Regulator_of_chromosome_condensation_(RCC1)_repea t

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulator of chromosome condensation (RCC1) repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B271_LEIMU

TriTrypDb:

LmxM.30.2720

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B271

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B271

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.763
CLV_C14_Caspase3-7	244	248	PF00656	0.405
CLV_C14_Caspase3-7	75	79	PF00656	0.450
CLV_C14_Caspase3-7	97	101	PF00656	0.406
CLV_NRD_NRD_1	186	188	PF00675	0.339
CLV_NRD_NRD_1	3	5	PF00675	0.429
CLV_NRD_NRD_1	43	45	PF00675	0.522
CLV_PCSK_KEX2_1	186	188	PF00082	0.339
CLV_PCSK_KEX2_1	3	5	PF00082	0.429
CLV_PCSK_KEX2_1	43	45	PF00082	0.522
CLV_PCSK_KEX2_1	456	458	PF00082	0.501
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.397
CLV_PCSK_SKI1_1	274	278	PF00082	0.382
CLV_PCSK_SKI1_1	284	288	PF00082	0.282
DEG_Nend_Nbox_1	1	3	PF02207	0.517
DEG_ODPH_VHL_1	460	472	PF01847	0.492
DOC_CKS1_1	475	480	PF01111	0.417
DOC_MAPK_gen_1	183	191	PF00069	0.433
DOC_MAPK_gen_1	281	290	PF00069	0.309
DOC_MAPK_MEF2A_6	281	290	PF00069	0.297
DOC_PP1_RVXF_1	185	192	PF00149	0.352
DOC_PP1_RVXF_1	272	278	PF00149	0.341
DOC_PP2B_LxvP_1	67	70	PF13499	0.545
DOC_USP7_MATH_1	122	126	PF00917	0.644
DOC_USP7_MATH_1	164	168	PF00917	0.445
DOC_USP7_MATH_1	172	176	PF00917	0.376
DOC_USP7_MATH_1	218	222	PF00917	0.478
DOC_USP7_MATH_1	407	411	PF00917	0.515
DOC_WW_Pin1_4	120	125	PF00397	0.684
DOC_WW_Pin1_4	18	23	PF00397	0.460
DOC_WW_Pin1_4	268	273	PF00397	0.291
DOC_WW_Pin1_4	30	35	PF00397	0.462
DOC_WW_Pin1_4	383	388	PF00397	0.397
DOC_WW_Pin1_4	474	479	PF00397	0.401
DOC_WW_Pin1_4	62	67	PF00397	0.689
LIG_14-3-3_CanoR_1	142	147	PF00244	0.638
LIG_14-3-3_CanoR_1	340	344	PF00244	0.422
LIG_14-3-3_CanoR_1	529	535	PF00244	0.567
LIG_14-3-3_CanoR_1	56	66	PF00244	0.737
LIG_BRCT_BRCA1_1	385	389	PF00533	0.391
LIG_deltaCOP1_diTrp_1	215	223	PF00928	0.393
LIG_deltaCOP1_diTrp_1	481	491	PF00928	0.307
LIG_EVH1_2	316	320	PF00568	0.461
LIG_FHA_1	104	110	PF00498	0.522
LIG_FHA_1	293	299	PF00498	0.300
LIG_FHA_1	423	429	PF00498	0.348
LIG_FHA_1	448	454	PF00498	0.510
LIG_FHA_1	5	11	PF00498	0.425
LIG_FHA_2	242	248	PF00498	0.468
LIG_FHA_2	410	416	PF00498	0.571
LIG_FHA_2	95	101	PF00498	0.387
LIG_Integrin_isoDGR_2	184	186	PF01839	0.372
LIG_KLC1_Yacidic_2	151	156	PF13176	0.473
LIG_LIR_Apic_2	499	504	PF02991	0.581
LIG_LIR_Gen_1	151	162	PF02991	0.489
LIG_LIR_Gen_1	175	181	PF02991	0.306
LIG_LIR_Gen_1	293	298	PF02991	0.277
LIG_LIR_Gen_1	386	397	PF02991	0.374
LIG_LIR_Gen_1	411	419	PF02991	0.449
LIG_LIR_Gen_1	71	81	PF02991	0.456
LIG_LIR_Nem_3	151	157	PF02991	0.424
LIG_LIR_Nem_3	175	180	PF02991	0.305
LIG_LIR_Nem_3	232	238	PF02991	0.342
LIG_LIR_Nem_3	293	297	PF02991	0.277
LIG_LIR_Nem_3	386	392	PF02991	0.373
LIG_LIR_Nem_3	411	417	PF02991	0.460
LIG_LIR_Nem_3	467	473	PF02991	0.473
LIG_LIR_Nem_3	71	77	PF02991	0.420
LIG_MYND_1	471	475	PF01753	0.295
LIG_Pex14_2	491	495	PF04695	0.403
LIG_REV1ctd_RIR_1	275	285	PF16727	0.335
LIG_SH2_CRK	414	418	PF00017	0.391
LIG_SH2_NCK_1	414	418	PF00017	0.435
LIG_SH2_NCK_1	74	78	PF00017	0.460
LIG_SH2_PTP2	154	157	PF00017	0.373
LIG_SH2_SRC	414	417	PF00017	0.439
LIG_SH2_STAT5	154	157	PF00017	0.373
LIG_SH2_STAT5	235	238	PF00017	0.344
LIG_SH2_STAT5	400	403	PF00017	0.412
LIG_SH3_2	269	274	PF14604	0.335
LIG_SH3_3	17	23	PF00018	0.466
LIG_SH3_3	266	272	PF00018	0.276
LIG_SH3_3	320	326	PF00018	0.443
LIG_SH3_3	379	385	PF00018	0.422
LIG_SH3_3	472	478	PF00018	0.455
LIG_SUMO_SIM_par_1	94	100	PF11976	0.448
LIG_TYR_ITSM	410	417	PF00017	0.417
MOD_CDC14_SPxK_1	271	274	PF00782	0.385
MOD_CDK_SPK_2	383	388	PF00069	0.397
MOD_CDK_SPxK_1	268	274	PF00069	0.323
MOD_CK1_1	127	133	PF00069	0.679
MOD_CK1_1	135	141	PF00069	0.603
MOD_CK1_1	175	181	PF00069	0.312
MOD_CK1_1	65	71	PF00069	0.634
MOD_CK2_1	373	379	PF00069	0.410
MOD_CK2_1	65	71	PF00069	0.611
MOD_Cter_Amidation	184	187	PF01082	0.349
MOD_Cter_Amidation	454	457	PF01082	0.405
MOD_GlcNHglycan	114	118	PF01048	0.650
MOD_GlcNHglycan	134	137	PF01048	0.674
MOD_GlcNHglycan	365	368	PF01048	0.356
MOD_GlcNHglycan	486	489	PF01048	0.357
MOD_GlcNHglycan	505	508	PF01048	0.713
MOD_GlcNHglycan	515	518	PF01048	0.517
MOD_GlcNHglycan	67	70	PF01048	0.656
MOD_GlcNHglycan	78	82	PF01048	0.387
MOD_GSK3_1	120	127	PF00069	0.744
MOD_GSK3_1	128	135	PF00069	0.675
MOD_GSK3_1	292	299	PF00069	0.276
MOD_GSK3_1	417	424	PF00069	0.375
MOD_GSK3_1	58	65	PF00069	0.690
MOD_N-GLC_1	175	180	PF02516	0.331
MOD_N-GLC_1	447	452	PF02516	0.510
MOD_N-GLC_2	432	434	PF02516	0.357
MOD_NEK2_1	27	32	PF00069	0.472
MOD_NEK2_1	290	295	PF00069	0.393
MOD_NEK2_1	327	332	PF00069	0.415
MOD_NEK2_1	479	484	PF00069	0.546
MOD_NEK2_1	530	535	PF00069	0.627
MOD_PK_1	142	148	PF00069	0.631
MOD_PKA_2	141	147	PF00069	0.617
MOD_PKA_2	339	345	PF00069	0.414
MOD_Plk_1	164	170	PF00069	0.386
MOD_Plk_1	175	181	PF00069	0.313
MOD_Plk_4	136	142	PF00069	0.724
MOD_Plk_4	164	170	PF00069	0.498
MOD_Plk_4	218	224	PF00069	0.477
MOD_Plk_4	230	236	PF00069	0.238
MOD_Plk_4	422	428	PF00069	0.331
MOD_ProDKin_1	120	126	PF00069	0.685
MOD_ProDKin_1	18	24	PF00069	0.455
MOD_ProDKin_1	268	274	PF00069	0.291
MOD_ProDKin_1	30	36	PF00069	0.468
MOD_ProDKin_1	383	389	PF00069	0.389
MOD_ProDKin_1	474	480	PF00069	0.410
MOD_ProDKin_1	62	68	PF00069	0.685
MOD_SUMO_for_1	367	370	PF00179	0.469
TRG_ENDOCYTIC_2	154	157	PF00928	0.373
TRG_ENDOCYTIC_2	235	238	PF00928	0.344
TRG_ENDOCYTIC_2	380	383	PF00928	0.544
TRG_ENDOCYTIC_2	414	417	PF00928	0.541
TRG_ENDOCYTIC_2	42	45	PF00928	0.453
TRG_ENDOCYTIC_2	74	77	PF00928	0.518
TRG_ER_diArg_1	186	188	PF00400	0.366
TRG_ER_diArg_1	2	4	PF00400	0.466
TRG_ER_diArg_1	42	44	PF00400	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIU3	Leptomonas seymouri	71%	99%
A0A0S4JSP7	Bodo saltans	37%	86%
A0A3Q8ICS2	Leishmania donovani	94%	100%
A4HJR0	Leishmania braziliensis	84%	100%
A4I777	Leishmania infantum	94%	100%
C9ZWM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
Q4Q5Y8	Leishmania major	93%	100%
V5BGM3	Trypanosoma cruzi	54%	100%