Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B283_LEIMU

TriTrypDb:

LmxM.30.2840

Length:

384

Annotations

LeishMANIAdb annotations

Appears to be unique to Kinetoplastids, with very unclear topology, localization and function.. Despite the topology, no signal peptides are present, although a mitochondrial transit signal cannot be excluded

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9B283

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B283

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.551
CLV_NRD_NRD_1	47	49	PF00675	0.625
CLV_PCSK_KEX2_1	13	15	PF00082	0.552
CLV_PCSK_KEX2_1	370	372	PF00082	0.450
CLV_PCSK_KEX2_1	47	49	PF00082	0.625
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.446
CLV_PCSK_SKI1_1	59	63	PF00082	0.544
DEG_Nend_Nbox_1	1	3	PF02207	0.359
DOC_ANK_TNKS_1	359	366	PF00023	0.647
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.404
DOC_PP2B_LxvP_1	35	38	PF13499	0.320
DOC_SPAK_OSR1_1	253	257	PF12202	0.395
DOC_USP7_MATH_1	111	115	PF00917	0.346
DOC_USP7_MATH_1	276	280	PF00917	0.417
DOC_USP7_MATH_1	89	93	PF00917	0.413
DOC_WW_Pin1_4	13	18	PF00397	0.351
DOC_WW_Pin1_4	155	160	PF00397	0.634
DOC_WW_Pin1_4	85	90	PF00397	0.451
DOC_WW_Pin1_4	93	98	PF00397	0.461
LIG_14-3-3_CanoR_1	15	21	PF00244	0.328
LIG_14-3-3_CanoR_1	255	263	PF00244	0.290
LIG_14-3-3_CanoR_1	67	72	PF00244	0.374
LIG_BRCT_BRCA1_1	69	73	PF00533	0.426
LIG_Clathr_ClatBox_1	335	339	PF01394	0.552
LIG_deltaCOP1_diTrp_1	292	298	PF00928	0.492
LIG_EH_1	63	67	PF12763	0.336
LIG_eIF4E_1	330	336	PF01652	0.492
LIG_FHA_1	161	167	PF00498	0.662
LIG_FHA_1	18	24	PF00498	0.370
LIG_FHA_1	224	230	PF00498	0.509
LIG_FHA_1	237	243	PF00498	0.376
LIG_FHA_1	289	295	PF00498	0.576
LIG_FHA_1	347	353	PF00498	0.569
LIG_FHA_1	357	363	PF00498	0.594
LIG_FHA_2	155	161	PF00498	0.712
LIG_FHA_2	171	177	PF00498	0.481
LIG_FHA_2	287	293	PF00498	0.614
LIG_LIR_Gen_1	107	117	PF02991	0.444
LIG_LIR_Gen_1	196	205	PF02991	0.716
LIG_LIR_Gen_1	291	301	PF02991	0.525
LIG_LIR_Nem_3	107	112	PF02991	0.403
LIG_LIR_Nem_3	196	200	PF02991	0.716
LIG_LIR_Nem_3	295	301	PF02991	0.367
LIG_LIR_Nem_3	377	382	PF02991	0.678
LIG_NRBOX	237	243	PF00104	0.348
LIG_Pex14_2	130	134	PF04695	0.314
LIG_REV1ctd_RIR_1	132	143	PF16727	0.458
LIG_SH2_CRK	197	201	PF00017	0.764
LIG_SH2_CRK	379	383	PF00017	0.580
LIG_SH2_NCK_1	197	201	PF00017	0.769
LIG_SH2_PTP2	28	31	PF00017	0.329
LIG_SH2_STAP1	136	140	PF00017	0.554
LIG_SH2_STAT5	25	28	PF00017	0.333
LIG_SH2_STAT5	262	265	PF00017	0.306
LIG_SH2_STAT5	330	333	PF00017	0.350
LIG_SH3_2	43	48	PF14604	0.346
LIG_SH3_3	185	191	PF00018	0.707
LIG_SH3_3	26	32	PF00018	0.395
LIG_SH3_3	34	40	PF00018	0.394
LIG_SH3_3	358	364	PF00018	0.610
LIG_SH3_3	43	49	PF00018	0.390
LIG_SUMO_SIM_anti_2	162	169	PF11976	0.593
LIG_SUMO_SIM_anti_2	226	232	PF11976	0.413
LIG_SUMO_SIM_par_1	162	169	PF11976	0.593
LIG_SUMO_SIM_par_1	226	232	PF11976	0.346
LIG_UBA3_1	335	340	PF00899	0.558
LIG_WW_3	44	48	PF00397	0.346
MOD_CK1_1	16	22	PF00069	0.390
MOD_CK1_1	90	96	PF00069	0.425
MOD_CK2_1	286	292	PF00069	0.564
MOD_GlcNHglycan	307	310	PF01048	0.423
MOD_GlcNHglycan	372	375	PF01048	0.467
MOD_GlcNHglycan	379	382	PF01048	0.507
MOD_GSK3_1	13	20	PF00069	0.378
MOD_GSK3_1	166	173	PF00069	0.590
MOD_GSK3_1	276	283	PF00069	0.507
MOD_GSK3_1	288	295	PF00069	0.628
MOD_GSK3_1	366	373	PF00069	0.713
MOD_GSK3_1	377	384	PF00069	0.562
MOD_GSK3_1	85	92	PF00069	0.453
MOD_GSK3_1	93	100	PF00069	0.460
MOD_N-GLC_1	85	90	PF02516	0.638
MOD_N-GLC_1	93	98	PF02516	0.613
MOD_NEK2_1	113	118	PF00069	0.380
MOD_NEK2_1	170	175	PF00069	0.578
MOD_NEK2_1	249	254	PF00069	0.351
MOD_NEK2_1	286	291	PF00069	0.528
MOD_NEK2_1	305	310	PF00069	0.420
MOD_NEK2_1	324	329	PF00069	0.437
MOD_NEK2_1	5	10	PF00069	0.341
MOD_PIKK_1	346	352	PF00454	0.571
MOD_PKA_1	370	376	PF00069	0.648
MOD_PKA_2	104	110	PF00069	0.414
MOD_PKA_2	183	189	PF00069	0.664
MOD_PKA_2	346	352	PF00069	0.612
MOD_PKA_2	370	376	PF00069	0.700
MOD_PKB_1	13	21	PF00069	0.349
MOD_PKB_1	253	261	PF00069	0.218
MOD_Plk_1	280	286	PF00069	0.623
MOD_Plk_1	356	362	PF00069	0.645
MOD_Plk_4	223	229	PF00069	0.503
MOD_Plk_4	236	242	PF00069	0.327
MOD_Plk_4	244	250	PF00069	0.487
MOD_ProDKin_1	13	19	PF00069	0.349
MOD_ProDKin_1	155	161	PF00069	0.627
MOD_ProDKin_1	85	91	PF00069	0.450
MOD_ProDKin_1	93	99	PF00069	0.462
MOD_SUMO_rev_2	367	372	PF00179	0.679
TRG_ENDOCYTIC_2	197	200	PF00928	0.705
TRG_ENDOCYTIC_2	28	31	PF00928	0.329
TRG_ENDOCYTIC_2	379	382	PF00928	0.601
TRG_ER_diArg_1	13	15	PF00400	0.352
TRG_ER_diArg_1	182	185	PF00400	0.624
TRG_ER_diArg_1	46	48	PF00400	0.427
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U5	Leptomonas seymouri	69%	100%
A0A0S4JIB3	Bodo saltans	32%	100%
A0A1X0NIE1	Trypanosomatidae	44%	100%
A0A3R7NC34	Trypanosoma rangeli	44%	100%
A0A3S7X4W5	Leishmania donovani	89%	100%
A4HJS2	Leishmania braziliensis	81%	100%
A4I788	Leishmania infantum	89%	100%
C9ZMG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZWL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q5X5	Leishmania major	81%	98%
V5BC20	Trypanosoma cruzi	42%	100%