Putative 3,2-trans-enoyl-CoA isomerase, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative

Species:

Leishmania mexicana

UniProt:

E9B233_LEIMU

TriTrypDb:

LmxM.30.2330

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	4
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

E9B233

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B233

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006635	fatty acid beta-oxidation	6	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009062	fatty acid catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0016042	lipid catabolic process	4	2
GO:0016054	organic acid catabolic process	4	2
GO:0019395	fatty acid oxidation	5	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0030258	lipid modification	4	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0034440	lipid oxidation	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072329	monocarboxylic acid catabolic process	6	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0016853	isomerase activity	2	19
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	5	4
GO:0016491	oxidoreductase activity	2	4
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	4
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	4
GO:0004165	delta(3)-delta(2)-enoyl-CoA isomerase activity	5	11
GO:0016860	intramolecular oxidoreductase activity	3	11
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4	11
GO:0004300	enoyl-CoA hydratase activity	5	2
GO:0016829	lyase activity	2	2
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0016836	hydro-lyase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.559
CLV_NRD_NRD_1	202	204	PF00675	0.155
CLV_NRD_NRD_1	285	287	PF00675	0.338
CLV_NRD_NRD_1	337	339	PF00675	0.623
CLV_PCSK_KEX2_1	2	4	PF00082	0.560
CLV_PCSK_KEX2_1	202	204	PF00082	0.155
CLV_PCSK_KEX2_1	285	287	PF00082	0.323
CLV_PCSK_SKI1_1	71	75	PF00082	0.378
CLV_PCSK_SKI1_1	80	84	PF00082	0.335
DEG_MDM2_SWIB_1	153	160	PF02201	0.230
DEG_Nend_UBRbox_1	1	4	PF02207	0.582
DEG_SPOP_SBC_1	4	8	PF00917	0.692
DOC_CYCLIN_yClb5_NLxxxL_5	324	330	PF00134	0.416
DOC_MAPK_gen_1	202	209	PF00069	0.195
DOC_PP2B_LxvP_1	216	219	PF13499	0.362
DOC_PP2B_LxvP_1	278	281	PF13499	0.360
DOC_PP4_FxxP_1	163	166	PF00568	0.287
DOC_PP4_FxxP_1	30	33	PF00568	0.462
DOC_PP4_FxxP_1	60	63	PF00568	0.458
DOC_USP7_MATH_1	91	95	PF00917	0.279
DOC_WW_Pin1_4	172	177	PF00397	0.262
DOC_WW_Pin1_4	241	246	PF00397	0.309
LIG_14-3-3_CanoR_1	11	17	PF00244	0.534
LIG_14-3-3_CanoR_1	158	164	PF00244	0.305
LIG_14-3-3_CanoR_1	276	281	PF00244	0.404
LIG_14-3-3_CanoR_1	298	308	PF00244	0.222
LIG_BRCT_BRCA1_1	19	23	PF00533	0.518
LIG_deltaCOP1_diTrp_1	155	163	PF00928	0.287
LIG_EVH1_1	32	36	PF00568	0.408
LIG_FHA_1	114	120	PF00498	0.333
LIG_FHA_1	13	19	PF00498	0.668
LIG_FHA_2	300	306	PF00498	0.298
LIG_LIR_Apic_2	162	166	PF02991	0.308
LIG_LIR_Apic_2	59	63	PF02991	0.483
LIG_LIR_Gen_1	134	143	PF02991	0.233
LIG_LIR_Gen_1	224	232	PF02991	0.214
LIG_LIR_Gen_1	275	284	PF02991	0.287
LIG_LIR_Nem_3	134	138	PF02991	0.233
LIG_LIR_Nem_3	155	160	PF02991	0.301
LIG_LIR_Nem_3	224	229	PF02991	0.214
LIG_LIR_Nem_3	275	280	PF02991	0.287
LIG_LIR_Nem_3	310	316	PF02991	0.385
LIG_LYPXL_SIV_4	270	278	PF13949	0.432
LIG_MAD2	158	166	PF02301	0.207
LIG_PCNA_PIPBox_1	323	332	PF02747	0.360
LIG_PCNA_yPIPBox_3	319	330	PF02747	0.323
LIG_Pex14_2	149	153	PF04695	0.287
LIG_SH2_CRK	226	230	PF00017	0.282
LIG_SH2_STAP1	226	230	PF00017	0.282
LIG_SH2_STAP1	308	312	PF00017	0.275
LIG_SH2_STAT3	28	31	PF00017	0.682
LIG_SH2_STAT5	228	231	PF00017	0.299
LIG_SH2_STAT5	329	332	PF00017	0.335
LIG_SH3_3	135	141	PF00018	0.432
LIG_SH3_3	214	220	PF00018	0.395
LIG_SH3_3	30	36	PF00018	0.626
LIG_SH3_3	52	58	PF00018	0.488
LIG_SH3_3	60	66	PF00018	0.448
LIG_SUMO_SIM_anti_2	96	102	PF11976	0.200
LIG_SxIP_EBH_1	117	131	PF03271	0.300
LIG_TRAF2_1	112	115	PF00917	0.416
LIG_TRAF2_1	261	264	PF00917	0.473
LIG_WW_2	33	36	PF00397	0.405
MOD_CK1_1	7	13	PF00069	0.705
MOD_CK2_1	109	115	PF00069	0.369
MOD_CMANNOS	106	109	PF00535	0.309
MOD_GlcNHglycan	122	125	PF01048	0.335
MOD_GlcNHglycan	129	132	PF01048	0.287
MOD_GlcNHglycan	19	22	PF01048	0.614
MOD_GSK3_1	109	116	PF00069	0.309
MOD_GSK3_1	120	127	PF00069	0.279
MOD_GSK3_1	3	10	PF00069	0.675
MOD_GSK3_1	307	314	PF00069	0.422
MOD_NEK2_1	23	28	PF00069	0.544
MOD_PIKK_1	23	29	PF00454	0.602
MOD_PIKK_1	311	317	PF00454	0.286
MOD_PK_1	276	282	PF00069	0.391
MOD_PKA_1	64	70	PF00069	0.585
MOD_Plk_1	262	268	PF00069	0.445
MOD_Plk_4	124	130	PF00069	0.305
MOD_ProDKin_1	172	178	PF00069	0.262
MOD_ProDKin_1	241	247	PF00069	0.309
MOD_SUMO_rev_2	112	119	PF00179	0.389
TRG_DiLeu_BaEn_1	295	300	PF01217	0.222
TRG_DiLeu_BaEn_2	67	73	PF01217	0.543
TRG_DiLeu_LyEn_5	295	300	PF01217	0.222
TRG_ENDOCYTIC_2	188	191	PF00928	0.432
TRG_ENDOCYTIC_2	226	229	PF00928	0.297
TRG_ER_diArg_1	1	3	PF00400	0.567
TRG_ER_diArg_1	202	204	PF00400	0.155
TRG_ER_diArg_1	285	287	PF00400	0.320
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4C8	Leptomonas seymouri	67%	97%
A0A0S4IKH3	Bodo saltans	53%	98%
A0A0S4JA19	Bodo saltans	35%	100%
A0A1X0NRI1	Trypanosomatidae	53%	92%
A0A1X0P9A2	Trypanosomatidae	24%	100%
A0A3Q8IE71	Leishmania donovani	35%	100%
A0A3Q8IIZ5	Leishmania donovani	28%	100%
A0A3R7N7B2	Trypanosoma rangeli	25%	100%
A0A3S7X4R5	Leishmania donovani	78%	99%
A0A3S7X4T7	Leishmania donovani	81%	99%
A0A422N418	Trypanosoma rangeli	57%	98%
A0A422NUW6	Trypanosoma rangeli	32%	100%
A4HH09	Leishmania braziliensis	34%	100%
A4HHN0	Leishmania braziliensis	27%	100%
A4HJK3	Leishmania braziliensis	67%	98%
A4HJK8	Leishmania braziliensis	70%	98%
A4HJL5	Leishmania braziliensis	68%	98%
A4HM74	Leishmania braziliensis	24%	100%
A4I438	Leishmania infantum	35%	100%
A4I4U5	Leishmania infantum	28%	100%
A4I708	Leishmania infantum	79%	99%
A4I738	Leishmania infantum	82%	97%
A9MR28	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	25%	100%
C9ZKS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZLJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZME0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	72%
C9ZWP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	95%
E9ADK3	Leishmania major	34%	100%
E9AE93	Leishmania major	28%	100%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AM78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B226	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%
O35459	Mus musculus	21%	100%
O75521	Homo sapiens	24%	86%
P14604	Rattus norvegicus	24%	100%
P23965	Rattus norvegicus	37%	100%
P30084	Homo sapiens	23%	100%
P34559	Caenorhabditis elegans	21%	100%
P42125	Mus musculus	37%	100%
P42126	Homo sapiens	35%	100%
P52046	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	25%	100%
P76082	Escherichia coli (strain K12)	23%	100%
P94549	Bacillus subtilis (strain 168)	26%	100%
Q0AVM1	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	25%	100%
Q13011	Homo sapiens	23%	100%
Q1ZXF1	Dictyostelium discoideum	24%	100%
Q4Q628	Leishmania major	85%	100%
Q4Q636	Leishmania major	78%	100%
Q52995	Rhizobium meliloti (strain 1021)	22%	100%
Q58DM8	Bos taurus	25%	100%
Q5R646	Pongo abelii	23%	100%
Q5RFG0	Pongo abelii	23%	100%
Q62651	Rattus norvegicus	21%	100%
Q78JN3	Mus musculus	22%	100%
Q8BH95	Mus musculus	24%	100%
V5B2L9	Trypanosoma cruzi	58%	87%
V5BK92	Trypanosoma cruzi	32%	100%
V5DTT7	Trypanosoma cruzi	24%	100%