Putative nucleoporin (NUP54/57)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP62

Species:

Leishmania mexicana

UniProt:

E9B289_LEIMU

TriTrypDb:

LmxM.30.2900

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	8
GO:0032991	protein-containing complex	1	8
GO:0140513	nuclear protein-containing complex	2	8
GO:0044613	nuclear pore central transport channel	3	1

Expansion

Sequence features

E9B289

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B289

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	1
GO:0006607	NLS-bearing protein import into nucleus	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0006996	organelle organization	4	1
GO:0006997	nucleus organization	5	1
GO:0006999	nuclear pore organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0036228	protein localization to nuclear inner membrane	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090435	protein localization to nuclear envelope	7	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	1
GO:0017056	structural constituent of nuclear pore	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	250	252	PF00675	0.410
CLV_NRD_NRD_1	285	287	PF00675	0.381
CLV_NRD_NRD_1	312	314	PF00675	0.369
CLV_NRD_NRD_1	331	333	PF00675	0.234
CLV_NRD_NRD_1	379	381	PF00675	0.495
CLV_PCSK_KEX2_1	250	252	PF00082	0.352
CLV_PCSK_KEX2_1	285	287	PF00082	0.381
CLV_PCSK_KEX2_1	312	314	PF00082	0.369
CLV_PCSK_KEX2_1	379	381	PF00082	0.495
CLV_PCSK_SKI1_1	264	268	PF00082	0.307
CLV_PCSK_SKI1_1	332	336	PF00082	0.352
CLV_PCSK_SKI1_1	349	353	PF00082	0.302
CLV_Separin_Metazoa	247	251	PF03568	0.307
CLV_Separin_Metazoa	309	313	PF03568	0.355
DEG_Nend_Nbox_1	1	3	PF02207	0.735
DEG_SPOP_SBC_1	61	65	PF00917	0.522
DOC_MAPK_gen_1	250	261	PF00069	0.352
DOC_PP2B_LxvP_1	335	338	PF13499	0.338
DOC_PP4_FxxP_1	113	116	PF00568	0.711
DOC_PP4_FxxP_1	59	62	PF00568	0.662
DOC_USP7_MATH_1	167	171	PF00917	0.444
DOC_USP7_MATH_1	437	441	PF00917	0.554
DOC_USP7_MATH_1	62	66	PF00917	0.639
DOC_USP7_UBL2_3	260	264	PF12436	0.307
DOC_USP7_UBL2_3	429	433	PF12436	0.461
DOC_WW_Pin1_4	237	242	PF00397	0.329
DOC_WW_Pin1_4	49	54	PF00397	0.634
LIG_14-3-3_CanoR_1	164	172	PF00244	0.474
LIG_14-3-3_CanoR_1	300	305	PF00244	0.343
LIG_14-3-3_CanoR_1	313	323	PF00244	0.352
LIG_14-3-3_CanoR_1	349	359	PF00244	0.398
LIG_14-3-3_CanoR_1	390	398	PF00244	0.450
LIG_BRCT_BRCA1_1	14	18	PF00533	0.465
LIG_BRCT_BRCA1_2	14	20	PF00533	0.465
LIG_Clathr_ClatBox_1	172	176	PF01394	0.395
LIG_deltaCOP1_diTrp_1	409	413	PF00928	0.411
LIG_FHA_1	154	160	PF00498	0.588
LIG_FHA_1	209	215	PF00498	0.486
LIG_FHA_1	25	31	PF00498	0.641
LIG_FHA_1	265	271	PF00498	0.307
LIG_FHA_2	156	162	PF00498	0.581
LIG_FHA_2	421	427	PF00498	0.425
LIG_LIR_Apic_2	111	116	PF02991	0.635
LIG_LIR_Apic_2	57	62	PF02991	0.589
LIG_LIR_Gen_1	176	184	PF02991	0.383
LIG_LIR_Gen_1	409	417	PF02991	0.414
LIG_LIR_Nem_3	176	182	PF02991	0.384
LIG_LIR_Nem_3	208	213	PF02991	0.417
LIG_LIR_Nem_3	409	413	PF02991	0.426
LIG_NRBOX	330	336	PF00104	0.460
LIG_NRBOX	423	429	PF00104	0.455
LIG_PCNA_PIPBox_1	165	174	PF02747	0.401
LIG_PCNA_yPIPBox_3	164	172	PF02747	0.474
LIG_PCNA_yPIPBox_3	256	270	PF02747	0.307
LIG_Pex14_2	55	59	PF04695	0.648
LIG_SH2_CRK	179	183	PF00017	0.388
LIG_SH2_CRK	302	306	PF00017	0.338
LIG_SH2_GRB2like	213	216	PF00017	0.504
LIG_SH2_SRC	213	216	PF00017	0.450
LIG_SH2_STAP1	210	214	PF00017	0.524
LIG_SH2_STAT5	171	174	PF00017	0.428
LIG_SH2_STAT5	210	213	PF00017	0.522
LIG_SH2_STAT5	405	408	PF00017	0.363
LIG_SH3_3	141	147	PF00018	0.702
LIG_SUMO_SIM_par_1	155	161	PF11976	0.665
MOD_CK1_1	108	114	PF00069	0.609
MOD_CK1_1	28	34	PF00069	0.615
MOD_CK1_1	78	84	PF00069	0.768
MOD_CK2_1	314	320	PF00069	0.355
MOD_CK2_1	323	329	PF00069	0.262
MOD_CK2_1	420	426	PF00069	0.429
MOD_CK2_1	437	443	PF00069	0.352
MOD_GlcNHglycan	107	110	PF01048	0.653
MOD_GlcNHglycan	14	17	PF01048	0.618
MOD_GlcNHglycan	165	168	PF01048	0.499
MOD_GlcNHglycan	30	33	PF01048	0.576
MOD_GlcNHglycan	365	368	PF01048	0.593
MOD_GlcNHglycan	383	386	PF01048	0.649
MOD_GlcNHglycan	49	52	PF01048	0.561
MOD_GlcNHglycan	65	68	PF01048	0.590
MOD_GlcNHglycan	72	75	PF01048	0.686
MOD_GlcNHglycan	77	80	PF01048	0.603
MOD_GlcNHglycan	86	89	PF01048	0.505
MOD_GSK3_1	114	121	PF00069	0.675
MOD_GSK3_1	163	170	PF00069	0.492
MOD_GSK3_1	2	9	PF00069	0.510
MOD_GSK3_1	20	27	PF00069	0.620
MOD_GSK3_1	28	35	PF00069	0.645
MOD_GSK3_1	350	357	PF00069	0.401
MOD_GSK3_1	363	370	PF00069	0.411
MOD_GSK3_1	70	77	PF00069	0.665
MOD_GSK3_1	80	87	PF00069	0.618
MOD_N-GLC_1	33	38	PF02516	0.739
MOD_N-GLC_1	367	372	PF02516	0.555
MOD_N-GLC_2	194	196	PF02516	0.360
MOD_NEK2_1	105	110	PF00069	0.592
MOD_NEK2_1	175	180	PF00069	0.482
MOD_NEK2_1	2	7	PF00069	0.575
MOD_NEK2_1	25	30	PF00069	0.641
MOD_NEK2_1	323	328	PF00069	0.355
MOD_NEK2_1	33	38	PF00069	0.455
MOD_NEK2_1	381	386	PF00069	0.561
MOD_NEK2_1	75	80	PF00069	0.598
MOD_PIKK_1	242	248	PF00454	0.385
MOD_PIKK_1	360	366	PF00454	0.508
MOD_PKA_1	264	270	PF00069	0.318
MOD_PKA_2	163	169	PF00069	0.486
MOD_PKA_2	208	214	PF00069	0.480
MOD_PKA_2	249	255	PF00069	0.355
MOD_PKA_2	389	395	PF00069	0.456
MOD_Plk_1	175	181	PF00069	0.458
MOD_Plk_1	354	360	PF00069	0.487
MOD_Plk_4	167	173	PF00069	0.466
MOD_Plk_4	25	31	PF00069	0.462
MOD_Plk_4	300	306	PF00069	0.297
MOD_ProDKin_1	237	243	PF00069	0.329
MOD_ProDKin_1	49	55	PF00069	0.639
MOD_SUMO_rev_2	426	435	PF00179	0.464
TRG_DiLeu_BaEn_2	346	352	PF01217	0.462
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.459
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.556
TRG_ENDOCYTIC_2	179	182	PF00928	0.413
TRG_ENDOCYTIC_2	302	305	PF00928	0.319
TRG_ER_diArg_1	249	251	PF00400	0.437
TRG_ER_diArg_1	284	286	PF00400	0.395
TRG_ER_diArg_1	311	313	PF00400	0.358
TRG_ER_diArg_1	379	381	PF00400	0.495
TRG_ER_diArg_1	438	441	PF00400	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JWT3	Bodo saltans	33%	95%
A0A3Q8ICT1	Leishmania donovani	88%	99%
A0A3R7KYW1	Trypanosoma rangeli	40%	100%
A4HJS8	Leishmania braziliensis	75%	100%
A4I794	Leishmania infantum	86%	99%
O42963	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
P48837	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	82%
Q4Q5W9	Leishmania major	80%	99%