Inositol monophosphatase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol polyphosphate 1-phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9B292_LEIMU

TriTrypDb:

LmxM.30.2920

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B292

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B292

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0006066	alcohol metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009987	cellular process	1	11
GO:0016311	dephosphorylation	5	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019751	polyol metabolic process	4	11
GO:0043647	inositol phosphate metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044262	obsolete cellular carbohydrate metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044282	small molecule catabolic process	3	11
GO:0046164	alcohol catabolic process	4	11
GO:0046174	polyol catabolic process	5	11
GO:0046434	organophosphate catabolic process	4	11
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	11
GO:0046855	obsolete inositol phosphate dephosphorylation	5	11
GO:0071545	inositol phosphate catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901575	organic substance catabolic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901616	organic hydroxy compound catabolic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity	8	5
GO:0016312	inositol bisphosphate phosphatase activity	7	5
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016791	phosphatase activity	5	5
GO:0042578	phosphoric ester hydrolase activity	4	5
GO:0052745	inositol phosphate phosphatase activity	6	5
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	96	100	PF00656	0.362
CLV_NRD_NRD_1	285	287	PF00675	0.330
CLV_NRD_NRD_1	47	49	PF00675	0.369
CLV_PCSK_KEX2_1	285	287	PF00082	0.330
CLV_PCSK_KEX2_1	46	48	PF00082	0.370
CLV_PCSK_SKI1_1	163	167	PF00082	0.464
CLV_PCSK_SKI1_1	194	198	PF00082	0.326
DEG_COP1_1	104	115	PF00400	0.155
DOC_CKS1_1	119	124	PF01111	0.394
DOC_CKS1_1	206	211	PF01111	0.219
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.401
DOC_MAPK_DCC_7	109	117	PF00069	0.362
DOC_MAPK_FxFP_2	91	94	PF00069	0.401
DOC_MAPK_gen_1	285	293	PF00069	0.508
DOC_MAPK_gen_1	46	53	PF00069	0.281
DOC_MAPK_MEF2A_6	109	117	PF00069	0.362
DOC_MAPK_MEF2A_6	46	53	PF00069	0.276
DOC_PP1_RVXF_1	283	290	PF00149	0.375
DOC_PP4_FxxP_1	166	169	PF00568	0.155
DOC_PP4_FxxP_1	213	216	PF00568	0.276
DOC_PP4_FxxP_1	52	55	PF00568	0.247
DOC_PP4_FxxP_1	91	94	PF00568	0.401
DOC_WW_Pin1_4	118	123	PF00397	0.417
DOC_WW_Pin1_4	149	154	PF00397	0.364
DOC_WW_Pin1_4	205	210	PF00397	0.334
DOC_WW_Pin1_4	258	263	PF00397	0.580
DOC_WW_Pin1_4	273	278	PF00397	0.420
DOC_WW_Pin1_4	66	71	PF00397	0.155
LIG_14-3-3_CanoR_1	140	144	PF00244	0.277
LIG_14-3-3_CanoR_1	158	167	PF00244	0.369
LIG_14-3-3_CanoR_1	286	292	PF00244	0.430
LIG_APCC_ABBA_1	49	54	PF00400	0.203
LIG_APCC_ABBAyCdc20_2	48	54	PF00400	0.247
LIG_BIR_II_1	1	5	PF00653	0.548
LIG_eIF4E_1	187	193	PF01652	0.401
LIG_FHA_1	119	125	PF00498	0.359
LIG_FHA_1	160	166	PF00498	0.378
LIG_FHA_1	267	273	PF00498	0.494
LIG_FHA_1	288	294	PF00498	0.519
LIG_FHA_2	159	165	PF00498	0.354
LIG_FHA_2	170	176	PF00498	0.354
LIG_FHA_2	206	212	PF00498	0.401
LIG_FHA_2	94	100	PF00498	0.376
LIG_GBD_Chelix_1	283	291	PF00786	0.389
LIG_LIR_Apic_2	164	169	PF02991	0.155
LIG_LIR_Apic_2	211	216	PF02991	0.276
LIG_LIR_Apic_2	64	70	PF02991	0.265
LIG_LIR_Gen_1	126	136	PF02991	0.391
LIG_LIR_Gen_1	16	23	PF02991	0.543
LIG_LIR_Nem_3	126	131	PF02991	0.391
LIG_LIR_Nem_3	16	21	PF02991	0.477
LIG_LYPXL_yS_3	249	252	PF13949	0.394
LIG_PTB_Apo_2	85	92	PF02174	0.276
LIG_SH2_CRK	190	194	PF00017	0.401
LIG_SH2_CRK	5	9	PF00017	0.599
LIG_SH2_STAP1	13	17	PF00017	0.480
LIG_SH3_3	133	139	PF00018	0.355
LIG_SH3_3	203	209	PF00018	0.413
LIG_SH3_3	211	217	PF00018	0.392
LIG_SUMO_SIM_anti_2	114	119	PF11976	0.216
LIG_SUMO_SIM_anti_2	290	295	PF11976	0.321
LIG_SUMO_SIM_par_1	269	276	PF11976	0.442
LIG_TYR_ITIM	247	252	PF00017	0.354
LIG_TYR_ITIM	90	95	PF00017	0.349
MOD_CK1_1	159	165	PF00069	0.285
MOD_CK1_1	24	30	PF00069	0.477
MOD_CK1_1	69	75	PF00069	0.171
MOD_CK2_1	158	164	PF00069	0.401
MOD_CK2_1	169	175	PF00069	0.401
MOD_GlcNHglycan	262	265	PF01048	0.478
MOD_GlcNHglycan	8	11	PF01048	0.515
MOD_LATS_1	4	10	PF00433	0.441
MOD_NEK2_1	251	256	PF00069	0.288
MOD_NEK2_1	287	292	PF00069	0.398
MOD_PIKK_1	169	175	PF00454	0.380
MOD_PKA_2	139	145	PF00069	0.325
MOD_PKA_2	157	163	PF00069	0.332
MOD_Plk_4	113	119	PF00069	0.270
MOD_Plk_4	289	295	PF00069	0.366
MOD_Plk_4	69	75	PF00069	0.276
MOD_ProDKin_1	118	124	PF00069	0.417
MOD_ProDKin_1	149	155	PF00069	0.364
MOD_ProDKin_1	205	211	PF00069	0.334
MOD_ProDKin_1	258	264	PF00069	0.575
MOD_ProDKin_1	273	279	PF00069	0.418
MOD_ProDKin_1	66	72	PF00069	0.155
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.394
TRG_ENDOCYTIC_2	18	21	PF00928	0.399
TRG_ENDOCYTIC_2	190	193	PF00928	0.401
TRG_ENDOCYTIC_2	249	252	PF00928	0.354
TRG_ENDOCYTIC_2	5	8	PF00928	0.553
TRG_ENDOCYTIC_2	92	95	PF00928	0.290
TRG_ER_diArg_1	285	287	PF00400	0.346
TRG_ER_diArg_1	45	48	PF00400	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U3	Leptomonas seymouri	58%	68%
A0A1X0NIY3	Trypanosomatidae	41%	75%
A0A3R7KA15	Trypanosoma rangeli	39%	69%
A0A3S5H7Q8	Leishmania donovani	90%	100%
A4HJT1	Leishmania braziliensis	75%	100%
A4I797	Leishmania infantum	90%	100%
C9ZWL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	76%
P21327	Bos taurus	27%	74%
P49442	Mus musculus	26%	74%
Q4Q5W6	Leishmania major	86%	100%
V5AS37	Trypanosoma cruzi	39%	76%