Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B285_LEIMU

TriTrypDb:

LmxM.30.2860

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B285

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B285

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006260	DNA replication	5	1
GO:0006281	DNA repair	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0007059	chromosome segregation	2	1
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035556	intracellular signal transduction	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0065007	biological regulation	1	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.460
CLV_C14_Caspase3-7	21	25	PF00656	0.583
CLV_C14_Caspase3-7	287	291	PF00656	0.528
CLV_C14_Caspase3-7	68	72	PF00656	0.572
CLV_C14_Caspase3-7	96	100	PF00656	0.701
CLV_NRD_NRD_1	123	125	PF00675	0.517
CLV_NRD_NRD_1	169	171	PF00675	0.517
CLV_NRD_NRD_1	211	213	PF00675	0.369
CLV_NRD_NRD_1	335	337	PF00675	0.332
CLV_NRD_NRD_1	585	587	PF00675	0.260
CLV_NRD_NRD_1	644	646	PF00675	0.498
CLV_PCSK_KEX2_1	123	125	PF00082	0.657
CLV_PCSK_KEX2_1	169	171	PF00082	0.517
CLV_PCSK_KEX2_1	17	19	PF00082	0.573
CLV_PCSK_KEX2_1	211	213	PF00082	0.369
CLV_PCSK_KEX2_1	254	256	PF00082	0.341
CLV_PCSK_KEX2_1	335	337	PF00082	0.332
CLV_PCSK_KEX2_1	452	454	PF00082	0.236
CLV_PCSK_KEX2_1	575	577	PF00082	0.236
CLV_PCSK_KEX2_1	585	587	PF00082	0.236
CLV_PCSK_KEX2_1	644	646	PF00082	0.498
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.573
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.408
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.236
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.308
CLV_PCSK_PC7_1	207	213	PF00082	0.365
CLV_PCSK_SKI1_1	123	127	PF00082	0.511
CLV_PCSK_SKI1_1	211	215	PF00082	0.375
CLV_PCSK_SKI1_1	242	246	PF00082	0.442
CLV_PCSK_SKI1_1	327	331	PF00082	0.362
CLV_PCSK_SKI1_1	356	360	PF00082	0.309
CLV_PCSK_SKI1_1	455	459	PF00082	0.318
CLV_PCSK_SKI1_1	463	467	PF00082	0.258
DEG_APCC_DBOX_1	355	363	PF00400	0.271
DEG_Nend_UBRbox_2	1	3	PF02207	0.698
DEG_SCF_FBW7_1	603	609	PF00400	0.230
DEG_SCF_FBW7_1	664	670	PF00400	0.426
DEG_SPOP_SBC_1	658	662	PF00917	0.681
DEG_SPOP_SBC_1	85	89	PF00917	0.743
DOC_ANK_TNKS_1	575	582	PF00023	0.236
DOC_CKS1_1	45	50	PF01111	0.615
DOC_CKS1_1	603	608	PF01111	0.230
DOC_CKS1_1	664	669	PF01111	0.425
DOC_CYCLIN_RxL_1	239	250	PF00134	0.341
DOC_CYCLIN_yCln2_LP_2	479	485	PF00134	0.380
DOC_MAPK_gen_1	169	176	PF00069	0.507
DOC_MAPK_gen_1	240	248	PF00069	0.372
DOC_MAPK_MEF2A_6	240	248	PF00069	0.409
DOC_MAPK_MEF2A_6	430	438	PF00069	0.380
DOC_PP1_RVXF_1	461	467	PF00149	0.380
DOC_PP1_RVXF_1	596	603	PF00149	0.271
DOC_PP2B_LxvP_1	346	349	PF13499	0.426
DOC_PP2B_LxvP_1	665	668	PF13499	0.634
DOC_PP4_FxxP_1	125	128	PF00568	0.664
DOC_USP7_MATH_1	606	610	PF00917	0.236
DOC_USP7_MATH_1	653	657	PF00917	0.512
DOC_USP7_MATH_1	93	97	PF00917	0.641
DOC_USP7_UBL2_3	328	332	PF12436	0.373
DOC_WW_Pin1_4	44	49	PF00397	0.675
DOC_WW_Pin1_4	478	483	PF00397	0.380
DOC_WW_Pin1_4	549	554	PF00397	0.236
DOC_WW_Pin1_4	602	607	PF00397	0.230
DOC_WW_Pin1_4	663	668	PF00397	0.691
DOC_WW_Pin1_4	670	675	PF00397	0.694
DOC_WW_Pin1_4	86	91	PF00397	0.678
LIG_14-3-3_CanoR_1	240	245	PF00244	0.402
LIG_14-3-3_CanoR_1	302	309	PF00244	0.472
LIG_14-3-3_CanoR_1	453	458	PF00244	0.250
LIG_14-3-3_CanoR_1	474	480	PF00244	0.389
LIG_Actin_WH2_2	306	321	PF00022	0.414
LIG_APCC_ABBA_1	493	498	PF00400	0.380
LIG_deltaCOP1_diTrp_1	370	375	PF00928	0.236
LIG_deltaCOP1_diTrp_1	560	568	PF00928	0.236
LIG_DLG_GKlike_1	430	438	PF00625	0.133
LIG_eIF4E_1	357	363	PF01652	0.236
LIG_EVH1_2	543	547	PF00568	0.236
LIG_FHA_1	137	143	PF00498	0.569
LIG_FHA_1	241	247	PF00498	0.445
LIG_FHA_1	308	314	PF00498	0.479
LIG_FHA_1	398	404	PF00498	0.308
LIG_FHA_1	44	50	PF00498	0.667
LIG_FHA_1	550	556	PF00498	0.236
LIG_FHA_1	603	609	PF00498	0.230
LIG_FHA_1	660	666	PF00498	0.470
LIG_FHA_1	86	92	PF00498	0.674
LIG_FHA_2	24	30	PF00498	0.558
LIG_FHA_2	310	316	PF00498	0.465
LIG_FHA_2	319	325	PF00498	0.477
LIG_FHA_2	348	354	PF00498	0.474
LIG_FHA_2	454	460	PF00498	0.334
LIG_FHA_2	499	505	PF00498	0.380
LIG_FHA_2	516	522	PF00498	0.380
LIG_Integrin_RGD_1	430	432	PF01839	0.380
LIG_LIR_Apic_2	538	544	PF02991	0.236
LIG_LIR_Gen_1	189	199	PF02991	0.453
LIG_LIR_Gen_1	243	251	PF02991	0.407
LIG_LIR_Gen_1	342	351	PF02991	0.346
LIG_LIR_Gen_1	355	363	PF02991	0.211
LIG_LIR_Gen_1	422	429	PF02991	0.236
LIG_LIR_Gen_1	432	441	PF02991	0.236
LIG_LIR_LC3C_4	52	56	PF02991	0.617
LIG_LIR_Nem_3	189	194	PF02991	0.422
LIG_LIR_Nem_3	243	248	PF02991	0.412
LIG_LIR_Nem_3	342	348	PF02991	0.378
LIG_LIR_Nem_3	369	375	PF02991	0.236
LIG_LIR_Nem_3	422	428	PF02991	0.236
LIG_LIR_Nem_3	432	438	PF02991	0.236
LIG_LIR_Nem_3	536	542	PF02991	0.239
LIG_NRBOX	358	364	PF00104	0.271
LIG_Pex14_2	368	372	PF04695	0.236
LIG_Rb_pABgroove_1	419	427	PF01858	0.236
LIG_SH2_CRK	133	137	PF00017	0.524
LIG_SH2_CRK	569	573	PF00017	0.236
LIG_SH2_GRB2like	441	444	PF00017	0.308
LIG_SH2_SRC	541	544	PF00017	0.236
LIG_SH2_STAT5	357	360	PF00017	0.236
LIG_SH2_STAT5	382	385	PF00017	0.236
LIG_SH2_STAT5	402	405	PF00017	0.110
LIG_SH2_STAT5	450	453	PF00017	0.380
LIG_SH2_STAT5	475	478	PF00017	0.236
LIG_SH2_STAT5	541	544	PF00017	0.279
LIG_SH2_STAT5	638	641	PF00017	0.339
LIG_SH3_3	42	48	PF00018	0.615
LIG_SH3_3	55	61	PF00018	0.496
LIG_SH3_3	6	12	PF00018	0.514
LIG_SH3_3	600	606	PF00018	0.236
LIG_SH3_3	666	672	PF00018	0.627
LIG_SH3_3	67	73	PF00018	0.638
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.271
LIG_SUMO_SIM_par_1	52	59	PF11976	0.691
LIG_TRAF2_1	19	22	PF00917	0.650
LIG_TRAF2_1	26	29	PF00917	0.754
LIG_TRAF2_1	273	276	PF00917	0.535
LIG_TRFH_1	486	490	PF08558	0.236
LIG_TYR_ITIM	567	572	PF00017	0.236
LIG_UBA3_1	359	365	PF00899	0.236
LIG_UBA3_1	502	506	PF00899	0.380
LIG_UBA3_1	567	575	PF00899	0.363
LIG_WRC_WIRS_1	454	459	PF05994	0.250
MOD_CDK_SPK_2	549	554	PF00069	0.236
MOD_CDK_SPK_2	602	607	PF00069	0.230
MOD_CK1_1	114	120	PF00069	0.621
MOD_CK1_1	31	37	PF00069	0.700
MOD_CK1_1	44	50	PF00069	0.663
MOD_CK1_1	478	484	PF00069	0.377
MOD_CK1_1	533	539	PF00069	0.271
MOD_CK1_1	596	602	PF00069	0.236
MOD_CK1_1	643	649	PF00069	0.539
MOD_CK1_1	660	666	PF00069	0.433
MOD_CK2_1	148	154	PF00069	0.544
MOD_CK2_1	23	29	PF00069	0.624
MOD_CK2_1	318	324	PF00069	0.549
MOD_CK2_1	347	353	PF00069	0.473
MOD_CK2_1	434	440	PF00069	0.236
MOD_CK2_1	453	459	PF00069	0.236
MOD_CK2_1	515	521	PF00069	0.304
MOD_Cter_Amidation	167	170	PF01082	0.442
MOD_Cter_Amidation	573	576	PF01082	0.236
MOD_GlcNHglycan	116	119	PF01048	0.635
MOD_GlcNHglycan	200	203	PF01048	0.477
MOD_GlcNHglycan	280	284	PF01048	0.586
MOD_GlcNHglycan	31	34	PF01048	0.507
MOD_GlcNHglycan	562	565	PF01048	0.440
MOD_GlcNHglycan	595	598	PF01048	0.236
MOD_GlcNHglycan	645	648	PF01048	0.624
MOD_GlcNHglycan	651	654	PF01048	0.617
MOD_GlcNHglycan	655	658	PF01048	0.544
MOD_GlcNHglycan	67	70	PF01048	0.580
MOD_GlcNHglycan	95	98	PF01048	0.701
MOD_GSK3_1	108	115	PF00069	0.626
MOD_GSK3_1	144	151	PF00069	0.535
MOD_GSK3_1	226	233	PF00069	0.566
MOD_GSK3_1	31	38	PF00069	0.713
MOD_GSK3_1	430	437	PF00069	0.173
MOD_GSK3_1	521	528	PF00069	0.284
MOD_GSK3_1	529	536	PF00069	0.272
MOD_GSK3_1	549	556	PF00069	0.236
MOD_GSK3_1	602	609	PF00069	0.264
MOD_GSK3_1	639	646	PF00069	0.451
MOD_GSK3_1	649	656	PF00069	0.536
MOD_GSK3_1	659	666	PF00069	0.493
MOD_GSK3_1	91	98	PF00069	0.707
MOD_NEK2_1	113	118	PF00069	0.709
MOD_NEK2_1	221	226	PF00069	0.423
MOD_NEK2_1	261	266	PF00069	0.261
MOD_NEK2_1	309	314	PF00069	0.394
MOD_NEK2_1	434	439	PF00069	0.244
MOD_NEK2_1	510	515	PF00069	0.330
MOD_NEK2_1	547	552	PF00069	0.248
MOD_NEK2_1	639	644	PF00069	0.448
MOD_PIKK_1	249	255	PF00454	0.493
MOD_PIKK_1	530	536	PF00454	0.236
MOD_PIKK_1	580	586	PF00454	0.236
MOD_PIKK_1	631	637	PF00454	0.251
MOD_PKA_2	148	154	PF00069	0.544
MOD_PKA_2	301	307	PF00069	0.476
MOD_PKA_2	553	559	PF00069	0.236
MOD_PKA_2	640	646	PF00069	0.458
MOD_PKB_1	18	26	PF00069	0.651
MOD_PKB_1	277	285	PF00069	0.570
MOD_Plk_1	23	29	PF00069	0.517
MOD_Plk_1	41	47	PF00069	0.579
MOD_Plk_2-3	498	504	PF00069	0.380
MOD_Plk_2-3	525	531	PF00069	0.236
MOD_Plk_4	190	196	PF00069	0.570
MOD_Plk_4	230	236	PF00069	0.533
MOD_Plk_4	430	436	PF00069	0.171
MOD_Plk_4	446	452	PF00069	0.303
MOD_Plk_4	498	504	PF00069	0.325
MOD_Plk_4	535	541	PF00069	0.236
MOD_Plk_4	660	666	PF00069	0.463
MOD_ProDKin_1	44	50	PF00069	0.676
MOD_ProDKin_1	478	484	PF00069	0.380
MOD_ProDKin_1	549	555	PF00069	0.236
MOD_ProDKin_1	602	608	PF00069	0.230
MOD_ProDKin_1	663	669	PF00069	0.690
MOD_ProDKin_1	670	676	PF00069	0.699
MOD_ProDKin_1	86	92	PF00069	0.678
MOD_SUMO_for_1	142	145	PF00179	0.499
MOD_SUMO_rev_2	322	330	PF00179	0.336
MOD_SUMO_rev_2	481	491	PF00179	0.355
MOD_SUMO_rev_2	498	508	PF00179	0.159
MOD_SUMO_rev_2	609	615	PF00179	0.236
TRG_DiLeu_BaEn_2	325	331	PF01217	0.355
TRG_DiLeu_BaEn_3	610	616	PF01217	0.262
TRG_DiLeu_BaEn_4	256	262	PF01217	0.425
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.251
TRG_ENDOCYTIC_2	133	136	PF00928	0.527
TRG_ENDOCYTIC_2	357	360	PF00928	0.270
TRG_ENDOCYTIC_2	425	428	PF00928	0.271
TRG_ENDOCYTIC_2	454	457	PF00928	0.330
TRG_ENDOCYTIC_2	539	542	PF00928	0.244
TRG_ENDOCYTIC_2	569	572	PF00928	0.254
TRG_ER_diArg_1	123	125	PF00400	0.661
TRG_ER_diArg_1	211	213	PF00400	0.499
TRG_ER_diArg_1	334	336	PF00400	0.351
TRG_ER_diArg_1	585	587	PF00400	0.260
TRG_ER_diArg_1	73	76	PF00400	0.630
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	585	589	PF00026	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBJ1	Leptomonas seymouri	78%	99%
A0A1X0NJ50	Trypanosomatidae	59%	100%
A0A3S5IR34	Trypanosoma rangeli	58%	100%
A0A3S7WQK7	Leishmania donovani	22%	100%
A0A3S7X4W6	Leishmania donovani	97%	100%
A4HJS4	Leishmania braziliensis	91%	100%
A4HTV4	Leishmania infantum	22%	100%
A4I790	Leishmania infantum	97%	100%
C9ZMG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
C9ZWL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
O55047	Mus musculus	35%	94%
Q08CW1	Xenopus tropicalis	36%	97%
Q1ECX4	Danio rerio	35%	97%
Q39238	Arabidopsis thaliana	35%	98%
Q4Q5X3	Leishmania major	96%	100%
Q86UE8	Homo sapiens	38%	88%
Q8C0V0	Mus musculus	38%	88%
Q90ZY6	Danio rerio	36%	89%
Q9UKI8	Homo sapiens	37%	88%
V5B7L8	Trypanosoma cruzi	61%	100%