Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B224_LEIMU

TriTrypDb:

LmxM.30.2230

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B224

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B224

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.582
CLV_C14_Caspase3-7	238	242	PF00656	0.537
CLV_C14_Caspase3-7	404	408	PF00656	0.728
CLV_C14_Caspase3-7	89	93	PF00656	0.616
CLV_C14_Caspase3-7	9	13	PF00656	0.657
CLV_NRD_NRD_1	235	237	PF00675	0.689
CLV_NRD_NRD_1	247	249	PF00675	0.645
CLV_NRD_NRD_1	318	320	PF00675	0.516
CLV_NRD_NRD_1	68	70	PF00675	0.663
CLV_PCSK_FUR_1	245	249	PF00082	0.622
CLV_PCSK_KEX2_1	234	236	PF00082	0.703
CLV_PCSK_KEX2_1	245	247	PF00082	0.644
CLV_PCSK_KEX2_1	318	320	PF00082	0.516
CLV_PCSK_KEX2_1	68	70	PF00082	0.663
CLV_PCSK_SKI1_1	235	239	PF00082	0.544
CLV_PCSK_SKI1_1	281	285	PF00082	0.646
CLV_PCSK_SKI1_1	289	293	PF00082	0.589
CLV_PCSK_SKI1_1	442	446	PF00082	0.622
DOC_CDC14_PxL_1	38	46	PF14671	0.589
DOC_CKS1_1	322	327	PF01111	0.507
DOC_CKS1_1	61	66	PF01111	0.580
DOC_PP1_RVXF_1	365	372	PF00149	0.587
DOC_PP2B_LxvP_1	385	388	PF13499	0.493
DOC_USP7_MATH_1	136	140	PF00917	0.643
DOC_USP7_MATH_1	19	23	PF00917	0.624
DOC_USP7_MATH_1	32	36	PF00917	0.665
DOC_USP7_MATH_1	358	362	PF00917	0.621
DOC_USP7_MATH_1	372	376	PF00917	0.501
DOC_USP7_MATH_1	419	423	PF00917	0.537
DOC_WW_Pin1_4	117	122	PF00397	0.538
DOC_WW_Pin1_4	160	165	PF00397	0.599
DOC_WW_Pin1_4	191	196	PF00397	0.723
DOC_WW_Pin1_4	321	326	PF00397	0.508
DOC_WW_Pin1_4	356	361	PF00397	0.753
DOC_WW_Pin1_4	383	388	PF00397	0.603
DOC_WW_Pin1_4	60	65	PF00397	0.638
DOC_WW_Pin1_4	94	99	PF00397	0.696
LIG_14-3-3_CanoR_1	15	24	PF00244	0.687
LIG_14-3-3_CanoR_1	37	42	PF00244	0.635
LIG_14-3-3_CanoR_1	403	412	PF00244	0.610
LIG_14-3-3_CanoR_1	51	55	PF00244	0.594
LIG_BIR_III_4	92	96	PF00653	0.555
LIG_BRCT_BRCA1_1	138	142	PF00533	0.587
LIG_BRCT_BRCA1_1	6	10	PF00533	0.613
LIG_deltaCOP1_diTrp_1	363	371	PF00928	0.512
LIG_FHA_1	123	129	PF00498	0.570
LIG_FHA_1	199	205	PF00498	0.699
LIG_FHA_1	351	357	PF00498	0.621
LIG_FHA_1	54	60	PF00498	0.775
LIG_FHA_2	152	158	PF00498	0.587
LIG_FHA_2	236	242	PF00498	0.581
LIG_FHA_2	250	256	PF00498	0.645
LIG_FHA_2	322	328	PF00498	0.506
LIG_FHA_2	9	15	PF00498	0.718
LIG_LIR_Gen_1	137	148	PF02991	0.671
LIG_LIR_LC3C_4	56	61	PF02991	0.686
LIG_LIR_Nem_3	137	143	PF02991	0.672
LIG_LIR_Nem_3	176	180	PF02991	0.628
LIG_LIR_Nem_3	202	208	PF02991	0.634
LIG_LIR_Nem_3	363	369	PF02991	0.578
LIG_NRBOX	328	334	PF00104	0.502
LIG_Pex14_1	155	159	PF04695	0.616
LIG_SH2_NCK_1	38	42	PF00017	0.589
LIG_SH2_NCK_1	49	53	PF00017	0.665
LIG_SH2_STAT5	153	156	PF00017	0.606
LIG_SH2_STAT5	159	162	PF00017	0.619
LIG_SH3_2	64	69	PF14604	0.696
LIG_SH3_3	192	198	PF00018	0.702
LIG_SH3_3	220	226	PF00018	0.718
LIG_SH3_3	311	317	PF00018	0.697
LIG_SH3_3	354	360	PF00018	0.535
LIG_SH3_3	58	64	PF00018	0.644
LIG_SUMO_SIM_anti_2	56	63	PF11976	0.617
LIG_SUMO_SIM_par_1	56	63	PF11976	0.623
LIG_WW_3	386	390	PF00397	0.506
LIG_WW_3	437	441	PF00397	0.759
MOD_CDC14_SPxK_1	386	389	PF00782	0.599
MOD_CDC14_SPxK_1	66	69	PF00782	0.698
MOD_CDK_SPK_2	191	196	PF00069	0.709
MOD_CDK_SPK_2	63	68	PF00069	0.521
MOD_CDK_SPxK_1	383	389	PF00069	0.599
MOD_CDK_SPxK_1	63	69	PF00069	0.698
MOD_CDK_SPxxK_3	321	328	PF00069	0.505
MOD_CK1_1	122	128	PF00069	0.803
MOD_CK1_1	129	135	PF00069	0.673
MOD_CK1_1	163	169	PF00069	0.662
MOD_CK1_1	189	195	PF00069	0.665
MOD_CK1_1	212	218	PF00069	0.530
MOD_CK1_1	297	303	PF00069	0.651
MOD_CK1_1	305	311	PF00069	0.574
MOD_CK1_1	349	355	PF00069	0.672
MOD_CK1_1	359	365	PF00069	0.809
MOD_CK1_1	402	408	PF00069	0.690
MOD_CK1_1	50	56	PF00069	0.714
MOD_CK1_1	8	14	PF00069	0.651
MOD_CK1_1	88	94	PF00069	0.570
MOD_CK2_1	249	255	PF00069	0.670
MOD_CK2_1	321	327	PF00069	0.506
MOD_CK2_1	417	423	PF00069	0.715
MOD_Cter_Amidation	232	235	PF01082	0.566
MOD_GlcNHglycan	121	124	PF01048	0.766
MOD_GlcNHglycan	17	20	PF01048	0.722
MOD_GlcNHglycan	21	24	PF01048	0.780
MOD_GlcNHglycan	211	214	PF01048	0.708
MOD_GlcNHglycan	231	234	PF01048	0.633
MOD_GlcNHglycan	28	32	PF01048	0.678
MOD_GlcNHglycan	296	299	PF01048	0.654
MOD_GlcNHglycan	307	310	PF01048	0.620
MOD_GlcNHglycan	333	336	PF01048	0.566
MOD_GlcNHglycan	372	375	PF01048	0.711
MOD_GlcNHglycan	39	42	PF01048	0.543
MOD_GSK3_1	122	129	PF00069	0.572
MOD_GSK3_1	147	154	PF00069	0.584
MOD_GSK3_1	15	22	PF00069	0.614
MOD_GSK3_1	160	167	PF00069	0.575
MOD_GSK3_1	185	192	PF00069	0.661
MOD_GSK3_1	294	301	PF00069	0.570
MOD_GSK3_1	346	353	PF00069	0.669
MOD_GSK3_1	379	386	PF00069	0.708
MOD_GSK3_1	399	406	PF00069	0.665
MOD_GSK3_1	4	11	PF00069	0.676
MOD_GSK3_1	82	89	PF00069	0.641
MOD_N-GLC_1	24	29	PF02516	0.687
MOD_N-GLC_1	294	299	PF02516	0.607
MOD_N-GLC_1	305	310	PF02516	0.701
MOD_NEK2_1	151	156	PF00069	0.769
MOD_NEK2_1	249	254	PF00069	0.680
MOD_NEK2_1	26	31	PF00069	0.780
MOD_NEK2_1	302	307	PF00069	0.553
MOD_NEK2_1	310	315	PF00069	0.596
MOD_NEK2_1	417	422	PF00069	0.691
MOD_NEK2_1	431	436	PF00069	0.708
MOD_PIKK_1	259	265	PF00454	0.539
MOD_PIKK_1	50	56	PF00454	0.589
MOD_PIKK_1	82	88	PF00454	0.666
MOD_PKA_1	235	241	PF00069	0.542
MOD_PKA_2	235	241	PF00069	0.643
MOD_PKA_2	402	408	PF00069	0.717
MOD_PKA_2	431	437	PF00069	0.617
MOD_PKA_2	47	53	PF00069	0.760
MOD_PKB_1	401	409	PF00069	0.724
MOD_Plk_1	126	132	PF00069	0.691
MOD_Plk_1	305	311	PF00069	0.609
MOD_Plk_4	126	132	PF00069	0.642
MOD_Plk_4	155	161	PF00069	0.586
MOD_Plk_4	200	206	PF00069	0.556
MOD_ProDKin_1	117	123	PF00069	0.536
MOD_ProDKin_1	160	166	PF00069	0.596
MOD_ProDKin_1	191	197	PF00069	0.719
MOD_ProDKin_1	321	327	PF00069	0.506
MOD_ProDKin_1	356	362	PF00069	0.752
MOD_ProDKin_1	383	389	PF00069	0.608
MOD_ProDKin_1	60	66	PF00069	0.638
MOD_ProDKin_1	94	100	PF00069	0.694
TRG_AP2beta_CARGO_1	138	147	PF09066	0.664
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.508
TRG_ER_diArg_1	234	236	PF00400	0.652
TRG_ER_diArg_1	245	248	PF00400	0.629
TRG_ER_diArg_1	317	319	PF00400	0.521
TRG_ER_diArg_1	400	403	PF00400	0.719
TRG_ER_diArg_1	439	442	PF00400	0.620
TRG_ER_diArg_1	67	69	PF00400	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ50	Leptomonas seymouri	36%	98%
A0A3S7X4S8	Leishmania donovani	76%	100%
A4HJK4	Leishmania braziliensis	52%	99%
A4HJK7	Leishmania braziliensis	52%	99%
A4I706	Leishmania infantum	76%	100%
Q4Q638	Leishmania major	74%	100%