NAD(+) diphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mutt/nudix family protein-like protein

Species:

Leishmania mexicana

UniProt:

E9B295_LEIMU

TriTrypDb:

LmxM.30.2950

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B295

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B295

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006734	NADH metabolic process	2	1
GO:0006739	NADP metabolic process	7	1
GO:0006742	NADP catabolic process	7	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009166	nucleotide catabolic process	6	1
GO:0009987	cellular process	1	1
GO:0019362	pyridine nucleotide metabolic process	5	1
GO:0019364	pyridine nucleotide catabolic process	6	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019677	NAD catabolic process	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046496	nicotinamide nucleotide metabolic process	6	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072524	pyridine-containing compound metabolic process	4	1
GO:0072526	pyridine-containing compound catabolic process	5	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000210	NAD+ diphosphatase activity	7	7
GO:0003824	catalytic activity	1	7
GO:0004551	dinucleotide phosphatase activity	6	7
GO:0005488	binding	1	4
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0035529	NADH pyrophosphatase activity	7	7
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	95	99	PF00656	0.499
CLV_NRD_NRD_1	103	105	PF00675	0.446
CLV_NRD_NRD_1	15	17	PF00675	0.513
CLV_NRD_NRD_1	195	197	PF00675	0.310
CLV_NRD_NRD_1	220	222	PF00675	0.328
CLV_NRD_NRD_1	281	283	PF00675	0.292
CLV_NRD_NRD_1	34	36	PF00675	0.284
CLV_PCSK_KEX2_1	103	105	PF00082	0.446
CLV_PCSK_KEX2_1	15	17	PF00082	0.513
CLV_PCSK_KEX2_1	195	197	PF00082	0.310
CLV_PCSK_KEX2_1	220	222	PF00082	0.324
CLV_PCSK_KEX2_1	281	283	PF00082	0.364
CLV_PCSK_SKI1_1	200	204	PF00082	0.288
CLV_PCSK_SKI1_1	281	285	PF00082	0.310
CLV_PCSK_SKI1_1	74	78	PF00082	0.517
DEG_APCC_KENBOX_2	43	47	PF00400	0.365
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.393
DOC_MAPK_gen_1	195	204	PF00069	0.310
DOC_MAPK_gen_1	35	42	PF00069	0.254
DOC_MAPK_gen_1	43	49	PF00069	0.270
DOC_MAPK_gen_1	74	82	PF00069	0.496
DOC_PP1_RVXF_1	269	275	PF00149	0.309
DOC_USP7_MATH_1	229	233	PF00917	0.325
DOC_USP7_MATH_1	258	262	PF00917	0.297
DOC_WW_Pin1_4	256	261	PF00397	0.431
DOC_WW_Pin1_4	296	301	PF00397	0.405
LIG_14-3-3_CanoR_1	103	112	PF00244	0.566
LIG_APCC_ABBA_1	208	213	PF00400	0.428
LIG_BIR_III_2	257	261	PF00653	0.428
LIG_BRCT_BRCA1_1	140	144	PF00533	0.281
LIG_FHA_2	148	154	PF00498	0.551
LIG_FHA_2	70	76	PF00498	0.295
LIG_LIR_Apic_2	239	245	PF02991	0.310
LIG_LIR_Gen_1	298	308	PF02991	0.383
LIG_LIR_Gen_1	90	101	PF02991	0.491
LIG_LIR_LC3C_4	259	264	PF02991	0.288
LIG_LIR_Nem_3	298	304	PF02991	0.395
LIG_MYND_1	173	177	PF01753	0.459
LIG_PDZ_Class_1	320	325	PF00595	0.600
LIG_Pex14_1	242	246	PF04695	0.428
LIG_SH2_CRK	301	305	PF00017	0.386
LIG_SH2_NCK_1	253	257	PF00017	0.310
LIG_SH2_STAT5	117	120	PF00017	0.289
LIG_SH2_STAT5	236	239	PF00017	0.310
LIG_SH2_STAT5	246	249	PF00017	0.310
LIG_SH2_STAT5	81	84	PF00017	0.359
LIG_SH3_3	106	112	PF00018	0.366
LIG_SUMO_SIM_par_1	179	185	PF11976	0.434
LIG_SUMO_SIM_par_1	198	206	PF11976	0.314
LIG_SUMO_SIM_par_1	3	8	PF11976	0.386
LIG_TRAF2_1	214	217	PF00917	0.310
MOD_CK1_1	227	233	PF00069	0.205
MOD_CK2_1	119	125	PF00069	0.368
MOD_CK2_1	211	217	PF00069	0.324
MOD_CK2_1	227	233	PF00069	0.189
MOD_CK2_1	264	270	PF00069	0.364
MOD_Cter_Amidation	101	104	PF01082	0.450
MOD_GlcNHglycan	205	208	PF01048	0.310
MOD_GlcNHglycan	213	216	PF01048	0.310
MOD_GlcNHglycan	224	229	PF01048	0.310
MOD_GlcNHglycan	9	12	PF01048	0.409
MOD_GSK3_1	196	203	PF00069	0.310
MOD_GSK3_1	211	218	PF00069	0.357
MOD_GSK3_1	316	323	PF00069	0.571
MOD_NEK2_1	119	124	PF00069	0.401
MOD_NEK2_1	131	136	PF00069	0.417
MOD_NEK2_1	273	278	PF00069	0.269
MOD_NEK2_1	5	10	PF00069	0.500
MOD_NEK2_2	215	220	PF00069	0.310
MOD_NEK2_2	69	74	PF00069	0.293
MOD_PIKK_1	103	109	PF00454	0.513
MOD_PIKK_1	190	196	PF00454	0.310
MOD_PIKK_1	236	242	PF00454	0.310
MOD_PKA_1	103	109	PF00069	0.449
MOD_PKA_1	196	202	PF00069	0.310
MOD_PKA_2	103	109	PF00069	0.513
MOD_PKA_2	316	322	PF00069	0.463
MOD_Plk_1	215	221	PF00069	0.310
MOD_Plk_1	5	11	PF00069	0.419
MOD_Plk_4	131	137	PF00069	0.409
MOD_Plk_4	200	206	PF00069	0.326
MOD_Plk_4	258	264	PF00069	0.393
MOD_ProDKin_1	256	262	PF00069	0.431
MOD_ProDKin_1	296	302	PF00069	0.401
MOD_SUMO_for_1	42	45	PF00179	0.479
MOD_SUMO_rev_2	193	202	PF00179	0.364
MOD_SUMO_rev_2	313	321	PF00179	0.353
TRG_DiLeu_BaEn_2	44	50	PF01217	0.371
TRG_ENDOCYTIC_2	246	249	PF00928	0.331
TRG_ENDOCYTIC_2	252	255	PF00928	0.332
TRG_ENDOCYTIC_2	301	304	PF00928	0.392
TRG_ER_diArg_1	103	105	PF00400	0.446
TRG_ER_diArg_1	14	16	PF00400	0.509
TRG_ER_diArg_1	219	221	PF00400	0.310
TRG_ER_diArg_1	280	282	PF00400	0.364
TRG_NLS_MonoCore_2	34	39	PF00514	0.274
TRG_NLS_MonoExtN_4	33	39	PF00514	0.281
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP7	Leptomonas seymouri	64%	100%
A0A3Q8IKF6	Leishmania donovani	91%	100%
A4HJT4	Leishmania braziliensis	82%	100%
A4I7A0	Leishmania infantum	91%	100%
P53164	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	85%
Q4Q5W3	Leishmania major	94%	100%
Q4R7L8	Macaca fascicularis	30%	70%
Q5RD76	Pongo abelii	30%	70%
Q94A82	Arabidopsis thaliana	33%	74%
Q9BQG2	Homo sapiens	30%	70%