF02991	0.335
LIG_LIR_Gen_1	14	19	PF02991	0.400
LIG_LIR_Nem_3	14	18	PF02991	0.532
LIG_LIR_Nem_3	166	171	PF02991	0.395
LIG_MLH1_MIPbox_1	165	169	PF16413	0.336
LIG_MYND_1	173	177	PF01753	0.450
LIG_PCNA_yPIPBox_3	148	161	PF02747	0.365
LIG_Pex14_2	69	73	PF04695	0.398
LIG_PTB_Apo_2	67	74	PF02174	0.393
LIG_PTB_Apo_2	94	101	PF02174	0.377
LIG_SH2_STAT5	168	171	PF00017	0.416
LIG_SH3_3	113	119	PF00018	0.521
LIG_SH3_3	167	173	PF00018	0.437
LIG_Sin3_3	172	179	PF02671	0.439
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.237
LIG_SUMO_SIM_par_1	59	64	PF11976	0.237
LIG_WRC_WIRS_1	120	125	PF05994	0.415
MOD_CK1_1	84	90	PF00069	0.476
MOD_CK2_1	102	108	PF00069	0.427
MOD_CK2_1	23	29	PF00069	0.546
MOD_CK2_1	49	55	PF00069	0.414
MOD_GlcNHglycan	55	59	PF01048	0.629
MOD_GSK3_1	50	57	PF00069	0.586
MOD_GSK3_1	80	87	PF00069	0.463
MOD_N-GLC_1	81	86	PF02516	0.444
MOD_N-GLC_1	96	101	PF02516	0.293
MOD_N-GLC_2	49	51	PF02516	0.393
MOD_NEK2_1	44	49	PF00069	0.358
MOD_NEK2_1	54	59	PF00069	0.344
MOD_NEK2_1	80	85	PF00069	0.461
MOD_PKA_2	11	17	PF00069	0.452
MOD_Plk_1	44	50	PF00069	0.385
MOD_Plk_1	81	87	PF00069	0.444
MOD_Plk_1	96	102	PF00069	0.309
MOD_Plk_4	56	62	PF00069	0.331
MOD_Plk_4	81	87	PF00069	0.330
MOD_Plk_4	96	102	PF00069	0.426
MOD_ProDKin_1	23	29	PF00069	0.452
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.418
TRG_ENDOCYTIC_2	132	135	PF00928	0.421
TRG_ENDOCYTIC_2	168	171	PF00928	0.416
TRG_ER_diArg_1	145	148	PF00400	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N4	Leptomonas seymouri	50%	100%
A0A1X0NI81	Trypanosomatidae	28%	100%
A0A3S5H7Q9	Leishmania donovani	93%	74%
A4HJV5	Leishmania braziliensis	75%	100%
A4I7B7	Leishmania infantum	93%	85%
C9ZWJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4Q5U6	Leishmania major	91%	100%