LeishMANIAdb
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Membrane-associated protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-associated protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B253_LEIMU
TriTrypDb:
LmxM.30.2530
Length:
823

Annotations

LeishMANIAdb annotations

The last domain of this multidomain protein is related to animal Stabilins, known lipoprotein receptors. related to the T. cruzi protein “Enriched in surface-labeled proteome protein 10”. Family has expanded on multiple Kinetoplastid branches, also in free-living species. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 11, no: 5
NetGPI no yes: 0, no: 16
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15
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Expansion

Sequence features

E9B253
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B253

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 403 407 PF00656 0.299
CLV_C14_Caspase3-7 643 647 PF00656 0.452
CLV_NRD_NRD_1 15 17 PF00675 0.443
CLV_NRD_NRD_1 7 9 PF00675 0.493
CLV_NRD_NRD_1 754 756 PF00675 0.460
CLV_NRD_NRD_1 778 780 PF00675 0.451
CLV_NRD_NRD_1 809 811 PF00675 0.532
CLV_NRD_NRD_1 814 816 PF00675 0.511
CLV_NRD_NRD_1 86 88 PF00675 0.654
CLV_PCSK_KEX2_1 7 9 PF00082 0.493
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0S4JPQ5 Bodo saltans 27% 98%
A0A0S4KNZ3 Bodo saltans 26% 97%
A0A1X0NFL6 Trypanosomatidae 32% 100%
A0A3Q8IFR8 Leishmania donovani 65% 100%
A0A3S7X4W3 Leishmania donovani 82% 100%
A4HJP2 Leishmania braziliensis 68% 100%
A4I711 Leishmania infantum 65% 100%
A4I759 Leishmania infantum 82% 100%
C9ZIV1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZIW8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS