CrcB-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

CrcB-like protein

Gene product:

CrcB-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9B261_LEIMU

TriTrypDb:

LmxM.30.2620

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	5
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9B261

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B261

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	5
GO:0008509	monoatomic anion transmembrane transporter activity	4	5
GO:0015075	monoatomic ion transmembrane transporter activity	3	5
GO:0015103	inorganic anion transmembrane transporter activity	4	5
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	5
GO:0022857	transmembrane transporter activity	2	5
GO:1903425	fluoride transmembrane transporter activity	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	147	151	PF00082	0.288
CLV_PCSK_SKI1_1	223	227	PF00082	0.469
CLV_PCSK_SKI1_1	92	96	PF00082	0.415
DEG_APCC_DBOX_1	222	230	PF00400	0.297
DEG_APCC_DBOX_1	91	99	PF00400	0.575
DEG_ODPH_VHL_1	139	152	PF01847	0.377
DOC_CYCLIN_RxL_1	89	99	PF00134	0.635
DOC_MAPK_MEF2A_6	147	154	PF00069	0.377
DOC_MAPK_MEF2A_6	96	105	PF00069	0.503
DOC_USP7_MATH_1	231	235	PF00917	0.374
DOC_WW_Pin1_4	80	85	PF00397	0.655
LIG_14-3-3_CanoR_1	127	137	PF00244	0.385
LIG_14-3-3_CanoR_1	147	153	PF00244	0.447
LIG_14-3-3_CterR_2	252	255	PF00244	0.646
LIG_FHA_1	121	127	PF00498	0.414
LIG_FHA_1	129	135	PF00498	0.336
LIG_FHA_1	144	150	PF00498	0.447
LIG_FHA_1	85	91	PF00498	0.641
LIG_FHA_2	42	48	PF00498	0.367
LIG_GBD_Chelix_1	168	176	PF00786	0.391
LIG_LIR_Gen_1	47	57	PF02991	0.263
LIG_LIR_Gen_1	99	109	PF02991	0.434
LIG_LIR_Nem_3	17	21	PF02991	0.453
LIG_LIR_Nem_3	47	52	PF02991	0.306
LIG_LIR_Nem_3	99	105	PF02991	0.447
LIG_NRBOX	172	178	PF00104	0.447
LIG_Pex14_2	25	29	PF04695	0.368
LIG_Pex14_2	49	53	PF04695	0.285
LIG_SH2_CRK	18	22	PF00017	0.463
LIG_SH2_GRB2like	120	123	PF00017	0.373
LIG_SH2_GRB2like	153	156	PF00017	0.497
LIG_SH2_NCK_1	230	234	PF00017	0.377
LIG_SH2_SRC	228	231	PF00017	0.297
LIG_SH2_STAT5	120	123	PF00017	0.373
LIG_SH2_STAT5	153	156	PF00017	0.497
LIG_SH2_STAT5	228	231	PF00017	0.301
LIG_SH3_3	135	141	PF00018	0.263
LIG_SH3_3	241	247	PF00018	0.447
LIG_SH3_3	4	10	PF00018	0.574
LIG_SUMO_SIM_anti_2	4	9	PF11976	0.615
LIG_TYR_ITIM	16	21	PF00017	0.563
LIG_Vh1_VBS_1	94	112	PF01044	0.547
LIG_WRC_WIRS_1	215	220	PF05994	0.285
MOD_CK1_1	130	136	PF00069	0.405
MOD_CK1_1	206	212	PF00069	0.244
MOD_CK1_1	28	34	PF00069	0.319
MOD_CK2_1	41	47	PF00069	0.422
MOD_CK2_1	80	86	PF00069	0.660
MOD_GlcNHglycan	209	212	PF01048	0.505
MOD_GlcNHglycan	220	223	PF01048	0.470
MOD_GlcNHglycan	55	58	PF01048	0.338
MOD_GSK3_1	203	210	PF00069	0.244
MOD_GSK3_1	214	221	PF00069	0.225
MOD_GSK3_1	27	34	PF00069	0.330
MOD_GSK3_1	41	48	PF00069	0.334
MOD_GSK3_1	80	87	PF00069	0.662
MOD_NEK2_1	1	6	PF00069	0.534
MOD_NEK2_1	107	112	PF00069	0.173
MOD_NEK2_1	148	153	PF00069	0.363
MOD_NEK2_1	218	223	PF00069	0.285
MOD_NEK2_1	25	30	PF00069	0.297
MOD_NEK2_1	53	58	PF00069	0.356
MOD_NEK2_1	90	95	PF00069	0.568
MOD_OFUCOSY	26	32	PF10250	0.447
MOD_Plk_4	107	113	PF00069	0.338
MOD_Plk_4	148	154	PF00069	0.447
MOD_Plk_4	214	220	PF00069	0.240
MOD_Plk_4	3	9	PF00069	0.536
MOD_Plk_4	31	37	PF00069	0.328
MOD_ProDKin_1	80	86	PF00069	0.660
TRG_ENDOCYTIC_2	18	21	PF00928	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P462	Leptomonas seymouri	58%	91%
A0A1X0NID7	Trypanosomatidae	34%	76%
A0A422NPK8	Trypanosoma rangeli	34%	69%
P0CU19	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	82%
P0CU20	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	82%