LeishMANIAdb
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Membrane-associated protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-associated protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B253_LEIMU
TriTrypDb:
LmxM.30.2530
Length:
823

Annotations

LeishMANIAdb annotations

The last domain of this multidomain protein is related to animal Stabilins, known lipoprotein receptors. related to the T. cruzi protein “Enriched in surface-labeled proteome protein 10”. Family has expanded on multiple Kinetoplastid branches, also in free-living species. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 11, no: 5
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15

Expansion

Sequence features

E9B253
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B253

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 403 407 PF00656 0.299
CLV_C14_Caspase3-7 643 647 PF00656 0.452
CLV_NRD_NRD_1 15 17 PF00675 0.443
CLV_NRD_NRD_1 7 9 PF00675 0.493
CLV_NRD_NRD_1 754 756 PF00675 0.460
CLV_NRD_NRD_1 778 780 PF00675 0.451
CLV_NRD_NRD_1 809 811 PF00675 0.532
CLV_NRD_NRD_1 814 816 PF00675 0.511
CLV_NRD_NRD_1 86 88 PF00675 0.654
CLV_PCSK_KEX2_1 7 9 PF00082 0.493
CLV_PCSK_KEX2_1 754 756 PF00082 0.462
CLV_PCSK_KEX2_1 778 780 PF00082 0.444
CLV_PCSK_KEX2_1 809 811 PF00082 0.532
CLV_PCSK_KEX2_1 813 815 PF00082 0.476
CLV_PCSK_PC1ET2_1 813 815 PF00082 0.537
CLV_PCSK_PC7_1 809 815 PF00082 0.540
CLV_PCSK_SKI1_1 212 216 PF00082 0.605
CLV_PCSK_SKI1_1 30 34 PF00082 0.192
CLV_PCSK_SKI1_1 718 722 PF00082 0.602
CLV_PCSK_SKI1_1 809 813 PF00082 0.503
CLV_PCSK_SKI1_1 87 91 PF00082 0.607
DEG_APCC_DBOX_1 756 764 PF00400 0.607
DEG_SCF_FBW7_1 384 391 PF00400 0.385
DEG_SCF_TRCP1_1 197 203 PF00400 0.299
DOC_CKS1_1 266 271 PF01111 0.488
DOC_CKS1_1 328 333 PF01111 0.461
DOC_CKS1_1 350 355 PF01111 0.407
DOC_CKS1_1 385 390 PF01111 0.428
DOC_CKS1_1 702 707 PF01111 0.412
DOC_CYCLIN_yClb1_LxF_4 725 731 PF00134 0.310
DOC_CYCLIN_yCln2_LP_2 738 744 PF00134 0.266
DOC_MAPK_gen_1 16 23 PF00069 0.566
DOC_MAPK_MEF2A_6 16 25 PF00069 0.594
DOC_MAPK_MEF2A_6 342 350 PF00069 0.440
DOC_MAPK_MEF2A_6 541 548 PF00069 0.422
DOC_MAPK_MEF2A_6 796 803 PF00069 0.676
DOC_MAPK_RevD_3 801 815 PF00069 0.729
DOC_PP2B_LxvP_1 738 741 PF13499 0.266
DOC_PP4_FxxP_1 126 129 PF00568 0.382
DOC_PP4_FxxP_1 350 353 PF00568 0.486
DOC_PP4_FxxP_1 385 388 PF00568 0.373
DOC_USP7_MATH_1 113 117 PF00917 0.373
DOC_USP7_MATH_1 184 188 PF00917 0.442
DOC_USP7_MATH_1 191 195 PF00917 0.502
DOC_USP7_MATH_1 214 218 PF00917 0.434
DOC_USP7_MATH_1 242 246 PF00917 0.486
DOC_USP7_MATH_1 331 335 PF00917 0.501
DOC_USP7_MATH_1 388 392 PF00917 0.405
DOC_USP7_MATH_1 397 401 PF00917 0.382
DOC_USP7_MATH_1 428 432 PF00917 0.421
DOC_USP7_MATH_1 550 554 PF00917 0.439
DOC_USP7_MATH_1 615 619 PF00917 0.369
DOC_USP7_MATH_1 623 627 PF00917 0.321
DOC_USP7_MATH_1 651 655 PF00917 0.445
DOC_WW_Pin1_4 125 130 PF00397 0.404
DOC_WW_Pin1_4 265 270 PF00397 0.408
DOC_WW_Pin1_4 327 332 PF00397 0.401
DOC_WW_Pin1_4 349 354 PF00397 0.382
DOC_WW_Pin1_4 384 389 PF00397 0.412
DOC_WW_Pin1_4 701 706 PF00397 0.457
LIG_14-3-3_CanoR_1 101 110 PF00244 0.492
LIG_14-3-3_CanoR_1 201 205 PF00244 0.322
LIG_14-3-3_CanoR_1 237 242 PF00244 0.394
LIG_14-3-3_CanoR_1 30 35 PF00244 0.403
LIG_14-3-3_CanoR_1 333 340 PF00244 0.465
LIG_14-3-3_CanoR_1 476 482 PF00244 0.334
LIG_14-3-3_CanoR_1 662 667 PF00244 0.397
LIG_14-3-3_CanoR_1 755 761 PF00244 0.597
LIG_APCC_ABBA_1 371 376 PF00400 0.448
LIG_APCC_ABBA_1 487 492 PF00400 0.411
LIG_BIR_III_4 492 496 PF00653 0.319
LIG_BIR_III_4 631 635 PF00653 0.466
LIG_BRCT_BRCA1_1 122 126 PF00533 0.367
LIG_BRCT_BRCA1_1 431 435 PF00533 0.416
LIG_BRCT_BRCA1_1 477 481 PF00533 0.338
LIG_BRCT_BRCA1_1 683 687 PF00533 0.447
LIG_deltaCOP1_diTrp_1 166 172 PF00928 0.444
LIG_EH1_1 28 36 PF00400 0.399
LIG_eIF4E_1 479 485 PF01652 0.459
LIG_EVH1_2 140 144 PF00568 0.298
LIG_FHA_1 102 108 PF00498 0.285
LIG_FHA_1 18 24 PF00498 0.737
LIG_FHA_1 221 227 PF00498 0.362
LIG_FHA_1 242 248 PF00498 0.478
LIG_FHA_1 252 258 PF00498 0.408
LIG_FHA_1 31 37 PF00498 0.379
LIG_FHA_1 350 356 PF00498 0.412
LIG_FHA_1 421 427 PF00498 0.391
LIG_FHA_1 462 468 PF00498 0.356
LIG_FHA_1 56 62 PF00498 0.271
LIG_FHA_2 200 206 PF00498 0.479
LIG_FHA_2 298 304 PF00498 0.450
LIG_FHA_2 385 391 PF00498 0.378
LIG_FHA_2 401 407 PF00498 0.401
LIG_FHA_2 76 82 PF00498 0.443
LIG_LIR_Apic_2 123 129 PF02991 0.386
LIG_LIR_Apic_2 136 141 PF02991 0.418
LIG_LIR_Apic_2 347 353 PF02991 0.402
LIG_LIR_Apic_2 699 705 PF02991 0.428
LIG_LIR_Gen_1 203 214 PF02991 0.438
LIG_LIR_Gen_1 352 362 PF02991 0.434
LIG_LIR_Gen_1 478 487 PF02991 0.351
LIG_LIR_Gen_1 729 738 PF02991 0.342
LIG_LIR_Gen_1 764 774 PF02991 0.621
LIG_LIR_LC3C_4 33 36 PF02991 0.188
LIG_LIR_Nem_3 166 170 PF02991 0.393
LIG_LIR_Nem_3 203 209 PF02991 0.366
LIG_LIR_Nem_3 358 363 PF02991 0.431
LIG_LIR_Nem_3 478 484 PF02991 0.294
LIG_LIR_Nem_3 70 76 PF02991 0.348
LIG_LIR_Nem_3 729 733 PF02991 0.284
LIG_LIR_Nem_3 764 769 PF02991 0.670
LIG_LYPXL_yS_3 515 518 PF13949 0.435
LIG_PCNA_PIPBox_1 805 814 PF02747 0.651
LIG_PCNA_yPIPBox_3 804 812 PF02747 0.654
LIG_Pex14_2 350 354 PF04695 0.473
LIG_Pex14_2 481 485 PF04695 0.250
LIG_PTB_Apo_2 365 372 PF02174 0.411
LIG_SH2_CRK 138 142 PF00017 0.503
LIG_SH2_CRK 173 177 PF00017 0.516
LIG_SH2_CRK 206 210 PF00017 0.487
LIG_SH2_CRK 238 242 PF00017 0.443
LIG_SH2_CRK 413 417 PF00017 0.327
LIG_SH2_CRK 702 706 PF00017 0.440
LIG_SH2_GRB2like 229 232 PF00017 0.463
LIG_SH2_NCK_1 173 177 PF00017 0.516
LIG_SH2_NCK_1 490 494 PF00017 0.362
LIG_SH2_NCK_1 702 706 PF00017 0.404
LIG_SH2_SRC 229 232 PF00017 0.463
LIG_SH2_SRC 490 493 PF00017 0.338
LIG_SH2_STAP1 258 262 PF00017 0.523
LIG_SH2_STAP1 344 348 PF00017 0.365
LIG_SH2_STAP1 422 426 PF00017 0.330
LIG_SH2_STAP1 698 702 PF00017 0.445
LIG_SH2_STAT3 377 380 PF00017 0.332
LIG_SH2_STAT5 120 123 PF00017 0.404
LIG_SH2_STAT5 138 141 PF00017 0.442
LIG_SH2_STAT5 173 176 PF00017 0.303
LIG_SH2_STAT5 206 209 PF00017 0.429
LIG_SH2_STAT5 362 365 PF00017 0.398
LIG_SH2_STAT5 422 425 PF00017 0.394
LIG_SH2_STAT5 55 58 PF00017 0.419
LIG_SH2_STAT5 698 701 PF00017 0.422
LIG_SH3_3 104 110 PF00018 0.406
LIG_SH3_3 263 269 PF00018 0.480
LIG_SH3_3 530 536 PF00018 0.379
LIG_SH3_3 766 772 PF00018 0.784
LIG_SUMO_SIM_anti_2 423 428 PF11976 0.388
LIG_SUMO_SIM_anti_2 729 735 PF11976 0.380
LIG_SUMO_SIM_par_1 187 198 PF11976 0.366
LIG_SUMO_SIM_par_1 32 38 PF11976 0.329
LIG_SUMO_SIM_par_1 425 432 PF11976 0.423
LIG_SUMO_SIM_par_1 495 500 PF11976 0.354
LIG_TYR_ITIM 204 209 PF00017 0.504
LIG_UBA3_1 798 804 PF00899 0.638
LIG_WRC_WIRS_1 185 190 PF05994 0.513
LIG_WRC_WIRS_1 357 362 PF05994 0.309
LIG_WW_3 139 143 PF00397 0.351
MOD_CDK_SPxK_1 327 333 PF00069 0.529
MOD_CK1_1 195 201 PF00069 0.502
MOD_CK1_1 217 223 PF00069 0.532
MOD_CK1_1 294 300 PF00069 0.546
MOD_CK1_1 308 314 PF00069 0.229
MOD_CK1_1 400 406 PF00069 0.448
MOD_CK1_1 431 437 PF00069 0.375
MOD_CK1_1 618 624 PF00069 0.682
MOD_CK1_1 63 69 PF00069 0.429
MOD_CK1_1 701 707 PF00069 0.643
MOD_CK2_1 199 205 PF00069 0.620
MOD_CK2_1 361 367 PF00069 0.396
MOD_CK2_1 384 390 PF00069 0.420
MOD_GlcNHglycan 196 200 PF01048 0.559
MOD_GlcNHglycan 216 219 PF01048 0.648
MOD_GlcNHglycan 310 313 PF01048 0.543
MOD_GlcNHglycan 541 544 PF01048 0.500
MOD_GlcNHglycan 564 569 PF01048 0.582
MOD_GlcNHglycan 599 602 PF01048 0.462
MOD_GlcNHglycan 605 608 PF01048 0.499
MOD_GlcNHglycan 617 620 PF01048 0.617
MOD_GlcNHglycan 64 68 PF01048 0.287
MOD_GlcNHglycan 648 651 PF01048 0.465
MOD_GlcNHglycan 691 694 PF01048 0.610
MOD_GlcNHglycan 738 741 PF01048 0.332
MOD_GlcNHglycan 820 823 PF01048 0.677
MOD_GlcNHglycan 84 87 PF01048 0.414
MOD_GSK3_1 115 122 PF00069 0.425
MOD_GSK3_1 147 154 PF00069 0.546
MOD_GSK3_1 191 198 PF00069 0.557
MOD_GSK3_1 237 244 PF00069 0.575
MOD_GSK3_1 261 268 PF00069 0.539
MOD_GSK3_1 313 320 PF00069 0.468
MOD_GSK3_1 327 334 PF00069 0.512
MOD_GSK3_1 349 356 PF00069 0.511
MOD_GSK3_1 384 391 PF00069 0.506
MOD_GSK3_1 400 407 PF00069 0.464
MOD_GSK3_1 471 478 PF00069 0.468
MOD_GSK3_1 599 606 PF00069 0.497
MOD_GSK3_1 614 621 PF00069 0.496
MOD_GSK3_1 63 70 PF00069 0.535
MOD_GSK3_1 696 703 PF00069 0.541
MOD_GSK3_1 732 739 PF00069 0.362
MOD_GSK3_1 75 82 PF00069 0.533
MOD_N-GLC_1 102 107 PF02516 0.454
MOD_N-GLC_1 114 119 PF02516 0.408
MOD_N-GLC_1 155 160 PF02516 0.625
MOD_N-GLC_1 17 22 PF02516 0.447
MOD_N-GLC_1 230 235 PF02516 0.467
MOD_N-GLC_1 367 372 PF02516 0.381
MOD_N-GLC_1 420 425 PF02516 0.456
MOD_N-GLC_1 615 620 PF02516 0.654
MOD_NEK2_1 134 139 PF00069 0.564
MOD_NEK2_1 147 152 PF00069 0.576
MOD_NEK2_1 256 261 PF00069 0.529
MOD_NEK2_1 41 46 PF00069 0.432
MOD_NEK2_1 429 434 PF00069 0.332
MOD_NEK2_1 475 480 PF00069 0.477
MOD_NEK2_1 539 544 PF00069 0.441
MOD_NEK2_1 736 741 PF00069 0.285
MOD_NEK2_1 79 84 PF00069 0.381
MOD_NEK2_1 91 96 PF00069 0.688
MOD_NEK2_2 258 263 PF00069 0.648
MOD_NEK2_2 550 555 PF00069 0.570
MOD_OFUCOSY 395 401 PF10250 0.587
MOD_OFUCOSY 681 686 PF10250 0.581
MOD_PIKK_1 217 223 PF00454 0.625
MOD_PIKK_1 400 406 PF00454 0.498
MOD_PIKK_1 55 61 PF00454 0.476
MOD_PKA_2 147 153 PF00069 0.506
MOD_PKA_2 200 206 PF00069 0.534
MOD_PKA_2 332 338 PF00069 0.465
MOD_PKA_2 475 481 PF00069 0.441
MOD_PKA_2 756 762 PF00069 0.550
MOD_Plk_1 114 120 PF00069 0.454
MOD_Plk_1 155 161 PF00069 0.658
MOD_Plk_1 17 23 PF00069 0.629
MOD_Plk_1 242 248 PF00069 0.570
MOD_Plk_1 291 297 PF00069 0.579
MOD_Plk_1 344 350 PF00069 0.502
MOD_Plk_1 367 373 PF00069 0.371
MOD_Plk_1 420 426 PF00069 0.427
MOD_Plk_1 429 435 PF00069 0.432
MOD_Plk_1 497 503 PF00069 0.514
MOD_Plk_1 528 534 PF00069 0.521
MOD_Plk_1 53 59 PF00069 0.594
MOD_Plk_1 682 688 PF00069 0.599
MOD_Plk_4 115 121 PF00069 0.444
MOD_Plk_4 155 161 PF00069 0.614
MOD_Plk_4 184 190 PF00069 0.585
MOD_Plk_4 230 236 PF00069 0.435
MOD_Plk_4 242 248 PF00069 0.520
MOD_Plk_4 30 36 PF00069 0.384
MOD_Plk_4 388 394 PF00069 0.573
MOD_Plk_4 477 483 PF00069 0.468
MOD_Plk_4 529 535 PF00069 0.444
MOD_ProDKin_1 125 131 PF00069 0.505
MOD_ProDKin_1 265 271 PF00069 0.512
MOD_ProDKin_1 327 333 PF00069 0.507
MOD_ProDKin_1 349 355 PF00069 0.468
MOD_ProDKin_1 384 390 PF00069 0.526
MOD_ProDKin_1 701 707 PF00069 0.584
TRG_ENDOCYTIC_2 206 209 PF00928 0.475
TRG_ENDOCYTIC_2 238 241 PF00928 0.486
TRG_ENDOCYTIC_2 413 416 PF00928 0.529
TRG_ENDOCYTIC_2 479 482 PF00928 0.489
TRG_ENDOCYTIC_2 515 518 PF00928 0.582
TRG_ENDOCYTIC_2 725 728 PF00928 0.611
TRG_ENDOCYTIC_2 76 79 PF00928 0.597
TRG_ER_diArg_1 23 26 PF00400 0.451
TRG_ER_diArg_1 6 8 PF00400 0.626
TRG_ER_diArg_1 753 755 PF00400 0.537
TRG_ER_diArg_1 777 779 PF00400 0.594
TRG_ER_diArg_1 790 793 PF00400 0.729
TRG_ER_diArg_1 808 810 PF00400 0.664
TRG_Pf-PMV_PEXEL_1 775 780 PF00026 0.713

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JPQ5 Bodo saltans 27% 98%
A0A0S4KNZ3 Bodo saltans 26% 97%
A0A1X0NFL6 Trypanosomatidae 32% 100%
A0A3Q8IFR8 Leishmania donovani 65% 100%
A0A3S7X4W3 Leishmania donovani 82% 100%
A4HJP2 Leishmania braziliensis 68% 100%
A4I711 Leishmania infantum 65% 100%
A4I759 Leishmania infantum 82% 100%
C9ZIV1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZIW8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9B252 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 100%
Q4Q607 Leishmania major 72% 100%
Q4Q608 Leishmania major 73% 100%
Q4Q609 Leishmania major 72% 100%
V5BQ27 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS