Ferredoxin, 2fe-2s-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferredoxin, 2fe-2s-like protein

Species:

Leishmania mexicana

UniProt:

E9B251_LEIMU

TriTrypDb:

LmxM.30.2510

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 21
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9B251

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B251

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	24
GO:0008152	metabolic process	1	24
GO:0009987	cellular process	1	24
GO:0022900	electron transport chain	4	24
GO:0044237	cellular metabolic process	2	24
GO:0140647	P450-containing electron transport chain	5	24

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	24
GO:0051536	iron-sulfur cluster binding	3	24
GO:0051537	2 iron, 2 sulfur cluster binding	4	24
GO:0051540	metal cluster binding	2	24
GO:0003824	catalytic activity	1	5
GO:0009055	electron transfer activity	3	5
GO:0016491	oxidoreductase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	5	7	PF00675	0.528
CLV_PCSK_KEX2_1	4	6	PF00082	0.524
CLV_PCSK_SKI1_1	51	55	PF00082	0.404
DEG_Nend_Nbox_1	1	3	PF02207	0.466
DEG_SPOP_SBC_1	44	48	PF00917	0.480
DOC_MAPK_gen_1	4	13	PF00069	0.461
DOC_MAPK_MEF2A_6	85	94	PF00069	0.304
DOC_USP7_MATH_1	138	142	PF00917	0.211
DOC_USP7_MATH_1	36	40	PF00917	0.581
DOC_USP7_MATH_1	42	46	PF00917	0.557
DOC_WW_Pin1_4	15	20	PF00397	0.454
DOC_WW_Pin1_4	21	26	PF00397	0.708
DOC_WW_Pin1_4	37	42	PF00397	0.591
DOC_WW_Pin1_4	51	56	PF00397	0.564
LIG_14-3-3_CanoR_1	145	152	PF00244	0.287
LIG_14-3-3_CanoR_1	4	9	PF00244	0.604
LIG_FHA_1	104	110	PF00498	0.360
LIG_FHA_1	165	171	PF00498	0.557
LIG_FHA_1	87	93	PF00498	0.323
LIG_FHA_2	125	131	PF00498	0.274
LIG_FHA_2	149	155	PF00498	0.427
LIG_FHA_2	66	72	PF00498	0.356
LIG_LIR_Gen_1	68	74	PF02991	0.285
LIG_LIR_Gen_1	7	16	PF02991	0.395
LIG_LIR_Nem_3	7	11	PF02991	0.420
LIG_Pex14_1	172	176	PF04695	0.417
LIG_SH2_STAP1	70	74	PF00017	0.287
LIG_SH3_3	8	14	PF00018	0.462
LIG_SH3_3	89	95	PF00018	0.324
LIG_WW_3	14	18	PF00397	0.387
MOD_CDK_SPxK_1	21	27	PF00069	0.461
MOD_CDK_SPxK_1	51	57	PF00069	0.565
MOD_CK1_1	141	147	PF00069	0.348
MOD_CK1_1	29	35	PF00069	0.671
MOD_CK1_1	43	49	PF00069	0.571
MOD_CK1_1	9	15	PF00069	0.621
MOD_CK2_1	124	130	PF00069	0.322
MOD_CK2_1	148	154	PF00069	0.257
MOD_CK2_1	65	71	PF00069	0.263
MOD_DYRK1A_RPxSP_1	51	55	PF00069	0.415
MOD_GlcNHglycan	112	115	PF01048	0.283
MOD_GlcNHglycan	34	37	PF01048	0.565
MOD_GSK3_1	144	151	PF00069	0.292
MOD_GSK3_1	17	24	PF00069	0.648
MOD_GSK3_1	28	35	PF00069	0.613
MOD_GSK3_1	36	43	PF00069	0.587
MOD_GSK3_1	98	105	PF00069	0.387
MOD_LATS_1	63	69	PF00433	0.210
MOD_N-GLC_1	98	103	PF02516	0.304
MOD_OFUCOSY	102	107	PF10250	0.361
MOD_PKA_1	4	10	PF00069	0.406
MOD_PKA_2	144	150	PF00069	0.320
MOD_PKA_2	29	35	PF00069	0.650
MOD_PKA_2	4	10	PF00069	0.490
MOD_PKB_1	4	12	PF00069	0.450
MOD_Plk_1	141	147	PF00069	0.291
MOD_Plk_1	85	91	PF00069	0.224
MOD_ProDKin_1	15	21	PF00069	0.460
MOD_ProDKin_1	37	43	PF00069	0.594
MOD_ProDKin_1	51	57	PF00069	0.558
MOD_SUMO_for_1	118	121	PF00179	0.183
TRG_DiLeu_BaEn_1	76	81	PF01217	0.261
TRG_ENDOCYTIC_2	70	73	PF00928	0.336
TRG_ER_diArg_1	3	6	PF00400	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	40%	100%
A0A0N1I5P4	Leptomonas seymouri	40%	100%
A0A0N1ILD8	Leptomonas seymouri	57%	100%
A0A0N1PE81	Leptomonas seymouri	39%	100%
A0A3Q8IIS3	Leishmania donovani	45%	100%
A0A3S7X4S6	Leishmania donovani	39%	100%
A0A3S7X4U4	Leishmania donovani	82%	100%
A0A3S7X4W8	Leishmania donovani	37%	100%
A4HEW1	Leishmania braziliensis	32%	100%
A4HJN2	Leishmania braziliensis	35%	100%
A4HJN3	Leishmania braziliensis	42%	100%
A4HJN4	Leishmania braziliensis	33%	95%
A4HJN8	Leishmania braziliensis	39%	100%
A4HJN9	Leishmania braziliensis	66%	98%
A4I755	Leishmania infantum	39%	100%
A4I756	Leishmania infantum	45%	100%
A4I757	Leishmania infantum	35%	100%
A4I758	Leishmania infantum	83%	100%
E9B248	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B249	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B250	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
P13216	Gallus gallus	29%	100%
P24483	Rattus norvegicus	33%	97%
P46656	Mus musculus	33%	97%
Q05B51	Bos taurus	36%	98%
Q12184	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
Q4Q610	Leishmania major	84%	100%
Q4Q611	Leishmania major	41%	100%
Q4Q612	Leishmania major	42%	100%
Q4Q613	Leishmania major	39%	100%
Q4Q989	Leishmania major	37%	100%
Q6P4F2	Homo sapiens	35%	98%
Q8S904	Arabidopsis thaliana	34%	92%
Q9M0V0	Arabidopsis thaliana	31%	92%