Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B265_LEIMU

TriTrypDb:

LmxM.30.2655

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B265

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B265

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.768
CLV_C14_Caspase3-7	434	438	PF00656	0.655
CLV_C14_Caspase3-7	491	495	PF00656	0.557
CLV_MEL_PAP_1	229	235	PF00089	0.525
CLV_NRD_NRD_1	201	203	PF00675	0.617
CLV_NRD_NRD_1	426	428	PF00675	0.844
CLV_NRD_NRD_1	431	433	PF00675	0.755
CLV_NRD_NRD_1	443	445	PF00675	0.549
CLV_NRD_NRD_1	481	483	PF00675	0.756
CLV_PCSK_KEX2_1	201	203	PF00082	0.617
CLV_PCSK_KEX2_1	426	428	PF00082	0.844
CLV_PCSK_KEX2_1	430	432	PF00082	0.774
CLV_PCSK_KEX2_1	443	445	PF00082	0.549
CLV_PCSK_KEX2_1	481	483	PF00082	0.756
CLV_PCSK_KEX2_1	536	538	PF00082	0.523
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.523
CLV_PCSK_PC7_1	426	432	PF00082	0.839
CLV_PCSK_SKI1_1	390	394	PF00082	0.698
CLV_PCSK_SKI1_1	533	537	PF00082	0.728
DEG_SPOP_SBC_1	556	560	PF00917	0.682
DEG_SPOP_SBC_1	8	12	PF00917	0.734
DOC_CKS1_1	406	411	PF01111	0.700
DOC_MAPK_gen_1	153	162	PF00069	0.710
DOC_MAPK_gen_1	443	451	PF00069	0.754
DOC_MAPK_gen_1	481	487	PF00069	0.743
DOC_PP1_SILK_1	189	194	PF00149	0.732
DOC_PP4_FxxP_1	529	532	PF00568	0.503
DOC_SPAK_OSR1_1	528	532	PF12202	0.506
DOC_USP7_MATH_1	113	117	PF00917	0.700
DOC_USP7_MATH_1	13	17	PF00917	0.557
DOC_USP7_MATH_1	139	143	PF00917	0.787
DOC_USP7_MATH_1	271	275	PF00917	0.689
DOC_USP7_MATH_1	29	33	PF00917	0.782
DOC_USP7_MATH_1	318	322	PF00917	0.830
DOC_USP7_MATH_1	327	331	PF00917	0.681
DOC_USP7_MATH_1	398	402	PF00917	0.803
DOC_USP7_MATH_1	455	459	PF00917	0.699
DOC_USP7_UBL2_3	305	309	PF12436	0.833
DOC_WW_Pin1_4	103	108	PF00397	0.714
DOC_WW_Pin1_4	142	147	PF00397	0.817
DOC_WW_Pin1_4	299	304	PF00397	0.769
DOC_WW_Pin1_4	309	314	PF00397	0.798
DOC_WW_Pin1_4	321	326	PF00397	0.684
DOC_WW_Pin1_4	385	390	PF00397	0.748
DOC_WW_Pin1_4	405	410	PF00397	0.610
DOC_WW_Pin1_4	56	61	PF00397	0.815
LIG_14-3-3_CanoR_1	108	113	PF00244	0.670
LIG_14-3-3_CanoR_1	216	224	PF00244	0.657
LIG_14-3-3_CanoR_1	232	236	PF00244	0.575
LIG_14-3-3_CanoR_1	286	292	PF00244	0.767
LIG_14-3-3_CanoR_1	384	392	PF00244	0.800
LIG_14-3-3_CanoR_1	430	440	PF00244	0.795
LIG_14-3-3_CanoR_1	48	52	PF00244	0.630
LIG_14-3-3_CanoR_1	486	496	PF00244	0.706
LIG_14-3-3_CanoR_1	507	513	PF00244	0.771
LIG_14-3-3_CanoR_1	516	524	PF00244	0.668
LIG_14-3-3_CanoR_1	528	532	PF00244	0.599
LIG_14-3-3_CanoR_1	69	74	PF00244	0.743
LIG_BRCT_BRCA1_1	233	237	PF00533	0.818
LIG_CSL_BTD_1	406	409	PF09270	0.572
LIG_DLG_GKlike_1	443	451	PF00625	0.754
LIG_DLG_GKlike_1	69	77	PF00625	0.738
LIG_FHA_1	112	118	PF00498	0.695
LIG_FHA_1	142	148	PF00498	0.758
LIG_FHA_1	167	173	PF00498	0.602
LIG_FHA_1	174	180	PF00498	0.567
LIG_FHA_1	224	230	PF00498	0.686
LIG_FHA_1	242	248	PF00498	0.685
LIG_FHA_1	398	404	PF00498	0.609
LIG_FHA_1	9	15	PF00498	0.746
LIG_FHA_2	469	475	PF00498	0.522
LIG_FHA_2	75	81	PF00498	0.730
LIG_Integrin_isoDGR_2	67	69	PF01839	0.751
LIG_LIR_Apic_2	526	532	PF02991	0.503
LIG_LIR_Nem_3	326	331	PF02991	0.784
LIG_LIR_Nem_3	347	353	PF02991	0.665
LIG_Pex14_2	118	122	PF04695	0.752
LIG_PTAP_UEV_1	51	56	PF05743	0.546
LIG_SH2_STAT5	166	169	PF00017	0.473
LIG_SH2_STAT5	350	353	PF00017	0.722
LIG_SH3_3	143	149	PF00018	0.621
LIG_SH3_3	328	334	PF00018	0.765
LIG_SH3_3	33	39	PF00018	0.810
LIG_SH3_3	371	377	PF00018	0.760
LIG_SH3_3	406	412	PF00018	0.716
LIG_SH3_3	446	452	PF00018	0.820
LIG_SH3_3	49	55	PF00018	0.568
LIG_SUMO_SIM_par_1	38	43	PF11976	0.746
LIG_SxIP_EBH_1	121	131	PF03271	0.540
MOD_CDC14_SPxK_1	302	305	PF00782	0.762
MOD_CDK_SPK_2	103	108	PF00069	0.760
MOD_CDK_SPK_2	299	304	PF00069	0.691
MOD_CDK_SPK_2	385	390	PF00069	0.748
MOD_CDK_SPxK_1	299	305	PF00069	0.769
MOD_CK1_1	141	147	PF00069	0.823
MOD_CK1_1	196	202	PF00069	0.772
MOD_CK1_1	218	224	PF00069	0.742
MOD_CK1_1	231	237	PF00069	0.604
MOD_CK1_1	257	263	PF00069	0.589
MOD_CK1_1	321	327	PF00069	0.805
MOD_CK1_1	336	342	PF00069	0.587
MOD_CK1_1	354	360	PF00069	0.502
MOD_CK1_1	383	389	PF00069	0.827
MOD_CK1_1	397	403	PF00069	0.728
MOD_CK1_1	420	426	PF00069	0.743
MOD_CK1_1	506	512	PF00069	0.661
MOD_CK1_1	548	554	PF00069	0.765
MOD_CK1_1	555	561	PF00069	0.652
MOD_CK1_1	569	575	PF00069	0.585
MOD_CK1_1	71	77	PF00069	0.734
MOD_CK2_1	468	474	PF00069	0.665
MOD_CK2_1	516	522	PF00069	0.536
MOD_CK2_1	74	80	PF00069	0.730
MOD_GlcNHglycan	136	139	PF01048	0.831
MOD_GlcNHglycan	179	182	PF01048	0.623
MOD_GlcNHglycan	195	198	PF01048	0.614
MOD_GlcNHglycan	273	276	PF01048	0.681
MOD_GlcNHglycan	31	34	PF01048	0.690
MOD_GlcNHglycan	335	338	PF01048	0.635
MOD_GlcNHglycan	358	362	PF01048	0.801
MOD_GlcNHglycan	368	371	PF01048	0.692
MOD_GlcNHglycan	396	399	PF01048	0.809
MOD_GlcNHglycan	400	403	PF01048	0.738
MOD_GlcNHglycan	419	422	PF01048	0.501
MOD_GlcNHglycan	457	460	PF01048	0.685
MOD_GlcNHglycan	467	471	PF01048	0.662
MOD_GlcNHglycan	509	512	PF01048	0.728
MOD_GlcNHglycan	547	550	PF01048	0.838
MOD_GlcNHglycan	552	555	PF01048	0.793
MOD_GlcNHglycan	559	562	PF01048	0.682
MOD_GlcNHglycan	98	102	PF01048	0.759
MOD_GSK3_1	113	120	PF00069	0.706
MOD_GSK3_1	123	130	PF00069	0.706
MOD_GSK3_1	134	141	PF00069	0.656
MOD_GSK3_1	156	163	PF00069	0.564
MOD_GSK3_1	173	180	PF00069	0.627
MOD_GSK3_1	192	199	PF00069	0.600
MOD_GSK3_1	210	217	PF00069	0.637
MOD_GSK3_1	219	226	PF00069	0.722
MOD_GSK3_1	237	244	PF00069	0.614
MOD_GSK3_1	27	34	PF00069	0.608
MOD_GSK3_1	271	278	PF00069	0.685
MOD_GSK3_1	299	306	PF00069	0.556
MOD_GSK3_1	309	316	PF00069	0.801
MOD_GSK3_1	323	330	PF00069	0.646
MOD_GSK3_1	353	360	PF00069	0.577
MOD_GSK3_1	379	386	PF00069	0.712
MOD_GSK3_1	394	401	PF00069	0.813
MOD_GSK3_1	46	53	PF00069	0.520
MOD_GSK3_1	499	506	PF00069	0.751
MOD_GSK3_1	507	514	PF00069	0.583
MOD_GSK3_1	543	550	PF00069	0.722
MOD_GSK3_1	552	559	PF00069	0.637
MOD_GSK3_1	566	573	PF00069	0.562
MOD_GSK3_1	68	75	PF00069	0.787
MOD_GSK3_1	9	16	PF00069	0.533
MOD_LATS_1	175	181	PF00433	0.592
MOD_LATS_1	7	13	PF00433	0.736
MOD_N-GLC_1	142	147	PF02516	0.756
MOD_N-GLC_1	173	178	PF02516	0.595
MOD_N-GLC_1	398	403	PF02516	0.804
MOD_NEK2_1	118	123	PF00069	0.771
MOD_NEK2_1	186	191	PF00069	0.697
MOD_NEK2_1	224	229	PF00069	0.557
MOD_NEK2_1	247	252	PF00069	0.561
MOD_NEK2_1	379	384	PF00069	0.826
MOD_NEK2_1	545	550	PF00069	0.853
MOD_NEK2_1	73	78	PF00069	0.805
MOD_NEK2_2	113	118	PF00069	0.749
MOD_PIKK_1	216	222	PF00454	0.652
MOD_PIKK_1	254	260	PF00454	0.561
MOD_PIKK_1	383	389	PF00454	0.666
MOD_PKA_1	426	432	PF00069	0.839
MOD_PKA_1	443	449	PF00069	0.550
MOD_PKA_2	123	129	PF00069	0.815
MOD_PKA_2	192	198	PF00069	0.740
MOD_PKA_2	215	221	PF00069	0.656
MOD_PKA_2	231	237	PF00069	0.687
MOD_PKA_2	383	389	PF00069	0.827
MOD_PKA_2	394	400	PF00069	0.502
MOD_PKA_2	426	432	PF00069	0.839
MOD_PKA_2	443	449	PF00069	0.550
MOD_PKA_2	455	461	PF00069	0.651
MOD_PKA_2	47	53	PF00069	0.544
MOD_PKA_2	506	512	PF00069	0.752
MOD_PKA_2	522	528	PF00069	0.587
MOD_PKA_2	68	74	PF00069	0.818
MOD_Plk_1	118	124	PF00069	0.754
MOD_Plk_2-3	158	164	PF00069	0.553
MOD_Plk_2-3	468	474	PF00069	0.602
MOD_Plk_4	113	119	PF00069	0.748
MOD_Plk_4	187	193	PF00069	0.623
MOD_Plk_4	224	230	PF00069	0.672
MOD_Plk_4	388	394	PF00069	0.833
MOD_Plk_4	74	80	PF00069	0.693
MOD_ProDKin_1	103	109	PF00069	0.711
MOD_ProDKin_1	142	148	PF00069	0.817
MOD_ProDKin_1	299	305	PF00069	0.769
MOD_ProDKin_1	309	315	PF00069	0.794
MOD_ProDKin_1	321	327	PF00069	0.684
MOD_ProDKin_1	385	391	PF00069	0.749
MOD_ProDKin_1	405	411	PF00069	0.609
MOD_ProDKin_1	56	62	PF00069	0.817
MOD_SUMO_rev_2	240	245	PF00179	0.814
TRG_DiLeu_BaEn_1	435	440	PF01217	0.755
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.746
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.772
TRG_ENDOCYTIC_2	350	353	PF00928	0.722
TRG_ER_diArg_1	201	203	PF00400	0.612
TRG_ER_diArg_1	425	427	PF00400	0.839
TRG_ER_diArg_1	430	432	PF00400	0.758
TRG_ER_diArg_1	443	445	PF00400	0.533
TRG_ER_diArg_1	480	482	PF00400	0.745

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IKC7	Leishmania donovani	83%	100%
A4HJQ4	Leishmania braziliensis	51%	100%
A4I770	Leishmania infantum	82%	100%
Q4Q5Z5	Leishmania major	79%	100%