VASt domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B243_LEIMU

TriTrypDb:

LmxM.30.2430

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B243

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B243

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.480
CLV_NRD_NRD_1	199	201	PF00675	0.591
CLV_NRD_NRD_1	25	27	PF00675	0.406
CLV_NRD_NRD_1	53	55	PF00675	0.518
CLV_PCSK_KEX2_1	140	142	PF00082	0.779
CLV_PCSK_KEX2_1	199	201	PF00082	0.532
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.779
CLV_PCSK_SKI1_1	145	149	PF00082	0.637
CLV_PCSK_SKI1_1	200	204	PF00082	0.506
CLV_PCSK_SKI1_1	226	230	PF00082	0.569
CLV_PCSK_SKI1_1	39	43	PF00082	0.430
CLV_PCSK_SKI1_1	92	96	PF00082	0.451
DEG_APCC_DBOX_1	140	148	PF00400	0.514
DEG_Nend_UBRbox_2	1	3	PF02207	0.546
DOC_CYCLIN_RxL_1	137	146	PF00134	0.462
DOC_MAPK_gen_1	90	97	PF00069	0.488
DOC_MAPK_MEF2A_6	90	97	PF00069	0.509
DOC_MAPK_NFAT4_5	90	98	PF00069	0.511
DOC_PP1_RVXF_1	198	205	PF00149	0.299
DOC_PP2B_PxIxI_1	20	26	PF00149	0.406
DOC_USP7_MATH_1	157	161	PF00917	0.654
DOC_WW_Pin1_4	106	111	PF00397	0.436
DOC_WW_Pin1_4	153	158	PF00397	0.550
DOC_WW_Pin1_4	164	169	PF00397	0.369
DOC_WW_Pin1_4	75	80	PF00397	0.378
LIG_14-3-3_CanoR_1	33	43	PF00244	0.390
LIG_deltaCOP1_diTrp_1	216	225	PF00928	0.350
LIG_FHA_1	169	175	PF00498	0.465
LIG_FHA_1	36	42	PF00498	0.415
LIG_FHA_1	47	53	PF00498	0.428
LIG_FHA_2	175	181	PF00498	0.432
LIG_FHA_2	225	231	PF00498	0.505
LIG_FHA_2	96	102	PF00498	0.427
LIG_LIR_Gen_1	83	94	PF02991	0.504
LIG_LIR_Nem_3	60	66	PF02991	0.433
LIG_LIR_Nem_3	72	77	PF02991	0.510
LIG_LIR_Nem_3	83	89	PF02991	0.507
LIG_MYND_1	153	157	PF01753	0.560
LIG_PDZ_Class_3	229	234	PF00595	0.721
LIG_Pex14_1	172	176	PF04695	0.373
LIG_SH2_CRK	63	67	PF00017	0.480
LIG_SH2_CRK	86	90	PF00017	0.355
LIG_SH2_STAP1	182	186	PF00017	0.442
LIG_SUMO_SIM_anti_2	183	188	PF11976	0.478
LIG_SUMO_SIM_par_1	37	44	PF11976	0.436
LIG_SUMO_SIM_par_1	48	53	PF11976	0.452
LIG_TYR_ITIM	61	66	PF00017	0.564
LIG_UBA3_1	187	193	PF00899	0.503
LIG_WRC_WIRS_1	111	116	PF05994	0.402
MOD_CK1_1	121	127	PF00069	0.565
MOD_CK1_1	178	184	PF00069	0.459
MOD_CK2_1	174	180	PF00069	0.438
MOD_CK2_1	226	232	PF00069	0.693
MOD_CK2_1	95	101	PF00069	0.552
MOD_GlcNHglycan	123	126	PF01048	0.611
MOD_GlcNHglycan	160	163	PF01048	0.706
MOD_GSK3_1	102	109	PF00069	0.542
MOD_GSK3_1	110	117	PF00069	0.465
MOD_GSK3_1	121	128	PF00069	0.510
MOD_GSK3_1	132	139	PF00069	0.643
MOD_GSK3_1	153	160	PF00069	0.589
MOD_GSK3_1	162	169	PF00069	0.578
MOD_GSK3_1	174	181	PF00069	0.431
MOD_GSK3_1	226	233	PF00069	0.559
MOD_GSK3_1	35	42	PF00069	0.415
MOD_GSK3_1	46	53	PF00069	0.468
MOD_LATS_1	224	230	PF00433	0.374
MOD_N-GLC_1	105	110	PF02516	0.450
MOD_N-GLC_1	15	20	PF02516	0.755
MOD_NEK2_1	114	119	PF00069	0.348
MOD_NEK2_1	15	20	PF00069	0.441
MOD_NEK2_1	62	67	PF00069	0.451
MOD_NEK2_1	95	100	PF00069	0.507
MOD_PKA_2	34	40	PF00069	0.518
MOD_PKB_1	33	41	PF00069	0.417
MOD_Plk_1	100	106	PF00069	0.445
MOD_Plk_1	129	135	PF00069	0.637
MOD_Plk_4	110	116	PF00069	0.610
MOD_Plk_4	118	124	PF00069	0.554
MOD_ProDKin_1	106	112	PF00069	0.429
MOD_ProDKin_1	153	159	PF00069	0.552
MOD_ProDKin_1	164	170	PF00069	0.352
MOD_ProDKin_1	75	81	PF00069	0.376
MOD_SUMO_for_1	192	195	PF00179	0.399
TRG_ENDOCYTIC_2	63	66	PF00928	0.460
TRG_ENDOCYTIC_2	86	89	PF00928	0.432
TRG_ER_diArg_1	33	36	PF00400	0.552
TRG_NLS_MonoExtC_3	53	58	PF00514	0.440
TRG_Pf-PMV_PEXEL_1	39	44	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I730	Leptomonas seymouri	23%	100%
A0A0N1I8Q6	Leptomonas seymouri	41%	100%
A0A0N1ILD5	Leptomonas seymouri	28%	83%
A0A0N1PCW5	Leptomonas seymouri	33%	100%
A0A3Q8IF19	Leishmania donovani	40%	100%
A0A3S5H7Q5	Leishmania donovani	81%	99%
A4HJM7	Leishmania braziliensis	50%	100%
A4HJM8	Leishmania braziliensis	38%	100%
A4I749	Leishmania infantum	82%	100%
A4I750	Leishmania infantum	40%	100%
E9B244	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q4Q617	Leishmania major	39%	100%
Q4Q618	Leishmania major	76%	100%