Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B221_LEIMU

TriTrypDb:

LmxM.30.2200

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B221

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B221

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.499
CLV_C14_Caspase3-7	261	265	PF00656	0.720
CLV_NRD_NRD_1	24	26	PF00675	0.789
CLV_NRD_NRD_1	300	302	PF00675	0.798
CLV_NRD_NRD_1	339	341	PF00675	0.711
CLV_NRD_NRD_1	44	46	PF00675	0.522
CLV_NRD_NRD_1	456	458	PF00675	0.485
CLV_PCSK_KEX2_1	24	26	PF00082	0.792
CLV_PCSK_KEX2_1	300	302	PF00082	0.798
CLV_PCSK_KEX2_1	339	341	PF00082	0.726
CLV_PCSK_KEX2_1	44	46	PF00082	0.518
CLV_PCSK_KEX2_1	455	457	PF00082	0.495
CLV_PCSK_KEX2_1	473	475	PF00082	0.548
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.421
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.537
CLV_PCSK_SKI1_1	456	460	PF00082	0.441
DEG_COP1_1	433	443	PF00400	0.718
DEG_SCF_FBW7_1	140	145	PF00400	0.503
DEG_SPOP_SBC_1	11	15	PF00917	0.697
DOC_MAPK_gen_1	344	351	PF00069	0.721
DOC_MAPK_gen_1	455	463	PF00069	0.478
DOC_USP7_MATH_1	110	114	PF00917	0.760
DOC_USP7_MATH_1	142	146	PF00917	0.771
DOC_USP7_MATH_1	173	177	PF00917	0.531
DOC_USP7_MATH_1	284	288	PF00917	0.762
DOC_USP7_MATH_1	330	334	PF00917	0.659
DOC_USP7_MATH_1	338	342	PF00917	0.671
DOC_USP7_MATH_1	392	396	PF00917	0.734
DOC_USP7_MATH_1	69	73	PF00917	0.573
DOC_WW_Pin1_4	115	120	PF00397	0.684
DOC_WW_Pin1_4	138	143	PF00397	0.522
DOC_WW_Pin1_4	180	185	PF00397	0.589
DOC_WW_Pin1_4	328	333	PF00397	0.705
DOC_WW_Pin1_4	439	444	PF00397	0.718
DOC_WW_Pin1_4	45	50	PF00397	0.558
LIG_14-3-3_CanoR_1	123	127	PF00244	0.715
LIG_14-3-3_CanoR_1	215	222	PF00244	0.738
LIG_14-3-3_CanoR_1	223	228	PF00244	0.660
LIG_14-3-3_CanoR_1	300	305	PF00244	0.781
LIG_14-3-3_CanoR_1	33	39	PF00244	0.727
LIG_14-3-3_CanoR_1	339	343	PF00244	0.771
LIG_14-3-3_CanoR_1	456	463	PF00244	0.406
LIG_14-3-3_CanoR_1	92	99	PF00244	0.591
LIG_BRCT_BRCA1_1	271	275	PF00533	0.700
LIG_BRCT_BRCA1_1	420	424	PF00533	0.749
LIG_BRCT_BRCA1_1	435	439	PF00533	0.511
LIG_FHA_1	110	116	PF00498	0.667
LIG_FHA_1	150	156	PF00498	0.744
LIG_FHA_1	232	238	PF00498	0.503
LIG_FHA_1	301	307	PF00498	0.782
LIG_FHA_1	350	356	PF00498	0.654
LIG_FHA_1	457	463	PF00498	0.405
LIG_FHA_2	280	286	PF00498	0.777
LIG_LIR_Apic_2	125	130	PF02991	0.709
LIG_LIR_Apic_2	145	150	PF02991	0.675
LIG_LIR_Nem_3	141	146	PF02991	0.559
LIG_LIR_Nem_3	442	448	PF02991	0.714
LIG_PDZ_Class_2	480	485	PF00595	0.606
LIG_PTAP_UEV_1	118	123	PF05743	0.603
LIG_SH2_CRK	147	151	PF00017	0.520
LIG_SH2_STAT5	138	141	PF00017	0.757
LIG_SH2_STAT5	147	150	PF00017	0.481
LIG_SH3_3	116	122	PF00018	0.611
LIG_SH3_3	253	259	PF00018	0.527
LIG_SH3_3	303	309	PF00018	0.722
LIG_SH3_3	386	392	PF00018	0.601
LIG_SH3_3	437	443	PF00018	0.723
LIG_SH3_3	74	80	PF00018	0.727
LIG_SUMO_SIM_par_1	71	79	PF11976	0.508
LIG_TRAF2_1	130	133	PF00917	0.512
LIG_TRAF2_1	451	454	PF00917	0.395
LIG_TRFH_1	138	142	PF08558	0.679
MOD_CDK_SPK_2	180	185	PF00069	0.571
MOD_CDK_SPxK_1	138	144	PF00069	0.505
MOD_CK1_1	15	21	PF00069	0.594
MOD_CK1_1	176	182	PF00069	0.614
MOD_CK1_1	197	203	PF00069	0.803
MOD_CK1_1	214	220	PF00069	0.490
MOD_CK1_1	231	237	PF00069	0.580
MOD_CK1_1	246	252	PF00069	0.686
MOD_CK1_1	287	293	PF00069	0.756
MOD_CK1_1	294	300	PF00069	0.677
MOD_CK1_1	36	42	PF00069	0.668
MOD_CK1_1	416	422	PF00069	0.763
MOD_CK1_1	433	439	PF00069	0.471
MOD_CK1_1	95	101	PF00069	0.537
MOD_CK2_1	100	106	PF00069	0.561
MOD_CK2_1	24	30	PF00069	0.721
MOD_CK2_1	246	252	PF00069	0.774
MOD_CK2_1	264	270	PF00069	0.517
MOD_CK2_1	448	454	PF00069	0.413
MOD_CK2_1	73	79	PF00069	0.611
MOD_CK2_1	85	91	PF00069	0.749
MOD_GlcNHglycan	14	17	PF01048	0.698
MOD_GlcNHglycan	252	255	PF01048	0.671
MOD_GlcNHglycan	264	267	PF01048	0.722
MOD_GlcNHglycan	432	435	PF01048	0.692
MOD_GSK3_1	100	107	PF00069	0.685
MOD_GSK3_1	11	18	PF00069	0.688
MOD_GSK3_1	138	145	PF00069	0.517
MOD_GSK3_1	176	183	PF00069	0.690
MOD_GSK3_1	20	27	PF00069	0.740
MOD_GSK3_1	205	212	PF00069	0.645
MOD_GSK3_1	242	249	PF00069	0.690
MOD_GSK3_1	258	265	PF00069	0.614
MOD_GSK3_1	286	293	PF00069	0.758
MOD_GSK3_1	29	36	PF00069	0.709
MOD_GSK3_1	296	303	PF00069	0.652
MOD_GSK3_1	345	352	PF00069	0.680
MOD_GSK3_1	393	400	PF00069	0.704
MOD_GSK3_1	426	433	PF00069	0.665
MOD_GSK3_1	69	76	PF00069	0.518
MOD_GSK3_1	81	88	PF00069	0.570
MOD_GSK3_1	91	98	PF00069	0.643
MOD_N-GLC_1	416	421	PF02516	0.759
MOD_N-GLC_1	95	100	PF02516	0.515
MOD_N-GLC_2	62	64	PF02516	0.545
MOD_NEK2_1	1	6	PF00069	0.768
MOD_NEK2_1	20	25	PF00069	0.507
MOD_NEK2_1	29	34	PF00069	0.537
MOD_NEK2_1	349	354	PF00069	0.734
MOD_NEK2_1	418	423	PF00069	0.757
MOD_NEK2_1	430	435	PF00069	0.534
MOD_NEK2_1	81	86	PF00069	0.524
MOD_NEK2_2	122	127	PF00069	0.538
MOD_NEK2_2	142	147	PF00069	0.638
MOD_NMyristoyl	1	7	PF02799	0.769
MOD_OFUCOSY	57	64	PF10250	0.477
MOD_PIKK_1	194	200	PF00454	0.601
MOD_PIKK_1	291	297	PF00454	0.793
MOD_PIKK_1	310	316	PF00454	0.513
MOD_PIKK_1	456	462	PF00454	0.409
MOD_PKA_1	24	30	PF00069	0.790
MOD_PKA_1	300	306	PF00069	0.780
MOD_PKA_1	456	462	PF00069	0.409
MOD_PKA_2	122	128	PF00069	0.713
MOD_PKA_2	214	220	PF00069	0.689
MOD_PKA_2	24	30	PF00069	0.747
MOD_PKA_2	276	282	PF00069	0.693
MOD_PKA_2	300	306	PF00069	0.780
MOD_PKA_2	338	344	PF00069	0.785
MOD_PKA_2	456	462	PF00069	0.409
MOD_PKA_2	91	97	PF00069	0.706
MOD_PKB_1	45	53	PF00069	0.709
MOD_Plk_1	105	111	PF00069	0.512
MOD_Plk_1	243	249	PF00069	0.692
MOD_Plk_1	269	275	PF00069	0.693
MOD_Plk_1	426	432	PF00069	0.706
MOD_Plk_1	95	101	PF00069	0.518
MOD_Plk_4	110	116	PF00069	0.713
MOD_Plk_4	122	128	PF00069	0.599
MOD_Plk_4	142	148	PF00069	0.516
MOD_Plk_4	270	276	PF00069	0.766
MOD_Plk_4	287	293	PF00069	0.545
MOD_Plk_4	81	87	PF00069	0.523
MOD_ProDKin_1	115	121	PF00069	0.680
MOD_ProDKin_1	138	144	PF00069	0.522
MOD_ProDKin_1	180	186	PF00069	0.590
MOD_ProDKin_1	328	334	PF00069	0.705
MOD_ProDKin_1	439	445	PF00069	0.718
MOD_ProDKin_1	45	51	PF00069	0.557
MOD_SUMO_rev_2	187	195	PF00179	0.727
TRG_DiLeu_BaEn_4	453	459	PF01217	0.656
TRG_ER_diArg_1	420	423	PF00400	0.679
TRG_ER_diArg_1	44	47	PF00400	0.613
TRG_ER_diArg_1	456	458	PF00400	0.485
TRG_NES_CRM1_1	65	79	PF08389	0.673
TRG_NLS_Bipartite_1	455	474	PF00514	0.400
TRG_NLS_MonoExtC_3	469	474	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4Q7	Leishmania donovani	79%	100%
A4HJK2	Leishmania braziliensis	53%	99%
A4I703	Leishmania infantum	80%	100%
Q4Q641	Leishmania major	77%	100%