WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B237_LEIMU

TriTrypDb:

LmxM.30.2370

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B237

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B237

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	354	360	PF00089	0.475
CLV_NRD_NRD_1	145	147	PF00675	0.460
CLV_NRD_NRD_1	197	199	PF00675	0.619
CLV_NRD_NRD_1	490	492	PF00675	0.399
CLV_NRD_NRD_1	80	82	PF00675	0.670
CLV_NRD_NRD_1	83	85	PF00675	0.652
CLV_PCSK_KEX2_1	157	159	PF00082	0.530
CLV_PCSK_KEX2_1	199	201	PF00082	0.410
CLV_PCSK_KEX2_1	490	492	PF00082	0.432
CLV_PCSK_KEX2_1	67	69	PF00082	0.724
CLV_PCSK_KEX2_1	80	82	PF00082	0.637
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.530
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.450
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.748
CLV_PCSK_SKI1_1	127	131	PF00082	0.438
CLV_PCSK_SKI1_1	181	185	PF00082	0.372
CLV_PCSK_SKI1_1	298	302	PF00082	0.496
CLV_PCSK_SKI1_1	387	391	PF00082	0.432
CLV_PCSK_SKI1_1	63	67	PF00082	0.539
DEG_APCC_DBOX_1	495	503	PF00400	0.462
DEG_ODPH_VHL_1	218	229	PF01847	0.410
DEG_SCF_SKP2-CKS1_1	409	416	PF00560	0.514
DOC_AGCK_PIF_1	355	360	PF00069	0.478
DOC_CKS1_1	443	448	PF01111	0.581
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.559
DOC_MAPK_gen_1	146	154	PF00069	0.423
DOC_MAPK_gen_1	2	10	PF00069	0.470
DOC_MAPK_MEF2A_6	264	271	PF00069	0.488
DOC_MAPK_MEF2A_6	337	345	PF00069	0.512
DOC_MIT_MIM_1	206	215	PF04212	0.485
DOC_PP1_RVXF_1	349	356	PF00149	0.447
DOC_PP1_RVXF_1	385	391	PF00149	0.354
DOC_USP7_MATH_1	104	108	PF00917	0.595
DOC_USP7_MATH_1	111	115	PF00917	0.577
DOC_USP7_MATH_1	125	129	PF00917	0.482
DOC_USP7_MATH_1	230	234	PF00917	0.521
DOC_USP7_MATH_1	3	7	PF00917	0.470
DOC_USP7_MATH_1	311	315	PF00917	0.711
DOC_USP7_MATH_1	370	374	PF00917	0.517
DOC_USP7_MATH_1	379	383	PF00917	0.304
DOC_USP7_MATH_1	88	92	PF00917	0.679
DOC_USP7_UBL2_3	149	153	PF12436	0.506
DOC_USP7_UBL2_3	298	302	PF12436	0.496
DOC_USP7_UBL2_3	63	67	PF12436	0.711
DOC_WW_Pin1_4	19	24	PF00397	0.450
DOC_WW_Pin1_4	343	348	PF00397	0.423
DOC_WW_Pin1_4	39	44	PF00397	0.759
DOC_WW_Pin1_4	410	415	PF00397	0.574
DOC_WW_Pin1_4	442	447	PF00397	0.495
DOC_WW_Pin1_4	97	102	PF00397	0.616
LIG_14-3-3_CanoR_1	162	167	PF00244	0.525
LIG_14-3-3_CanoR_1	2	8	PF00244	0.469
LIG_14-3-3_CanoR_1	357	361	PF00244	0.452
LIG_14-3-3_CanoR_1	490	494	PF00244	0.562
LIG_14-3-3_CanoR_1	496	500	PF00244	0.295
LIG_14-3-3_CanoR_1	510	518	PF00244	0.214
LIG_14-3-3_CanoR_1	70	75	PF00244	0.757
LIG_Actin_WH2_2	444	462	PF00022	0.551
LIG_BIR_III_2	76	80	PF00653	0.626
LIG_BRCT_BRCA1_1	472	476	PF00533	0.506
LIG_CtBP_PxDLS_1	417	421	PF00389	0.523
LIG_DLG_GKlike_1	70	78	PF00625	0.497
LIG_FHA_1	15	21	PF00498	0.511
LIG_FHA_1	223	229	PF00498	0.517
LIG_FHA_1	256	262	PF00498	0.467
LIG_FHA_1	276	282	PF00498	0.405
LIG_FHA_1	3	9	PF00498	0.503
LIG_FHA_1	348	354	PF00498	0.509
LIG_FHA_1	392	398	PF00498	0.421
LIG_FHA_1	419	425	PF00498	0.607
LIG_FHA_2	258	264	PF00498	0.468
LIG_FHA_2	280	286	PF00498	0.514
LIG_FHA_2	317	323	PF00498	0.734
LIG_FHA_2	428	434	PF00498	0.524
LIG_FHA_2	490	496	PF00498	0.494
LIG_FHA_2	510	516	PF00498	0.391
LIG_LIR_Gen_1	148	156	PF02991	0.502
LIG_LIR_Gen_1	356	366	PF02991	0.465
LIG_LIR_LC3C_4	128	133	PF02991	0.401
LIG_LIR_LC3C_4	350	354	PF02991	0.285
LIG_LIR_Nem_3	148	154	PF02991	0.502
LIG_LIR_Nem_3	356	361	PF02991	0.457
LIG_PDZ_Class_2	516	521	PF00595	0.430
LIG_Pex14_2	150	154	PF04695	0.416
LIG_RPA_C_Fungi	485	497	PF08784	0.465
LIG_SH2_CRK	21	25	PF00017	0.545
LIG_SH2_STAP1	363	367	PF00017	0.486
LIG_SH2_STAT5	151	154	PF00017	0.540
LIG_SH2_STAT5	172	175	PF00017	0.399
LIG_SH2_STAT5	501	504	PF00017	0.425
LIG_SH3_3	24	30	PF00018	0.443
LIG_SH3_3	364	370	PF00018	0.489
LIG_SH3_3	411	417	PF00018	0.539
LIG_SH3_3	426	432	PF00018	0.323
LIG_SH3_3	95	101	PF00018	0.724
LIG_SUMO_SIM_anti_2	128	135	PF11976	0.433
LIG_SUMO_SIM_par_1	128	135	PF11976	0.367
LIG_SUMO_SIM_par_1	256	263	PF11976	0.488
LIG_SUMO_SIM_par_1	277	282	PF11976	0.445
LIG_SUMO_SIM_par_1	425	430	PF11976	0.517
LIG_TRAF2_1	336	339	PF00917	0.624
MOD_CDK_SPxK_1	410	416	PF00069	0.514
MOD_CDK_SPxK_1	442	448	PF00069	0.575
MOD_CK1_1	222	228	PF00069	0.430
MOD_CK1_1	254	260	PF00069	0.435
MOD_CK1_1	275	281	PF00069	0.530
MOD_CK1_1	316	322	PF00069	0.725
MOD_CK1_1	356	362	PF00069	0.475
MOD_CK1_1	47	53	PF00069	0.659
MOD_CK1_1	477	483	PF00069	0.436
MOD_CK1_1	99	105	PF00069	0.577
MOD_CK2_1	257	263	PF00069	0.461
MOD_CK2_1	279	285	PF00069	0.502
MOD_CK2_1	332	338	PF00069	0.669
MOD_CK2_1	389	395	PF00069	0.524
MOD_CK2_1	427	433	PF00069	0.496
MOD_CK2_1	509	515	PF00069	0.511
MOD_CK2_1	80	86	PF00069	0.643
MOD_GlcNHglycan	113	116	PF01048	0.734
MOD_GlcNHglycan	127	130	PF01048	0.366
MOD_GlcNHglycan	175	178	PF01048	0.385
MOD_GlcNHglycan	334	337	PF01048	0.641
MOD_GlcNHglycan	39	42	PF01048	0.635
MOD_GlcNHglycan	479	483	PF01048	0.431
MOD_GlcNHglycan	503	506	PF01048	0.397
MOD_GlcNHglycan	56	61	PF01048	0.771
MOD_GlcNHglycan	92	95	PF01048	0.794
MOD_GSK3_1	109	116	PF00069	0.505
MOD_GSK3_1	162	169	PF00069	0.450
MOD_GSK3_1	251	258	PF00069	0.406
MOD_GSK3_1	275	282	PF00069	0.502
MOD_GSK3_1	328	335	PF00069	0.673
MOD_GSK3_1	343	350	PF00069	0.321
MOD_GSK3_1	427	434	PF00069	0.474
MOD_GSK3_1	470	477	PF00069	0.427
MOD_GSK3_1	80	87	PF00069	0.703
MOD_N-GLC_1	418	423	PF02516	0.613
MOD_NEK2_1	131	136	PF00069	0.487
MOD_NEK2_1	183	188	PF00069	0.383
MOD_NEK2_1	279	284	PF00069	0.355
MOD_NEK2_1	418	423	PF00069	0.579
MOD_NEK2_2	370	375	PF00069	0.526
MOD_PIKK_1	230	236	PF00454	0.415
MOD_PIKK_1	313	319	PF00454	0.717
MOD_PK_1	162	168	PF00069	0.525
MOD_PK_1	251	257	PF00069	0.428
MOD_PKA_1	80	86	PF00069	0.670
MOD_PKA_2	191	197	PF00069	0.620
MOD_PKA_2	3	9	PF00069	0.469
MOD_PKA_2	328	334	PF00069	0.746
MOD_PKA_2	356	362	PF00069	0.452
MOD_PKA_2	489	495	PF00069	0.487
MOD_PKA_2	509	515	PF00069	0.384
MOD_PKA_2	80	86	PF00069	0.705
MOD_PKB_1	249	257	PF00069	0.407
MOD_PKB_1	68	76	PF00069	0.762
MOD_Plk_1	222	228	PF00069	0.464
MOD_Plk_1	251	257	PF00069	0.406
MOD_Plk_4	3	9	PF00069	0.469
MOD_Plk_4	328	334	PF00069	0.718
MOD_Plk_4	471	477	PF00069	0.417
MOD_ProDKin_1	19	25	PF00069	0.448
MOD_ProDKin_1	343	349	PF00069	0.417
MOD_ProDKin_1	39	45	PF00069	0.759
MOD_ProDKin_1	410	416	PF00069	0.579
MOD_ProDKin_1	442	448	PF00069	0.497
MOD_ProDKin_1	97	103	PF00069	0.616
TRG_DiLeu_BaEn_1	223	228	PF01217	0.438
TRG_ENDOCYTIC_2	151	154	PF00928	0.540
TRG_ER_diArg_1	1	4	PF00400	0.464
TRG_ER_diArg_1	198	201	PF00400	0.422
TRG_ER_diArg_1	248	251	PF00400	0.384
TRG_ER_diArg_1	51	54	PF00400	0.506
TRG_ER_diArg_1	79	81	PF00400	0.602
TRG_NLS_MonoCore_2	66	71	PF00514	0.752
TRG_NLS_MonoExtC_3	197	202	PF00514	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5P1	Leptomonas seymouri	62%	100%
A0A0S4JK75	Bodo saltans	34%	100%
A0A1X0NFD4	Trypanosomatidae	38%	100%
A0A3Q8ICP9	Leishmania donovani	87%	100%
A0A3R7KS12	Trypanosoma rangeli	47%	100%
A4HJM1	Leishmania braziliensis	79%	100%
A4I743	Leishmania infantum	87%	100%
C9ZME4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	91%
C9ZWN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	92%
Q4Q624	Leishmania major	88%	100%
V5B2M4	Trypanosoma cruzi	47%	100%