3'-5' exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B268_LEIMU

TriTrypDb:

LmxM.30.2700

Length:

890

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B268

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B268

Function

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	5
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	5
GO:0000469	cleavage involved in rRNA processing	7	5
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006364	rRNA processing	8	5
GO:0006396	RNA processing	6	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016070	RNA metabolic process	5	5
GO:0016072	rRNA metabolic process	7	5
GO:0031123	RNA 3'-end processing	7	5
GO:0031125	rRNA 3'-end processing	9	5
GO:0034470	ncRNA processing	7	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0034660	ncRNA metabolic process	6	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043628	regulatory ncRNA 3'-end processing	8	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0046483	heterocycle metabolic process	3	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	5
GO:0090501	RNA phosphodiester bond hydrolysis	6	5
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	5
GO:1901360	organic cyclic compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004527	exonuclease activity	5	7
GO:0008408	3'-5' exonuclease activity	6	6
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0000175	3'-5'-RNA exonuclease activity	7	5
GO:0004532	RNA exonuclease activity	5	5
GO:0004540	RNA nuclease activity	4	5
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	5
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	5
GO:0140098	catalytic activity, acting on RNA	3	5
GO:0140640	catalytic activity, acting on a nucleic acid	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.513
CLV_C14_Caspase3-7	282	286	PF00656	0.605
CLV_C14_Caspase3-7	426	430	PF00656	0.669
CLV_NRD_NRD_1	149	151	PF00675	0.578
CLV_NRD_NRD_1	196	198	PF00675	0.522
CLV_NRD_NRD_1	4	6	PF00675	0.410
CLV_NRD_NRD_1	453	455	PF00675	0.503
CLV_NRD_NRD_1	487	489	PF00675	0.406
CLV_NRD_NRD_1	514	516	PF00675	0.464
CLV_NRD_NRD_1	548	550	PF00675	0.353
CLV_NRD_NRD_1	660	662	PF00675	0.746
CLV_NRD_NRD_1	681	683	PF00675	0.555
CLV_NRD_NRD_1	72	74	PF00675	0.546
CLV_PCSK_FUR_1	654	658	PF00082	0.576
CLV_PCSK_KEX2_1	149	151	PF00082	0.494
CLV_PCSK_KEX2_1	3	5	PF00082	0.416
CLV_PCSK_KEX2_1	453	455	PF00082	0.503
CLV_PCSK_KEX2_1	487	489	PF00082	0.510
CLV_PCSK_KEX2_1	514	516	PF00082	0.464
CLV_PCSK_KEX2_1	548	550	PF00082	0.353
CLV_PCSK_KEX2_1	656	658	PF00082	0.734
CLV_PCSK_KEX2_1	660	662	PF00082	0.713
CLV_PCSK_KEX2_1	681	683	PF00082	0.520
CLV_PCSK_KEX2_1	72	74	PF00082	0.568
CLV_PCSK_PC1ET2_1	656	658	PF00082	0.664
CLV_PCSK_SKI1_1	149	153	PF00082	0.448
CLV_PCSK_SKI1_1	213	217	PF00082	0.413
CLV_PCSK_SKI1_1	302	306	PF00082	0.505
CLV_PCSK_SKI1_1	487	491	PF00082	0.434
CLV_PCSK_SKI1_1	603	607	PF00082	0.344
CLV_PCSK_SKI1_1	72	76	PF00082	0.581
CLV_PCSK_SKI1_1	733	737	PF00082	0.455
CLV_PCSK_SKI1_1	763	767	PF00082	0.387
CLV_PCSK_SKI1_1	838	842	PF00082	0.456
DEG_APCC_DBOX_1	586	594	PF00400	0.480
DEG_APCC_DBOX_1	602	610	PF00400	0.359
DEG_APCC_DBOX_1	71	79	PF00400	0.551
DEG_APCC_DBOX_1	732	740	PF00400	0.516
DEG_APCC_KENBOX_2	462	466	PF00400	0.364
DEG_COP1_1	42	52	PF00400	0.529
DEG_MDM2_SWIB_1	39	47	PF02201	0.568
DOC_CDC14_PxL_1	844	852	PF14671	0.344
DOC_CKS1_1	408	413	PF01111	0.543
DOC_CKS1_1	639	644	PF01111	0.667
DOC_CYCLIN_RxL_1	832	845	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	109	115	PF00134	0.552
DOC_MAPK_gen_1	149	158	PF00069	0.421
DOC_MAPK_gen_1	164	174	PF00069	0.357
DOC_MAPK_gen_1	460	468	PF00069	0.468
DOC_MAPK_gen_1	548	556	PF00069	0.274
DOC_MAPK_MEF2A_6	167	174	PF00069	0.535
DOC_MAPK_MEF2A_6	487	495	PF00069	0.377
DOC_PP1_RVXF_1	402	409	PF00149	0.440
DOC_PP2B_LxvP_1	47	50	PF13499	0.643
DOC_PP4_FxxP_1	459	462	PF00568	0.436
DOC_PP4_FxxP_1	528	531	PF00568	0.384
DOC_SPAK_OSR1_1	478	482	PF12202	0.357
DOC_USP7_MATH_1	193	197	PF00917	0.584
DOC_USP7_MATH_1	257	261	PF00917	0.323
DOC_USP7_MATH_1	281	285	PF00917	0.696
DOC_USP7_MATH_1	326	330	PF00917	0.737
DOC_USP7_MATH_1	344	348	PF00917	0.693
DOC_USP7_MATH_1	629	633	PF00917	0.700
DOC_USP7_MATH_1	640	644	PF00917	0.520
DOC_USP7_MATH_1	794	798	PF00917	0.651
DOC_WW_Pin1_4	243	248	PF00397	0.413
DOC_WW_Pin1_4	407	412	PF00397	0.518
DOC_WW_Pin1_4	56	61	PF00397	0.641
DOC_WW_Pin1_4	638	643	PF00397	0.723
DOC_WW_Pin1_4	648	653	PF00397	0.747
DOC_WW_Pin1_4	809	814	PF00397	0.725
DOC_WW_Pin1_4	880	885	PF00397	0.553
LIG_14-3-3_CanoR_1	197	206	PF00244	0.578
LIG_14-3-3_CanoR_1	446	452	PF00244	0.323
LIG_14-3-3_CanoR_1	567	577	PF00244	0.423
LIG_14-3-3_CanoR_1	681	685	PF00244	0.545
LIG_14-3-3_CanoR_1	792	800	PF00244	0.672
LIG_14-3-3_CanoR_1	864	870	PF00244	0.353
LIG_Actin_WH2_2	128	146	PF00022	0.399
LIG_AP2alpha_2	111	113	PF02296	0.549
LIG_APCC_ABBA_1	156	161	PF00400	0.448
LIG_APCC_ABBA_1	163	168	PF00400	0.462
LIG_APCC_ABBA_1	599	604	PF00400	0.417
LIG_BIR_III_4	336	340	PF00653	0.552
LIG_BIR_III_4	744	748	PF00653	0.566
LIG_BRCT_BRCA1_1	269	273	PF00533	0.442
LIG_BRCT_BRCA1_1	32	36	PF00533	0.414
LIG_BRCT_BRCA1_1	830	834	PF00533	0.380
LIG_DLG_GKlike_1	208	215	PF00625	0.464
LIG_EH1_1	833	841	PF00400	0.448
LIG_FHA_1	138	144	PF00498	0.499
LIG_FHA_1	207	213	PF00498	0.539
LIG_FHA_1	42	48	PF00498	0.491
LIG_FHA_1	681	687	PF00498	0.528
LIG_FHA_1	78	84	PF00498	0.431
LIG_FHA_1	87	93	PF00498	0.368
LIG_FHA_2	198	204	PF00498	0.662
LIG_FHA_2	221	227	PF00498	0.453
LIG_FHA_2	280	286	PF00498	0.678
LIG_FHA_2	293	299	PF00498	0.404
LIG_FHA_2	331	337	PF00498	0.495
LIG_FHA_2	351	357	PF00498	0.627
LIG_FHA_2	389	395	PF00498	0.449
LIG_FHA_2	421	427	PF00498	0.592
LIG_FHA_2	783	789	PF00498	0.600
LIG_FHA_2	881	887	PF00498	0.526
LIG_LIR_Apic_2	457	462	PF02991	0.435
LIG_LIR_Apic_2	526	531	PF02991	0.375
LIG_LIR_Gen_1	137	146	PF02991	0.292
LIG_LIR_Gen_1	22	32	PF02991	0.385
LIG_LIR_Gen_1	445	452	PF02991	0.529
LIG_LIR_Gen_1	499	507	PF02991	0.352
LIG_LIR_Gen_1	541	550	PF02991	0.564
LIG_LIR_Gen_1	595	601	PF02991	0.415
LIG_LIR_Gen_1	831	841	PF02991	0.366
LIG_LIR_Nem_3	117	123	PF02991	0.579
LIG_LIR_Nem_3	137	142	PF02991	0.226
LIG_LIR_Nem_3	168	172	PF02991	0.353
LIG_LIR_Nem_3	22	27	PF02991	0.358
LIG_LIR_Nem_3	33	39	PF02991	0.314
LIG_LIR_Nem_3	443	447	PF02991	0.507
LIG_LIR_Nem_3	499	503	PF02991	0.356
LIG_LIR_Nem_3	541	546	PF02991	0.576
LIG_LIR_Nem_3	595	599	PF02991	0.412
LIG_LIR_Nem_3	831	837	PF02991	0.368
LIG_LIR_Nem_3	9	15	PF02991	0.360
LIG_LYPXL_yS_3	169	172	PF13949	0.472
LIG_NRBOX	776	782	PF00104	0.320
LIG_Pex14_1	865	869	PF04695	0.366
LIG_Pex14_2	39	43	PF04695	0.419
LIG_Pex14_2	440	444	PF04695	0.408
LIG_Pex14_2	861	865	PF04695	0.350
LIG_Rb_LxCxE_1	295	314	PF01857	0.562
LIG_REV1ctd_RIR_1	696	705	PF16727	0.572
LIG_RPA_C_Fungi	665	677	PF08784	0.621
LIG_SH2_CRK	34	38	PF00017	0.425
LIG_SH2_CRK	372	376	PF00017	0.378
LIG_SH2_CRK	500	504	PF00017	0.339
LIG_SH2_CRK	517	521	PF00017	0.399
LIG_SH2_GRB2like	372	375	PF00017	0.379
LIG_SH2_GRB2like	396	399	PF00017	0.490
LIG_SH2_NCK_1	372	376	PF00017	0.403
LIG_SH2_SRC	372	375	PF00017	0.405
LIG_SH2_SRC	543	546	PF00017	0.518
LIG_SH2_SRC	561	564	PF00017	0.535
LIG_SH2_SRC	828	831	PF00017	0.498
LIG_SH2_SRC	846	849	PF00017	0.443
LIG_SH2_STAP1	139	143	PF00017	0.462
LIG_SH2_STAP1	261	265	PF00017	0.442
LIG_SH2_STAP1	500	504	PF00017	0.339
LIG_SH2_STAP1	543	547	PF00017	0.502
LIG_SH2_STAP1	86	90	PF00017	0.374
LIG_SH2_STAT3	252	255	PF00017	0.407
LIG_SH2_STAT3	458	461	PF00017	0.383
LIG_SH2_STAT5	139	142	PF00017	0.461
LIG_SH2_STAT5	396	399	PF00017	0.397
LIG_SH2_STAT5	458	461	PF00017	0.383
LIG_SH2_STAT5	688	691	PF00017	0.453
LIG_SH2_STAT5	748	751	PF00017	0.573
LIG_SH2_STAT5	828	831	PF00017	0.503
LIG_SH3_3	109	115	PF00018	0.552
LIG_SH3_3	374	380	PF00018	0.478
LIG_SH3_3	4	10	PF00018	0.403
LIG_SH3_3	636	642	PF00018	0.724
LIG_SH3_3	691	697	PF00018	0.287
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.508
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.389
LIG_SUMO_SIM_anti_2	203	211	PF11976	0.501
LIG_SUMO_SIM_anti_2	501	506	PF11976	0.343
LIG_SUMO_SIM_anti_2	775	783	PF11976	0.497
LIG_SUMO_SIM_par_1	179	185	PF11976	0.446
LIG_TRAF2_1	200	203	PF00917	0.700
LIG_TRAF2_1	560	563	PF00917	0.532
LIG_TYR_ITIM	32	37	PF00017	0.408
LIG_UBA3_1	532	538	PF00899	0.479
LIG_WRC_WIRS_1	609	614	PF05994	0.496
MOD_CDK_SPxK_1	648	654	PF00069	0.514
MOD_CK1_1	211	217	PF00069	0.559
MOD_CK1_1	220	226	PF00069	0.499
MOD_CK1_1	284	290	PF00069	0.686
MOD_CK1_1	445	451	PF00069	0.327
MOD_CK1_1	472	478	PF00069	0.468
MOD_CK1_1	496	502	PF00069	0.389
MOD_CK1_1	56	62	PF00069	0.483
MOD_CK1_1	66	72	PF00069	0.734
MOD_CK1_1	761	767	PF00069	0.472
MOD_CK1_1	803	809	PF00069	0.757
MOD_CK1_1	821	827	PF00069	0.589
MOD_CK1_1	84	90	PF00069	0.330
MOD_CK2_1	19	25	PF00069	0.418
MOD_CK2_1	197	203	PF00069	0.630
MOD_CK2_1	220	226	PF00069	0.488
MOD_CK2_1	420	426	PF00069	0.444
MOD_CK2_1	782	788	PF00069	0.598
MOD_CK2_1	793	799	PF00069	0.705
MOD_CK2_1	865	871	PF00069	0.469
MOD_GlcNHglycan	116	119	PF01048	0.616
MOD_GlcNHglycan	175	178	PF01048	0.467
MOD_GlcNHglycan	219	222	PF01048	0.462
MOD_GlcNHglycan	269	272	PF01048	0.581
MOD_GlcNHglycan	279	282	PF01048	0.611
MOD_GlcNHglycan	313	316	PF01048	0.608
MOD_GlcNHglycan	319	322	PF01048	0.593
MOD_GlcNHglycan	328	331	PF01048	0.489
MOD_GlcNHglycan	432	436	PF01048	0.457
MOD_GlcNHglycan	471	474	PF01048	0.529
MOD_GlcNHglycan	557	560	PF01048	0.444
MOD_GlcNHglycan	631	634	PF01048	0.706
MOD_GlcNHglycan	642	645	PF01048	0.762
MOD_GlcNHglycan	65	68	PF01048	0.726
MOD_GlcNHglycan	727	730	PF01048	0.574
MOD_GlcNHglycan	739	742	PF01048	0.618
MOD_GlcNHglycan	752	755	PF01048	0.712
MOD_GSK3_1	193	200	PF00069	0.602
MOD_GSK3_1	202	209	PF00069	0.468
MOD_GSK3_1	275	282	PF00069	0.525
MOD_GSK3_1	326	333	PF00069	0.527
MOD_GSK3_1	384	391	PF00069	0.455
MOD_GSK3_1	468	475	PF00069	0.280
MOD_GSK3_1	489	496	PF00069	0.371
MOD_GSK3_1	58	65	PF00069	0.601
MOD_GSK3_1	77	84	PF00069	0.404
MOD_GSK3_1	805	812	PF00069	0.758
MOD_GSK3_1	842	849	PF00069	0.490
MOD_LATS_1	195	201	PF00433	0.538
MOD_N-GLC_1	342	347	PF02516	0.567
MOD_N-GLC_1	373	378	PF02516	0.423
MOD_N-GLC_1	56	61	PF02516	0.551
MOD_N-GLC_1	759	764	PF02516	0.519
MOD_N-GLC_1	803	808	PF02516	0.721
MOD_N-GLC_2	217	219	PF02516	0.486
MOD_N-GLC_2	465	467	PF02516	0.355
MOD_NEK2_1	316	321	PF00069	0.723
MOD_NEK2_1	41	46	PF00069	0.386
MOD_NEK2_1	431	436	PF00069	0.477
MOD_NEK2_1	510	515	PF00069	0.427
MOD_NEK2_1	568	573	PF00069	0.401
MOD_NEK2_1	734	739	PF00069	0.507
MOD_NEK2_1	780	785	PF00069	0.376
MOD_NEK2_1	800	805	PF00069	0.766
MOD_NEK2_2	292	297	PF00069	0.506
MOD_PIKK_1	805	811	PF00454	0.711
MOD_PK_1	128	134	PF00069	0.456
MOD_PKA_1	197	203	PF00069	0.570
MOD_PKA_2	445	451	PF00069	0.327
MOD_PKA_2	680	686	PF00069	0.548
MOD_PKA_2	750	756	PF00069	0.667
MOD_PKA_2	800	806	PF00069	0.777
MOD_PKA_2	865	871	PF00069	0.421
MOD_Plk_1	202	208	PF00069	0.494
MOD_Plk_1	275	281	PF00069	0.583
MOD_Plk_1	342	348	PF00069	0.609
MOD_Plk_1	373	379	PF00069	0.422
MOD_Plk_1	431	437	PF00069	0.435
MOD_Plk_1	442	448	PF00069	0.454
MOD_Plk_1	704	710	PF00069	0.369
MOD_Plk_2-3	373	379	PF00069	0.422
MOD_Plk_2-3	420	426	PF00069	0.450
MOD_Plk_4	19	25	PF00069	0.418
MOD_Plk_4	202	208	PF00069	0.649
MOD_Plk_4	472	478	PF00069	0.473
MOD_Plk_4	489	495	PF00069	0.350
MOD_Plk_4	672	678	PF00069	0.595
MOD_Plk_4	86	92	PF00069	0.336
MOD_Plk_4	865	871	PF00069	0.398
MOD_ProDKin_1	243	249	PF00069	0.406
MOD_ProDKin_1	407	413	PF00069	0.522
MOD_ProDKin_1	56	62	PF00069	0.642
MOD_ProDKin_1	638	644	PF00069	0.723
MOD_ProDKin_1	648	654	PF00069	0.747
MOD_ProDKin_1	809	815	PF00069	0.725
MOD_ProDKin_1	880	886	PF00069	0.549
MOD_SUMO_rev_2	161	165	PF00179	0.498
MOD_SUMO_rev_2	418	423	PF00179	0.572
TRG_DiLeu_BaEn_1	773	778	PF01217	0.463
TRG_DiLeu_BaEn_3	679	685	PF01217	0.498
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.400
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.616
TRG_DiLeu_BaLyEn_6	835	840	PF01217	0.448
TRG_ENDOCYTIC_2	139	142	PF00928	0.455
TRG_ENDOCYTIC_2	169	172	PF00928	0.355
TRG_ENDOCYTIC_2	20	23	PF00928	0.520
TRG_ENDOCYTIC_2	34	37	PF00928	0.350
TRG_ENDOCYTIC_2	372	375	PF00928	0.383
TRG_ENDOCYTIC_2	447	450	PF00928	0.559
TRG_ENDOCYTIC_2	486	489	PF00928	0.412
TRG_ENDOCYTIC_2	500	503	PF00928	0.282
TRG_ENDOCYTIC_2	517	520	PF00928	0.401
TRG_ENDOCYTIC_2	543	546	PF00928	0.518
TRG_ENDOCYTIC_2	620	623	PF00928	0.569
TRG_ENDOCYTIC_2	696	699	PF00928	0.485
TRG_ER_diArg_1	149	151	PF00400	0.448
TRG_ER_diArg_1	2	5	PF00400	0.458
TRG_ER_diArg_1	452	454	PF00400	0.497
TRG_ER_diArg_1	486	488	PF00400	0.501
TRG_ER_diArg_1	514	516	PF00400	0.422
TRG_ER_diArg_1	547	549	PF00400	0.351
TRG_ER_diArg_1	586	589	PF00400	0.503
TRG_ER_diArg_1	72	74	PF00400	0.600
TRG_NES_CRM1_1	173	185	PF08389	0.481
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	838	842	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJE4	Leptomonas seymouri	53%	97%
A0A1X0NK05	Trypanosomatidae	34%	100%
A0A3Q8ISV5	Leishmania donovani	91%	100%
A0A422NPF9	Trypanosoma rangeli	35%	100%
A4HJQ7	Leishmania braziliensis	77%	100%
A4I774	Leishmania infantum	91%	100%
Q4Q5Z1	Leishmania major	89%	100%
V5D1X6	Trypanosoma cruzi	36%	100%