Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B222_LEIMU

TriTrypDb:

LmxM.30.2210

Length:

832

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B222

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B222

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.748
CLV_C14_Caspase3-7	275	279	PF00656	0.650
CLV_MEL_PAP_1	521	527	PF00089	0.481
CLV_NRD_NRD_1	201	203	PF00675	0.697
CLV_NRD_NRD_1	273	275	PF00675	0.741
CLV_NRD_NRD_1	488	490	PF00675	0.615
CLV_NRD_NRD_1	510	512	PF00675	0.565
CLV_NRD_NRD_1	644	646	PF00675	0.605
CLV_NRD_NRD_1	673	675	PF00675	0.676
CLV_NRD_NRD_1	718	720	PF00675	0.471
CLV_NRD_NRD_1	736	738	PF00675	0.544
CLV_NRD_NRD_1	769	771	PF00675	0.566
CLV_PCSK_FUR_1	671	675	PF00082	0.638
CLV_PCSK_KEX2_1	201	203	PF00082	0.697
CLV_PCSK_KEX2_1	272	274	PF00082	0.756
CLV_PCSK_KEX2_1	488	490	PF00082	0.615
CLV_PCSK_KEX2_1	644	646	PF00082	0.605
CLV_PCSK_KEX2_1	673	675	PF00082	0.676
CLV_PCSK_KEX2_1	718	720	PF00082	0.638
CLV_PCSK_KEX2_1	736	738	PF00082	0.449
CLV_PCSK_KEX2_1	769	771	PF00082	0.566
CLV_PCSK_KEX2_1	814	816	PF00082	0.655
CLV_PCSK_PC1ET2_1	814	816	PF00082	0.655
CLV_PCSK_PC7_1	765	771	PF00082	0.564
CLV_PCSK_SKI1_1	201	205	PF00082	0.691
CLV_PCSK_SKI1_1	44	48	PF00082	0.734
CLV_PCSK_SKI1_1	565	569	PF00082	0.677
CLV_PCSK_SKI1_1	583	587	PF00082	0.635
DEG_APCC_DBOX_1	102	110	PF00400	0.561
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DEG_SCF_FBW7_1	19	26	PF00400	0.565
DEG_SCF_FBW7_1	31	38	PF00400	0.537
DEG_SPOP_SBC_1	354	358	PF00917	0.626
DEG_SPOP_SBC_1	414	418	PF00917	0.685
DOC_CDC14_PxL_1	109	117	PF14671	0.729
DOC_CKS1_1	32	37	PF01111	0.562
DOC_CKS1_1	379	384	PF01111	0.669
DOC_CKS1_1	420	425	PF01111	0.686
DOC_MAPK_gen_1	488	495	PF00069	0.599
DOC_PP1_RVXF_1	370	376	PF00149	0.675
DOC_PP1_RVXF_1	796	803	PF00149	0.647
DOC_PP2B_LxvP_1	175	178	PF13499	0.659
DOC_PP2B_LxvP_1	57	60	PF13499	0.719
DOC_PP2B_LxvP_1	585	588	PF13499	0.630
DOC_PP4_FxxP_1	379	382	PF00568	0.665
DOC_PP4_FxxP_1	400	403	PF00568	0.621
DOC_PP4_FxxP_1	420	423	PF00568	0.549
DOC_USP7_MATH_1	133	137	PF00917	0.710
DOC_USP7_MATH_1	144	148	PF00917	0.613
DOC_USP7_MATH_1	180	184	PF00917	0.735
DOC_USP7_MATH_1	21	25	PF00917	0.724
DOC_USP7_MATH_1	235	239	PF00917	0.629
DOC_USP7_MATH_1	331	335	PF00917	0.671
DOC_USP7_MATH_1	353	357	PF00917	0.622
DOC_USP7_MATH_1	380	384	PF00917	0.510
DOC_USP7_MATH_1	458	462	PF00917	0.710
DOC_USP7_MATH_1	588	592	PF00917	0.632
DOC_USP7_MATH_1	638	642	PF00917	0.683
DOC_USP7_MATH_1	647	651	PF00917	0.670
DOC_USP7_MATH_1	773	777	PF00917	0.615
DOC_USP7_MATH_1	91	95	PF00917	0.583
DOC_USP7_UBL2_3	123	127	PF12436	0.561
DOC_WW_Pin1_4	115	120	PF00397	0.724
DOC_WW_Pin1_4	129	134	PF00397	0.578
DOC_WW_Pin1_4	137	142	PF00397	0.646
DOC_WW_Pin1_4	151	156	PF00397	0.607
DOC_WW_Pin1_4	181	186	PF00397	0.732
DOC_WW_Pin1_4	19	24	PF00397	0.634
DOC_WW_Pin1_4	229	234	PF00397	0.670
DOC_WW_Pin1_4	31	36	PF00397	0.667
DOC_WW_Pin1_4	378	383	PF00397	0.666
DOC_WW_Pin1_4	419	424	PF00397	0.685
DOC_WW_Pin1_4	636	641	PF00397	0.710
DOC_WW_Pin1_4	80	85	PF00397	0.724
DOC_WW_Pin1_4	815	820	PF00397	0.753
LIG_14-3-3_CanoR_1	149	155	PF00244	0.656
LIG_14-3-3_CanoR_1	272	280	PF00244	0.743
LIG_14-3-3_CanoR_1	344	353	PF00244	0.735
LIG_14-3-3_CanoR_1	511	515	PF00244	0.607
LIG_14-3-3_CanoR_1	519	528	PF00244	0.727
LIG_14-3-3_CanoR_1	598	608	PF00244	0.574
LIG_14-3-3_CanoR_1	67	77	PF00244	0.630
LIG_14-3-3_CanoR_1	809	816	PF00244	0.643
LIG_Actin_WH2_2	246	262	PF00022	0.542
LIG_APCC_ABBAyCdc20_2	727	733	PF00400	0.429
LIG_BIR_III_2	20	24	PF00653	0.662
LIG_BIR_III_4	579	583	PF00653	0.649
LIG_BRCT_BRCA1_1	605	609	PF00533	0.749
LIG_BRCT_BRCA1_1	78	82	PF00533	0.730
LIG_CtBP_PxDLS_1	424	428	PF00389	0.700
LIG_deltaCOP1_diTrp_1	592	597	PF00928	0.643
LIG_FHA_1	138	144	PF00498	0.732
LIG_FHA_1	151	157	PF00498	0.599
LIG_FHA_1	202	208	PF00498	0.687
LIG_FHA_1	247	253	PF00498	0.598
LIG_FHA_1	420	426	PF00498	0.787
LIG_FHA_1	482	488	PF00498	0.636
LIG_FHA_2	217	223	PF00498	0.689
LIG_FHA_2	23	29	PF00498	0.743
LIG_FHA_2	273	279	PF00498	0.575
LIG_FHA_2	307	313	PF00498	0.662
LIG_FHA_2	414	420	PF00498	0.686
LIG_FHA_2	452	458	PF00498	0.710
LIG_FHA_2	46	52	PF00498	0.553
LIG_FHA_2	614	620	PF00498	0.761
LIG_FHA_2	647	653	PF00498	0.596
LIG_LIR_Apic_2	377	382	PF02991	0.665
LIG_LIR_Apic_2	398	403	PF02991	0.747
LIG_LIR_Apic_2	417	423	PF02991	0.563
LIG_LIR_Apic_2	658	662	PF02991	0.562
LIG_LIR_Apic_2	785	790	PF02991	0.655
LIG_LIR_Gen_1	239	250	PF02991	0.547
LIG_LIR_Gen_1	368	378	PF02991	0.674
LIG_LIR_Gen_1	797	805	PF02991	0.643
LIG_LIR_Gen_1	818	827	PF02991	0.574
LIG_LIR_Nem_3	239	245	PF02991	0.554
LIG_LIR_Nem_3	368	373	PF02991	0.678
LIG_LIR_Nem_3	374	378	PF02991	0.610
LIG_LIR_Nem_3	496	501	PF02991	0.575
LIG_LIR_Nem_3	591	597	PF02991	0.659
LIG_LIR_Nem_3	699	705	PF02991	0.694
LIG_LIR_Nem_3	797	802	PF02991	0.646
LIG_LIR_Nem_3	818	824	PF02991	0.741
LIG_MYND_1	584	588	PF01753	0.630
LIG_Pex14_2	375	379	PF04695	0.668
LIG_Rb_LxCxE_1	381	398	PF01857	0.685
LIG_SH2_CRK	197	201	PF00017	0.627
LIG_SH2_CRK	217	221	PF00017	0.555
LIG_SH2_CRK	242	246	PF00017	0.720
LIG_SH2_CRK	659	663	PF00017	0.561
LIG_SH2_CRK	787	791	PF00017	0.653
LIG_SH2_GRB2like	221	224	PF00017	0.695
LIG_SH2_GRB2like	694	697	PF00017	0.670
LIG_SH2_NCK_1	659	663	PF00017	0.561
LIG_SH2_PTP2	500	503	PF00017	0.568
LIG_SH2_SRC	221	224	PF00017	0.695
LIG_SH2_SRC	692	695	PF00017	0.673
LIG_SH2_SRC	758	761	PF00017	0.573
LIG_SH2_STAT3	793	796	PF00017	0.671
LIG_SH2_STAT5	197	200	PF00017	0.625
LIG_SH2_STAT5	301	304	PF00017	0.586
LIG_SH2_STAT5	500	503	PF00017	0.568
LIG_SH2_STAT5	566	569	PF00017	0.675
LIG_SH2_STAT5	793	796	PF00017	0.671
LIG_SH3_1	659	665	PF00018	0.708
LIG_SH3_3	152	158	PF00018	0.726
LIG_SH3_3	171	177	PF00018	0.541
LIG_SH3_3	234	240	PF00018	0.651
LIG_SH3_3	249	255	PF00018	0.622
LIG_SH3_3	283	289	PF00018	0.722
LIG_SH3_3	29	35	PF00018	0.725
LIG_SH3_3	634	640	PF00018	0.713
LIG_SH3_3	659	665	PF00018	0.824
LIG_SH3_3	813	819	PF00018	0.756
LIG_SH3_3	85	91	PF00018	0.650
LIG_SUMO_SIM_anti_2	249	254	PF11976	0.530
LIG_TYR_ITIM	215	220	PF00017	0.581
LIG_UBA3_1	1	10	PF00899	0.556
LIG_WW_1	656	659	PF00397	0.559
MOD_CDC14_SPxK_1	132	135	PF00782	0.645
MOD_CDK_SPK_2	181	186	PF00069	0.732
MOD_CDK_SPK_2	35	40	PF00069	0.727
MOD_CDK_SPxK_1	129	135	PF00069	0.653
MOD_CDK_SPxxK_3	142	149	PF00069	0.563
MOD_CK1_1	12	18	PF00069	0.561
MOD_CK1_1	347	353	PF00069	0.749
MOD_CK1_1	365	371	PF00069	0.682
MOD_CK1_1	426	432	PF00069	0.642
MOD_CK1_1	45	51	PF00069	0.644
MOD_CK1_1	476	482	PF00069	0.676
MOD_CK1_1	526	532	PF00069	0.588
MOD_CK1_1	599	605	PF00069	0.669
MOD_CK1_1	61	67	PF00069	0.648
MOD_CK1_1	68	74	PF00069	0.659
MOD_CK1_1	80	86	PF00069	0.533
MOD_CK1_1	94	100	PF00069	0.599
MOD_CK2_1	221	227	PF00069	0.708
MOD_CK2_1	282	288	PF00069	0.561
MOD_CK2_1	306	312	PF00069	0.611
MOD_CK2_1	451	457	PF00069	0.684
MOD_CK2_1	599	605	PF00069	0.727
MOD_CK2_1	636	642	PF00069	0.649
MOD_DYRK1A_RPxSP_1	636	640	PF00069	0.708
MOD_DYRK1A_RPxSP_1	815	819	PF00069	0.637
MOD_GlcNHglycan	109	112	PF01048	0.584
MOD_GlcNHglycan	129	132	PF01048	0.528
MOD_GlcNHglycan	135	138	PF01048	0.657
MOD_GlcNHglycan	222	226	PF01048	0.704
MOD_GlcNHglycan	306	309	PF01048	0.592
MOD_GlcNHglycan	333	336	PF01048	0.689
MOD_GlcNHglycan	357	360	PF01048	0.785
MOD_GlcNHglycan	366	370	PF01048	0.578
MOD_GlcNHglycan	406	409	PF01048	0.686
MOD_GlcNHglycan	44	47	PF01048	0.577
MOD_GlcNHglycan	5	8	PF01048	0.644
MOD_GlcNHglycan	528	531	PF01048	0.651
MOD_GlcNHglycan	544	548	PF01048	0.538
MOD_GlcNHglycan	765	768	PF01048	0.729
MOD_GlcNHglycan	775	778	PF01048	0.600
MOD_GlcNHglycan	787	790	PF01048	0.526
MOD_GlcNHglycan	805	808	PF01048	0.692
MOD_GSK3_1	101	108	PF00069	0.572
MOD_GSK3_1	127	134	PF00069	0.722
MOD_GSK3_1	176	183	PF00069	0.732
MOD_GSK3_1	19	26	PF00069	0.649
MOD_GSK3_1	272	279	PF00069	0.744
MOD_GSK3_1	300	307	PF00069	0.624
MOD_GSK3_1	31	38	PF00069	0.621
MOD_GSK3_1	311	318	PF00069	0.653
MOD_GSK3_1	336	343	PF00069	0.705
MOD_GSK3_1	344	351	PF00069	0.663
MOD_GSK3_1	361	368	PF00069	0.697
MOD_GSK3_1	374	381	PF00069	0.539
MOD_GSK3_1	409	416	PF00069	0.686
MOD_GSK3_1	419	426	PF00069	0.588
MOD_GSK3_1	456	463	PF00069	0.603
MOD_GSK3_1	515	522	PF00069	0.638
MOD_GSK3_1	58	65	PF00069	0.698
MOD_GSK3_1	596	603	PF00069	0.707
MOD_GSK3_1	632	639	PF00069	0.722
MOD_GSK3_1	679	686	PF00069	0.643
MOD_GSK3_1	692	699	PF00069	0.608
MOD_GSK3_1	76	83	PF00069	0.573
MOD_GSK3_1	90	97	PF00069	0.593
MOD_N-GLC_1	228	233	PF02516	0.671
MOD_N-GLC_1	282	287	PF02516	0.654
MOD_N-GLC_1	310	315	PF02516	0.619
MOD_N-GLC_1	331	336	PF02516	0.602
MOD_N-GLC_1	354	359	PF02516	0.657
MOD_N-GLC_1	395	400	PF02516	0.703
MOD_N-GLC_1	552	557	PF02516	0.689
MOD_N-GLC_1	588	593	PF02516	0.630
MOD_N-GLC_1	600	605	PF02516	0.552
MOD_N-GLC_1	679	684	PF02516	0.714
MOD_NEK2_1	216	221	PF00069	0.618
MOD_NEK2_1	300	305	PF00069	0.734
MOD_NEK2_1	306	311	PF00069	0.734
MOD_NEK2_1	336	341	PF00069	0.768
MOD_NEK2_1	413	418	PF00069	0.657
MOD_NEK2_1	473	478	PF00069	0.616
MOD_NEK2_1	493	498	PF00069	0.372
MOD_NEK2_1	597	602	PF00069	0.565
MOD_NEK2_1	632	637	PF00069	0.724
MOD_NEK2_2	820	825	PF00069	0.630
MOD_PIKK_1	144	150	PF00454	0.721
MOD_PIKK_1	476	482	PF00454	0.673
MOD_PIKK_1	493	499	PF00454	0.424
MOD_PIKK_1	519	525	PF00454	0.650
MOD_PIKK_1	710	716	PF00454	0.471
MOD_PIKK_1	748	754	PF00454	0.711
MOD_PK_1	524	530	PF00069	0.553
MOD_PKA_1	201	207	PF00069	0.691
MOD_PKA_1	272	278	PF00069	0.745
MOD_PKA_2	12	18	PF00069	0.525
MOD_PKA_2	150	156	PF00069	0.559
MOD_PKA_2	201	207	PF00069	0.691
MOD_PKA_2	272	278	PF00069	0.720
MOD_PKA_2	340	346	PF00069	0.794
MOD_PKA_2	510	516	PF00069	0.633
MOD_PKA_2	523	529	PF00069	0.674
MOD_PKA_2	597	603	PF00069	0.705
MOD_PKA_2	62	68	PF00069	0.625
MOD_PKA_2	808	814	PF00069	0.639
MOD_PKB_1	272	280	PF00069	0.576
MOD_Plk_1	282	288	PF00069	0.651
MOD_Plk_1	473	479	PF00069	0.714
MOD_Plk_1	573	579	PF00069	0.760
MOD_Plk_1	603	609	PF00069	0.745
MOD_Plk_1	61	67	PF00069	0.562
MOD_Plk_1	800	806	PF00069	0.642
MOD_Plk_2-3	276	282	PF00069	0.670
MOD_Plk_2-3	573	579	PF00069	0.644
MOD_Plk_4	216	222	PF00069	0.683
MOD_Plk_4	240	246	PF00069	0.716
MOD_Plk_4	374	380	PF00069	0.668
MOD_Plk_4	510	516	PF00069	0.574
MOD_Plk_4	552	558	PF00069	0.687
MOD_Plk_4	573	579	PF00069	0.644
MOD_Plk_4	603	609	PF00069	0.751
MOD_ProDKin_1	115	121	PF00069	0.722
MOD_ProDKin_1	129	135	PF00069	0.580
MOD_ProDKin_1	137	143	PF00069	0.649
MOD_ProDKin_1	151	157	PF00069	0.606
MOD_ProDKin_1	181	187	PF00069	0.731
MOD_ProDKin_1	19	25	PF00069	0.636
MOD_ProDKin_1	229	235	PF00069	0.670
MOD_ProDKin_1	31	37	PF00069	0.670
MOD_ProDKin_1	378	384	PF00069	0.670
MOD_ProDKin_1	419	425	PF00069	0.687
MOD_ProDKin_1	636	642	PF00069	0.714
MOD_ProDKin_1	80	86	PF00069	0.723
MOD_ProDKin_1	815	821	PF00069	0.752
MOD_SUMO_rev_2	806	816	PF00179	0.640
TRG_DiLeu_BaEn_1	510	515	PF01217	0.623
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.562
TRG_DiLeu_BaLyEn_6	581	586	PF01217	0.639
TRG_ENDOCYTIC_2	217	220	PF00928	0.519
TRG_ENDOCYTIC_2	242	245	PF00928	0.723
TRG_ENDOCYTIC_2	500	503	PF00928	0.568
TRG_ER_diArg_1	149	152	PF00400	0.558
TRG_ER_diArg_1	200	202	PF00400	0.694
TRG_ER_diArg_1	271	274	PF00400	0.749
TRG_ER_diArg_1	487	489	PF00400	0.636
TRG_ER_diArg_1	644	646	PF00400	0.576
TRG_ER_diArg_1	671	674	PF00400	0.638
TRG_ER_diArg_1	717	719	PF00400	0.601
TRG_Pf-PMV_PEXEL_1	519	523	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	565	569	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICP0	Leishmania donovani	81%	99%
A4I704	Leishmania infantum	81%	99%
Q4Q640	Leishmania major	79%	100%