Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B254_LEIMU

TriTrypDb:

LmxM.30.2550

Length:

788

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 14
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B254

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B254

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.453
CLV_C14_Caspase3-7	469	473	PF00656	0.415
CLV_C14_Caspase3-7	57	61	PF00656	0.748
CLV_C14_Caspase3-7	672	676	PF00656	0.603
CLV_NRD_NRD_1	101	103	PF00675	0.608
CLV_NRD_NRD_1	261	263	PF00675	0.418
CLV_NRD_NRD_1	28	30	PF00675	0.420
CLV_NRD_NRD_1	445	447	PF00675	0.475
CLV_NRD_NRD_1	462	464	PF00675	0.478
CLV_NRD_NRD_1	488	490	PF00675	0.588
CLV_NRD_NRD_1	564	566	PF00675	0.650
CLV_PCSK_FUR_1	354	358	PF00082	0.334
CLV_PCSK_FUR_1	562	566	PF00082	0.667
CLV_PCSK_KEX2_1	101	103	PF00082	0.604
CLV_PCSK_KEX2_1	261	263	PF00082	0.418
CLV_PCSK_KEX2_1	28	30	PF00082	0.420
CLV_PCSK_KEX2_1	356	358	PF00082	0.506
CLV_PCSK_KEX2_1	445	447	PF00082	0.445
CLV_PCSK_KEX2_1	462	464	PF00082	0.478
CLV_PCSK_KEX2_1	488	490	PF00082	0.588
CLV_PCSK_KEX2_1	564	566	PF00082	0.629
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.506
CLV_PCSK_PC7_1	484	490	PF00082	0.358
CLV_PCSK_SKI1_1	102	106	PF00082	0.415
CLV_PCSK_SKI1_1	182	186	PF00082	0.485
CLV_PCSK_SKI1_1	249	253	PF00082	0.455
CLV_PCSK_SKI1_1	311	315	PF00082	0.417
CLV_PCSK_SKI1_1	356	360	PF00082	0.502
CLV_PCSK_SKI1_1	489	493	PF00082	0.535
CLV_PCSK_SKI1_1	749	753	PF00082	0.500
DEG_APCC_DBOX_1	779	787	PF00400	0.571
DEG_MDM2_SWIB_1	260	267	PF02201	0.315
DEG_Nend_Nbox_1	1	3	PF02207	0.403
DEG_SPOP_SBC_1	54	58	PF00917	0.616
DOC_CKS1_1	589	594	PF01111	0.554
DOC_CKS1_1	647	652	PF01111	0.754
DOC_CKS1_1	76	81	PF01111	0.536
DOC_CYCLIN_RxL_1	176	187	PF00134	0.481
DOC_CYCLIN_RxL_1	379	388	PF00134	0.494
DOC_CYCLIN_yClb1_LxF_4	247	252	PF00134	0.399
DOC_MAPK_gen_1	356	366	PF00069	0.380
DOC_MAPK_gen_1	599	607	PF00069	0.554
DOC_MAPK_gen_1	99	106	PF00069	0.445
DOC_PP1_RVXF_1	18	25	PF00149	0.475
DOC_PP1_RVXF_1	247	253	PF00149	0.472
DOC_PP4_FxxP_1	422	425	PF00568	0.475
DOC_USP7_MATH_1	206	210	PF00917	0.560
DOC_USP7_MATH_1	398	402	PF00917	0.307
DOC_USP7_MATH_1	616	620	PF00917	0.703
DOC_USP7_MATH_1	731	735	PF00917	0.706
DOC_USP7_MATH_1	77	81	PF00917	0.726
DOC_USP7_UBL2_3	356	360	PF12436	0.409
DOC_USP7_UBL2_3	99	103	PF12436	0.304
DOC_WW_Pin1_4	143	148	PF00397	0.623
DOC_WW_Pin1_4	228	233	PF00397	0.527
DOC_WW_Pin1_4	436	441	PF00397	0.525
DOC_WW_Pin1_4	588	593	PF00397	0.653
DOC_WW_Pin1_4	609	614	PF00397	0.724
DOC_WW_Pin1_4	626	631	PF00397	0.754
DOC_WW_Pin1_4	646	651	PF00397	0.788
DOC_WW_Pin1_4	703	708	PF00397	0.567
DOC_WW_Pin1_4	723	728	PF00397	0.670
DOC_WW_Pin1_4	75	80	PF00397	0.740
DOC_WW_Pin1_4	753	758	PF00397	0.595
LIG_14-3-3_CanoR_1	20	25	PF00244	0.223
LIG_14-3-3_CanoR_1	732	738	PF00244	0.550
LIG_Actin_WH2_2	346	362	PF00022	0.349
LIG_AP2alpha_2	177	179	PF02296	0.421
LIG_APCC_ABBA_1	605	610	PF00400	0.502
LIG_APCC_ABBAyCdc20_2	604	610	PF00400	0.506
LIG_BRCT_BRCA1_1	345	349	PF00533	0.622
LIG_DLG_GKlike_1	20	27	PF00625	0.227
LIG_EVH1_2	94	98	PF00568	0.426
LIG_FHA_1	105	111	PF00498	0.379
LIG_FHA_1	350	356	PF00498	0.619
LIG_FHA_1	430	436	PF00498	0.556
LIG_FHA_1	437	443	PF00498	0.487
LIG_FHA_1	459	465	PF00498	0.534
LIG_FHA_1	631	637	PF00498	0.723
LIG_FHA_1	641	647	PF00498	0.729
LIG_FHA_2	112	118	PF00498	0.499
LIG_FHA_2	2	8	PF00498	0.460
LIG_FHA_2	322	328	PF00498	0.411
LIG_FHA_2	480	486	PF00498	0.539
LIG_FHA_2	55	61	PF00498	0.771
LIG_FHA_2	762	768	PF00498	0.589
LIG_LIR_Apic_2	420	425	PF02991	0.472
LIG_LIR_Apic_2	695	700	PF02991	0.732
LIG_LIR_Gen_1	117	124	PF02991	0.487
LIG_LIR_Gen_1	183	192	PF02991	0.433
LIG_LIR_Gen_1	23	32	PF02991	0.265
LIG_LIR_Gen_1	301	309	PF02991	0.463
LIG_LIR_Gen_1	391	402	PF02991	0.429
LIG_LIR_Gen_1	453	464	PF02991	0.562
LIG_LIR_Gen_1	513	523	PF02991	0.635
LIG_LIR_Gen_1	708	718	PF02991	0.486
LIG_LIR_Nem_3	117	121	PF02991	0.514
LIG_LIR_Nem_3	126	132	PF02991	0.402
LIG_LIR_Nem_3	183	188	PF02991	0.413
LIG_LIR_Nem_3	190	195	PF02991	0.420
LIG_LIR_Nem_3	23	27	PF02991	0.392
LIG_LIR_Nem_3	257	263	PF02991	0.386
LIG_LIR_Nem_3	301	306	PF02991	0.464
LIG_LIR_Nem_3	391	397	PF02991	0.393
LIG_LIR_Nem_3	420	426	PF02991	0.428
LIG_LIR_Nem_3	453	459	PF02991	0.542
LIG_LIR_Nem_3	513	518	PF02991	0.628
LIG_LIR_Nem_3	692	697	PF02991	0.699
LIG_LIR_Nem_3	708	713	PF02991	0.677
LIG_LYPXL_SIV_4	714	722	PF13949	0.529
LIG_MYND_1	151	155	PF01753	0.554
LIG_Pex14_2	13	17	PF04695	0.596
LIG_Pex14_2	260	264	PF04695	0.317
LIG_Rb_pABgroove_1	179	187	PF01858	0.479
LIG_REV1ctd_RIR_1	177	186	PF16727	0.477
LIG_SH2_CRK	273	277	PF00017	0.440
LIG_SH2_CRK	281	285	PF00017	0.411
LIG_SH2_CRK	438	442	PF00017	0.413
LIG_SH2_NCK_1	715	719	PF00017	0.620
LIG_SH2_PTP2	704	707	PF00017	0.465
LIG_SH2_SRC	194	197	PF00017	0.342
LIG_SH2_STAP1	273	277	PF00017	0.508
LIG_SH2_STAP1	33	37	PF00017	0.536
LIG_SH2_STAP1	537	541	PF00017	0.589
LIG_SH2_STAP1	694	698	PF00017	0.603
LIG_SH2_STAP1	715	719	PF00017	0.528
LIG_SH2_STAT3	265	268	PF00017	0.398
LIG_SH2_STAT5	174	177	PF00017	0.480
LIG_SH2_STAT5	194	197	PF00017	0.342
LIG_SH2_STAT5	265	268	PF00017	0.398
LIG_SH2_STAT5	3	6	PF00017	0.441
LIG_SH2_STAT5	30	33	PF00017	0.437
LIG_SH2_STAT5	315	318	PF00017	0.354
LIG_SH2_STAT5	323	326	PF00017	0.381
LIG_SH2_STAT5	363	366	PF00017	0.376
LIG_SH2_STAT5	438	441	PF00017	0.391
LIG_SH2_STAT5	478	481	PF00017	0.436
LIG_SH2_STAT5	697	700	PF00017	0.701
LIG_SH2_STAT5	704	707	PF00017	0.675
LIG_SH3_3	145	151	PF00018	0.503
LIG_SH3_3	229	235	PF00018	0.624
LIG_SH3_3	241	247	PF00018	0.655
LIG_SH3_3	283	289	PF00018	0.430
LIG_SH3_3	402	408	PF00018	0.485
LIG_SH3_3	422	428	PF00018	0.386
LIG_SH3_3	566	572	PF00018	0.611
LIG_SH3_3	586	592	PF00018	0.452
LIG_SH3_3	88	94	PF00018	0.634
LIG_TRAF2_1	324	327	PF00917	0.364
LIG_TRAF2_1	706	709	PF00917	0.640
LIG_TRAF2_1	775	778	PF00917	0.573
LIG_TYR_ITIM	271	276	PF00017	0.450
LIG_WRC_WIRS_1	314	319	PF05994	0.428
MOD_CDK_SPK_2	228	233	PF00069	0.527
MOD_CDK_SPxK_1	609	615	PF00069	0.546
MOD_CDK_SPxxK_3	588	595	PF00069	0.561
MOD_CK1_1	23	29	PF00069	0.501
MOD_CK1_1	343	349	PF00069	0.511
MOD_CK1_1	458	464	PF00069	0.647
MOD_CK1_1	46	52	PF00069	0.685
MOD_CK1_1	474	480	PF00069	0.547
MOD_CK1_1	500	506	PF00069	0.602
MOD_CK1_1	626	632	PF00069	0.788
MOD_CK1_1	678	684	PF00069	0.746
MOD_CK1_1	685	691	PF00069	0.713
MOD_CK1_1	692	698	PF00069	0.690
MOD_CK1_1	720	726	PF00069	0.711
MOD_CK1_1	80	86	PF00069	0.661
MOD_CK1_1	89	95	PF00069	0.525
MOD_CK2_1	1	7	PF00069	0.424
MOD_CK2_1	111	117	PF00069	0.463
MOD_CK2_1	157	163	PF00069	0.596
MOD_CK2_1	321	327	PF00069	0.572
MOD_CK2_1	479	485	PF00069	0.582
MOD_CK2_1	549	555	PF00069	0.633
MOD_CK2_1	680	686	PF00069	0.768
MOD_CK2_1	703	709	PF00069	0.656
MOD_CK2_1	761	767	PF00069	0.645
MOD_GlcNHglycan	117	121	PF01048	0.512
MOD_GlcNHglycan	208	211	PF01048	0.584
MOD_GlcNHglycan	345	348	PF01048	0.493
MOD_GlcNHglycan	376	379	PF01048	0.351
MOD_GlcNHglycan	400	403	PF01048	0.327
MOD_GlcNHglycan	551	554	PF01048	0.549
MOD_GlcNHglycan	57	60	PF01048	0.787
MOD_GlcNHglycan	616	619	PF01048	0.750
MOD_GlcNHglycan	625	628	PF01048	0.768
MOD_GlcNHglycan	63	66	PF01048	0.835
MOD_GlcNHglycan	661	664	PF01048	0.649
MOD_GlcNHglycan	719	722	PF01048	0.719
MOD_GlcNHglycan	733	736	PF01048	0.576
MOD_GlcNHglycan	80	83	PF01048	0.625
MOD_GSK3_1	298	305	PF00069	0.515
MOD_GSK3_1	326	333	PF00069	0.548
MOD_GSK3_1	341	348	PF00069	0.651
MOD_GSK3_1	451	458	PF00069	0.478
MOD_GSK3_1	626	633	PF00069	0.710
MOD_GSK3_1	674	681	PF00069	0.755
MOD_GSK3_1	685	692	PF00069	0.727
MOD_GSK3_1	71	78	PF00069	0.714
MOD_GSK3_1	743	750	PF00069	0.749
MOD_GSK3_1	89	96	PF00069	0.477
MOD_N-GLC_1	167	172	PF02516	0.473
MOD_N-GLC_1	498	503	PF02516	0.625
MOD_N-GLC_1	60	65	PF02516	0.679
MOD_NEK2_1	1	6	PF00069	0.473
MOD_NEK2_1	13	18	PF00069	0.584
MOD_NEK2_1	184	189	PF00069	0.496
MOD_NEK2_1	340	345	PF00069	0.639
MOD_NEK2_1	349	354	PF00069	0.552
MOD_NEK2_1	374	379	PF00069	0.481
MOD_NEK2_1	776	781	PF00069	0.711
MOD_OFUCOSY	449	455	PF10250	0.479
MOD_PIKK_1	157	163	PF00454	0.617
MOD_PKA_2	374	380	PF00069	0.506
MOD_PKA_2	398	404	PF00069	0.310
MOD_PKA_2	600	606	PF00069	0.625
MOD_PKA_2	61	67	PF00069	0.825
MOD_PKA_2	614	620	PF00069	0.640
MOD_PKA_2	731	737	PF00069	0.546
MOD_Plk_1	116	122	PF00069	0.658
MOD_Plk_1	341	347	PF00069	0.692
MOD_Plk_1	471	477	PF00069	0.493
MOD_Plk_1	498	504	PF00069	0.508
MOD_Plk_1	674	680	PF00069	0.643
MOD_Plk_1	685	691	PF00069	0.692
MOD_Plk_1	692	698	PF00069	0.591
MOD_Plk_1	761	767	PF00069	0.623
MOD_Plk_1	89	95	PF00069	0.711
MOD_Plk_2-3	761	767	PF00069	0.645
MOD_Plk_4	217	223	PF00069	0.662
MOD_Plk_4	225	231	PF00069	0.551
MOD_Plk_4	266	272	PF00069	0.421
MOD_Plk_4	298	304	PF00069	0.433
MOD_Plk_4	313	319	PF00069	0.337
MOD_Plk_4	367	373	PF00069	0.469
MOD_Plk_4	474	480	PF00069	0.532
MOD_Plk_4	510	516	PF00069	0.669
MOD_Plk_4	685	691	PF00069	0.603
MOD_Plk_4	693	699	PF00069	0.550
MOD_ProDKin_1	143	149	PF00069	0.629
MOD_ProDKin_1	228	234	PF00069	0.532
MOD_ProDKin_1	436	442	PF00069	0.520
MOD_ProDKin_1	588	594	PF00069	0.658
MOD_ProDKin_1	609	615	PF00069	0.728
MOD_ProDKin_1	626	632	PF00069	0.749
MOD_ProDKin_1	646	652	PF00069	0.752
MOD_ProDKin_1	703	709	PF00069	0.562
MOD_ProDKin_1	723	729	PF00069	0.672
MOD_ProDKin_1	75	81	PF00069	0.738
MOD_ProDKin_1	753	759	PF00069	0.594
MOD_SUMO_for_1	235	238	PF00179	0.591
MOD_SUMO_for_1	37	40	PF00179	0.410
TRG_AP2beta_CARGO_1	190	199	PF09066	0.521
TRG_AP2beta_CARGO_1	453	463	PF09066	0.559
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.546
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.414
TRG_ENDOCYTIC_2	273	276	PF00928	0.437
TRG_ENDOCYTIC_2	281	284	PF00928	0.445
TRG_ENDOCYTIC_2	315	318	PF00928	0.379
TRG_ENDOCYTIC_2	363	366	PF00928	0.367
TRG_ENDOCYTIC_2	438	441	PF00928	0.417
TRG_ER_diArg_1	100	102	PF00400	0.604
TRG_ER_diArg_1	260	262	PF00400	0.385
TRG_ER_diArg_1	27	29	PF00400	0.478
TRG_ER_diArg_1	444	446	PF00400	0.455
TRG_ER_diArg_1	462	464	PF00400	0.392
TRG_ER_diArg_1	465	468	PF00400	0.417
TRG_ER_diArg_1	488	490	PF00400	0.579
TRG_ER_diArg_1	596	599	PF00400	0.716
TRG_NLS_MonoExtN_4	99	106	PF00514	0.431
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	763	767	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW18	Leptomonas seymouri	41%	88%
A0A0N1PBA0	Leptomonas seymouri	57%	96%
A0A1X0NIQ9	Trypanosomatidae	36%	100%
A0A3Q8ICR1	Leishmania donovani	43%	89%
A0A3Q8ISU5	Leishmania donovani	89%	100%
A0A3R7KGN9	Trypanosoma rangeli	34%	100%
A4HJP3	Leishmania braziliensis	72%	99%
A4HJP4	Leishmania braziliensis	41%	100%
A4I760	Leishmania infantum	89%	100%
A4I761	Leishmania infantum	41%	89%
E9B255	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	76%
Q4Q605	Leishmania major	42%	78%
Q4Q606	Leishmania major	88%	100%
V5BC23	Trypanosoma cruzi	35%	100%