Maf1 regulator

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Maf1 regulator

Gene product:

Maf1 regulator, putative

Species:

Leishmania mexicana

UniProt:

E9B281_LEIMU

TriTrypDb:

LmxM.30.2820

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B281

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B281

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	13
GO:0006359	regulation of transcription by RNA polymerase III	7	13
GO:0009889	regulation of biosynthetic process	4	13
GO:0009890	negative regulation of biosynthetic process	5	13
GO:0009892	negative regulation of metabolic process	4	13
GO:0010468	regulation of gene expression	5	13
GO:0010556	regulation of macromolecule biosynthetic process	5	13
GO:0010558	negative regulation of macromolecule biosynthetic process	6	13
GO:0010605	negative regulation of macromolecule metabolic process	5	13
GO:0016480	negative regulation of transcription by RNA polymerase III	8	13
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	13
GO:0019222	regulation of metabolic process	3	13
GO:0031323	regulation of cellular metabolic process	4	13
GO:0031324	negative regulation of cellular metabolic process	5	13
GO:0031326	regulation of cellular biosynthetic process	5	13
GO:0031327	negative regulation of cellular biosynthetic process	6	13
GO:0045892	negative regulation of DNA-templated transcription	7	13
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	13
GO:0048519	negative regulation of biological process	3	13
GO:0048523	negative regulation of cellular process	4	13
GO:0050789	regulation of biological process	2	13
GO:0050794	regulation of cellular process	3	13
GO:0051171	regulation of nitrogen compound metabolic process	4	13
GO:0051172	negative regulation of nitrogen compound metabolic process	5	13
GO:0051252	regulation of RNA metabolic process	5	13
GO:0051253	negative regulation of RNA metabolic process	6	13
GO:0060255	regulation of macromolecule metabolic process	4	13
GO:0065007	biological regulation	1	13
GO:0080090	regulation of primary metabolic process	4	13
GO:1902679	negative regulation of RNA biosynthetic process	7	13
GO:1903506	regulation of nucleic acid-templated transcription	7	13
GO:1903507	negative regulation of nucleic acid-templated transcription	8	13
GO:2001141	regulation of RNA biosynthetic process	6	13

Molecular functions
Term	Name	Level	Count
GO:0000994	RNA polymerase III core binding	6	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0043175	RNA polymerase core enzyme binding	5	1
GO:0070063	RNA polymerase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	205	207	PF00675	0.278
CLV_PCSK_KEX2_1	205	207	PF00082	0.261
CLV_PCSK_SKI1_1	207	211	PF00082	0.302
DEG_Nend_UBRbox_1	1	4	PF02207	0.464
DEG_SCF_FBW7_1	55	62	PF00400	0.535
DOC_CKS1_1	56	61	PF01111	0.535
DOC_CYCLIN_RxL_1	205	215	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.535
DOC_MAPK_gen_1	205	214	PF00069	0.444
DOC_MAPK_HePTP_8	202	214	PF00069	0.535
DOC_MAPK_MEF2A_6	205	214	PF00069	0.444
DOC_MAPK_NFAT4_5	207	215	PF00069	0.535
DOC_PP1_RVXF_1	103	110	PF00149	0.464
DOC_PP2B_LxvP_1	57	60	PF13499	0.535
DOC_PP4_FxxP_1	182	185	PF00568	0.444
DOC_USP7_MATH_1	11	15	PF00917	0.357
DOC_USP7_MATH_1	5	9	PF00917	0.375
DOC_WW_Pin1_4	239	244	PF00397	0.641
DOC_WW_Pin1_4	245	250	PF00397	0.609
DOC_WW_Pin1_4	55	60	PF00397	0.454
DOC_WW_Pin1_4	95	100	PF00397	0.489
LIG_14-3-3_CanoR_1	134	138	PF00244	0.551
LIG_FHA_1	25	31	PF00498	0.309
LIG_FHA_1	56	62	PF00498	0.497
LIG_FHA_2	113	119	PF00498	0.497
LIG_FHA_2	163	169	PF00498	0.535
LIG_FHA_2	36	42	PF00498	0.512
LIG_IBAR_NPY_1	220	222	PF08397	0.594
LIG_Integrin_RGD_1	223	225	PF01839	0.539
LIG_LIR_Apic_2	181	185	PF02991	0.535
LIG_LIR_Gen_1	123	132	PF02991	0.444
LIG_LIR_Gen_1	7	16	PF02991	0.357
LIG_LIR_Gen_1	91	102	PF02991	0.478
LIG_LIR_Nem_3	123	127	PF02991	0.444
LIG_LIR_Nem_3	129	135	PF02991	0.444
LIG_LIR_Nem_3	178	182	PF02991	0.444
LIG_LIR_Nem_3	7	12	PF02991	0.388
LIG_LIR_Nem_3	91	97	PF02991	0.497
LIG_NRBOX	11	17	PF00104	0.370
LIG_PCNA_PIPBox_1	156	165	PF02747	0.340
LIG_RPA_C_Fungi	201	213	PF08784	0.427
LIG_SH2_CRK	94	98	PF00017	0.423
LIG_SH2_GRB2like	51	54	PF00017	0.309
LIG_SH2_NCK_1	135	139	PF00017	0.423
LIG_SH2_NCK_1	94	98	PF00017	0.423
LIG_SH2_STAP1	122	126	PF00017	0.309
LIG_SH2_STAP1	196	200	PF00017	0.423
LIG_SH2_STAT5	108	111	PF00017	0.364
LIG_SH2_STAT5	135	138	PF00017	0.397
LIG_SH2_STAT5	200	203	PF00017	0.298
LIG_SH2_STAT5	33	36	PF00017	0.391
LIG_SH3_3	57	63	PF00018	0.309
LIG_SUMO_SIM_par_1	209	215	PF11976	0.423
LIG_TRAF2_1	165	168	PF00917	0.391
LIG_TRAF2_1	38	41	PF00917	0.391
LIG_WRC_WIRS_1	6	11	PF05994	0.389
MOD_CK1_1	95	101	PF00069	0.336
MOD_CK2_1	112	118	PF00069	0.400
MOD_CK2_1	147	153	PF00069	0.423
MOD_CK2_1	162	168	PF00069	0.423
MOD_CK2_1	172	178	PF00069	0.423
MOD_CK2_1	35	41	PF00069	0.362
MOD_CK2_1	95	101	PF00069	0.410
MOD_GlcNHglycan	174	177	PF01048	0.353
MOD_GlcNHglycan	235	238	PF01048	0.672
MOD_GlcNHglycan	85	88	PF01048	0.425
MOD_GlcNHglycan	9	12	PF01048	0.471
MOD_GSK3_1	112	119	PF00069	0.430
MOD_GSK3_1	139	146	PF00069	0.331
MOD_GSK3_1	241	248	PF00069	0.700
MOD_GSK3_1	31	38	PF00069	0.296
MOD_GSK3_1	55	62	PF00069	0.423
MOD_GSK3_1	7	14	PF00069	0.484
MOD_GSK3_1	88	95	PF00069	0.344
MOD_N-GLC_1	88	93	PF02516	0.388
MOD_NEK2_1	190	195	PF00069	0.412
MOD_NEK2_1	90	95	PF00069	0.325
MOD_NEK2_2	112	117	PF00069	0.301
MOD_NEK2_2	191	196	PF00069	0.410
MOD_NEK2_2	24	29	PF00069	0.309
MOD_PKA_2	133	139	PF00069	0.436
MOD_PKA_2	35	41	PF00069	0.296
MOD_Plk_1	122	128	PF00069	0.296
MOD_Plk_1	191	197	PF00069	0.408
MOD_Plk_4	11	17	PF00069	0.362
MOD_Plk_4	112	118	PF00069	0.114
MOD_Plk_4	191	197	PF00069	0.384
MOD_Plk_4	92	98	PF00069	0.430
MOD_ProDKin_1	239	245	PF00069	0.643
MOD_ProDKin_1	55	61	PF00069	0.311
MOD_ProDKin_1	95	101	PF00069	0.359
TRG_ENDOCYTIC_2	179	182	PF00928	0.296
TRG_ENDOCYTIC_2	70	73	PF00928	0.353
TRG_ENDOCYTIC_2	94	97	PF00928	0.423
TRG_NLS_MonoExtN_4	205	210	PF00514	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP0	Leptomonas seymouri	72%	99%
A0A0S4JIA8	Bodo saltans	39%	81%
A0A1X0NFF7	Trypanosomatidae	46%	99%
A0A3Q8IFK2	Leishmania donovani	97%	100%
A0A422NF87	Trypanosoma rangeli	46%	100%
A4H980	Leishmania braziliensis	90%	100%
A4I786	Leishmania infantum	97%	100%
A5D9C6	Bos taurus	27%	100%
C9ZMG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
C9ZWM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4Q5X7	Leishmania major	96%	100%
Q5XIH0	Rattus norvegicus	28%	100%
Q9D0U6	Mus musculus	28%	100%
Q9H063	Homo sapiens	27%	100%
V5AS30	Trypanosoma cruzi	47%	100%