Putative p-nitrophenylphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p-nitrophenylphosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9B234_LEIMU

TriTrypDb:

LmxM.30.2340

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B234

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B234

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.381
CLV_PCSK_KEX2_1	170	172	PF00082	0.555
CLV_PCSK_KEX2_1	274	276	PF00082	0.470
CLV_PCSK_KEX2_1	51	53	PF00082	0.371
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.436
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.425
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.196
CLV_PCSK_PC7_1	47	53	PF00082	0.196
CLV_PCSK_SKI1_1	19	23	PF00082	0.407
CLV_PCSK_SKI1_1	96	100	PF00082	0.378
DEG_ODPH_VHL_1	131	142	PF01847	0.411
DOC_CYCLIN_RxL_1	93	103	PF00134	0.493
DOC_MAPK_gen_1	282	292	PF00069	0.338
DOC_MAPK_gen_1	72	81	PF00069	0.511
DOC_PP1_RVXF_1	49	56	PF00149	0.487
DOC_PP2B_LxvP_1	165	168	PF13499	0.424
DOC_USP7_MATH_1	155	159	PF00917	0.541
DOC_USP7_MATH_1	217	221	PF00917	0.438
DOC_WW_Pin1_4	13	18	PF00397	0.522
DOC_WW_Pin1_4	233	238	PF00397	0.559
LIG_14-3-3_CanoR_1	310	317	PF00244	0.321
LIG_Actin_WH2_2	200	217	PF00022	0.370
LIG_Actin_WH2_2	6	21	PF00022	0.400
LIG_BIR_III_4	154	158	PF00653	0.448
LIG_Clathr_ClatBox_1	22	26	PF01394	0.495
LIG_FHA_1	135	141	PF00498	0.435
LIG_FHA_1	151	157	PF00498	0.568
LIG_FHA_1	188	194	PF00498	0.392
LIG_FHA_1	234	240	PF00498	0.572
LIG_FHA_1	310	316	PF00498	0.350
LIG_FHA_1	345	351	PF00498	0.428
LIG_FHA_1	4	10	PF00498	0.544
LIG_FHA_1	88	94	PF00498	0.493
LIG_FHA_2	241	247	PF00498	0.410
LIG_FHA_2	334	340	PF00498	0.268
LIG_FHA_2	78	84	PF00498	0.571
LIG_GBD_Chelix_1	354	362	PF00786	0.373
LIG_LIR_Apic_2	158	163	PF02991	0.543
LIG_LIR_Apic_2	232	238	PF02991	0.485
LIG_LIR_Gen_1	208	218	PF02991	0.411
LIG_LIR_Nem_3	208	214	PF02991	0.406
LIG_MYND_1	163	167	PF01753	0.492
LIG_NRBOX	94	100	PF00104	0.493
LIG_SH2_CRK	218	222	PF00017	0.437
LIG_SH2_CRK	235	239	PF00017	0.460
LIG_SH2_NCK_1	85	89	PF00017	0.577
LIG_SH2_PTP2	20	23	PF00017	0.322
LIG_SH2_STAP1	151	155	PF00017	0.518
LIG_SH2_STAP1	89	93	PF00017	0.521
LIG_SH2_STAT5	20	23	PF00017	0.304
LIG_SH2_STAT5	235	238	PF00017	0.480
LIG_SH2_STAT5	353	356	PF00017	0.440
LIG_SH2_STAT5	45	48	PF00017	0.492
LIG_SH2_STAT5	89	92	PF00017	0.540
LIG_SH3_3	11	17	PF00018	0.498
LIG_SH3_3	127	133	PF00018	0.564
LIG_SH3_3	160	166	PF00018	0.511
LIG_SH3_3	244	250	PF00018	0.478
LIG_SH3_3	99	105	PF00018	0.396
LIG_SUMO_SIM_par_1	21	26	PF11976	0.499
LIG_SUMO_SIM_par_1	325	330	PF11976	0.352
LIG_TRAF2_1	105	108	PF00917	0.542
LIG_TRAF2_1	300	303	PF00917	0.483
LIG_TYR_ITIM	18	23	PF00017	0.345
LIG_TYR_ITIM	216	221	PF00017	0.437
LIG_UBA3_1	67	74	PF00899	0.542
LIG_WW_3	166	170	PF00397	0.279
MOD_CDC14_SPxK_1	16	19	PF00782	0.459
MOD_CDK_SPxK_1	13	19	PF00069	0.458
MOD_CK1_1	87	93	PF00069	0.593
MOD_CK2_1	327	333	PF00069	0.327
MOD_CK2_1	77	83	PF00069	0.571
MOD_Cter_Amidation	272	275	PF01082	0.479
MOD_Cter_Amidation	49	52	PF01082	0.196
MOD_GlcNHglycan	157	160	PF01048	0.487
MOD_GlcNHglycan	329	332	PF01048	0.366
MOD_GlcNHglycan	86	89	PF01048	0.291
MOD_GSK3_1	187	194	PF00069	0.538
MOD_GSK3_1	54	61	PF00069	0.495
MOD_N-GLC_1	187	192	PF02516	0.444
MOD_N-GLC_1	58	63	PF02516	0.292
MOD_NEK2_1	327	332	PF00069	0.321
MOD_NEK2_1	67	72	PF00069	0.585
MOD_PKA_2	3	9	PF00069	0.475
MOD_PKA_2	309	315	PF00069	0.327
MOD_PKB_1	52	60	PF00069	0.396
MOD_Plk_1	231	237	PF00069	0.429
MOD_Plk_1	58	64	PF00069	0.492
MOD_Plk_2-3	191	197	PF00069	0.487
MOD_Plk_2-3	333	339	PF00069	0.203
MOD_Plk_2-3	77	83	PF00069	0.542
MOD_Plk_4	217	223	PF00069	0.455
MOD_Plk_4	260	266	PF00069	0.388
MOD_Plk_4	322	328	PF00069	0.388
MOD_Plk_4	345	351	PF00069	0.224
MOD_ProDKin_1	13	19	PF00069	0.523
MOD_ProDKin_1	233	239	PF00069	0.551
TRG_ENDOCYTIC_2	20	23	PF00928	0.329
TRG_ENDOCYTIC_2	218	221	PF00928	0.462
TRG_ER_diArg_1	168	171	PF00400	0.393
TRG_ER_diArg_1	52	55	PF00400	0.444
TRG_NLS_MonoExtN_4	166	173	PF00514	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P266	Leptomonas seymouri	40%	100%
A0A0S4IZ46	Bodo saltans	46%	100%
A0A3Q8IFQ8	Leishmania donovani	92%	88%
A0A422N412	Trypanosoma rangeli	55%	98%
A4HJL7	Leishmania braziliensis	85%	100%
A4HJL8	Leishmania braziliensis	85%	100%
A4I739	Leishmania infantum	92%	88%
A4I740	Leishmania infantum	42%	100%
A6NDG6	Homo sapiens	29%	100%
C9ZWP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	94%
D3ZDK7	Rattus norvegicus	30%	100%
P0AF24	Escherichia coli (strain K12)	28%	100%
P0AF25	Escherichia coli O157:H7	28%	100%
P0DKC3	Arabidopsis thaliana	32%	100%
P0DKC4	Arabidopsis thaliana	32%	100%
P19881	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P34492	Caenorhabditis elegans	28%	69%
P60487	Mus musculus	30%	100%
Q00472	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q2T9S4	Bos taurus	30%	100%
Q3ZBF9	Bos taurus	31%	100%
Q4Q627	Leishmania major	92%	100%
Q5F4B1	Gallus gallus	29%	100%
Q8CHP8	Mus musculus	30%	100%
Q8GWU0	Arabidopsis thaliana	33%	100%
Q8VD52	Rattus norvegicus	31%	100%
Q96GD0	Homo sapiens	32%	100%
V5D2X9	Trypanosoma cruzi	54%	83%