RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9B276_LEIMU

TriTrypDb:

LmxM.30.2770

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B276

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B276

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.475
CLV_NRD_NRD_1	128	130	PF00675	0.544
CLV_NRD_NRD_1	61	63	PF00675	0.275
CLV_PCSK_KEX2_1	128	130	PF00082	0.544
CLV_PCSK_KEX2_1	61	63	PF00082	0.275
CLV_Separin_Metazoa	125	129	PF03568	0.517
DEG_APCC_DBOX_1	225	233	PF00400	0.675
DEG_SCF_FBW7_2	55	60	PF00400	0.475
DOC_PP4_FxxP_1	89	92	PF00568	0.464
DOC_USP7_MATH_1	176	180	PF00917	0.699
DOC_USP7_MATH_2	250	256	PF00917	0.660
DOC_WW_Pin1_4	107	112	PF00397	0.477
DOC_WW_Pin1_4	156	161	PF00397	0.747
DOC_WW_Pin1_4	53	58	PF00397	0.486
DOC_WW_Pin1_4	88	93	PF00397	0.487
LIG_14-3-3_CanoR_1	118	127	PF00244	0.553
LIG_14-3-3_CanoR_1	178	186	PF00244	0.633
LIG_14-3-3_CanoR_1	197	203	PF00244	0.675
LIG_14-3-3_CanoR_1	261	270	PF00244	0.661
LIG_14-3-3_CanoR_1	284	294	PF00244	0.617
LIG_14-3-3_CanoR_1	50	56	PF00244	0.475
LIG_14-3-3_CanoR_1	9	19	PF00244	0.453
LIG_APCC_ABBA_1	202	207	PF00400	0.634
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_FHA_1	304	310	PF00498	0.546
LIG_FHA_1	63	69	PF00498	0.476
LIG_FHA_2	120	126	PF00498	0.468
LIG_FHA_2	27	33	PF00498	0.475
LIG_FHA_2	276	282	PF00498	0.707
LIG_FHA_2	290	296	PF00498	0.560
LIG_FHA_2	54	60	PF00498	0.503
LIG_FHA_2	70	76	PF00498	0.503
LIG_LIR_Apic_2	155	160	PF02991	0.567
LIG_LIR_Apic_2	288	294	PF02991	0.604
LIG_LIR_Apic_2	88	92	PF02991	0.455
LIG_LIR_Gen_1	216	223	PF02991	0.647
LIG_LIR_Nem_3	216	220	PF02991	0.650
LIG_LIR_Nem_3	32	37	PF02991	0.475
LIG_LIR_Nem_3	38	43	PF02991	0.475
LIG_LIR_Nem_3	65	70	PF02991	0.475
LIG_LYPXL_S_1	33	37	PF13949	0.275
LIG_SH2_CRK	157	161	PF00017	0.566
LIG_SH2_CRK	217	221	PF00017	0.654
LIG_SH2_CRK	40	44	PF00017	0.475
LIG_SH2_GRB2like	217	220	PF00017	0.656
LIG_SH2_NCK_1	146	150	PF00017	0.691
LIG_SH2_NCK_1	157	161	PF00017	0.566
LIG_SH2_NCK_1	291	295	PF00017	0.591
LIG_SH2_PTP2	101	104	PF00017	0.410
LIG_SH2_STAP1	217	221	PF00017	0.654
LIG_SH2_STAT5	101	104	PF00017	0.411
LIG_SH2_STAT5	242	245	PF00017	0.651
LIG_SH2_STAT5	27	30	PF00017	0.475
LIG_SH2_STAT5	291	294	PF00017	0.595
LIG_SH3_2	192	197	PF14604	0.572
LIG_SH3_3	189	195	PF00018	0.610
LIG_TRAF2_1	57	60	PF00917	0.491
LIG_TRAF2_1	92	95	PF00917	0.605
LIG_TYR_ITIM	99	104	PF00017	0.426
LIG_WRC_WIRS_1	86	91	PF05994	0.439
MOD_CK1_1	147	153	PF00069	0.792
MOD_CK1_1	155	161	PF00069	0.520
MOD_CK1_1	179	185	PF00069	0.619
MOD_CK1_1	263	269	PF00069	0.618
MOD_CK2_1	119	125	PF00069	0.466
MOD_CK2_1	289	295	PF00069	0.676
MOD_CK2_1	53	59	PF00069	0.503
MOD_CK2_1	69	75	PF00069	0.503
MOD_CK2_1	88	94	PF00069	0.557
MOD_CMANNOS	116	119	PF00535	0.460
MOD_GlcNHglycan	132	135	PF01048	0.607
MOD_GlcNHglycan	170	173	PF01048	0.753
MOD_GlcNHglycan	182	185	PF01048	0.656
MOD_GlcNHglycan	255	258	PF01048	0.628
MOD_GlcNHglycan	310	313	PF01048	0.550
MOD_GSK3_1	107	114	PF00069	0.452
MOD_GSK3_1	130	137	PF00069	0.590
MOD_GSK3_1	152	159	PF00069	0.602
MOD_GSK3_1	166	173	PF00069	0.695
MOD_GSK3_1	176	183	PF00069	0.706
MOD_GSK3_1	285	292	PF00069	0.616
MOD_GSK3_1	303	310	PF00069	0.710
MOD_GSK3_1	49	56	PF00069	0.494
MOD_N-GLC_1	252	257	PF02516	0.614
MOD_N-GLC_1	268	273	PF02516	0.718
MOD_NEK2_1	127	132	PF00069	0.559
MOD_NEK2_1	168	173	PF00069	0.588
MOD_NEK2_1	240	245	PF00069	0.655
MOD_NEK2_1	285	290	PF00069	0.690
MOD_NEK2_1	307	312	PF00069	0.564
MOD_NEK2_1	87	92	PF00069	0.451
MOD_NEK2_2	35	40	PF00069	0.497
MOD_PIKK_1	10	16	PF00454	0.478
MOD_PIKK_1	119	125	PF00454	0.466
MOD_PIKK_1	177	183	PF00454	0.665
MOD_PKA_1	275	281	PF00069	0.642
MOD_PKA_2	127	133	PF00069	0.566
MOD_PKA_2	177	183	PF00069	0.629
MOD_PKA_2	260	266	PF00069	0.680
MOD_PKA_2	285	291	PF00069	0.615
MOD_PKA_2	49	55	PF00069	0.475
MOD_PKA_2	5	11	PF00069	0.537
MOD_Plk_1	111	117	PF00069	0.355
MOD_Plk_1	184	190	PF00069	0.652
MOD_Plk_2-3	71	77	PF00069	0.475
MOD_Plk_4	263	269	PF00069	0.679
MOD_ProDKin_1	107	113	PF00069	0.477
MOD_ProDKin_1	156	162	PF00069	0.748
MOD_ProDKin_1	53	59	PF00069	0.486
MOD_ProDKin_1	88	94	PF00069	0.497
MOD_SUMO_rev_2	90	99	PF00179	0.499
TRG_ENDOCYTIC_2	101	104	PF00928	0.410
TRG_ENDOCYTIC_2	146	149	PF00928	0.693
TRG_ENDOCYTIC_2	217	220	PF00928	0.670
TRG_ENDOCYTIC_2	34	37	PF00928	0.475
TRG_ENDOCYTIC_2	40	43	PF00928	0.475
TRG_ER_diArg_1	127	129	PF00400	0.539
TRG_ER_diArg_1	61	63	PF00400	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M2	Leptomonas seymouri	69%	100%
A0A3S5H7Q7	Leishmania donovani	96%	100%
A4HJR5	Leishmania braziliensis	85%	100%
A4I782	Leishmania infantum	97%	100%
Q4Q5Y3	Leishmania major	96%	100%