Putative lipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative lipase

Gene product:

lipase, putative

Species:

Leishmania mexicana

UniProt:

E9B246_LEIMU

TriTrypDb:

LmxM.30.2460

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 9
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9B246

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B246

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	20
GO:0008152	metabolic process	1	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004806	triglyceride lipase activity	5	10
GO:0016298	lipase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0052689	carboxylic ester hydrolase activity	4	11
GO:0004620	phospholipase activity	5	1
GO:0008970	phospholipase A1 activity	5	1
GO:0052739	phosphatidylserine 1-acylhydrolase activity	5	1
GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.304
CLV_PCSK_KEX2_1	110	112	PF00082	0.261
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.257
CLV_PCSK_SKI1_1	209	213	PF00082	0.208
DEG_APCC_DBOX_1	170	178	PF00400	0.380
DOC_CYCLIN_RxL_1	52	60	PF00134	0.209
DOC_MAPK_gen_1	110	116	PF00069	0.370
DOC_MAPK_HePTP_8	211	223	PF00069	0.259
DOC_MAPK_MEF2A_6	214	223	PF00069	0.260
DOC_PP1_RVXF_1	53	60	PF00149	0.302
DOC_PP1_RVXF_1	6	13	PF00149	0.456
DOC_PP4_FxxP_1	231	234	PF00568	0.325
DOC_USP7_MATH_1	153	157	PF00917	0.387
DOC_USP7_MATH_1	302	306	PF00917	0.383
DOC_USP7_UBL2_3	285	289	PF12436	0.317
DOC_WW_Pin1_4	215	220	PF00397	0.287
DOC_WW_Pin1_4	221	226	PF00397	0.256
DOC_WW_Pin1_4	80	85	PF00397	0.341
LIG_14-3-3_CanoR_1	148	157	PF00244	0.285
LIG_14-3-3_CanoR_1	252	256	PF00244	0.346
LIG_14-3-3_CanoR_1	270	275	PF00244	0.466
LIG_14-3-3_CanoR_1	47	57	PF00244	0.486
LIG_deltaCOP1_diTrp_1	52	59	PF00928	0.281
LIG_eIF4E_1	172	178	PF01652	0.413
LIG_FHA_1	157	163	PF00498	0.502
LIG_FHA_1	174	180	PF00498	0.444
LIG_FHA_1	252	258	PF00498	0.308
LIG_FHA_2	195	201	PF00498	0.281
LIG_FHA_2	228	234	PF00498	0.413
LIG_FHA_2	322	328	PF00498	0.547
LIG_GBD_Chelix_1	15	23	PF00786	0.432
LIG_LIR_Apic_2	135	139	PF02991	0.320
LIG_LIR_Apic_2	230	234	PF02991	0.337
LIG_LIR_Apic_2	338	342	PF02991	0.339
LIG_LIR_Gen_1	130	139	PF02991	0.305
LIG_LIR_Gen_1	152	162	PF02991	0.338
LIG_LIR_Gen_1	271	281	PF02991	0.469
LIG_LIR_Gen_1	344	354	PF02991	0.505
LIG_LIR_Nem_3	130	136	PF02991	0.320
LIG_LIR_Nem_3	152	157	PF02991	0.352
LIG_LIR_Nem_3	344	349	PF02991	0.526
LIG_LIR_Nem_3	51	57	PF02991	0.396
LIG_LIR_Nem_3	83	89	PF02991	0.494
LIG_NRP_CendR_1	362	363	PF00754	0.504
LIG_PCNA_yPIPBox_3	8	20	PF02747	0.371
LIG_Pex14_1	54	58	PF04695	0.213
LIG_PTB_Apo_2	125	132	PF02174	0.296
LIG_PTB_Apo_2	235	242	PF02174	0.334
LIG_SH2_CRK	154	158	PF00017	0.458
LIG_SH2_CRK	346	350	PF00017	0.392
LIG_SH2_GRB2like	92	95	PF00017	0.455
LIG_SH2_NCK_1	120	124	PF00017	0.487
LIG_SH2_NCK_1	339	343	PF00017	0.342
LIG_SH2_STAP1	151	155	PF00017	0.423
LIG_SH2_STAP1	175	179	PF00017	0.340
LIG_SH2_STAP1	26	30	PF00017	0.374
LIG_SH2_STAP1	337	341	PF00017	0.372
LIG_SH2_STAT5	151	154	PF00017	0.346
LIG_SH2_STAT5	175	178	PF00017	0.435
LIG_SH2_STAT5	229	232	PF00017	0.335
LIG_SH2_STAT5	26	29	PF00017	0.620
LIG_SH2_STAT5	274	277	PF00017	0.434
LIG_SH2_STAT5	291	294	PF00017	0.587
LIG_SH2_STAT5	303	306	PF00017	0.351
LIG_SH2_STAT5	319	322	PF00017	0.381
LIG_SH2_STAT5	58	61	PF00017	0.294
LIG_SH2_STAT5	64	67	PF00017	0.340
LIG_SH3_2	265	270	PF14604	0.413
LIG_SH3_3	213	219	PF00018	0.520
LIG_SH3_3	262	268	PF00018	0.313
LIG_SH3_3	272	278	PF00018	0.382
LIG_SUMO_SIM_anti_2	164	169	PF11976	0.284
LIG_SUMO_SIM_anti_2	245	250	PF11976	0.257
LIG_SUMO_SIM_anti_2	33	42	PF11976	0.590
LIG_SUMO_SIM_par_1	224	230	PF11976	0.475
LIG_SUMO_SIM_par_1	347	353	PF11976	0.530
LIG_TRFH_1	339	343	PF08558	0.516
LIG_TYR_ITIM	317	322	PF00017	0.372
LIG_WRC_WIRS_1	228	233	PF05994	0.350
LIG_WW_3	267	271	PF00397	0.413
MOD_CDK_SPxxK_3	80	87	PF00069	0.272
MOD_CK1_1	156	162	PF00069	0.348
MOD_CK1_1	242	248	PF00069	0.403
MOD_CK2_1	199	205	PF00069	0.213
MOD_CK2_1	227	233	PF00069	0.382
MOD_CK2_1	321	327	PF00069	0.476
MOD_GlcNHglycan	102	105	PF01048	0.423
MOD_GlcNHglycan	28	31	PF01048	0.505
MOD_GSK3_1	149	156	PF00069	0.407
MOD_GSK3_1	173	180	PF00069	0.434
MOD_GSK3_1	195	202	PF00069	0.291
MOD_GSK3_1	247	254	PF00069	0.380
MOD_GSK3_1	26	33	PF00069	0.642
MOD_GSK3_1	304	311	PF00069	0.452
MOD_GSK3_1	71	78	PF00069	0.556
MOD_N-GLC_1	242	247	PF02516	0.432
MOD_N-GLC_1	358	363	PF02516	0.678
MOD_N-GLC_1	48	53	PF02516	0.462
MOD_N-GLC_1	80	85	PF02516	0.394
MOD_N-GLC_1	93	98	PF02516	0.335
MOD_NEK2_1	100	105	PF00069	0.343
MOD_NEK2_1	116	121	PF00069	0.376
MOD_NEK2_1	177	182	PF00069	0.364
MOD_NEK2_1	255	260	PF00069	0.408
MOD_NEK2_1	57	62	PF00069	0.364
MOD_NEK2_2	153	158	PF00069	0.378
MOD_NEK2_2	173	178	PF00069	0.428
MOD_NEK2_2	251	256	PF00069	0.298
MOD_NEK2_2	304	309	PF00069	0.395
MOD_PIKK_1	156	162	PF00454	0.251
MOD_PIKK_1	308	314	PF00454	0.334
MOD_PKA_2	116	122	PF00069	0.324
MOD_PKA_2	251	257	PF00069	0.341
MOD_PKB_1	45	53	PF00069	0.275
MOD_Plk_1	194	200	PF00069	0.402
MOD_Plk_1	242	248	PF00069	0.276
MOD_Plk_2-3	195	201	PF00069	0.187
MOD_Plk_2-3	335	341	PF00069	0.422
MOD_Plk_4	11	17	PF00069	0.580
MOD_Plk_4	173	179	PF00069	0.454
MOD_Plk_4	21	27	PF00069	0.640
MOD_Plk_4	244	250	PF00069	0.321
MOD_Plk_4	270	276	PF00069	0.461
MOD_Plk_4	304	310	PF00069	0.400
MOD_ProDKin_1	215	221	PF00069	0.287
MOD_ProDKin_1	80	86	PF00069	0.336
MOD_SUMO_rev_2	29	39	PF00179	0.367
TRG_ENDOCYTIC_2	102	105	PF00928	0.422
TRG_ENDOCYTIC_2	154	157	PF00928	0.368
TRG_ENDOCYTIC_2	175	178	PF00928	0.475
TRG_ENDOCYTIC_2	274	277	PF00928	0.456
TRG_ENDOCYTIC_2	319	322	PF00928	0.357
TRG_ENDOCYTIC_2	346	349	PF00928	0.549
TRG_ER_diArg_1	45	48	PF00400	0.314
TRG_NES_CRM1_1	340	353	PF08389	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D0	Leptomonas seymouri	54%	100%
A0A0S4IJE8	Bodo saltans	38%	100%
A0A0S4J5D7	Bodo saltans	38%	100%
A0A0S4JTA1	Bodo saltans	38%	100%
A0A1X0NZH3	Trypanosomatidae	38%	86%
A0A1X0P001	Trypanosomatidae	36%	100%
A0A3Q8IFI3	Leishmania donovani	77%	99%
A0A3Q8IG97	Leishmania donovani	33%	100%
A0A422NPJ5	Trypanosoma rangeli	37%	73%
A2QSY5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	28%	100%
A4HJN0	Leishmania braziliensis	58%	100%
A4HLK7	Leishmania braziliensis	37%	100%
A4I6H7	Leishmania infantum	33%	100%
A4I752	Leishmania infantum	77%	99%
C9ZME7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	99%
O42807	Aspergillus niger	28%	100%
O59952	Thermomyces lanuginosus	30%	100%
P61869	Penicillium cyclopium	30%	100%
P61870	Penicillium camembertii	30%	100%
P61871	Rhizopus niveus	31%	93%
P61872	Rhizopus oryzae	31%	93%
Q4Q615	Leishmania major	74%	100%
Q4Q6I0	Leishmania major	32%	100%
Q9BHD5	Leishmania major	39%	100%
Q9XTR8	Caenorhabditis elegans	28%	100%
V5B761	Trypanosoma cruzi	41%	100%