LeishMANIAdb
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LysM domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
LysM domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B252_LEIMU
TriTrypDb:
LmxM.30.2520
Length:
824

Annotations

LeishMANIAdb annotations

The last domain of this multidomain protein is related to animal Stabilins, known lipoprotein receptors. related to the T. cruzi protein “Enriched in surface-labeled proteome protein 10”. Family has expanded on multiple Kinetoplastid branches, also in free-living species. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 4
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15

Expansion

Sequence features

E9B252
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B252

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 174 178 PF00656 0.494
CLV_C14_Caspase3-7 447 451 PF00656 0.376
CLV_C14_Caspase3-7 641 645 PF00656 0.416
CLV_NRD_NRD_1 49 51 PF00675 0.538
CLV_NRD_NRD_1 6 8 PF00675 0.618
CLV_NRD_NRD_1 790 792 PF00675 0.531
CLV_NRD_NRD_1 808 810 PF00675 0.486
CLV_NRD_NRD_1 813 815 PF00675 0.460
CLV_PCSK_KEX2_1 6 8 PF00082 0.618
CLV_PCSK_KEX2_1 789 791 PF00082 0.535
CLV_PCSK_KEX2_1 808 810 PF00082 0.531
CLV_PCSK_KEX2_1 812 814 PF00082 0.522
CLV_PCSK_PC1ET2_1 812 814 PF00082 0.524
CLV_PCSK_PC7_1 808 814 PF00082 0.495
CLV_PCSK_SKI1_1 215 219 PF00082 0.609
CLV_PCSK_SKI1_1 7 11 PF00082 0.614
CLV_PCSK_SKI1_1 76 80 PF00082 0.570
CLV_PCSK_SKI1_1 808 812 PF00082 0.503
DEG_APCC_DBOX_1 41 49 PF00400 0.349
DOC_CKS1_1 269 274 PF01111 0.419
DOC_CKS1_1 331 336 PF01111 0.465
DOC_CKS1_1 454 459 PF01111 0.315
DOC_CKS1_1 700 705 PF01111 0.384
DOC_MAPK_FxFP_2 77 80 PF00069 0.356
DOC_MAPK_gen_1 757 764 PF00069 0.659
DOC_MAPK_MEF2A_6 345 353 PF00069 0.443
DOC_MAPK_MEF2A_6 482 489 PF00069 0.215
DOC_MAPK_MEF2A_6 539 546 PF00069 0.389
DOC_MAPK_MEF2A_6 795 802 PF00069 0.656
DOC_MAPK_RevD_3 800 814 PF00069 0.716
DOC_PP1_RVXF_1 429 435 PF00149 0.221
DOC_PP4_FxxP_1 106 109 PF00568 0.331
DOC_PP4_FxxP_1 77 80 PF00568 0.436
DOC_USP7_MATH_1 179 183 PF00917 0.604
DOC_USP7_MATH_1 217 221 PF00917 0.424
DOC_USP7_MATH_1 245 249 PF00917 0.423
DOC_USP7_MATH_1 334 338 PF00917 0.516
DOC_USP7_MATH_1 548 552 PF00917 0.432
DOC_USP7_MATH_1 613 617 PF00917 0.359
DOC_USP7_MATH_1 621 625 PF00917 0.316
DOC_USP7_MATH_1 649 653 PF00917 0.409
DOC_USP7_MATH_1 85 89 PF00917 0.468
DOC_USP7_MATH_1 93 97 PF00917 0.316
DOC_WW_Pin1_4 105 110 PF00397 0.384
DOC_WW_Pin1_4 160 165 PF00397 0.456
DOC_WW_Pin1_4 189 194 PF00397 0.481
DOC_WW_Pin1_4 268 273 PF00397 0.421
DOC_WW_Pin1_4 330 335 PF00397 0.404
DOC_WW_Pin1_4 392 397 PF00397 0.250
DOC_WW_Pin1_4 442 447 PF00397 0.461
DOC_WW_Pin1_4 453 458 PF00397 0.468
DOC_WW_Pin1_4 477 482 PF00397 0.440
DOC_WW_Pin1_4 505 510 PF00397 0.326
DOC_WW_Pin1_4 59 64 PF00397 0.412
DOC_WW_Pin1_4 699 704 PF00397 0.467
DOC_WW_Pin1_4 767 772 PF00397 0.644
LIG_14-3-3_CanoR_1 240 245 PF00244 0.413
LIG_14-3-3_CanoR_1 328 334 PF00244 0.440
LIG_14-3-3_CanoR_1 336 343 PF00244 0.459
LIG_14-3-3_CanoR_1 365 373 PF00244 0.285
LIG_14-3-3_CanoR_1 386 392 PF00244 0.261
LIG_14-3-3_CanoR_1 660 665 PF00244 0.379
LIG_14-3-3_CanoR_1 813 822 PF00244 0.651
LIG_14-3-3_CanoR_1 84 94 PF00244 0.464
LIG_APCC_ABBA_1 485 490 PF00400 0.386
LIG_BIR_III_4 629 633 PF00653 0.426
LIG_BRCT_BRCA1_1 191 195 PF00533 0.393
LIG_BRCT_BRCA1_1 479 483 PF00533 0.296
LIG_BRCT_BRCA1_1 681 685 PF00533 0.448
LIG_BRCT_BRCA1_1 87 91 PF00533 0.311
LIG_deltaCOP1_diTrp_1 146 152 PF00928 0.396
LIG_FHA_1 14 20 PF00498 0.529
LIG_FHA_1 224 230 PF00498 0.338
LIG_FHA_1 245 251 PF00498 0.481
LIG_FHA_1 255 261 PF00498 0.383
LIG_FHA_1 420 426 PF00498 0.406
LIG_FHA_1 482 488 PF00498 0.240
LIG_FHA_1 506 512 PF00498 0.323
LIG_FHA_1 725 731 PF00498 0.232
LIG_FHA_1 740 746 PF00498 0.195
LIG_FHA_1 795 801 PF00498 0.607
LIG_FHA_2 172 178 PF00498 0.464
LIG_FHA_2 203 209 PF00498 0.391
LIG_FHA_2 301 307 PF00498 0.414
LIG_FHA_2 375 381 PF00498 0.474
LIG_FHA_2 445 451 PF00498 0.392
LIG_FHA_2 66 72 PF00498 0.423
LIG_LIR_Apic_2 103 109 PF02991 0.323
LIG_LIR_Apic_2 697 703 PF02991 0.416
LIG_LIR_Gen_1 201 212 PF02991 0.433
LIG_LIR_Gen_1 372 380 PF02991 0.306
LIG_LIR_Nem_3 146 150 PF02991 0.364
LIG_LIR_Nem_3 16 20 PF02991 0.519
LIG_LIR_Nem_3 201 207 PF02991 0.376
LIG_LIR_Nem_3 208 212 PF02991 0.309
LIG_LIR_Nem_3 361 367 PF02991 0.412
LIG_LIR_Nem_3 372 376 PF02991 0.394
LIG_LIR_Nem_3 377 382 PF02991 0.337
LIG_LIR_Nem_3 712 716 PF02991 0.474
LIG_LIR_Nem_3 720 726 PF02991 0.428
LIG_LYPXL_yS_3 513 516 PF13949 0.399
LIG_PCNA_PIPBox_1 804 813 PF02747 0.626
LIG_PCNA_yPIPBox_3 803 811 PF02747 0.629
LIG_Pex14_2 10 14 PF04695 0.586
LIG_Pex14_2 353 357 PF04695 0.434
LIG_Rb_pABgroove_1 135 143 PF01858 0.349
LIG_SH2_CRK 124 128 PF00017 0.460
LIG_SH2_CRK 153 157 PF00017 0.396
LIG_SH2_CRK 209 213 PF00017 0.404
LIG_SH2_CRK 241 245 PF00017 0.425
LIG_SH2_CRK 364 368 PF00017 0.403
LIG_SH2_CRK 56 60 PF00017 0.385
LIG_SH2_CRK 700 704 PF00017 0.406
LIG_SH2_CRK 726 730 PF00017 0.210
LIG_SH2_GRB2like 232 235 PF00017 0.402
LIG_SH2_NCK_1 153 157 PF00017 0.396
LIG_SH2_NCK_1 700 704 PF00017 0.377
LIG_SH2_SRC 232 235 PF00017 0.402
LIG_SH2_STAP1 261 265 PF00017 0.447
LIG_SH2_STAP1 347 351 PF00017 0.350
LIG_SH2_STAP1 421 425 PF00017 0.318
LIG_SH2_STAP1 696 700 PF00017 0.448
LIG_SH2_STAP1 726 730 PF00017 0.181
LIG_SH2_STAT5 100 103 PF00017 0.363
LIG_SH2_STAT5 204 207 PF00017 0.387
LIG_SH2_STAT5 209 212 PF00017 0.355
LIG_SH2_STAT5 35 38 PF00017 0.351
LIG_SH2_STAT5 421 424 PF00017 0.397
LIG_SH2_STAT5 488 491 PF00017 0.230
LIG_SH2_STAT5 696 699 PF00017 0.448
LIG_SH2_STAT5 726 729 PF00017 0.291
LIG_SH3_3 266 272 PF00018 0.428
LIG_SH3_3 443 449 PF00018 0.363
LIG_SH3_3 528 534 PF00018 0.361
LIG_SH3_3 577 583 PF00018 0.387
LIG_SH3_3 75 81 PF00018 0.287
LIG_SUMO_SIM_anti_2 422 427 PF11976 0.349
LIG_SUMO_SIM_anti_2 43 49 PF11976 0.322
LIG_SUMO_SIM_anti_2 727 732 PF11976 0.372
LIG_SUMO_SIM_anti_2 742 748 PF11976 0.251
LIG_SUMO_SIM_par_1 726 732 PF11976 0.232
LIG_SUMO_SIM_par_1 763 768 PF11976 0.558
LIG_TYR_ITIM 207 212 PF00017 0.414
LIG_TYR_ITIM 711 716 PF00017 0.668
LIG_Vh1_VBS_1 729 747 PF01044 0.187
MOD_CDK_SPK_2 477 482 PF00069 0.326
MOD_CDK_SPxK_1 330 336 PF00069 0.532
MOD_CDK_SPxxK_3 189 196 PF00069 0.482
MOD_CK1_1 160 166 PF00069 0.578
MOD_CK1_1 168 174 PF00069 0.454
MOD_CK1_1 220 226 PF00069 0.530
MOD_CK1_1 297 303 PF00069 0.554
MOD_CK1_1 311 317 PF00069 0.443
MOD_CK1_1 442 448 PF00069 0.451
MOD_CK1_1 505 511 PF00069 0.297
MOD_CK1_1 616 622 PF00069 0.628
MOD_CK1_1 699 705 PF00069 0.593
MOD_CK1_1 816 822 PF00069 0.470
MOD_CK2_1 202 208 PF00069 0.559
MOD_CK2_1 374 380 PF00069 0.548
MOD_CMANNOS 11 14 PF00535 0.493
MOD_GlcNHglycan 159 162 PF01048 0.548
MOD_GlcNHglycan 181 184 PF01048 0.786
MOD_GlcNHglycan 197 200 PF01048 0.634
MOD_GlcNHglycan 219 222 PF01048 0.650
MOD_GlcNHglycan 23 26 PF01048 0.576
MOD_GlcNHglycan 313 316 PF01048 0.530
MOD_GlcNHglycan 367 370 PF01048 0.493
MOD_GlcNHglycan 504 507 PF01048 0.371
MOD_GlcNHglycan 539 542 PF01048 0.479
MOD_GlcNHglycan 562 567 PF01048 0.572
MOD_GlcNHglycan 597 600 PF01048 0.427
MOD_GlcNHglycan 603 606 PF01048 0.467
MOD_GlcNHglycan 615 618 PF01048 0.592
MOD_GlcNHglycan 646 649 PF01048 0.448
MOD_GlcNHglycan 689 692 PF01048 0.583
MOD_GlcNHglycan 815 818 PF01048 0.610
MOD_GlcNHglycan 87 90 PF01048 0.562
MOD_GSK3_1 131 138 PF00069 0.614
MOD_GSK3_1 21 28 PF00069 0.596
MOD_GSK3_1 240 247 PF00069 0.558
MOD_GSK3_1 264 271 PF00069 0.531
MOD_GSK3_1 316 323 PF00069 0.428
MOD_GSK3_1 330 337 PF00069 0.515
MOD_GSK3_1 36 43 PF00069 0.470
MOD_GSK3_1 392 399 PF00069 0.296
MOD_GSK3_1 440 447 PF00069 0.445
MOD_GSK3_1 477 484 PF00069 0.468
MOD_GSK3_1 55 62 PF00069 0.410
MOD_GSK3_1 597 604 PF00069 0.464
MOD_GSK3_1 612 619 PF00069 0.467
MOD_GSK3_1 65 72 PF00069 0.441
MOD_GSK3_1 694 701 PF00069 0.550
MOD_GSK3_1 729 736 PF00069 0.321
MOD_GSK3_1 95 102 PF00069 0.377
MOD_N-GLC_1 135 140 PF02516 0.625
MOD_N-GLC_1 233 238 PF02516 0.429
MOD_N-GLC_1 33 38 PF02516 0.375
MOD_N-GLC_1 365 370 PF02516 0.517
MOD_N-GLC_1 387 392 PF02516 0.360
MOD_N-GLC_1 419 424 PF02516 0.423
MOD_N-GLC_1 613 618 PF02516 0.638
MOD_N-GLC_1 63 68 PF02516 0.475
MOD_N-GLC_1 94 99 PF02516 0.338
MOD_N-GLC_2 407 409 PF02516 0.415
MOD_NEK2_1 13 18 PF00069 0.520
MOD_NEK2_1 157 162 PF00069 0.571
MOD_NEK2_1 195 200 PF00069 0.749
MOD_NEK2_1 20 25 PF00069 0.613
MOD_NEK2_1 259 264 PF00069 0.513
MOD_NEK2_1 360 365 PF00069 0.417
MOD_NEK2_1 398 403 PF00069 0.395
MOD_NEK2_1 537 542 PF00069 0.433
MOD_NEK2_1 729 734 PF00069 0.261
MOD_NEK2_2 261 266 PF00069 0.556
MOD_NEK2_2 548 553 PF00069 0.571
MOD_OFUCOSY 394 400 PF10250 0.477
MOD_OFUCOSY 409 416 PF10250 0.384
MOD_OFUCOSY 679 684 PF10250 0.539
MOD_PIKK_1 220 226 PF00454 0.609
MOD_PIKK_1 40 46 PF00454 0.498
MOD_PIKK_1 444 450 PF00454 0.577
MOD_PIKK_1 63 69 PF00454 0.447
MOD_PIKK_1 717 723 PF00454 0.598
MOD_PKA_1 813 819 PF00069 0.476
MOD_PKA_2 195 201 PF00069 0.721
MOD_PKA_2 335 341 PF00069 0.459
MOD_PKA_2 794 800 PF00069 0.446
MOD_PKA_2 813 819 PF00069 0.556
MOD_Plk_1 135 141 PF00069 0.620
MOD_Plk_1 245 251 PF00069 0.529
MOD_Plk_1 294 300 PF00069 0.561
MOD_Plk_1 33 39 PF00069 0.563
MOD_Plk_1 347 353 PF00069 0.517
MOD_Plk_1 365 371 PF00069 0.422
MOD_Plk_1 387 393 PF00069 0.389
MOD_Plk_1 419 425 PF00069 0.392
MOD_Plk_1 526 532 PF00069 0.543
MOD_Plk_1 680 686 PF00069 0.532
MOD_Plk_1 69 75 PF00069 0.464
MOD_Plk_1 94 100 PF00069 0.381
MOD_Plk_4 135 141 PF00069 0.611
MOD_Plk_4 165 171 PF00069 0.487
MOD_Plk_4 233 239 PF00069 0.406
MOD_Plk_4 245 251 PF00069 0.501
MOD_Plk_4 387 393 PF00069 0.513
MOD_Plk_4 421 427 PF00069 0.405
MOD_Plk_4 527 533 PF00069 0.428
MOD_Plk_4 70 76 PF00069 0.480
MOD_Plk_4 724 730 PF00069 0.447
MOD_Plk_4 95 101 PF00069 0.435
MOD_ProDKin_1 105 111 PF00069 0.475
MOD_ProDKin_1 160 166 PF00069 0.570
MOD_ProDKin_1 189 195 PF00069 0.608
MOD_ProDKin_1 268 274 PF00069 0.533
MOD_ProDKin_1 330 336 PF00069 0.510
MOD_ProDKin_1 392 398 PF00069 0.281
MOD_ProDKin_1 442 448 PF00069 0.584
MOD_ProDKin_1 453 459 PF00069 0.582
MOD_ProDKin_1 477 483 PF00069 0.536
MOD_ProDKin_1 505 511 PF00069 0.387
MOD_ProDKin_1 59 65 PF00069 0.507
MOD_ProDKin_1 699 705 PF00069 0.595
MOD_ProDKin_1 767 773 PF00069 0.557
TRG_DiLeu_BaLyEn_6 506 511 PF01217 0.312
TRG_ENDOCYTIC_2 124 127 PF00928 0.552
TRG_ENDOCYTIC_2 204 207 PF00928 0.405
TRG_ENDOCYTIC_2 209 212 PF00928 0.382
TRG_ENDOCYTIC_2 241 244 PF00928 0.454
TRG_ENDOCYTIC_2 364 367 PF00928 0.522
TRG_ENDOCYTIC_2 513 516 PF00928 0.556
TRG_ENDOCYTIC_2 56 59 PF00928 0.515
TRG_ENDOCYTIC_2 713 716 PF00928 0.655
TRG_ENDOCYTIC_2 726 729 PF00928 0.476
TRG_ER_diArg_1 5 7 PF00400 0.522
TRG_ER_diArg_1 789 791 PF00400 0.735
TRG_ER_diArg_1 807 809 PF00400 0.617
TRG_NLS_MonoExtN_4 809 816 PF00514 0.385

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JPQ5 Bodo saltans 28% 98%
A0A1X0NFL6 Trypanosomatidae 32% 100%
A0A3Q8IFR8 Leishmania donovani 81% 100%
A0A3S7X4W3 Leishmania donovani 62% 100%
A4HJP2 Leishmania braziliensis 58% 100%
A4I711 Leishmania infantum 81% 100%
A4I759 Leishmania infantum 62% 100%
C9ZIV1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZIW8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9B253 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 100%
Q4Q607 Leishmania major 71% 100%
Q4Q608 Leishmania major 72% 100%
Q4Q609 Leishmania major 72% 100%
V5BQ27 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS