PRELI/MSF1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B244_LEIMU

TriTrypDb:

LmxM.30.2440

Length:

219

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B244

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B244

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.397
CLV_C14_Caspase3-7	210	214	PF00656	0.441
CLV_NRD_NRD_1	181	183	PF00675	0.430
CLV_NRD_NRD_1	37	39	PF00675	0.478
CLV_PCSK_KEX2_1	181	183	PF00082	0.430
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.430
CLV_PCSK_SKI1_1	183	187	PF00082	0.522
CLV_PCSK_SKI1_1	206	210	PF00082	0.516
CLV_PCSK_SKI1_1	23	27	PF00082	0.434
DEG_COP1_1	100	110	PF00400	0.572
DOC_CYCLIN_RxL_1	178	188	PF00134	0.425
DOC_MAPK_DCC_7	84	93	PF00069	0.328
DOC_MAPK_gen_1	74	81	PF00069	0.464
DOC_MAPK_HePTP_8	81	93	PF00069	0.307
DOC_MAPK_MEF2A_6	74	81	PF00069	0.464
DOC_MAPK_MEF2A_6	84	93	PF00069	0.432
DOC_MAPK_NFAT4_5	74	82	PF00069	0.465
DOC_PP1_RVXF_1	1	8	PF00149	0.416
DOC_PP2B_PxIxI_1	88	94	PF00149	0.351
DOC_USP7_MATH_1	130	134	PF00917	0.529
DOC_USP7_MATH_1	144	148	PF00917	0.738
DOC_USP7_MATH_1	214	218	PF00917	0.437
LIG_14-3-3_CanoR_1	158	165	PF00244	0.331
LIG_14-3-3_CanoR_1	60	70	PF00244	0.484
LIG_APCC_ABBAyCdc20_2	182	188	PF00400	0.414
LIG_BRCT_BRCA1_1	66	70	PF00533	0.378
LIG_deltaCOP1_diTrp_1	153	159	PF00928	0.353
LIG_FHA_1	166	172	PF00498	0.313
LIG_FHA_1	19	25	PF00498	0.433
LIG_FHA_1	31	37	PF00498	0.430
LIG_FHA_1	76	82	PF00498	0.335
LIG_FHA_1	96	102	PF00498	0.404
LIG_FHA_2	27	33	PF00498	0.495
LIG_FHA_2	95	101	PF00498	0.493
LIG_LIR_Gen_1	67	77	PF02991	0.512
LIG_LIR_Nem_3	67	73	PF02991	0.488
LIG_Pex14_1	155	159	PF04695	0.376
LIG_SH2_STAP1	165	169	PF00017	0.441
LIG_SH3_3	105	111	PF00018	0.678
LIG_SH3_3	83	89	PF00018	0.386
LIG_SUMO_SIM_anti_2	166	171	PF11976	0.461
LIG_SUMO_SIM_par_1	21	29	PF11976	0.425
LIG_SUMO_SIM_par_1	31	37	PF11976	0.447
LIG_TYR_ITIM	45	50	PF00017	0.513
LIG_UBA3_1	171	178	PF00899	0.490
MOD_CK1_1	109	115	PF00069	0.670
MOD_CK1_1	161	167	PF00069	0.453
MOD_CK1_1	64	70	PF00069	0.485
MOD_CK2_1	16	22	PF00069	0.304
MOD_CK2_1	94	100	PF00069	0.419
MOD_Cter_Amidation	179	182	PF01082	0.447
MOD_GlcNHglycan	216	219	PF01048	0.568
MOD_GlcNHglycan	65	69	PF01048	0.381
MOD_GSK3_1	106	113	PF00069	0.612
MOD_GSK3_1	140	147	PF00069	0.606
MOD_GSK3_1	157	164	PF00069	0.405
MOD_GSK3_1	26	33	PF00069	0.434
MOD_NEK2_1	116	121	PF00069	0.627
MOD_NEK2_1	151	156	PF00069	0.509
MOD_NEK2_2	75	80	PF00069	0.348
MOD_PK_1	158	164	PF00069	0.421
MOD_PKA_2	157	163	PF00069	0.404
MOD_Plk_1	116	122	PF00069	0.649
MOD_Plk_1	165	171	PF00069	0.278
MOD_Plk_2-3	16	22	PF00069	0.304
MOD_Plk_2-3	207	213	PF00069	0.368
MOD_Plk_4	151	157	PF00069	0.547
MOD_Plk_4	165	171	PF00069	0.313
MOD_SUMO_rev_2	202	211	PF00179	0.420
MOD_SUMO_rev_2	22	31	PF00179	0.401
TRG_ENDOCYTIC_2	47	50	PF00928	0.436
TRG_ER_diArg_1	182	185	PF00400	0.416
TRG_NLS_MonoCore_2	180	185	PF00514	0.426
TRG_NLS_MonoExtN_4	178	185	PF00514	0.430
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I730	Leptomonas seymouri	28%	100%
A0A0N1I8Q6	Leptomonas seymouri	42%	96%
A0A0N1PCW5	Leptomonas seymouri	36%	100%
A0A3Q8IF19	Leishmania donovani	89%	100%
A0A3Q8IKA6	Leishmania donovani	26%	100%
A0A3S5H7Q5	Leishmania donovani	37%	93%
A4HJM7	Leishmania braziliensis	38%	100%
A4HJM8	Leishmania braziliensis	76%	100%
A4I749	Leishmania infantum	37%	94%
A4I750	Leishmania infantum	88%	100%
A4I751	Leishmania infantum	26%	100%
E9B243	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B245	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4Q616	Leishmania major	24%	100%
Q4Q617	Leishmania major	89%	100%