Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B2A0_LEIMU

TriTrypDb:

LmxM.30.3010

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2A0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	448	452	PF00656	0.417
CLV_NRD_NRD_1	10	12	PF00675	0.510
CLV_NRD_NRD_1	143	145	PF00675	0.536
CLV_NRD_NRD_1	159	161	PF00675	0.389
CLV_NRD_NRD_1	233	235	PF00675	0.439
CLV_NRD_NRD_1	241	243	PF00675	0.495
CLV_NRD_NRD_1	263	265	PF00675	0.442
CLV_NRD_NRD_1	296	298	PF00675	0.532
CLV_NRD_NRD_1	523	525	PF00675	0.712
CLV_NRD_NRD_1	534	536	PF00675	0.638
CLV_NRD_NRD_1	553	555	PF00675	0.484
CLV_PCSK_FUR_1	203	207	PF00082	0.474
CLV_PCSK_KEX2_1	10	12	PF00082	0.525
CLV_PCSK_KEX2_1	115	117	PF00082	0.706
CLV_PCSK_KEX2_1	143	145	PF00082	0.536
CLV_PCSK_KEX2_1	205	207	PF00082	0.487
CLV_PCSK_KEX2_1	241	243	PF00082	0.504
CLV_PCSK_KEX2_1	262	264	PF00082	0.510
CLV_PCSK_KEX2_1	298	300	PF00082	0.527
CLV_PCSK_KEX2_1	310	312	PF00082	0.598
CLV_PCSK_KEX2_1	360	362	PF00082	0.389
CLV_PCSK_KEX2_1	423	425	PF00082	0.639
CLV_PCSK_KEX2_1	523	525	PF00082	0.709
CLV_PCSK_KEX2_1	534	536	PF00082	0.638
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.524
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.480
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.510
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.527
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.544
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.389
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.639
CLV_PCSK_SKI1_1	121	125	PF00082	0.607
CLV_PCSK_SKI1_1	167	171	PF00082	0.361
CLV_PCSK_SKI1_1	273	277	PF00082	0.397
CLV_PCSK_SKI1_1	357	361	PF00082	0.428
CLV_PCSK_SKI1_1	450	454	PF00082	0.513
DOC_CKS1_1	550	555	PF01111	0.667
DOC_MAPK_gen_1	10	16	PF00069	0.510
DOC_MAPK_gen_1	357	366	PF00069	0.382
DOC_MAPK_gen_1	506	513	PF00069	0.552
DOC_MAPK_gen_1	523	531	PF00069	0.576
DOC_MAPK_MEF2A_6	440	449	PF00069	0.577
DOC_MAPK_MEF2A_6	46	55	PF00069	0.410
DOC_MAPK_MEF2A_6	506	513	PF00069	0.541
DOC_MAPK_NFAT4_5	46	54	PF00069	0.410
DOC_PP1_RVXF_1	276	282	PF00149	0.448
DOC_PP2B_LxvP_1	62	65	PF13499	0.460
DOC_USP7_MATH_1	100	104	PF00917	0.619
DOC_USP7_MATH_1	171	175	PF00917	0.542
DOC_USP7_MATH_1	286	290	PF00917	0.504
DOC_USP7_MATH_1	319	323	PF00917	0.692
DOC_USP7_MATH_1	410	414	PF00917	0.594
DOC_USP7_MATH_1	459	463	PF00917	0.615
DOC_USP7_MATH_1	491	495	PF00917	0.722
DOC_USP7_MATH_1	519	523	PF00917	0.765
DOC_WW_Pin1_4	105	110	PF00397	0.720
DOC_WW_Pin1_4	125	130	PF00397	0.489
DOC_WW_Pin1_4	17	22	PF00397	0.515
DOC_WW_Pin1_4	463	468	PF00397	0.659
DOC_WW_Pin1_4	497	502	PF00397	0.663
DOC_WW_Pin1_4	549	554	PF00397	0.785
DOC_WW_Pin1_4	83	88	PF00397	0.619
LIG_14-3-3_CanoR_1	116	124	PF00244	0.697
LIG_14-3-3_CanoR_1	133	138	PF00244	0.429
LIG_14-3-3_CanoR_1	221	227	PF00244	0.390
LIG_14-3-3_CanoR_1	412	416	PF00244	0.511
LIG_14-3-3_CanoR_1	52	58	PF00244	0.521
LIG_14-3-3_CanoR_1	523	532	PF00244	0.736
LIG_14-3-3_CanoR_1	68	76	PF00244	0.476
LIG_BIR_II_1	1	5	PF00653	0.502
LIG_BRCT_BRCA1_1	527	531	PF00533	0.644
LIG_deltaCOP1_diTrp_1	538	547	PF00928	0.487
LIG_FHA_1	183	189	PF00498	0.396
LIG_FHA_1	274	280	PF00498	0.492
LIG_FHA_1	30	36	PF00498	0.538
LIG_FHA_1	330	336	PF00498	0.498
LIG_FHA_1	42	48	PF00498	0.397
LIG_FHA_1	437	443	PF00498	0.603
LIG_FHA_1	84	90	PF00498	0.499
LIG_FHA_2	134	140	PF00498	0.558
LIG_FHA_2	215	221	PF00498	0.484
LIG_FHA_2	446	452	PF00498	0.459
LIG_FHA_2	528	534	PF00498	0.587
LIG_GBD_Chelix_1	49	57	PF00786	0.412
LIG_Integrin_isoDGR_2	104	106	PF01839	0.600
LIG_LIR_Gen_1	322	331	PF02991	0.556
LIG_LIR_Gen_1	544	553	PF02991	0.660
LIG_LIR_Nem_3	135	140	PF02991	0.550
LIG_LIR_Nem_3	322	327	PF02991	0.593
LIG_LIR_Nem_3	44	48	PF02991	0.496
LIG_LIR_Nem_3	544	550	PF02991	0.661
LIG_Pex14_2	547	551	PF04695	0.667
LIG_SH2_NCK_1	265	269	PF00017	0.501
LIG_SH2_SRC	190	193	PF00017	0.378
LIG_SH2_STAT5	190	193	PF00017	0.511
LIG_SH2_STAT5	271	274	PF00017	0.453
LIG_SH3_1	506	512	PF00018	0.614
LIG_SH3_2	501	506	PF14604	0.551
LIG_SH3_3	123	129	PF00018	0.596
LIG_SH3_3	498	504	PF00018	0.592
LIG_SH3_3	506	512	PF00018	0.685
LIG_SH3_3	526	532	PF00018	0.595
LIG_SH3_4	342	349	PF00018	0.621
LIG_SUMO_SIM_par_1	484	489	PF11976	0.518
LIG_TRAF2_1	236	239	PF00917	0.501
LIG_TRAF2_1	293	296	PF00917	0.512
LIG_UBA3_1	355	360	PF00899	0.398
LIG_WRC_WIRS_1	134	139	PF05994	0.513
MOD_CDC14_SPxK_1	503	506	PF00782	0.561
MOD_CDK_SPK_2	17	22	PF00069	0.515
MOD_CDK_SPK_2	549	554	PF00069	0.664
MOD_CDK_SPxK_1	500	506	PF00069	0.585
MOD_CDK_SPxK_1	549	555	PF00069	0.787
MOD_CDK_SPxxK_3	463	470	PF00069	0.623
MOD_CK1_1	222	228	PF00069	0.353
MOD_CK1_1	3	9	PF00069	0.561
MOD_CK1_1	322	328	PF00069	0.547
MOD_CK1_1	436	442	PF00069	0.605
MOD_CK1_1	462	468	PF00069	0.656
MOD_CK1_1	494	500	PF00069	0.705
MOD_CK1_1	541	547	PF00069	0.689
MOD_CK1_1	71	77	PF00069	0.480
MOD_CK2_1	133	139	PF00069	0.664
MOD_CK2_1	214	220	PF00069	0.482
MOD_CK2_1	379	385	PF00069	0.537
MOD_CK2_1	410	416	PF00069	0.591
MOD_CK2_1	440	446	PF00069	0.503
MOD_CK2_1	527	533	PF00069	0.607
MOD_GlcNHglycan	117	120	PF01048	0.673
MOD_GlcNHglycan	173	176	PF01048	0.647
MOD_GlcNHglycan	2	5	PF01048	0.583
MOD_GlcNHglycan	323	327	PF01048	0.548
MOD_GlcNHglycan	381	384	PF01048	0.553
MOD_GlcNHglycan	442	445	PF01048	0.525
MOD_GlcNHglycan	461	464	PF01048	0.656
MOD_GlcNHglycan	467	470	PF01048	0.673
MOD_GlcNHglycan	487	491	PF01048	0.584
MOD_GlcNHglycan	497	500	PF01048	0.777
MOD_GlcNHglycan	70	73	PF01048	0.561
MOD_GSK3_1	215	222	PF00069	0.424
MOD_GSK3_1	436	443	PF00069	0.600
MOD_GSK3_1	459	466	PF00069	0.518
MOD_GSK3_1	491	498	PF00069	0.693
MOD_GSK3_1	514	521	PF00069	0.755
MOD_GSK3_1	523	530	PF00069	0.590
MOD_GSK3_1	64	71	PF00069	0.509
MOD_N-GLC_1	124	129	PF02516	0.593
MOD_N-GLC_1	491	496	PF02516	0.682
MOD_NEK2_1	124	129	PF00069	0.684
MOD_NEK2_1	366	371	PF00069	0.541
MOD_NEK2_1	445	450	PF00069	0.627
MOD_NEK2_1	486	491	PF00069	0.520
MOD_NEK2_1	53	58	PF00069	0.483
MOD_NEK2_1	89	94	PF00069	0.605
MOD_NEK2_2	399	404	PF00069	0.488
MOD_NEK2_2	41	46	PF00069	0.424
MOD_NEK2_2	546	551	PF00069	0.661
MOD_PKA_1	115	121	PF00069	0.623
MOD_PKA_1	523	529	PF00069	0.626
MOD_PKA_2	115	121	PF00069	0.713
MOD_PKA_2	132	138	PF00069	0.435
MOD_PKA_2	222	228	PF00069	0.353
MOD_PKA_2	329	335	PF00069	0.654
MOD_PKA_2	411	417	PF00069	0.486
MOD_PKA_2	523	529	PF00069	0.744
MOD_Plk_1	322	328	PF00069	0.564
MOD_Plk_1	445	451	PF00069	0.559
MOD_Plk_1	491	497	PF00069	0.583
MOD_Plk_1	538	544	PF00069	0.490
MOD_Plk_2-3	527	533	PF00069	0.590
MOD_Plk_4	399	405	PF00069	0.448
MOD_Plk_4	546	552	PF00069	0.669
MOD_ProDKin_1	105	111	PF00069	0.719
MOD_ProDKin_1	125	131	PF00069	0.485
MOD_ProDKin_1	17	23	PF00069	0.516
MOD_ProDKin_1	463	469	PF00069	0.663
MOD_ProDKin_1	497	503	PF00069	0.663
MOD_ProDKin_1	549	555	PF00069	0.787
MOD_ProDKin_1	83	89	PF00069	0.621
MOD_SUMO_for_1	204	207	PF00179	0.475
MOD_SUMO_for_1	277	280	PF00179	0.583
MOD_SUMO_rev_2	207	215	PF00179	0.480
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.533
TRG_DiLeu_BaLyEn_6	532	537	PF01217	0.688
TRG_ENDOCYTIC_2	254	257	PF00928	0.570
TRG_ER_diArg_1	263	265	PF00400	0.442
TRG_ER_diArg_1	297	300	PF00400	0.531
TRG_ER_diArg_1	534	536	PF00400	0.679
TRG_ER_diArg_1	9	11	PF00400	0.498
TRG_Pf-PMV_PEXEL_1	357	362	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	534	538	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X505	Leishmania donovani	82%	100%
A4HJU0	Leishmania braziliensis	62%	100%
A4I7A6	Leishmania infantum	82%	100%
Q4Q5V7	Leishmania major	81%	100%