HEAT repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B228_LEIMU

TriTrypDb:

LmxM.30.2270

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B228

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B228

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0000774	adenyl-nucleotide exchange factor activity	3	1
GO:0005488	binding	1	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0036094	small molecule binding	2	1
GO:0060590	ATPase regulator activity	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.351
CLV_NRD_NRD_1	439	441	PF00675	0.600
CLV_PCSK_KEX2_1	144	146	PF00082	0.325
CLV_PCSK_KEX2_1	151	153	PF00082	0.345
CLV_PCSK_KEX2_1	439	441	PF00082	0.420
CLV_PCSK_KEX2_1	91	93	PF00082	0.392
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.271
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.426
CLV_PCSK_PC7_1	435	441	PF00082	0.327
CLV_PCSK_SKI1_1	144	148	PF00082	0.368
CLV_PCSK_SKI1_1	365	369	PF00082	0.334
CLV_PCSK_SKI1_1	406	410	PF00082	0.352
CLV_PCSK_SKI1_1	417	421	PF00082	0.481
CLV_PCSK_SKI1_1	80	84	PF00082	0.483
CLV_PCSK_SKI1_1	91	95	PF00082	0.433
DEG_APCC_DBOX_1	79	87	PF00400	0.548
DOC_CYCLIN_RxL_1	91	101	PF00134	0.422
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.437
DOC_MAPK_gen_1	91	98	PF00069	0.484
DOC_MAPK_MEF2A_6	91	100	PF00069	0.315
DOC_PP1_RVXF_1	363	370	PF00149	0.368
DOC_PP1_RVXF_1	449	455	PF00149	0.413
DOC_PP2B_LxvP_1	213	216	PF13499	0.336
DOC_USP7_MATH_1	161	165	PF00917	0.612
DOC_USP7_MATH_1	167	171	PF00917	0.634
DOC_USP7_MATH_1	37	41	PF00917	0.695
DOC_USP7_MATH_1	374	378	PF00917	0.507
DOC_USP7_MATH_1	47	51	PF00917	0.700
DOC_USP7_MATH_1	82	86	PF00917	0.494
DOC_WW_Pin1_4	289	294	PF00397	0.421
DOC_WW_Pin1_4	328	333	PF00397	0.552
DOC_WW_Pin1_4	412	417	PF00397	0.491
DOC_WW_Pin1_4	45	50	PF00397	0.538
DOC_WW_Pin1_4	58	63	PF00397	0.475
DOC_WW_Pin1_4	85	90	PF00397	0.506
LIG_14-3-3_CanoR_1	399	408	PF00244	0.279
LIG_14-3-3_CanoR_1	71	79	PF00244	0.486
LIG_14-3-3_CterR_2	460	462	PF00244	0.439
LIG_APCC_ABBA_1	197	202	PF00400	0.384
LIG_APCC_ABBA_1	96	101	PF00400	0.306
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_BIR_III_2	22	26	PF00653	0.492
LIG_Clathr_ClatBox_1	83	87	PF01394	0.581
LIG_Clathr_ClatBox_1	97	101	PF01394	0.468
LIG_deltaCOP1_diTrp_1	129	137	PF00928	0.429
LIG_FHA_1	312	318	PF00498	0.431
LIG_FHA_1	329	335	PF00498	0.471
LIG_FHA_1	357	363	PF00498	0.481
LIG_FHA_1	407	413	PF00498	0.437
LIG_FHA_2	323	329	PF00498	0.423
LIG_FHA_2	445	451	PF00498	0.539
LIG_LIR_Gen_1	136	143	PF02991	0.375
LIG_LIR_Gen_1	74	84	PF02991	0.522
LIG_LIR_Nem_3	349	355	PF02991	0.481
LIG_LIR_Nem_3	74	79	PF02991	0.510
LIG_NRBOX	272	278	PF00104	0.388
LIG_Pex14_1	133	137	PF04695	0.379
LIG_PTAP_UEV_1	30	35	PF05743	0.657
LIG_SH2_CRK	352	356	PF00017	0.478
LIG_SH2_STAT5	372	375	PF00017	0.393
LIG_SH3_3	28	34	PF00018	0.685
LIG_SH3_3	66	72	PF00018	0.510
LIG_SH3_3	83	89	PF00018	0.494
LIG_SH3_5	72	76	PF00018	0.472
LIG_SUMO_SIM_anti_2	302	309	PF11976	0.454
LIG_SUMO_SIM_par_1	82	88	PF11976	0.382
LIG_TRAF2_1	344	347	PF00917	0.547
LIG_TRAF2_1	379	382	PF00917	0.541
MOD_CDC14_SPxK_1	88	91	PF00782	0.476
MOD_CDK_SPK_2	412	417	PF00069	0.444
MOD_CDK_SPxK_1	85	91	PF00069	0.502
MOD_CDK_SPxxK_3	85	92	PF00069	0.496
MOD_CK1_1	2	8	PF00069	0.581
MOD_CK1_1	292	298	PF00069	0.363
MOD_CK1_1	377	383	PF00069	0.298
MOD_CK1_1	393	399	PF00069	0.516
MOD_CK1_1	40	46	PF00069	0.630
MOD_CK1_1	85	91	PF00069	0.502
MOD_CK2_1	341	347	PF00069	0.628
MOD_CK2_1	376	382	PF00069	0.508
MOD_CK2_1	444	450	PF00069	0.436
MOD_CK2_1	71	77	PF00069	0.469
MOD_GlcNHglycan	166	170	PF01048	0.618
MOD_GlcNHglycan	194	197	PF01048	0.444
MOD_GlcNHglycan	209	212	PF01048	0.304
MOD_GlcNHglycan	254	257	PF01048	0.418
MOD_GlcNHglycan	301	304	PF01048	0.488
MOD_GlcNHglycan	31	34	PF01048	0.669
MOD_GlcNHglycan	38	42	PF01048	0.742
MOD_GlcNHglycan	395	398	PF01048	0.524
MOD_GlcNHglycan	4	7	PF01048	0.554
MOD_GlcNHglycan	402	405	PF01048	0.519
MOD_GlcNHglycan	49	52	PF01048	0.602
MOD_GSK3_1	161	168	PF00069	0.638
MOD_GSK3_1	258	265	PF00069	0.436
MOD_GSK3_1	356	363	PF00069	0.503
MOD_GSK3_1	372	379	PF00069	0.363
MOD_N-GLC_1	101	106	PF02516	0.557
MOD_N-GLC_2	13	15	PF02516	0.454
MOD_NEK2_1	159	164	PF00069	0.598
MOD_NEK2_1	299	304	PF00069	0.556
MOD_NEK2_1	311	316	PF00069	0.400
MOD_NEK2_1	355	360	PF00069	0.421
MOD_NEK2_1	373	378	PF00069	0.284
MOD_PIKK_1	433	439	PF00454	0.441
MOD_PIKK_1	444	450	PF00454	0.373
MOD_PKA_2	311	317	PF00069	0.536
MOD_PKA_2	393	399	PF00069	0.337
MOD_PKA_2	444	450	PF00069	0.436
MOD_Plk_2-3	341	347	PF00069	0.458
MOD_Plk_4	269	275	PF00069	0.405
MOD_Plk_4	294	300	PF00069	0.394
MOD_Plk_4	317	323	PF00069	0.439
MOD_Plk_4	422	428	PF00069	0.339
MOD_ProDKin_1	289	295	PF00069	0.415
MOD_ProDKin_1	328	334	PF00069	0.545
MOD_ProDKin_1	412	418	PF00069	0.490
MOD_ProDKin_1	45	51	PF00069	0.537
MOD_ProDKin_1	58	64	PF00069	0.474
MOD_ProDKin_1	85	91	PF00069	0.502
MOD_SUMO_rev_2	101	109	PF00179	0.545
TRG_DiLeu_BaEn_2	449	455	PF01217	0.404
TRG_DiLeu_BaEn_4	381	387	PF01217	0.390
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.442
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.402
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.409
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.479
TRG_ENDOCYTIC_2	352	355	PF00928	0.460
TRG_ENDOCYTIC_2	76	79	PF00928	0.514
TRG_ER_diArg_1	150	152	PF00400	0.344
TRG_ER_diArg_1	438	440	PF00400	0.580
TRG_NES_CRM1_1	236	250	PF08389	0.419
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXH6	Leptomonas seymouri	46%	100%
A0A3S7X4Q0	Leishmania donovani	83%	100%
A4HJL0	Leishmania braziliensis	66%	100%
A4I710	Leishmania infantum	83%	100%
Q4Q634	Leishmania major	83%	100%
V5BA98	Trypanosoma cruzi	26%	100%