Kinetoplastid_kinetochore_protein_2_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid kinetochore protein 8, putative

Species:

Leishmania mexicana

UniProt:

E9B274_LEIMU

TriTrypDb:

LmxM.30.2750

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B274

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B274

Function

Biological processes
Term	Name	Level	Count
GO:0007059	chromosome segregation	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.616
CLV_NRD_NRD_1	19	21	PF00675	0.614
CLV_NRD_NRD_1	191	193	PF00675	0.571
CLV_NRD_NRD_1	274	276	PF00675	0.473
CLV_NRD_NRD_1	287	289	PF00675	0.381
CLV_NRD_NRD_1	312	314	PF00675	0.526
CLV_NRD_NRD_1	342	344	PF00675	0.643
CLV_NRD_NRD_1	431	433	PF00675	0.660
CLV_PCSK_FUR_1	285	289	PF00082	0.530
CLV_PCSK_KEX2_1	19	21	PF00082	0.602
CLV_PCSK_KEX2_1	273	275	PF00082	0.489
CLV_PCSK_KEX2_1	285	287	PF00082	0.369
CLV_PCSK_KEX2_1	303	305	PF00082	0.483
CLV_PCSK_KEX2_1	342	344	PF00082	0.643
CLV_PCSK_KEX2_1	430	432	PF00082	0.560
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.424
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.560
CLV_PCSK_SKI1_1	320	324	PF00082	0.477
CLV_PCSK_SKI1_1	347	351	PF00082	0.573
DEG_APCC_DBOX_1	181	189	PF00400	0.501
DEG_APCC_DBOX_1	324	332	PF00400	0.624
DEG_COP1_1	76	86	PF00400	0.719
DEG_SPOP_SBC_1	42	46	PF00917	0.682
DOC_MAPK_gen_1	182	190	PF00069	0.466
DOC_MAPK_gen_1	430	436	PF00069	0.586
DOC_MAPK_MEF2A_6	215	224	PF00069	0.505
DOC_PP1_RVXF_1	345	352	PF00149	0.552
DOC_PP2B_LxvP_1	39	42	PF13499	0.602
DOC_USP7_MATH_1	353	357	PF00917	0.572
DOC_USP7_MATH_1	42	46	PF00917	0.663
DOC_USP7_MATH_1	65	69	PF00917	0.720
DOC_USP7_MATH_1	8	12	PF00917	0.692
DOC_USP7_MATH_1	96	100	PF00917	0.547
DOC_USP7_UBL2_3	310	314	PF12436	0.513
DOC_WW_Pin1_4	10	15	PF00397	0.545
DOC_WW_Pin1_4	92	97	PF00397	0.703
LIG_14-3-3_CanoR_1	10	14	PF00244	0.545
LIG_14-3-3_CanoR_1	141	145	PF00244	0.604
LIG_14-3-3_CanoR_1	215	220	PF00244	0.536
LIG_14-3-3_CanoR_1	342	349	PF00244	0.588
LIG_14-3-3_CanoR_1	40	48	PF00244	0.651
LIG_14-3-3_CanoR_1	66	72	PF00244	0.702
LIG_14-3-3_CanoR_1	77	81	PF00244	0.619
LIG_BIR_II_1	1	5	PF00653	0.712
LIG_BRCT_BRCA1_1	415	419	PF00533	0.700
LIG_CaM_IQ_9	185	201	PF13499	0.550
LIG_FHA_1	11	17	PF00498	0.543
LIG_FHA_1	216	222	PF00498	0.483
LIG_FHA_1	257	263	PF00498	0.577
LIG_FHA_1	31	37	PF00498	0.437
LIG_FHA_1	413	419	PF00498	0.705
LIG_FHA_2	372	378	PF00498	0.754
LIG_GSK3_LRP6_1	92	97	PF00069	0.586
LIG_IBAR_NPY_1	108	110	PF08397	0.675
LIG_LIR_Apic_2	143	147	PF02991	0.617
LIG_LIR_Apic_2	214	220	PF02991	0.468
LIG_LIR_Apic_2	27	32	PF02991	0.634
LIG_LIR_Apic_2	63	67	PF02991	0.787
LIG_LIR_Apic_2	99	104	PF02991	0.707
LIG_LIR_Gen_1	203	210	PF02991	0.421
LIG_LIR_Gen_1	278	284	PF02991	0.424
LIG_LIR_Nem_3	27	31	PF02991	0.635
LIG_LIR_Nem_3	278	283	PF02991	0.411
LIG_LIR_Nem_3	295	300	PF02991	0.409
LIG_LYPXL_yS_3	154	157	PF13949	0.669
LIG_MYND_1	155	159	PF01753	0.573
LIG_SH2_CRK	144	148	PF00017	0.571
LIG_SH2_CRK	29	33	PF00017	0.706
LIG_SH2_CRK	6	10	PF00017	0.630
LIG_SH2_NCK_1	29	33	PF00017	0.706
LIG_SH2_PTP2	101	104	PF00017	0.589
LIG_SH2_STAT3	132	135	PF00017	0.654
LIG_SH2_STAT5	101	104	PF00017	0.736
LIG_SH2_STAT5	132	135	PF00017	0.582
LIG_SH2_STAT5	201	204	PF00017	0.547
LIG_SH2_STAT5	217	220	PF00017	0.503
LIG_SH2_STAT5	261	264	PF00017	0.557
LIG_SH2_STAT5	29	32	PF00017	0.600
LIG_SH2_STAT5	297	300	PF00017	0.508
LIG_SH2_STAT5	386	389	PF00017	0.714
LIG_SH3_3	103	109	PF00018	0.571
LIG_SH3_3	120	126	PF00018	0.652
LIG_SH3_3	149	155	PF00018	0.637
LIG_SH3_3	88	94	PF00018	0.654
LIG_SH3_CIN85_PxpxPR_1	92	97	PF14604	0.586
LIG_SUMO_SIM_par_1	371	379	PF11976	0.651
LIG_TRAF2_1	175	178	PF00917	0.496
LIG_TRAF2_1	279	282	PF00917	0.531
LIG_WW_1	14	17	PF00397	0.542
MOD_CDK_SPK_2	92	97	PF00069	0.687
MOD_CK1_1	27	33	PF00069	0.655
MOD_CK1_1	366	372	PF00069	0.708
MOD_CK1_1	385	391	PF00069	0.725
MOD_CK1_1	43	49	PF00069	0.456
MOD_CK2_1	365	371	PF00069	0.646
MOD_Cter_Amidation	340	343	PF01082	0.639
MOD_DYRK1A_RPxSP_1	10	14	PF00069	0.545
MOD_GlcNHglycan	1	4	PF01048	0.732
MOD_GlcNHglycan	339	342	PF01048	0.664
MOD_GlcNHglycan	343	346	PF01048	0.648
MOD_GlcNHglycan	364	368	PF01048	0.643
MOD_GlcNHglycan	377	381	PF01048	0.747
MOD_GlcNHglycan	387	390	PF01048	0.764
MOD_GlcNHglycan	399	402	PF01048	0.766
MOD_GlcNHglycan	6	9	PF01048	0.666
MOD_GlcNHglycan	67	70	PF01048	0.701
MOD_GlcNHglycan	98	101	PF01048	0.654
MOD_GSK3_1	108	115	PF00069	0.460
MOD_GSK3_1	337	344	PF00069	0.631
MOD_GSK3_1	376	383	PF00069	0.725
MOD_GSK3_1	4	11	PF00069	0.705
MOD_GSK3_1	413	420	PF00069	0.603
MOD_GSK3_1	51	58	PF00069	0.661
MOD_GSK3_1	67	74	PF00069	0.598
MOD_GSK3_1	92	99	PF00069	0.640
MOD_N-GLC_1	421	426	PF02516	0.644
MOD_NEK2_1	200	205	PF00069	0.491
MOD_NEK2_1	382	387	PF00069	0.697
MOD_NEK2_1	9	14	PF00069	0.561
MOD_NEK2_2	67	72	PF00069	0.602
MOD_PIKK_1	108	114	PF00454	0.606
MOD_PIKK_1	251	257	PF00454	0.551
MOD_PIKK_1	314	320	PF00454	0.499
MOD_PKA_2	140	146	PF00069	0.565
MOD_PKA_2	341	347	PF00069	0.670
MOD_PKA_2	424	430	PF00069	0.694
MOD_PKA_2	65	71	PF00069	0.710
MOD_PKA_2	76	82	PF00069	0.651
MOD_PKA_2	9	15	PF00069	0.546
MOD_PKA_2	96	102	PF00069	0.706
MOD_Plk_1	177	183	PF00069	0.413
MOD_Plk_1	353	359	PF00069	0.648
MOD_Plk_1	75	81	PF00069	0.660
MOD_Plk_2-3	265	271	PF00069	0.461
MOD_Plk_2-3	371	377	PF00069	0.718
MOD_Plk_4	102	108	PF00069	0.602
MOD_Plk_4	128	134	PF00069	0.688
MOD_Plk_4	24	30	PF00069	0.714
MOD_Plk_4	353	359	PF00069	0.552
MOD_Plk_4	413	419	PF00069	0.635
MOD_Plk_4	424	430	PF00069	0.651
MOD_ProDKin_1	10	16	PF00069	0.546
MOD_ProDKin_1	92	98	PF00069	0.705
MOD_SUMO_rev_2	295	305	PF00179	0.424
TRG_DiLeu_BaEn_4	197	203	PF01217	0.499
TRG_ENDOCYTIC_2	154	157	PF00928	0.669
TRG_ENDOCYTIC_2	28	31	PF00928	0.746
TRG_ENDOCYTIC_2	297	300	PF00928	0.503
TRG_ENDOCYTIC_2	6	9	PF00928	0.748
TRG_ER_diArg_1	18	20	PF00400	0.626
TRG_ER_diArg_1	273	275	PF00400	0.472
TRG_ER_diArg_1	285	288	PF00400	0.383
TRG_NLS_MonoCore_2	429	434	PF00514	0.648
TRG_NLS_MonoExtC_3	429	435	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	313	318	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH8	Leptomonas seymouri	64%	100%
A0A0S4JLB3	Bodo saltans	24%	81%
A0A1X0NJ59	Trypanosomatidae	37%	100%
A0A3S7X4V3	Leishmania donovani	93%	100%
A0A422NPB6	Trypanosoma rangeli	39%	100%
A4HJR3	Leishmania braziliensis	85%	99%
A4I780	Leishmania infantum	94%	100%
C9ZMG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q5Y5	Leishmania major	95%	100%
V5D822	Trypanosoma cruzi	40%	100%