Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B238_LEIMU

TriTrypDb:

LmxM.30.2380

Length:

813

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B238

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B238

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.798
CLV_C14_Caspase3-7	773	777	PF00656	0.744
CLV_NRD_NRD_1	163	165	PF00675	0.734
CLV_NRD_NRD_1	193	195	PF00675	0.758
CLV_NRD_NRD_1	278	280	PF00675	0.723
CLV_NRD_NRD_1	397	399	PF00675	0.824
CLV_NRD_NRD_1	469	471	PF00675	0.868
CLV_NRD_NRD_1	473	475	PF00675	0.792
CLV_NRD_NRD_1	477	479	PF00675	0.710
CLV_NRD_NRD_1	589	591	PF00675	0.817
CLV_NRD_NRD_1	614	616	PF00675	0.777
CLV_NRD_NRD_1	784	786	PF00675	0.836
CLV_PCSK_FUR_1	785	789	PF00082	0.835
CLV_PCSK_KEX2_1	193	195	PF00082	0.758
CLV_PCSK_KEX2_1	278	280	PF00082	0.723
CLV_PCSK_KEX2_1	374	376	PF00082	0.681
CLV_PCSK_KEX2_1	397	399	PF00082	0.818
CLV_PCSK_KEX2_1	473	475	PF00082	0.859
CLV_PCSK_KEX2_1	588	590	PF00082	0.819
CLV_PCSK_KEX2_1	614	616	PF00082	0.777
CLV_PCSK_KEX2_1	787	789	PF00082	0.831
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.681
CLV_PCSK_PC1ET2_1	787	789	PF00082	0.831
CLV_PCSK_SKI1_1	122	126	PF00082	0.553
CLV_PCSK_SKI1_1	176	180	PF00082	0.586
CLV_PCSK_SKI1_1	674	678	PF00082	0.818
DEG_Nend_UBRbox_3	1	3	PF02207	0.632
DEG_SPOP_SBC_1	379	383	PF00917	0.761
DEG_SPOP_SBC_1	414	418	PF00917	0.607
DEG_SPOP_SBC_1	465	469	PF00917	0.576
DEG_SPOP_SBC_1	5	9	PF00917	0.639
DEG_SPOP_SBC_1	564	568	PF00917	0.658
DEG_SPOP_SBC_1	771	775	PF00917	0.729
DOC_PP2B_LxvP_1	200	203	PF13499	0.736
DOC_PP4_FxxP_1	136	139	PF00568	0.735
DOC_PP4_FxxP_1	312	315	PF00568	0.636
DOC_USP7_MATH_1	17	21	PF00917	0.683
DOC_USP7_MATH_1	203	207	PF00917	0.738
DOC_USP7_MATH_1	23	27	PF00917	0.625
DOC_USP7_MATH_1	336	340	PF00917	0.728
DOC_USP7_MATH_1	359	363	PF00917	0.765
DOC_USP7_MATH_1	365	369	PF00917	0.738
DOC_USP7_MATH_1	413	417	PF00917	0.812
DOC_USP7_MATH_1	507	511	PF00917	0.825
DOC_USP7_MATH_1	57	61	PF00917	0.747
DOC_USP7_MATH_1	6	10	PF00917	0.629
DOC_USP7_MATH_1	662	666	PF00917	0.718
DOC_USP7_MATH_1	732	736	PF00917	0.745
DOC_USP7_MATH_1	738	742	PF00917	0.673
DOC_USP7_MATH_1	809	813	PF00917	0.775
DOC_USP7_UBL2_3	471	475	PF12436	0.857
DOC_WW_Pin1_4	1	6	PF00397	0.605
DOC_WW_Pin1_4	168	173	PF00397	0.728
DOC_WW_Pin1_4	19	24	PF00397	0.633
DOC_WW_Pin1_4	311	316	PF00397	0.763
DOC_WW_Pin1_4	347	352	PF00397	0.558
DOC_WW_Pin1_4	367	372	PF00397	0.753
DOC_WW_Pin1_4	502	507	PF00397	0.686
DOC_WW_Pin1_4	571	576	PF00397	0.845
DOC_WW_Pin1_4	609	614	PF00397	0.840
DOC_WW_Pin1_4	654	659	PF00397	0.768
DOC_WW_Pin1_4	668	673	PF00397	0.587
DOC_WW_Pin1_4	9	14	PF00397	0.621
LIG_14-3-3_CanoR_1	112	116	PF00244	0.722
LIG_14-3-3_CanoR_1	146	151	PF00244	0.724
LIG_14-3-3_CanoR_1	193	197	PF00244	0.814
LIG_14-3-3_CanoR_1	251	258	PF00244	0.657
LIG_14-3-3_CanoR_1	267	276	PF00244	0.610
LIG_14-3-3_CanoR_1	390	396	PF00244	0.832
LIG_14-3-3_CanoR_1	397	407	PF00244	0.782
LIG_14-3-3_CanoR_1	484	492	PF00244	0.730
LIG_14-3-3_CanoR_1	562	571	PF00244	0.779
LIG_14-3-3_CanoR_1	621	625	PF00244	0.743
LIG_14-3-3_CanoR_1	74	79	PF00244	0.769
LIG_14-3-3_CanoR_1	762	767	PF00244	0.821
LIG_14-3-3_CanoR_1	772	781	PF00244	0.665
LIG_14-3-3_CanoR_1	792	798	PF00244	0.510
LIG_14-3-3_CanoR_1	83	92	PF00244	0.774
LIG_BRCT_BRCA1_1	388	392	PF00533	0.653
LIG_BRCT_BRCA1_1	664	668	PF00533	0.823
LIG_CSL_BTD_1	655	658	PF09270	0.825
LIG_EH_1	755	759	PF12763	0.721
LIG_FHA_1	288	294	PF00498	0.641
LIG_FHA_1	330	336	PF00498	0.590
LIG_FHA_1	355	361	PF00498	0.742
LIG_FHA_1	381	387	PF00498	0.669
LIG_FHA_1	493	499	PF00498	0.528
LIG_FHA_1	568	574	PF00498	0.733
LIG_FHA_1	627	633	PF00498	0.655
LIG_FHA_1	650	656	PF00498	0.657
LIG_FHA_2	123	129	PF00498	0.556
LIG_FHA_2	286	292	PF00498	0.773
LIG_FHA_2	318	324	PF00498	0.760
LIG_FHA_2	380	386	PF00498	0.763
LIG_FHA_2	531	537	PF00498	0.764
LIG_FHA_2	794	800	PF00498	0.549
LIG_Integrin_isoDGR_2	309	311	PF01839	0.544
LIG_Integrin_RGD_1	226	228	PF01839	0.671
LIG_LIR_Apic_2	114	119	PF02991	0.720
LIG_LIR_Apic_2	134	139	PF02991	0.485
LIG_LIR_Gen_1	389	400	PF02991	0.653
LIG_LIR_Nem_3	350	355	PF02991	0.730
LIG_LIR_Nem_3	389	395	PF02991	0.620
LIG_LIR_Nem_3	409	415	PF02991	0.534
LIG_MYND_1	430	434	PF01753	0.654
LIG_Pex14_2	51	55	PF04695	0.679
LIG_Pex14_2	58	62	PF04695	0.775
LIG_SH2_CRK	116	120	PF00017	0.738
LIG_SH2_CRK	3	7	PF00017	0.535
LIG_SH2_NCK_1	3	7	PF00017	0.535
LIG_SH2_SRC	591	594	PF00017	0.734
LIG_SH2_SRC	99	102	PF00017	0.741
LIG_SH2_STAT5	220	223	PF00017	0.807
LIG_SH2_STAT5	31	34	PF00017	0.798
LIG_SH2_STAT5	327	330	PF00017	0.527
LIG_SH2_STAT5	492	495	PF00017	0.526
LIG_SH2_STAT5	591	594	PF00017	0.651
LIG_SH3_2	610	615	PF14604	0.769
LIG_SH3_3	393	399	PF00018	0.556
LIG_SH3_3	424	430	PF00018	0.762
LIG_SH3_3	451	457	PF00018	0.579
LIG_SH3_3	547	553	PF00018	0.762
LIG_SH3_3	570	576	PF00018	0.749
LIG_SH3_3	607	613	PF00018	0.833
LIG_SH3_3	621	627	PF00018	0.623
LIG_SH3_3	634	640	PF00018	0.761
LIG_SH3_3	652	658	PF00018	0.589
LIG_SH3_4	471	478	PF00018	0.851
LIG_SH3_5	745	749	PF00018	0.522
LIG_SUMO_SIM_par_1	356	362	PF11976	0.625
LIG_SUMO_SIM_par_1	673	680	PF11976	0.553
LIG_WW_1	575	578	PF00397	0.760
MOD_CDC14_SPxK_1	612	615	PF00782	0.773
MOD_CDK_SPK_2	311	316	PF00069	0.759
MOD_CDK_SPK_2	609	614	PF00069	0.763
MOD_CDK_SPxK_1	609	615	PF00069	0.765
MOD_CDK_SPxK_1	668	674	PF00069	0.817
MOD_CDK_SPxxK_3	311	318	PF00069	0.760
MOD_CDK_SPxxK_3	367	374	PF00069	0.761
MOD_CK1_1	111	117	PF00069	0.720
MOD_CK1_1	149	155	PF00069	0.803
MOD_CK1_1	174	180	PF00069	0.673
MOD_CK1_1	181	187	PF00069	0.687
MOD_CK1_1	189	195	PF00069	0.827
MOD_CK1_1	205	211	PF00069	0.552
MOD_CK1_1	214	220	PF00069	0.663
MOD_CK1_1	266	272	PF00069	0.759
MOD_CK1_1	302	308	PF00069	0.676
MOD_CK1_1	329	335	PF00069	0.798
MOD_CK1_1	337	343	PF00069	0.709
MOD_CK1_1	34	40	PF00069	0.512
MOD_CK1_1	347	353	PF00069	0.530
MOD_CK1_1	4	10	PF00069	0.818
MOD_CK1_1	417	423	PF00069	0.765
MOD_CK1_1	438	444	PF00069	0.651
MOD_CK1_1	450	456	PF00069	0.832
MOD_CK1_1	483	489	PF00069	0.829
MOD_CK1_1	500	506	PF00069	0.549
MOD_CK1_1	510	516	PF00069	0.695
MOD_CK1_1	541	547	PF00069	0.729
MOD_CK1_1	56	62	PF00069	0.724
MOD_CK1_1	566	572	PF00069	0.846
MOD_CK1_1	574	580	PF00069	0.695
MOD_CK1_1	620	626	PF00069	0.858
MOD_CK1_1	664	670	PF00069	0.813
MOD_CK1_1	717	723	PF00069	0.845
MOD_CK1_1	743	749	PF00069	0.815
MOD_CK1_1	767	773	PF00069	0.817
MOD_CK1_1	84	90	PF00069	0.800
MOD_CK2_1	285	291	PF00069	0.683
MOD_CK2_1	311	317	PF00069	0.544
MOD_CK2_1	379	385	PF00069	0.763
MOD_CK2_1	530	536	PF00069	0.649
MOD_CK2_1	574	580	PF00069	0.835
MOD_CK2_1	597	603	PF00069	0.689
MOD_CK2_1	709	715	PF00069	0.783
MOD_CK2_1	722	728	PF00069	0.685
MOD_CK2_1	74	80	PF00069	0.852
MOD_CK2_1	747	753	PF00069	0.810
MOD_GlcNHglycan	142	145	PF01048	0.785
MOD_GlcNHglycan	152	155	PF01048	0.678
MOD_GlcNHglycan	173	176	PF01048	0.655
MOD_GlcNHglycan	19	22	PF01048	0.590
MOD_GlcNHglycan	216	219	PF01048	0.755
MOD_GlcNHglycan	237	240	PF01048	0.758
MOD_GlcNHglycan	245	248	PF01048	0.767
MOD_GlcNHglycan	301	304	PF01048	0.644
MOD_GlcNHglycan	328	331	PF01048	0.792
MOD_GlcNHglycan	33	36	PF01048	0.576
MOD_GlcNHglycan	339	342	PF01048	0.662
MOD_GlcNHglycan	346	349	PF01048	0.532
MOD_GlcNHglycan	437	440	PF01048	0.621
MOD_GlcNHglycan	46	49	PF01048	0.723
MOD_GlcNHglycan	509	512	PF01048	0.611
MOD_GlcNHglycan	530	533	PF01048	0.711
MOD_GlcNHglycan	55	58	PF01048	0.664
MOD_GlcNHglycan	59	62	PF01048	0.608
MOD_GlcNHglycan	599	602	PF01048	0.684
MOD_GlcNHglycan	624	627	PF01048	0.759
MOD_GlcNHglycan	658	661	PF01048	0.827
MOD_GlcNHglycan	664	667	PF01048	0.718
MOD_GlcNHglycan	679	682	PF01048	0.646
MOD_GlcNHglycan	724	727	PF01048	0.849
MOD_GlcNHglycan	762	765	PF01048	0.763
MOD_GlcNHglycan	769	772	PF01048	0.744
MOD_GlcNHglycan	776	779	PF01048	0.626
MOD_GlcNHglycan	93	96	PF01048	0.698
MOD_GSK3_1	1	8	PF00069	0.748
MOD_GSK3_1	140	147	PF00069	0.791
MOD_GSK3_1	174	181	PF00069	0.711
MOD_GSK3_1	19	26	PF00069	0.516
MOD_GSK3_1	192	199	PF00069	0.830
MOD_GSK3_1	203	210	PF00069	0.633
MOD_GSK3_1	263	270	PF00069	0.621
MOD_GSK3_1	280	287	PF00069	0.734
MOD_GSK3_1	299	306	PF00069	0.569
MOD_GSK3_1	359	366	PF00069	0.582
MOD_GSK3_1	386	393	PF00069	0.724
MOD_GSK3_1	413	420	PF00069	0.764
MOD_GSK3_1	435	442	PF00069	0.675
MOD_GSK3_1	480	487	PF00069	0.703
MOD_GSK3_1	497	504	PF00069	0.552
MOD_GSK3_1	506	513	PF00069	0.684
MOD_GSK3_1	524	531	PF00069	0.619
MOD_GSK3_1	53	60	PF00069	0.781
MOD_GSK3_1	537	544	PF00069	0.732
MOD_GSK3_1	563	570	PF00069	0.823
MOD_GSK3_1	622	629	PF00069	0.755
MOD_GSK3_1	645	652	PF00069	0.802
MOD_GSK3_1	654	661	PF00069	0.662
MOD_GSK3_1	662	669	PF00069	0.537
MOD_GSK3_1	706	713	PF00069	0.748
MOD_GSK3_1	743	750	PF00069	0.814
MOD_GSK3_1	760	767	PF00069	0.538
MOD_GSK3_1	770	777	PF00069	0.661
MOD_GSK3_1	803	810	PF00069	0.555
MOD_GSK3_1	81	88	PF00069	0.788
MOD_N-GLC_1	386	391	PF02516	0.630
MOD_N-GLC_1	418	423	PF02516	0.597
MOD_N-GLC_1	480	485	PF02516	0.814
MOD_N-GLC_1	564	569	PF02516	0.722
MOD_NEK2_1	150	155	PF00069	0.670
MOD_NEK2_1	207	212	PF00069	0.656
MOD_NEK2_1	221	226	PF00069	0.568
MOD_NEK2_1	252	257	PF00069	0.813
MOD_NEK2_1	304	309	PF00069	0.779
MOD_NEK2_1	44	49	PF00069	0.753
MOD_NEK2_1	53	58	PF00069	0.645
MOD_NEK2_1	545	550	PF00069	0.569
MOD_NEK2_1	632	637	PF00069	0.566
MOD_NEK2_1	697	702	PF00069	0.810
MOD_NEK2_1	740	745	PF00069	0.791
MOD_NEK2_1	793	798	PF00069	0.552
MOD_NEK2_2	764	769	PF00069	0.748
MOD_PIKK_1	304	310	PF00454	0.727
MOD_PIKK_1	363	369	PF00454	0.553
MOD_PIKK_1	545	551	PF00454	0.760
MOD_PIKK_1	626	632	PF00454	0.783
MOD_PIKK_1	684	690	PF00454	0.741
MOD_PK_1	484	490	PF00069	0.830
MOD_PKA_2	111	117	PF00069	0.720
MOD_PKA_2	192	198	PF00069	0.756
MOD_PKA_2	211	217	PF00069	0.565
MOD_PKA_2	250	256	PF00069	0.744
MOD_PKA_2	266	272	PF00069	0.723
MOD_PKA_2	284	290	PF00069	0.750
MOD_PKA_2	317	323	PF00069	0.759
MOD_PKA_2	483	489	PF00069	0.829
MOD_PKA_2	620	626	PF00069	0.742
MOD_PKA_2	771	777	PF00069	0.690
MOD_PKA_2	84	90	PF00069	0.750
MOD_PKB_1	83	91	PF00069	0.675
MOD_Plk_1	122	128	PF00069	0.602
MOD_Plk_1	181	187	PF00069	0.738
MOD_Plk_1	221	227	PF00069	0.817
MOD_Plk_1	714	720	PF00069	0.742
MOD_Plk_1	747	753	PF00069	0.732
MOD_Plk_2-3	317	323	PF00069	0.603
MOD_Plk_4	111	117	PF00069	0.720
MOD_Plk_4	196	202	PF00069	0.545
MOD_Plk_4	23	29	PF00069	0.716
MOD_Plk_4	428	434	PF00069	0.651
MOD_Plk_4	541	547	PF00069	0.574
MOD_ProDKin_1	1	7	PF00069	0.606
MOD_ProDKin_1	168	174	PF00069	0.727
MOD_ProDKin_1	19	25	PF00069	0.632
MOD_ProDKin_1	311	317	PF00069	0.762
MOD_ProDKin_1	347	353	PF00069	0.559
MOD_ProDKin_1	367	373	PF00069	0.752
MOD_ProDKin_1	502	508	PF00069	0.691
MOD_ProDKin_1	571	577	PF00069	0.843
MOD_ProDKin_1	609	615	PF00069	0.843
MOD_ProDKin_1	654	660	PF00069	0.768
MOD_ProDKin_1	668	674	PF00069	0.586
MOD_ProDKin_1	9	15	PF00069	0.618
MOD_SUMO_rev_2	438	447	PF00179	0.758
TRG_ENDOCYTIC_2	110	113	PF00928	0.722
TRG_ER_diArg_1	278	280	PF00400	0.630
TRG_ER_diArg_1	396	398	PF00400	0.834
TRG_ER_diArg_1	472	474	PF00400	0.860
TRG_ER_diArg_1	587	590	PF00400	0.817
TRG_ER_diArg_1	613	615	PF00400	0.775
TRG_ER_diArg_1	82	85	PF00400	0.681
TRG_NLS_MonoCore_2	469	474	PF00514	0.863
TRG_NLS_MonoCore_2	784	789	PF00514	0.834
TRG_NLS_MonoExtC_3	469	474	PF00514	0.863
TRG_NLS_MonoExtC_3	785	791	PF00514	0.832
TRG_NLS_MonoExtN_4	785	790	PF00514	0.833
TRG_Pf-PMV_PEXEL_1	590	595	PF00026	0.731

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGI6	Leishmania donovani	82%	99%
A4HJM2	Leishmania braziliensis	60%	100%
A4I744	Leishmania infantum	81%	100%
Q4Q623	Leishmania major	80%	100%