BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2A7_LEIMU

TriTrypDb:

LmxM.30.3080

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2A7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0051259	protein complex oligomerization	6	1
GO:0051260	protein homooligomerization	7	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.601
CLV_NRD_NRD_1	119	121	PF00675	0.767
CLV_NRD_NRD_1	40	42	PF00675	0.599
CLV_NRD_NRD_1	55	57	PF00675	0.631
CLV_PCSK_FUR_1	52	56	PF00082	0.426
CLV_PCSK_KEX2_1	121	123	PF00082	0.766
CLV_PCSK_KEX2_1	40	42	PF00082	0.678
CLV_PCSK_KEX2_1	54	56	PF00082	0.624
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.766
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.519
CLV_PCSK_SKI1_1	290	294	PF00082	0.489
CLV_PCSK_SKI1_1	30	34	PF00082	0.644
CLV_PCSK_SKI1_1	84	88	PF00082	0.440
DEG_Nend_UBRbox_2	1	3	PF02207	0.593
DEG_SPOP_SBC_1	14	18	PF00917	0.557
DOC_CKS1_1	248	253	PF01111	0.646
DOC_CYCLIN_RxL_1	27	35	PF00134	0.645
DOC_CYCLIN_RxL_1	78	90	PF00134	0.498
DOC_CYCLIN_yCln2_LP_2	281	287	PF00134	0.558
DOC_MAPK_gen_1	141	150	PF00069	0.546
DOC_MAPK_MEF2A_6	144	152	PF00069	0.529
DOC_PP1_RVXF_1	264	270	PF00149	0.534
DOC_PP1_RVXF_1	288	294	PF00149	0.492
DOC_PP1_RVXF_1	296	303	PF00149	0.507
DOC_PP4_FxxP_1	194	197	PF00568	0.574
DOC_SPAK_OSR1_1	184	188	PF12202	0.596
DOC_USP7_MATH_1	113	117	PF00917	0.753
DOC_USP7_MATH_1	134	138	PF00917	0.491
DOC_USP7_MATH_1	322	326	PF00917	0.430
DOC_USP7_MATH_1	327	331	PF00917	0.462
DOC_WW_Pin1_4	247	252	PF00397	0.644
LIG_14-3-3_CanoR_1	184	194	PF00244	0.543
LIG_14-3-3_CanoR_1	21	31	PF00244	0.727
LIG_14-3-3_CanoR_1	329	337	PF00244	0.458
LIG_BRCT_BRCA1_1	212	216	PF00533	0.550
LIG_BRCT_BRCA1_1	92	96	PF00533	0.398
LIG_FHA_1	130	136	PF00498	0.616
LIG_LIR_Nem_3	171	177	PF02991	0.388
LIG_MLH1_MIPbox_1	212	216	PF16413	0.550
LIG_NRBOX	148	154	PF00104	0.418
LIG_PCNA_yPIPBox_3	141	149	PF02747	0.445
LIG_Pex14_1	181	185	PF04695	0.450
LIG_PTB_Apo_2	179	186	PF02174	0.491
LIG_PTB_Apo_2	302	309	PF02174	0.539
LIG_PTB_Phospho_1	302	308	PF10480	0.539
LIG_SH2_GRB2like	261	264	PF00017	0.426
LIG_SH2_STAT5	193	196	PF00017	0.573
LIG_SH2_STAT5	270	273	PF00017	0.565
LIG_SH2_STAT5	308	311	PF00017	0.533
LIG_SH3_1	62	68	PF00018	0.280
LIG_SH3_3	133	139	PF00018	0.607
LIG_SH3_3	28	34	PF00018	0.613
LIG_SH3_3	62	68	PF00018	0.449
LIG_SUMO_SIM_anti_2	330	338	PF11976	0.558
LIG_SUMO_SIM_par_1	134	140	PF11976	0.559
LIG_TRAF2_1	3	6	PF00917	0.636
LIG_UBA3_1	148	157	PF00899	0.466
MOD_CK1_1	105	111	PF00069	0.645
MOD_CK1_1	26	32	PF00069	0.721
MOD_CK1_1	331	337	PF00069	0.559
MOD_CK2_1	134	140	PF00069	0.535
MOD_CK2_1	164	170	PF00069	0.579
MOD_CK2_1	42	48	PF00069	0.592
MOD_Cter_Amidation	118	121	PF01082	0.692
MOD_GlcNHglycan	107	110	PF01048	0.635
MOD_GlcNHglycan	114	118	PF01048	0.675
MOD_GlcNHglycan	177	180	PF01048	0.573
MOD_GlcNHglycan	34	37	PF01048	0.725
MOD_GSK3_1	103	110	PF00069	0.446
MOD_GSK3_1	120	127	PF00069	0.569
MOD_GSK3_1	198	205	PF00069	0.594
MOD_GSK3_1	210	217	PF00069	0.371
MOD_GSK3_1	22	29	PF00069	0.581
MOD_GSK3_1	237	244	PF00069	0.554
MOD_GSK3_1	327	334	PF00069	0.555
MOD_GSK3_1	90	97	PF00069	0.553
MOD_NEK2_1	103	108	PF00069	0.536
MOD_NEK2_1	15	20	PF00069	0.715
MOD_NEK2_1	180	185	PF00069	0.523
MOD_NEK2_1	198	203	PF00069	0.595
MOD_NEK2_1	215	220	PF00069	0.433
MOD_NEK2_1	225	230	PF00069	0.408
MOD_NEK2_1	237	242	PF00069	0.591
MOD_NEK2_1	80	85	PF00069	0.529
MOD_NEK2_1	94	99	PF00069	0.282
MOD_NEK2_2	164	169	PF00069	0.573
MOD_NEK2_2	265	270	PF00069	0.500
MOD_PIKK_1	187	193	PF00454	0.517
MOD_PIKK_1	225	231	PF00454	0.529
MOD_PIKK_1	328	334	PF00454	0.543
MOD_PKA_1	120	126	PF00069	0.751
MOD_PKA_1	40	46	PF00069	0.561
MOD_PKA_2	129	135	PF00069	0.537
MOD_PKA_2	328	334	PF00069	0.480
MOD_PKA_2	40	46	PF00069	0.638
MOD_PKB_1	118	126	PF00069	0.640
MOD_Plk_1	223	229	PF00069	0.488
MOD_Plk_2-3	42	48	PF00069	0.638
MOD_Plk_4	23	29	PF00069	0.728
MOD_Plk_4	265	271	PF00069	0.470
MOD_Plk_4	331	337	PF00069	0.543
MOD_Plk_4	90	96	PF00069	0.417
MOD_ProDKin_1	247	253	PF00069	0.645
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.722
TRG_ENDOCYTIC_2	174	177	PF00928	0.445
TRG_ENDOCYTIC_2	57	60	PF00928	0.565
TRG_ER_diArg_1	55	57	PF00400	0.615
TRG_NLS_MonoExtC_3	119	124	PF00514	0.683
TRG_NLS_MonoExtN_4	118	124	PF00514	0.596
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N2	Leptomonas seymouri	61%	97%
A0A1X0NIJ4	Trypanosomatidae	37%	100%
A0A3R7K9T3	Trypanosoma rangeli	34%	100%
A0A3S7X510	Leishmania donovani	94%	94%
A4HJU7	Leishmania braziliensis	82%	100%
A4HJV2	Leishmania braziliensis	82%	100%
A4I7B4	Leishmania infantum	93%	94%
C9ZWJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q5U9	Leishmania major	93%	100%
V5B9A8	Trypanosoma cruzi	37%	100%
V5DUU9	Trypanosoma cruzi	26%	66%