Smr domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KH domain/Domain of unknown function (DUF1771)/Smr domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B280_LEIMU

TriTrypDb:

LmxM.30.2810

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B280

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B280

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	81	83	PF00675	0.282
CLV_PCSK_KEX2_1	91	93	PF00082	0.276
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.291
CLV_PCSK_SKI1_1	168	172	PF00082	0.161
CLV_PCSK_SKI1_1	201	205	PF00082	0.352
CLV_PCSK_SKI1_1	250	254	PF00082	0.608
CLV_PCSK_SKI1_1	4	8	PF00082	0.149
DEG_SPOP_SBC_1	177	181	PF00917	0.278
DOC_CDC14_PxL_1	224	232	PF14671	0.408
DOC_USP7_MATH_1	176	180	PF00917	0.345
DOC_USP7_MATH_1	265	269	PF00917	0.701
DOC_USP7_UBL2_3	171	175	PF12436	0.278
DOC_USP7_UBL2_3	243	247	PF12436	0.654
LIG_14-3-3_CanoR_1	19	25	PF00244	0.454
LIG_14-3-3_CanoR_1	30	36	PF00244	0.375
LIG_Actin_WH2_2	9	27	PF00022	0.484
LIG_APCC_ABBAyCdc20_2	92	98	PF00400	0.340
LIG_BRCT_BRCA1_1	92	96	PF00533	0.340
LIG_FHA_1	178	184	PF00498	0.149
LIG_FHA_1	220	226	PF00498	0.362
LIG_FHA_1	32	38	PF00498	0.497
LIG_FHA_2	179	185	PF00498	0.312
LIG_FHA_2	45	51	PF00498	0.487
LIG_LIR_Gen_1	204	215	PF02991	0.280
LIG_LIR_Nem_3	204	210	PF02991	0.319
LIG_MAD2	63	71	PF02301	0.528
LIG_PTB_Apo_2	67	74	PF02174	0.399
LIG_PTB_Phospho_1	67	73	PF10480	0.403
LIG_SH2_NCK_1	215	219	PF00017	0.289
LIG_SH2_SRC	215	218	PF00017	0.285
LIG_SH2_STAT5	150	153	PF00017	0.342
LIG_SH2_STAT5	207	210	PF00017	0.309
LIG_SH3_3	222	228	PF00018	0.461
LIG_SUMO_SIM_anti_2	179	187	PF11976	0.225
LIG_TYR_ITIM	205	210	PF00017	0.219
MOD_CK1_1	264	270	PF00069	0.632
MOD_CK2_1	176	182	PF00069	0.290
MOD_CK2_1	233	239	PF00069	0.679
MOD_GlcNHglycan	109	112	PF01048	0.149
MOD_GlcNHglycan	192	195	PF01048	0.326
MOD_GlcNHglycan	250	253	PF01048	0.669
MOD_GlcNHglycan	263	266	PF01048	0.570
MOD_GSK3_1	261	268	PF00069	0.667
MOD_NEK2_1	248	253	PF00069	0.527
MOD_NEK2_1	7	12	PF00069	0.391
MOD_NEK2_2	20	25	PF00069	0.436
MOD_PIKK_1	269	275	PF00454	0.393
MOD_Plk_4	219	225	PF00069	0.324
MOD_SUMO_for_1	170	173	PF00179	0.149
MOD_SUMO_rev_2	123	127	PF00179	0.298
TRG_DiLeu_BaEn_2	2	8	PF01217	0.263
TRG_DiLeu_BaEn_3	159	165	PF01217	0.306
TRG_ENDOCYTIC_2	150	153	PF00928	0.342
TRG_ENDOCYTIC_2	207	210	PF00928	0.415
TRG_ENDOCYTIC_2	215	218	PF00928	0.395
TRG_ER_diArg_1	92	95	PF00400	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U4	Leptomonas seymouri	67%	100%
A0A0S4JKD1	Bodo saltans	32%	89%
A0A3Q8IKE2	Leishmania donovani	89%	100%
A0A422NF86	Trypanosoma rangeli	57%	100%
A4H981	Leishmania braziliensis	69%	96%
A4HJR9	Leishmania braziliensis	69%	96%
A4I785	Leishmania infantum	89%	100%
C9ZMG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
Q4Q5X8	Leishmania major	84%	100%
Q9UTP4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
V5BGM8	Trypanosoma cruzi	56%	98%