Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B282_LEIMU

TriTrypDb:

LmxM.30.2830

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B282

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B282

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.645
CLV_C14_Caspase3-7	198	202	PF00656	0.534
CLV_C14_Caspase3-7	56	60	PF00656	0.616
CLV_C14_Caspase3-7	65	69	PF00656	0.555
CLV_NRD_NRD_1	12	14	PF00675	0.597
CLV_NRD_NRD_1	123	125	PF00675	0.664
CLV_NRD_NRD_1	133	135	PF00675	0.678
CLV_NRD_NRD_1	140	142	PF00675	0.604
CLV_NRD_NRD_1	243	245	PF00675	0.542
CLV_NRD_NRD_1	251	253	PF00675	0.501
CLV_NRD_NRD_1	332	334	PF00675	0.510
CLV_NRD_NRD_1	425	427	PF00675	0.810
CLV_NRD_NRD_1	483	485	PF00675	0.684
CLV_NRD_NRD_1	522	524	PF00675	0.717
CLV_NRD_NRD_1	540	542	PF00675	0.551
CLV_NRD_NRD_1	557	559	PF00675	0.622
CLV_NRD_NRD_1	563	565	PF00675	0.678
CLV_NRD_NRD_1	614	616	PF00675	0.685
CLV_NRD_NRD_1	84	86	PF00675	0.707
CLV_PCSK_FUR_1	121	125	PF00082	0.601
CLV_PCSK_FUR_1	423	427	PF00082	0.548
CLV_PCSK_KEX2_1	123	125	PF00082	0.664
CLV_PCSK_KEX2_1	133	135	PF00082	0.678
CLV_PCSK_KEX2_1	140	142	PF00082	0.604
CLV_PCSK_KEX2_1	243	245	PF00082	0.542
CLV_PCSK_KEX2_1	251	253	PF00082	0.501
CLV_PCSK_KEX2_1	334	336	PF00082	0.514
CLV_PCSK_KEX2_1	425	427	PF00082	0.650
CLV_PCSK_KEX2_1	485	487	PF00082	0.682
CLV_PCSK_KEX2_1	521	523	PF00082	0.674
CLV_PCSK_KEX2_1	540	542	PF00082	0.540
CLV_PCSK_KEX2_1	563	565	PF00082	0.640
CLV_PCSK_KEX2_1	589	591	PF00082	0.666
CLV_PCSK_KEX2_1	609	611	PF00082	0.530
CLV_PCSK_KEX2_1	84	86	PF00082	0.707
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.514
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.663
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.674
CLV_PCSK_PC1ET2_1	589	591	PF00082	0.666
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.530
CLV_PCSK_PC7_1	119	125	PF00082	0.603
CLV_PCSK_PC7_1	518	524	PF00082	0.664
CLV_PCSK_SKI1_1	134	138	PF00082	0.690
CLV_PCSK_SKI1_1	170	174	PF00082	0.537
CLV_PCSK_SKI1_1	228	232	PF00082	0.510
CLV_PCSK_SKI1_1	264	268	PF00082	0.534
CLV_PCSK_SKI1_1	352	356	PF00082	0.543
CLV_PCSK_SKI1_1	586	590	PF00082	0.658
CLV_PCSK_SKI1_1	604	608	PF00082	0.543
DEG_APCC_DBOX_1	227	235	PF00400	0.507
DEG_APCC_DBOX_1	347	355	PF00400	0.523
DEG_SPOP_SBC_1	513	517	PF00917	0.542
DOC_CKS1_1	407	412	PF01111	0.527
DOC_CYCLIN_RxL_1	222	235	PF00134	0.517
DOC_CYCLIN_RxL_1	258	271	PF00134	0.536
DOC_MAPK_RevD_3	236	252	PF00069	0.526
DOC_PP4_FxxP_1	75	78	PF00568	0.618
DOC_USP7_MATH_1	147	151	PF00917	0.664
DOC_USP7_MATH_1	199	203	PF00917	0.570
DOC_USP7_MATH_1	221	225	PF00917	0.659
DOC_USP7_MATH_1	31	35	PF00917	0.657
DOC_USP7_MATH_1	41	45	PF00917	0.603
DOC_USP7_MATH_1	513	517	PF00917	0.566
DOC_USP7_MATH_1	542	546	PF00917	0.613
DOC_USP7_MATH_1	565	569	PF00917	0.652
DOC_USP7_MATH_1	611	615	PF00917	0.579
DOC_USP7_MATH_1	71	75	PF00917	0.780
DOC_USP7_MATH_2	146	152	PF00917	0.616
DOC_USP7_UBL2_3	485	489	PF12436	0.656
DOC_USP7_UBL2_3	495	499	PF12436	0.593
DOC_USP7_UBL2_3	555	559	PF12436	0.612
DOC_USP7_UBL2_3	603	607	PF12436	0.705
DOC_WW_Pin1_4	127	132	PF00397	0.696
DOC_WW_Pin1_4	142	147	PF00397	0.556
DOC_WW_Pin1_4	165	170	PF00397	0.668
DOC_WW_Pin1_4	406	411	PF00397	0.677
DOC_WW_Pin1_4	440	445	PF00397	0.536
DOC_WW_Pin1_4	591	596	PF00397	0.670
LIG_14-3-3_CanoR_1	13	17	PF00244	0.548
LIG_14-3-3_CanoR_1	133	139	PF00244	0.666
LIG_14-3-3_CanoR_1	140	146	PF00244	0.610
LIG_14-3-3_CanoR_1	22	31	PF00244	0.675
LIG_14-3-3_CanoR_1	243	249	PF00244	0.537
LIG_14-3-3_CanoR_1	251	256	PF00244	0.489
LIG_14-3-3_CanoR_1	258	266	PF00244	0.408
LIG_14-3-3_CanoR_1	423	433	PF00244	0.698
LIG_14-3-3_CanoR_1	558	563	PF00244	0.685
LIG_14-3-3_CanoR_1	590	595	PF00244	0.625
LIG_14-3-3_CanoR_1	610	617	PF00244	0.523
LIG_14-3-3_CanoR_1	93	102	PF00244	0.684
LIG_FHA_1	130	136	PF00498	0.600
LIG_FHA_1	258	264	PF00498	0.560
LIG_FHA_1	50	56	PF00498	0.626
LIG_FHA_2	204	210	PF00498	0.690
LIG_FHA_2	286	292	PF00498	0.486
LIG_FHA_2	307	313	PF00498	0.469
LIG_FHA_2	366	372	PF00498	0.659
LIG_FHA_2	453	459	PF00498	0.700
LIG_LIR_Apic_2	73	78	PF02991	0.613
LIG_LIR_Gen_1	265	273	PF02991	0.527
LIG_LIR_Gen_1	360	369	PF02991	0.525
LIG_LIR_Nem_3	224	230	PF02991	0.519
LIG_LIR_Nem_3	271	277	PF02991	0.557
LIG_LIR_Nem_3	360	365	PF02991	0.537
LIG_LIR_Nem_3	402	407	PF02991	0.671
LIG_NRBOX	350	356	PF00104	0.537
LIG_NRP_CendR_1	623	626	PF00754	0.648
LIG_PTB_Apo_2	69	76	PF02174	0.560
LIG_RPA_C_Fungi	247	259	PF08784	0.509
LIG_SH2_CRK	227	231	PF00017	0.514
LIG_SH2_CRK	80	84	PF00017	0.537
LIG_SH2_NCK_1	337	341	PF00017	0.625
LIG_SH2_SRC	337	340	PF00017	0.501
LIG_SH2_STAP1	337	341	PF00017	0.558
LIG_SH2_STAT5	293	296	PF00017	0.487
LIG_SH2_STAT5	318	321	PF00017	0.636
LIG_SH2_STAT5	353	356	PF00017	0.584
LIG_SH3_3	190	196	PF00018	0.606
LIG_SH3_3	280	286	PF00018	0.688
LIG_SH3_3	380	386	PF00018	0.640
LIG_SH3_3	404	410	PF00018	0.526
LIG_TRAF2_1	438	441	PF00917	0.683
MOD_CDC14_SPxK_1	130	133	PF00782	0.650
MOD_CDK_SPK_2	165	170	PF00069	0.690
MOD_CDK_SPK_2	406	411	PF00069	0.643
MOD_CDK_SPK_2	440	445	PF00069	0.536
MOD_CDK_SPxK_1	127	133	PF00069	0.705
MOD_CDK_SPxxK_3	127	134	PF00069	0.706
MOD_CK1_1	150	156	PF00069	0.612
MOD_CK1_1	164	170	PF00069	0.535
MOD_CK1_1	213	219	PF00069	0.616
MOD_CK1_1	247	253	PF00069	0.553
MOD_CK1_1	254	260	PF00069	0.485
MOD_CK1_1	424	430	PF00069	0.678
MOD_CK1_1	44	50	PF00069	0.658
MOD_CK1_1	526	532	PF00069	0.667
MOD_CK2_1	142	148	PF00069	0.596
MOD_CK2_1	165	171	PF00069	0.689
MOD_CK2_1	203	209	PF00069	0.692
MOD_CK2_1	306	312	PF00069	0.569
MOD_CK2_1	357	363	PF00069	0.637
MOD_CK2_1	365	371	PF00069	0.476
MOD_CK2_1	452	458	PF00069	0.684
MOD_Cter_Amidation	331	334	PF01082	0.513
MOD_Cter_Amidation	482	485	PF01082	0.663
MOD_DYRK1A_RPxSP_1	127	131	PF00069	0.659
MOD_GlcNHglycan	103	106	PF01048	0.690
MOD_GlcNHglycan	107	110	PF01048	0.657
MOD_GlcNHglycan	112	115	PF01048	0.629
MOD_GlcNHglycan	125	130	PF01048	0.537
MOD_GlcNHglycan	150	153	PF01048	0.583
MOD_GlcNHglycan	201	204	PF01048	0.677
MOD_GlcNHglycan	212	215	PF01048	0.573
MOD_GlcNHglycan	35	38	PF01048	0.671
MOD_GlcNHglycan	43	46	PF01048	0.585
MOD_GlcNHglycan	495	498	PF01048	0.666
MOD_GlcNHglycan	528	531	PF01048	0.606
MOD_GlcNHglycan	545	548	PF01048	0.559
MOD_GlcNHglycan	595	598	PF01048	0.682
MOD_GlcNHglycan	611	614	PF01048	0.571
MOD_GSK3_1	125	132	PF00069	0.597
MOD_GSK3_1	161	168	PF00069	0.538
MOD_GSK3_1	199	206	PF00069	0.632
MOD_GSK3_1	216	223	PF00069	0.471
MOD_GSK3_1	247	254	PF00069	0.648
MOD_GSK3_1	272	279	PF00069	0.708
MOD_GSK3_1	29	36	PF00069	0.687
MOD_GSK3_1	353	360	PF00069	0.590
MOD_GSK3_1	41	48	PF00069	0.568
MOD_GSK3_1	543	550	PF00069	0.594
MOD_GSK3_1	565	572	PF00069	0.591
MOD_GSK3_1	96	103	PF00069	0.698
MOD_N-GLC_1	199	204	PF02516	0.575
MOD_N-GLC_1	71	76	PF02516	0.562
MOD_NEK2_1	365	370	PF00069	0.508
MOD_NEK2_2	24	29	PF00069	0.643
MOD_NEK2_2	45	50	PF00069	0.606
MOD_PIKK_1	257	263	PF00454	0.546
MOD_PIKK_1	35	41	PF00454	0.530
MOD_PIKK_1	488	494	PF00454	0.664
MOD_PIKK_1	523	529	PF00454	0.667
MOD_PK_1	244	250	PF00069	0.538
MOD_PK_1	251	257	PF00069	0.497
MOD_PK_1	29	35	PF00069	0.644
MOD_PK_1	478	484	PF00069	0.671
MOD_PKA_1	251	257	PF00069	0.543
MOD_PKA_1	558	564	PF00069	0.613
MOD_PKA_1	609	615	PF00069	0.549
MOD_PKA_2	12	18	PF00069	0.537
MOD_PKA_2	24	30	PF00069	0.631
MOD_PKA_2	251	257	PF00069	0.647
MOD_PKA_2	3	9	PF00069	0.590
MOD_PKA_2	424	430	PF00069	0.701
MOD_PKA_2	542	548	PF00069	0.553
MOD_PKA_2	566	572	PF00069	0.675
MOD_PKA_2	609	615	PF00069	0.549
MOD_PKB_1	541	549	PF00069	0.558
MOD_Plk_1	370	376	PF00069	0.533
MOD_Plk_1	71	77	PF00069	0.565
MOD_Plk_2-3	462	468	PF00069	0.563
MOD_Plk_4	3	9	PF00069	0.526
MOD_Plk_4	45	51	PF00069	0.672
MOD_ProDKin_1	127	133	PF00069	0.698
MOD_ProDKin_1	142	148	PF00069	0.560
MOD_ProDKin_1	165	171	PF00069	0.667
MOD_ProDKin_1	406	412	PF00069	0.678
MOD_ProDKin_1	440	446	PF00069	0.538
MOD_ProDKin_1	591	597	PF00069	0.673
MOD_SUMO_rev_2	349	354	PF00179	0.530
MOD_SUMO_rev_2	556	561	PF00179	0.641
TRG_DiLeu_BaEn_1	350	355	PF01217	0.534
TRG_ENDOCYTIC_2	227	230	PF00928	0.517
TRG_ENDOCYTIC_2	326	329	PF00928	0.484
TRG_ENDOCYTIC_2	404	407	PF00928	0.669
TRG_ER_diArg_1	121	124	PF00400	0.671
TRG_ER_diArg_1	133	135	PF00400	0.645
TRG_ER_diArg_1	333	336	PF00400	0.519
TRG_ER_diArg_1	423	426	PF00400	0.548
TRG_ER_diArg_1	539	541	PF00400	0.565
TRG_ER_diArg_1	562	564	PF00400	0.607
TRG_ER_diArg_1	83	85	PF00400	0.697
TRG_ER_diArg_1	92	95	PF00400	0.621
TRG_ER_diLys_1	623	626	PF00400	0.689
TRG_NLS_Bipartite_1	484	503	PF00514	0.544
TRG_NLS_MonoExtC_3	332	338	PF00514	0.510
TRG_NLS_MonoExtC_3	498	503	PF00514	0.565
TRG_NLS_MonoExtC_3	585	590	PF00514	0.656
TRG_NLS_MonoExtN_4	330	337	PF00514	0.512
TRG_NLS_MonoExtN_4	518	525	PF00514	0.665
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIU7	Leishmania donovani	88%	100%
A4HJS1	Leishmania braziliensis	70%	100%
A4I787	Leishmania infantum	88%	100%
Q4Q5X6	Leishmania major	88%	100%