Endoplasmic reticulum transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B270_LEIMU

TriTrypDb:

LmxM.30.2715

Length:

146

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B270

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B270

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.525
CLV_PCSK_KEX2_1	126	128	PF00082	0.543
CLV_PCSK_KEX2_1	92	94	PF00082	0.643
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.643
DOC_CDC14_PxL_1	11	19	PF14671	0.427
DOC_MAPK_gen_1	77	85	PF00069	0.372
DOC_MAPK_gen_1	92	102	PF00069	0.306
DOC_MAPK_MEF2A_6	79	87	PF00069	0.372
DOC_MAPK_MEF2A_6	95	104	PF00069	0.350
DOC_MAPK_RevD_3	100	115	PF00069	0.348
DOC_USP7_MATH_1	131	135	PF00917	0.650
DOC_USP7_UBL2_3	73	77	PF12436	0.444
LIG_14-3-3_CanoR_1	135	143	PF00244	0.638
LIG_14-3-3_CanoR_1	28	37	PF00244	0.638
LIG_14-3-3_CanoR_1	79	87	PF00244	0.445
LIG_BRCT_BRCA1_1	59	63	PF00533	0.437
LIG_FHA_1	104	110	PF00498	0.406
LIG_FHA_1	16	22	PF00498	0.420
LIG_FHA_1	36	42	PF00498	0.618
LIG_LIR_Gen_1	3	12	PF02991	0.476
LIG_LIR_Gen_1	59	68	PF02991	0.348
LIG_LIR_Nem_3	18	23	PF02991	0.418
LIG_LIR_Nem_3	3	7	PF02991	0.484
LIG_LIR_Nem_3	59	64	PF02991	0.308
LIG_PCNA_PIPBox_1	13	22	PF02747	0.356
LIG_Pex14_1	70	74	PF04695	0.349
LIG_Pex14_2	61	65	PF04695	0.352
LIG_SH2_CRK	116	120	PF00017	0.181
LIG_SH2_CRK	23	27	PF00017	0.420
LIG_SH2_PTP2	101	104	PF00017	0.427
LIG_SH2_STAP1	116	120	PF00017	0.181
LIG_SH2_STAT5	101	104	PF00017	0.302
LIG_SH2_STAT5	23	26	PF00017	0.430
LIG_SH3_3	9	15	PF00018	0.427
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.183
LIG_TRAF2_1	121	124	PF00917	0.606
LIG_UBA3_1	64	73	PF00899	0.533
LIG_WRC_WIRS_1	1	6	PF05994	0.474
LIG_WRC_WIRS_1	58	63	PF05994	0.349
MOD_CK1_1	134	140	PF00069	0.684
MOD_CK1_1	47	53	PF00069	0.350
MOD_CK1_1	59	65	PF00069	0.413
MOD_CK2_1	118	124	PF00069	0.525
MOD_GlcNHglycan	128	132	PF01048	0.551
MOD_GlcNHglycan	30	33	PF01048	0.474
MOD_GlcNHglycan	46	49	PF01048	0.403
MOD_GlcNHglycan	52	55	PF01048	0.445
MOD_GSK3_1	127	134	PF00069	0.691
MOD_N-GLC_1	44	49	PF02516	0.229
MOD_NEK2_2	15	20	PF00069	0.356
MOD_PKA_2	134	140	PF00069	0.668
MOD_PKA_2	35	41	PF00069	0.604
MOD_PKA_2	78	84	PF00069	0.442
MOD_Plk_1	81	87	PF00069	0.370
MOD_Plk_4	15	21	PF00069	0.404
MOD_Plk_4	47	53	PF00069	0.300
MOD_SUMO_rev_2	84	94	PF00179	0.435
TRG_ENDOCYTIC_2	101	104	PF00928	0.425
TRG_ENDOCYTIC_2	116	119	PF00928	0.317
TRG_ER_diArg_1	125	127	PF00400	0.713
TRG_ER_diArg_1	93	96	PF00400	0.426
TRG_NLS_MonoExtC_3	91	97	PF00514	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A6	Leptomonas seymouri	69%	99%
A0A0S4IVS1	Bodo saltans	27%	90%
A0A1X0NIN7	Trypanosomatidae	36%	100%
A0A3R7L4C4	Trypanosoma rangeli	34%	87%
A0A3S7X4X5	Leishmania donovani	94%	100%
A4HJQ9	Leishmania braziliensis	79%	100%
A4I776	Leishmania infantum	94%	100%
C9ZMF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q5Y9	Leishmania major	92%	100%