TerD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TerD domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B258_LEIMU

TriTrypDb:

LmxM.30.2590

Length:

927

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B258

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B258

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	485	489	PF00656	0.670
CLV_C14_Caspase3-7	551	555	PF00656	0.791
CLV_MEL_PAP_1	875	881	PF00089	0.547
CLV_NRD_NRD_1	106	108	PF00675	0.619
CLV_NRD_NRD_1	113	115	PF00675	0.658
CLV_NRD_NRD_1	178	180	PF00675	0.683
CLV_NRD_NRD_1	314	316	PF00675	0.569
CLV_NRD_NRD_1	478	480	PF00675	0.487
CLV_NRD_NRD_1	520	522	PF00675	0.633
CLV_NRD_NRD_1	616	618	PF00675	0.716
CLV_NRD_NRD_1	686	688	PF00675	0.764
CLV_NRD_NRD_1	902	904	PF00675	0.409
CLV_PCSK_KEX2_1	106	108	PF00082	0.623
CLV_PCSK_KEX2_1	112	114	PF00082	0.663
CLV_PCSK_KEX2_1	178	180	PF00082	0.714
CLV_PCSK_KEX2_1	314	316	PF00082	0.617
CLV_PCSK_KEX2_1	435	437	PF00082	0.650
CLV_PCSK_KEX2_1	520	522	PF00082	0.636
CLV_PCSK_KEX2_1	528	530	PF00082	0.700
CLV_PCSK_KEX2_1	615	617	PF00082	0.727
CLV_PCSK_KEX2_1	902	904	PF00082	0.473
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.650
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.536
CLV_PCSK_SKI1_1	315	319	PF00082	0.557
CLV_PCSK_SKI1_1	439	443	PF00082	0.491
CLV_PCSK_SKI1_1	653	657	PF00082	0.784
CLV_PCSK_SKI1_1	810	814	PF00082	0.483
DEG_APCC_DBOX_1	313	321	PF00400	0.618
DEG_APCC_DBOX_1	585	593	PF00400	0.451
DEG_APCC_DBOX_1	721	729	PF00400	0.597
DEG_COP1_1	437	447	PF00400	0.576
DEG_Kelch_Keap1_1	230	235	PF01344	0.385
DEG_SPOP_SBC_1	792	796	PF00917	0.589
DOC_CDC14_PxL_1	441	449	PF14671	0.463
DOC_MAPK_DCC_7	439	449	PF00069	0.469
DOC_MAPK_gen_1	314	320	PF00069	0.554
DOC_MAPK_gen_1	44	54	PF00069	0.554
DOC_MAPK_gen_1	528	535	PF00069	0.538
DOC_MAPK_gen_1	774	782	PF00069	0.585
DOC_MAPK_gen_1	805	814	PF00069	0.458
DOC_MAPK_gen_1	876	884	PF00069	0.499
DOC_MAPK_gen_1	9	19	PF00069	0.464
DOC_MAPK_MEF2A_6	12	21	PF00069	0.490
DOC_MAPK_MEF2A_6	44	53	PF00069	0.552
DOC_MAPK_MEF2A_6	492	500	PF00069	0.421
DOC_MAPK_MEF2A_6	805	813	PF00069	0.434
DOC_PP1_RVXF_1	784	790	PF00149	0.602
DOC_PP4_FxxP_1	11	14	PF00568	0.459
DOC_PP4_FxxP_1	442	445	PF00568	0.487
DOC_SPAK_OSR1_1	345	349	PF12202	0.326
DOC_USP7_MATH_1	388	392	PF00917	0.468
DOC_USP7_MATH_1	538	542	PF00917	0.678
DOC_USP7_MATH_1	667	671	PF00917	0.788
DOC_USP7_MATH_1	792	796	PF00917	0.620
DOC_USP7_MATH_2	585	591	PF00917	0.604
DOC_USP7_UBL2_3	435	439	PF12436	0.564
DOC_USP7_UBL2_3	684	688	PF12436	0.499
DOC_WW_Pin1_4	627	632	PF00397	0.666
DOC_WW_Pin1_4	775	780	PF00397	0.470
LIG_14-3-3_CanoR_1	314	318	PF00244	0.625
LIG_14-3-3_CanoR_1	466	470	PF00244	0.419
LIG_14-3-3_CanoR_1	542	547	PF00244	0.641
LIG_Actin_WH2_2	366	383	PF00022	0.490
LIG_APCC_ABBA_1	226	231	PF00400	0.493
LIG_APCC_ABBA_1	359	364	PF00400	0.480
LIG_APCC_ABBAyCdc20_2	225	231	PF00400	0.494
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_BRCT_BRCA1_1	23	27	PF00533	0.565
LIG_Clathr_ClatBox_1	360	364	PF01394	0.525
LIG_deltaCOP1_diTrp_1	751	755	PF00928	0.520
LIG_eIF4E_1	776	782	PF01652	0.587
LIG_FHA_1	248	254	PF00498	0.467
LIG_FHA_1	300	306	PF00498	0.583
LIG_FHA_1	409	415	PF00498	0.469
LIG_FHA_1	650	656	PF00498	0.744
LIG_FHA_1	700	706	PF00498	0.719
LIG_FHA_1	756	762	PF00498	0.668
LIG_FHA_1	814	820	PF00498	0.568
LIG_FHA_2	212	218	PF00498	0.464
LIG_FHA_2	338	344	PF00498	0.562
LIG_FHA_2	424	430	PF00498	0.485
LIG_FHA_2	460	466	PF00498	0.418
LIG_FHA_2	841	847	PF00498	0.703
LIG_HCF-1_HBM_1	371	374	PF13415	0.548
LIG_Integrin_isoDGR_2	518	520	PF01839	0.708
LIG_LIR_Apic_2	411	415	PF02991	0.442
LIG_LIR_Apic_2	440	445	PF02991	0.454
LIG_LIR_Gen_1	204	213	PF02991	0.439
LIG_LIR_Gen_1	217	226	PF02991	0.408
LIG_LIR_Gen_1	24	33	PF02991	0.615
LIG_LIR_Gen_1	357	363	PF02991	0.383
LIG_LIR_Gen_1	403	414	PF02991	0.428
LIG_LIR_Gen_1	446	456	PF02991	0.600
LIG_LIR_Gen_1	45	54	PF02991	0.548
LIG_LIR_Gen_1	509	517	PF02991	0.573
LIG_LIR_Gen_1	710	719	PF02991	0.579
LIG_LIR_Nem_3	204	210	PF02991	0.421
LIG_LIR_Nem_3	217	221	PF02991	0.421
LIG_LIR_Nem_3	24	28	PF02991	0.593
LIG_LIR_Nem_3	270	276	PF02991	0.586
LIG_LIR_Nem_3	357	362	PF02991	0.441
LIG_LIR_Nem_3	403	409	PF02991	0.438
LIG_LIR_Nem_3	446	451	PF02991	0.569
LIG_LIR_Nem_3	45	51	PF02991	0.551
LIG_LIR_Nem_3	509	515	PF02991	0.599
LIG_LIR_Nem_3	630	635	PF02991	0.663
LIG_LIR_Nem_3	797	803	PF02991	0.501
LIG_LIR_Nem_3	846	851	PF02991	0.545
LIG_MYND_1	75	79	PF01753	0.624
LIG_Pex14_1	427	431	PF04695	0.571
LIG_Pex14_2	295	299	PF04695	0.436
LIG_Pex14_2	346	350	PF04695	0.322
LIG_Pex14_2	512	516	PF04695	0.647
LIG_Pex14_2	54	58	PF04695	0.466
LIG_PTB_Apo_2	137	144	PF02174	0.603
LIG_PTB_Apo_2	52	59	PF02174	0.448
LIG_PTB_Apo_2	770	777	PF02174	0.609
LIG_PTB_Apo_2	915	922	PF02174	0.656
LIG_PTB_Phospho_1	137	143	PF10480	0.597
LIG_PTB_Phospho_1	770	776	PF10480	0.609
LIG_PTB_Phospho_1	915	921	PF10480	0.652
LIG_SH2_CRK	412	416	PF00017	0.418
LIG_SH2_CRK	776	780	PF00017	0.504
LIG_SH2_CRK	80	84	PF00017	0.492
LIG_SH2_CRK	806	810	PF00017	0.537
LIG_SH2_GRB2like	131	134	PF00017	0.700
LIG_SH2_GRB2like	719	722	PF00017	0.676
LIG_SH2_GRB2like	916	919	PF00017	0.648
LIG_SH2_NCK_1	131	135	PF00017	0.665
LIG_SH2_PTP2	580	583	PF00017	0.511
LIG_SH2_SRC	369	372	PF00017	0.443
LIG_SH2_SRC	580	583	PF00017	0.478
LIG_SH2_STAP1	131	135	PF00017	0.700
LIG_SH2_STAP1	269	273	PF00017	0.494
LIG_SH2_STAP1	602	606	PF00017	0.636
LIG_SH2_STAP1	871	875	PF00017	0.483
LIG_SH2_STAP1	912	916	PF00017	0.673
LIG_SH2_STAT3	213	216	PF00017	0.605
LIG_SH2_STAT3	917	920	PF00017	0.694
LIG_SH2_STAT5	131	134	PF00017	0.707
LIG_SH2_STAT5	213	216	PF00017	0.487
LIG_SH2_STAT5	369	372	PF00017	0.443
LIG_SH2_STAT5	448	451	PF00017	0.490
LIG_SH2_STAT5	580	583	PF00017	0.496
LIG_SH2_STAT5	595	598	PF00017	0.393
LIG_SH2_STAT5	800	803	PF00017	0.542
LIG_SH3_2	740	745	PF14604	0.563
LIG_SH3_3	453	459	PF00018	0.679
LIG_SH3_3	579	585	PF00018	0.586
LIG_SH3_3	737	743	PF00018	0.489
LIG_SUMO_SIM_anti_2	316	322	PF11976	0.657
LIG_SUMO_SIM_anti_2	403	411	PF11976	0.429
LIG_SUMO_SIM_anti_2	823	828	PF11976	0.459
LIG_SUMO_SIM_par_1	31	36	PF11976	0.477
LIG_SUMO_SIM_par_1	530	536	PF11976	0.633
LIG_SUMO_SIM_par_1	778	783	PF11976	0.625
LIG_TRAF2_1	262	265	PF00917	0.683
LIG_TRAF2_1	281	284	PF00917	0.636
LIG_TRFH_1	572	576	PF08558	0.621
LIG_TYR_ITIM	78	83	PF00017	0.477
LIG_WRC_WIRS_1	191	196	PF05994	0.554
LIG_WRC_WIRS_1	292	297	PF05994	0.447
LIG_WRC_WIRS_1	428	433	PF05994	0.505
MOD_CAAXbox	924	927	PF01239	0.585
MOD_CK1_1	211	217	PF00069	0.606
MOD_CK1_1	313	319	PF00069	0.569
MOD_CK1_1	545	551	PF00069	0.727
MOD_CK1_1	794	800	PF00069	0.589
MOD_CK1_1	84	90	PF00069	0.543
MOD_CK2_1	229	235	PF00069	0.548
MOD_CK2_1	260	266	PF00069	0.727
MOD_CK2_1	423	429	PF00069	0.481
MOD_CK2_1	556	562	PF00069	0.733
MOD_CK2_1	630	636	PF00069	0.699
MOD_Cter_Amidation	104	107	PF01082	0.576
MOD_Cter_Amidation	518	521	PF01082	0.693
MOD_GlcNHglycan	2	5	PF01048	0.559
MOD_GlcNHglycan	350	353	PF01048	0.481
MOD_GlcNHglycan	36	40	PF01048	0.418
MOD_GlcNHglycan	390	393	PF01048	0.493
MOD_GlcNHglycan	535	538	PF01048	0.726
MOD_GlcNHglycan	542	545	PF01048	0.718
MOD_GlcNHglycan	632	635	PF01048	0.758
MOD_GlcNHglycan	669	672	PF01048	0.775
MOD_GlcNHglycan	83	86	PF01048	0.577
MOD_GlcNHglycan	865	868	PF01048	0.713
MOD_GlcNHglycan	871	874	PF01048	0.502
MOD_GSK3_1	125	132	PF00069	0.740
MOD_GSK3_1	13	20	PF00069	0.521
MOD_GSK3_1	190	197	PF00069	0.572
MOD_GSK3_1	243	250	PF00069	0.489
MOD_GSK3_1	291	298	PF00069	0.438
MOD_GSK3_1	335	342	PF00069	0.611
MOD_GSK3_1	423	430	PF00069	0.504
MOD_GSK3_1	538	545	PF00069	0.618
MOD_GSK3_1	630	637	PF00069	0.766
MOD_GSK3_1	642	649	PF00069	0.652
MOD_GSK3_1	665	672	PF00069	0.634
MOD_GSK3_1	696	703	PF00069	0.667
MOD_GSK3_1	81	88	PF00069	0.608
MOD_N-GLC_1	229	234	PF02516	0.523
MOD_N-GLC_1	247	252	PF02516	0.357
MOD_N-GLC_1	452	457	PF02516	0.535
MOD_N-GLC_1	627	632	PF02516	0.600
MOD_N-GLC_1	720	725	PF02516	0.647
MOD_N-GLC_1	792	797	PF02516	0.505
MOD_N-GLC_2	417	419	PF02516	0.300
MOD_NEK2_1	194	199	PF00069	0.511
MOD_NEK2_1	295	300	PF00069	0.435
MOD_NEK2_1	310	315	PF00069	0.475
MOD_NEK2_1	35	40	PF00069	0.404
MOD_NEK2_1	395	400	PF00069	0.663
MOD_NEK2_1	504	509	PF00069	0.598
MOD_NEK2_1	533	538	PF00069	0.723
MOD_NEK2_1	643	648	PF00069	0.775
MOD_NEK2_1	755	760	PF00069	0.658
MOD_NEK2_1	813	818	PF00069	0.575
MOD_NEK2_1	877	882	PF00069	0.479
MOD_NEK2_2	679	684	PF00069	0.594
MOD_NEK2_2	766	771	PF00069	0.638
MOD_PIKK_1	260	266	PF00454	0.599
MOD_PIKK_1	506	512	PF00454	0.615
MOD_PIKK_1	711	717	PF00454	0.414
MOD_PK_1	379	385	PF00069	0.559
MOD_PK_1	542	548	PF00069	0.668
MOD_PKA_2	242	248	PF00069	0.592
MOD_PKA_2	313	319	PF00069	0.630
MOD_PKA_2	388	394	PF00069	0.476
MOD_PKA_2	465	471	PF00069	0.382
MOD_PKA_2	607	613	PF00069	0.659
MOD_PKA_2	877	883	PF00069	0.481
MOD_Plk_1	216	222	PF00069	0.477
MOD_Plk_1	325	331	PF00069	0.522
MOD_Plk_1	35	41	PF00069	0.403
MOD_Plk_1	452	458	PF00069	0.618
MOD_Plk_1	62	68	PF00069	0.642
MOD_Plk_1	621	627	PF00069	0.464
MOD_Plk_1	679	685	PF00069	0.804
MOD_Plk_1	700	706	PF00069	0.652
MOD_Plk_1	85	91	PF00069	0.663
MOD_Plk_4	13	19	PF00069	0.567
MOD_Plk_4	190	196	PF00069	0.438
MOD_Plk_4	417	423	PF00069	0.408
MOD_Plk_4	437	443	PF00069	0.286
MOD_Plk_4	669	675	PF00069	0.624
MOD_Plk_4	766	772	PF00069	0.525
MOD_ProDKin_1	627	633	PF00069	0.668
MOD_ProDKin_1	775	781	PF00069	0.466
MOD_SUMO_rev_2	767	775	PF00179	0.623
TRG_AP2beta_CARGO_1	403	413	PF09066	0.431
TRG_DiLeu_BaEn_1	405	410	PF01217	0.427
TRG_DiLeu_BaEn_2	189	195	PF01217	0.431
TRG_ENDOCYTIC_2	448	451	PF00928	0.430
TRG_ENDOCYTIC_2	580	583	PF00928	0.476
TRG_ENDOCYTIC_2	632	635	PF00928	0.754
TRG_ENDOCYTIC_2	709	712	PF00928	0.641
TRG_ENDOCYTIC_2	80	83	PF00928	0.475
TRG_ENDOCYTIC_2	800	803	PF00928	0.515
TRG_ENDOCYTIC_2	806	809	PF00928	0.464
TRG_ER_diArg_1	111	114	PF00400	0.748
TRG_ER_diArg_1	177	179	PF00400	0.735
TRG_ER_diArg_1	520	522	PF00400	0.642
TRG_ER_diArg_1	615	617	PF00400	0.727
TRG_ER_diArg_1	808	811	PF00400	0.410
TRG_ER_diArg_1	875	878	PF00400	0.423
TRG_NES_CRM1_1	573	587	PF08389	0.607
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P463	Leptomonas seymouri	65%	100%
A0A1X0NIL2	Trypanosomatidae	41%	100%
A0A3S7X4T6	Leishmania donovani	90%	100%
A0A422NPC4	Trypanosoma rangeli	39%	100%
A4HJP7	Leishmania braziliensis	77%	98%
A4I764	Leishmania infantum	90%	100%
C9ZME9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZWN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q602	Leishmania major	90%	100%
V5B2Y1	Trypanosoma cruzi	49%	100%