Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B236_LEIMU

TriTrypDb:

LmxM.30.2360

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B236

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B236

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.780
CLV_NRD_NRD_1	449	451	PF00675	0.578
CLV_PCSK_KEX2_1	33	35	PF00082	0.732
CLV_PCSK_KEX2_1	449	451	PF00082	0.578
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.732
DEG_APCC_DBOX_1	473	481	PF00400	0.608
DEG_APCC_DBOX_1	484	492	PF00400	0.602
DEG_ODPH_VHL_1	377	389	PF01847	0.732
DEG_SCF_FBW7_2	472	479	PF00400	0.600
DEG_SPOP_SBC_1	66	70	PF00917	0.771
DOC_CDC14_PxL_1	251	259	PF14671	0.754
DOC_CDC14_PxL_1	304	312	PF14671	0.745
DOC_CKS1_1	123	128	PF01111	0.518
DOC_CKS1_1	43	48	PF01111	0.639
DOC_CKS1_1	473	478	PF01111	0.607
DOC_MAPK_FxFP_2	516	519	PF00069	0.538
DOC_MAPK_MEF2A_6	44	52	PF00069	0.711
DOC_MAPK_RevD_3	19	34	PF00069	0.737
DOC_PP2B_LxvP_1	469	472	PF13499	0.572
DOC_PP4_FxxP_1	194	197	PF00568	0.804
DOC_PP4_FxxP_1	435	438	PF00568	0.572
DOC_PP4_FxxP_1	516	519	PF00568	0.538
DOC_USP7_MATH_1	275	279	PF00917	0.605
DOC_USP7_MATH_1	326	330	PF00917	0.752
DOC_USP7_MATH_1	399	403	PF00917	0.518
DOC_USP7_MATH_1	66	70	PF00917	0.704
DOC_USP7_UBL2_3	419	423	PF12436	0.740
DOC_WW_Pin1_4	122	127	PF00397	0.751
DOC_WW_Pin1_4	137	142	PF00397	0.567
DOC_WW_Pin1_4	199	204	PF00397	0.769
DOC_WW_Pin1_4	234	239	PF00397	0.794
DOC_WW_Pin1_4	368	373	PF00397	0.818
DOC_WW_Pin1_4	42	47	PF00397	0.633
DOC_WW_Pin1_4	472	477	PF00397	0.593
DOC_WW_Pin1_4	81	86	PF00397	0.687
DOC_WW_Pin1_4	98	103	PF00397	0.669
LIG_14-3-3_CanoR_1	165	172	PF00244	0.758
LIG_14-3-3_CanoR_1	265	274	PF00244	0.676
LIG_14-3-3_CanoR_1	400	407	PF00244	0.810
LIG_14-3-3_CanoR_1	417	425	PF00244	0.620
LIG_deltaCOP1_diTrp_1	454	463	PF00928	0.535
LIG_deltaCOP1_diTrp_1	499	508	PF00928	0.485
LIG_deltaCOP1_diTrp_1	54	63	PF00928	0.660
LIG_EVH1_1	436	440	PF00568	0.571
LIG_EVH1_1	469	473	PF00568	0.569
LIG_FHA_1	126	132	PF00498	0.769
LIG_FHA_1	185	191	PF00498	0.667
LIG_FHA_1	393	399	PF00498	0.602
LIG_FHA_1	45	51	PF00498	0.625
LIG_FHA_1	464	470	PF00498	0.578
LIG_FHA_2	178	184	PF00498	0.731
LIG_FHA_2	20	26	PF00498	0.728
LIG_FHA_2	208	214	PF00498	0.726
LIG_FHA_2	49	55	PF00498	0.683
LIG_FXI_DFP_1	515	519	PF00024	0.591
LIG_Integrin_RGD_1	26	28	PF01839	0.817
LIG_LIR_Apic_2	191	197	PF02991	0.796
LIG_LIR_Apic_2	60	66	PF02991	0.718
LIG_LIR_Gen_1	499	509	PF02991	0.515
LIG_LIR_Gen_1	526	537	PF02991	0.652
LIG_LIR_Nem_3	175	181	PF02991	0.693
LIG_LIR_Nem_3	454	459	PF02991	0.534
LIG_LIR_Nem_3	505	511	PF02991	0.515
LIG_LIR_Nem_3	526	532	PF02991	0.653
LIG_LYPXL_yS_3	307	310	PF13949	0.751
LIG_MYND_3	254	258	PF01753	0.744
LIG_NRBOX	424	430	PF00104	0.576
LIG_Pex14_2	194	198	PF04695	0.514
LIG_Pex14_2	431	435	PF04695	0.594
LIG_Rb_pABgroove_1	510	518	PF01858	0.578
LIG_SH2_NCK_1	166	170	PF00017	0.495
LIG_SH2_SRC	282	285	PF00017	0.738
LIG_SH2_STAP1	166	170	PF00017	0.745
LIG_SH2_STAP1	174	178	PF00017	0.675
LIG_SH2_STAP1	459	463	PF00017	0.549
LIG_SH2_STAT3	209	212	PF00017	0.526
LIG_SH2_STAT5	209	212	PF00017	0.745
LIG_SH2_STAT5	253	256	PF00017	0.689
LIG_SH2_STAT5	282	285	PF00017	0.612
LIG_SH2_STAT5	424	427	PF00017	0.592
LIG_SH3_1	120	126	PF00018	0.532
LIG_SH3_1	346	352	PF00018	0.712
LIG_SH3_2	200	205	PF14604	0.601
LIG_SH3_2	438	443	PF14604	0.602
LIG_SH3_3	120	126	PF00018	0.532
LIG_SH3_3	151	157	PF00018	0.722
LIG_SH3_3	194	200	PF00018	0.690
LIG_SH3_3	285	291	PF00018	0.769
LIG_SH3_3	346	352	PF00018	0.712
LIG_SH3_3	40	46	PF00018	0.653
LIG_SH3_3	434	440	PF00018	0.580
LIG_SH3_3	467	473	PF00018	0.583
LIG_SH3_CIN85_PxpxPR_1	438	443	PF14604	0.602
LIG_SUMO_SIM_par_1	47	54	PF11976	0.663
LIG_TRAF2_1	210	213	PF00917	0.736
LIG_TRAF2_1	314	317	PF00917	0.750
LIG_WW_3	440	444	PF00397	0.606
LIG_WW_3	471	475	PF00397	0.587
MOD_CDC14_SPxK_1	202	205	PF00782	0.716
MOD_CDK_SPxK_1	199	205	PF00069	0.718
MOD_CDK_SPxxK_3	81	88	PF00069	0.733
MOD_CK1_1	237	243	PF00069	0.736
MOD_CK1_1	245	251	PF00069	0.612
MOD_CK1_1	329	335	PF00069	0.635
MOD_CK1_1	390	396	PF00069	0.703
MOD_CK1_1	81	87	PF00069	0.690
MOD_CK2_1	177	183	PF00069	0.732
MOD_CK2_1	207	213	PF00069	0.727
MOD_CK2_1	275	281	PF00069	0.605
MOD_CK2_1	48	54	PF00069	0.713
MOD_CK2_1	67	73	PF00069	0.482
MOD_GlcNHglycan	166	169	PF01048	0.628
MOD_GlcNHglycan	218	221	PF01048	0.700
MOD_GlcNHglycan	230	233	PF01048	0.814
MOD_GlcNHglycan	244	247	PF01048	0.759
MOD_GlcNHglycan	268	271	PF01048	0.650
MOD_GlcNHglycan	389	392	PF01048	0.698
MOD_GlcNHglycan	401	404	PF01048	0.774
MOD_GlcNHglycan	407	410	PF01048	0.737
MOD_GlcNHglycan	414	417	PF01048	0.514
MOD_GlcNHglycan	58	62	PF01048	0.781
MOD_GlcNHglycan	80	83	PF01048	0.748
MOD_GlcNHglycan	96	99	PF01048	0.721
MOD_GSK3_1	106	113	PF00069	0.699
MOD_GSK3_1	173	180	PF00069	0.748
MOD_GSK3_1	184	191	PF00069	0.652
MOD_GSK3_1	212	219	PF00069	0.689
MOD_GSK3_1	226	233	PF00069	0.825
MOD_GSK3_1	242	249	PF00069	0.634
MOD_GSK3_1	292	299	PF00069	0.638
MOD_GSK3_1	419	426	PF00069	0.607
MOD_GSK3_1	44	51	PF00069	0.709
MOD_GSK3_1	94	101	PF00069	0.724
MOD_N-GLC_1	308	313	PF02516	0.819
MOD_N-GLC_1	365	370	PF02516	0.541
MOD_NEK2_1	1	6	PF00069	0.738
MOD_NEK2_1	104	109	PF00069	0.550
MOD_NEK2_1	297	302	PF00069	0.704
MOD_NEK2_1	387	392	PF00069	0.684
MOD_NEK2_1	48	53	PF00069	0.660
MOD_PIKK_1	188	194	PF00454	0.787
MOD_PIKK_1	297	303	PF00454	0.704
MOD_PKA_1	33	39	PF00069	0.719
MOD_PKA_2	164	170	PF00069	0.788
MOD_PKA_2	17	23	PF00069	0.670
MOD_PKA_2	33	39	PF00069	0.671
MOD_PKA_2	399	405	PF00069	0.808
MOD_PKA_2	78	84	PF00069	0.740
MOD_Plk_1	188	194	PF00069	0.787
MOD_Plk_1	212	218	PF00069	0.625
MOD_Plk_1	316	322	PF00069	0.583
MOD_Plk_1	34	40	PF00069	0.741
MOD_Plk_1	356	362	PF00069	0.527
MOD_Plk_4	249	255	PF00069	0.668
MOD_Plk_4	275	281	PF00069	0.646
MOD_Plk_4	34	40	PF00069	0.688
MOD_Plk_4	44	50	PF00069	0.691
MOD_Plk_4	67	73	PF00069	0.673
MOD_ProDKin_1	122	128	PF00069	0.748
MOD_ProDKin_1	137	143	PF00069	0.568
MOD_ProDKin_1	199	205	PF00069	0.773
MOD_ProDKin_1	234	240	PF00069	0.793
MOD_ProDKin_1	368	374	PF00069	0.819
MOD_ProDKin_1	42	48	PF00069	0.636
MOD_ProDKin_1	472	478	PF00069	0.598
MOD_ProDKin_1	81	87	PF00069	0.687
MOD_ProDKin_1	98	104	PF00069	0.671
MOD_SUMO_for_1	32	35	PF00179	0.731
MOD_SUMO_rev_2	415	425	PF00179	0.682
TRG_ENDOCYTIC_2	208	211	PF00928	0.821
TRG_ENDOCYTIC_2	307	310	PF00928	0.697
TRG_ER_diArg_1	449	452	PF00400	0.564
TRG_NES_CRM1_1	521	535	PF08389	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC95	Leptomonas seymouri	51%	91%
A0A3Q8IST7	Leishmania donovani	92%	100%
A4HJM0	Leishmania braziliensis	72%	99%
A4I742	Leishmania infantum	92%	100%
Q4Q625	Leishmania major	88%	100%
V5BBS4	Trypanosoma cruzi	33%	100%