AMP-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B293_LEIMU

TriTrypDb:

LmxM.30.2930

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B293

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B293

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.282
CLV_C14_Caspase3-7	183	187	PF00656	0.600
CLV_PCSK_SKI1_1	108	112	PF00082	0.293
CLV_PCSK_SKI1_1	65	69	PF00082	0.553
CLV_Separin_Metazoa	78	82	PF03568	0.424
DEG_Nend_UBRbox_3	1	3	PF02207	0.553
DEG_SCF_FBW7_2	97	104	PF00400	0.299
DOC_CDC14_PxL_1	196	204	PF14671	0.676
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.481
DOC_MAPK_DCC_7	145	155	PF00069	0.393
DOC_MAPK_gen_1	7	15	PF00069	0.476
DOC_MAPK_MEF2A_6	7	15	PF00069	0.476
DOC_PP1_RVXF_1	234	241	PF00149	0.495
DOC_PP2B_LxvP_1	42	45	PF13499	0.460
DOC_USP7_MATH_1	169	173	PF00917	0.546
DOC_USP7_MATH_1	3	7	PF00917	0.368
DOC_WW_Pin1_4	154	159	PF00397	0.612
DOC_WW_Pin1_4	167	172	PF00397	0.641
DOC_WW_Pin1_4	19	24	PF00397	0.658
DOC_WW_Pin1_4	89	94	PF00397	0.526
DOC_WW_Pin1_4	97	102	PF00397	0.470
LIG_14-3-3_CanoR_1	108	113	PF00244	0.558
LIG_14-3-3_CanoR_1	208	218	PF00244	0.502
LIG_14-3-3_CanoR_1	65	70	PF00244	0.434
LIG_14-3-3_CanoR_1	7	12	PF00244	0.482
LIG_FHA_1	128	134	PF00498	0.508
LIG_FHA_1	19	25	PF00498	0.521
LIG_FHA_1	89	95	PF00498	0.431
LIG_FHA_1	98	104	PF00498	0.452
LIG_FHA_2	137	143	PF00498	0.537
LIG_FHA_2	66	72	PF00498	0.536
LIG_FHA_2	93	99	PF00498	0.454
LIG_LIR_Apic_2	163	169	PF02991	0.560
LIG_LIR_Apic_2	17	23	PF02991	0.568
LIG_LIR_Gen_1	132	143	PF02991	0.539
LIG_LIR_Gen_1	172	181	PF02991	0.589
LIG_LIR_Nem_3	132	138	PF02991	0.566
LIG_LIR_Nem_3	172	177	PF02991	0.583
LIG_LIR_Nem_3	197	202	PF02991	0.597
LIG_LIR_Nem_3	63	67	PF02991	0.509
LIG_LYPXL_yS_3	199	202	PF13949	0.619
LIG_NRBOX	230	236	PF00104	0.513
LIG_PDZ_Class_2	245	250	PF00595	0.585
LIG_SH2_CRK	135	139	PF00017	0.519
LIG_SH2_CRK	20	24	PF00017	0.575
LIG_SH2_CRK	64	68	PF00017	0.590
LIG_SH2_NCK_1	135	139	PF00017	0.493
LIG_SH2_STAP1	174	178	PF00017	0.639
LIG_SH2_STAT5	135	138	PF00017	0.524
LIG_SH2_STAT5	20	23	PF00017	0.575
LIG_SH3_1	145	151	PF00018	0.583
LIG_SH3_3	144	150	PF00018	0.567
LIG_SH3_3	152	158	PF00018	0.545
LIG_SH3_3	186	192	PF00018	0.587
LIG_SH3_3	215	221	PF00018	0.420
LIG_SUMO_SIM_anti_2	10	17	PF11976	0.472
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.451
LIG_SUMO_SIM_anti_2	91	98	PF11976	0.478
LIG_SUMO_SIM_par_1	10	17	PF11976	0.472
LIG_SUMO_SIM_par_1	136	142	PF11976	0.455
LIG_SUMO_SIM_par_1	151	157	PF11976	0.631
LIG_SUMO_SIM_par_1	65	71	PF11976	0.602
LIG_SUMO_SIM_par_1	91	98	PF11976	0.483
LIG_TRAF2_1	102	105	PF00917	0.353
LIG_TYR_ITIM	133	138	PF00017	0.333
LIG_TYR_ITIM	62	67	PF00017	0.580
LIG_UBA3_1	234	241	PF00899	0.495
MOD_CK1_1	122	128	PF00069	0.713
MOD_CK1_1	172	178	PF00069	0.632
MOD_CK1_1	180	186	PF00069	0.628
MOD_CK1_1	92	98	PF00069	0.448
MOD_CK2_1	126	132	PF00069	0.729
MOD_CK2_1	65	71	PF00069	0.524
MOD_GlcNHglycan	183	186	PF01048	0.674
MOD_GSK3_1	122	129	PF00069	0.588
MOD_GSK3_1	14	21	PF00069	0.510
MOD_GSK3_1	177	184	PF00069	0.622
MOD_GSK3_1	3	10	PF00069	0.546
MOD_GSK3_1	67	74	PF00069	0.531
MOD_GSK3_1	88	95	PF00069	0.475
MOD_N-GLC_1	60	65	PF02516	0.512
MOD_N-GLC_2	227	229	PF02516	0.611
MOD_NEK2_1	14	19	PF00069	0.523
MOD_NEK2_1	177	182	PF00069	0.648
MOD_PK_1	7	13	PF00069	0.479
MOD_PKA_2	209	215	PF00069	0.637
MOD_Plk_1	60	66	PF00069	0.511
MOD_Plk_4	108	114	PF00069	0.458
MOD_Plk_4	133	139	PF00069	0.494
MOD_Plk_4	169	175	PF00069	0.591
MOD_Plk_4	92	98	PF00069	0.445
MOD_ProDKin_1	154	160	PF00069	0.613
MOD_ProDKin_1	167	173	PF00069	0.636
MOD_ProDKin_1	19	25	PF00069	0.650
MOD_ProDKin_1	89	95	PF00069	0.523
MOD_ProDKin_1	97	103	PF00069	0.477
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.554
TRG_ENDOCYTIC_2	135	138	PF00928	0.524
TRG_ENDOCYTIC_2	174	177	PF00928	0.676
TRG_ENDOCYTIC_2	199	202	PF00928	0.566
TRG_ENDOCYTIC_2	64	67	PF00928	0.541
TRG_ER_diArg_1	207	210	PF00400	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJH1	Leptomonas seymouri	47%	97%
A0A3Q8IF52	Leishmania donovani	88%	100%
A0A3R7LVK8	Trypanosoma rangeli	25%	100%
A4HJT2	Leishmania braziliensis	70%	100%
A4I798	Leishmania infantum	88%	100%
Q4Q5W5	Leishmania major	87%	100%