Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B219_LEIMU

TriTrypDb:

LmxM.30.2190

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B219

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B219

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.701
CLV_NRD_NRD_1	274	276	PF00675	0.686
CLV_NRD_NRD_1	299	301	PF00675	0.696
CLV_NRD_NRD_1	340	342	PF00675	0.761
CLV_NRD_NRD_1	430	432	PF00675	0.782
CLV_PCSK_KEX2_1	273	275	PF00082	0.715
CLV_PCSK_KEX2_1	299	301	PF00082	0.696
CLV_PCSK_KEX2_1	339	341	PF00082	0.779
CLV_PCSK_SKI1_1	257	261	PF00082	0.595
CLV_PCSK_SKI1_1	275	279	PF00082	0.519
CLV_PCSK_SKI1_1	340	344	PF00082	0.693
CLV_PCSK_SKI1_1	399	403	PF00082	0.639
CLV_PCSK_SKI1_1	425	429	PF00082	0.699
DEG_APCC_DBOX_1	298	306	PF00400	0.558
DEG_APCC_DBOX_1	382	390	PF00400	0.548
DEG_SPOP_SBC_1	319	323	PF00917	0.626
DEG_SPOP_SBC_1	597	601	PF00917	0.549
DOC_ANK_TNKS_1	671	678	PF00023	0.615
DOC_CDC14_PxL_1	468	476	PF14671	0.528
DOC_CDC14_PxL_1	94	102	PF14671	0.551
DOC_CKS1_1	165	170	PF01111	0.578
DOC_CYCLIN_yCln2_LP_2	351	354	PF00134	0.540
DOC_PP1_RVXF_1	46	52	PF00149	0.549
DOC_PP1_SILK_1	700	705	PF00149	0.689
DOC_PP2B_LxvP_1	125	128	PF13499	0.650
DOC_PP2B_LxvP_1	173	176	PF13499	0.572
DOC_PP2B_LxvP_1	193	196	PF13499	0.624
DOC_PP2B_LxvP_1	351	354	PF13499	0.727
DOC_PP2B_LxvP_1	449	452	PF13499	0.685
DOC_PP4_FxxP_1	563	566	PF00568	0.583
DOC_PP4_MxPP_1	352	355	PF00568	0.599
DOC_USP7_MATH_1	118	122	PF00917	0.679
DOC_USP7_MATH_1	153	157	PF00917	0.598
DOC_USP7_MATH_1	213	217	PF00917	0.518
DOC_USP7_MATH_1	307	311	PF00917	0.643
DOC_USP7_MATH_1	319	323	PF00917	0.679
DOC_USP7_MATH_1	355	359	PF00917	0.585
DOC_USP7_MATH_1	536	540	PF00917	0.674
DOC_USP7_MATH_1	638	642	PF00917	0.614
DOC_USP7_MATH_1	723	727	PF00917	0.675
DOC_USP7_MATH_1	739	743	PF00917	0.481
DOC_USP7_MATH_2	84	90	PF00917	0.579
DOC_USP7_UBL2_3	365	369	PF12436	0.660
DOC_WW_Pin1_4	103	108	PF00397	0.624
DOC_WW_Pin1_4	164	169	PF00397	0.600
DOC_WW_Pin1_4	187	192	PF00397	0.679
DOC_WW_Pin1_4	197	202	PF00397	0.599
DOC_WW_Pin1_4	209	214	PF00397	0.574
DOC_WW_Pin1_4	240	245	PF00397	0.615
DOC_WW_Pin1_4	285	290	PF00397	0.652
DOC_WW_Pin1_4	373	378	PF00397	0.636
DOC_WW_Pin1_4	420	425	PF00397	0.853
DOC_WW_Pin1_4	438	443	PF00397	0.562
DOC_WW_Pin1_4	51	56	PF00397	0.737
DOC_WW_Pin1_4	537	542	PF00397	0.705
DOC_WW_Pin1_4	62	67	PF00397	0.739
DOC_WW_Pin1_4	639	644	PF00397	0.701
DOC_WW_Pin1_4	662	667	PF00397	0.758
DOC_WW_Pin1_4	687	692	PF00397	0.575
DOC_WW_Pin1_4	712	717	PF00397	0.657
DOC_WW_Pin1_4	80	85	PF00397	0.433
LIG_14-3-3_CanoR_1	102	109	PF00244	0.585
LIG_14-3-3_CanoR_1	162	166	PF00244	0.687
LIG_14-3-3_CanoR_1	21	29	PF00244	0.623
LIG_14-3-3_CanoR_1	250	259	PF00244	0.708
LIG_14-3-3_CanoR_1	34	40	PF00244	0.624
LIG_14-3-3_CanoR_1	478	486	PF00244	0.570
LIG_14-3-3_CanoR_1	505	513	PF00244	0.561
LIG_14-3-3_CanoR_1	516	525	PF00244	0.572
LIG_14-3-3_CanoR_1	559	564	PF00244	0.586
LIG_BIR_III_2	141	145	PF00653	0.630
LIG_BIR_III_4	405	409	PF00653	0.623
LIG_BRCT_BRCA1_1	162	166	PF00533	0.702
LIG_BRCT_BRCA1_1	725	729	PF00533	0.674
LIG_CtBP_PxDLS_1	176	180	PF00389	0.641
LIG_CtBP_PxDLS_1	84	88	PF00389	0.519
LIG_EH1_1	696	704	PF00400	0.636
LIG_EVH1_1	449	453	PF00568	0.635
LIG_FHA_1	104	110	PF00498	0.639
LIG_FHA_1	165	171	PF00498	0.549
LIG_FHA_1	235	241	PF00498	0.675
LIG_FHA_1	254	260	PF00498	0.500
LIG_FHA_1	315	321	PF00498	0.679
LIG_FHA_1	578	584	PF00498	0.580
LIG_FHA_1	598	604	PF00498	0.687
LIG_FHA_1	688	694	PF00498	0.518
LIG_FHA_2	278	284	PF00498	0.592
LIG_FHA_2	400	406	PF00498	0.699
LIG_FHA_2	498	504	PF00498	0.570
LIG_FHA_2	516	522	PF00498	0.627
LIG_FHA_2	585	591	PF00498	0.677
LIG_LIR_Apic_2	163	168	PF02991	0.584
LIG_LIR_Apic_2	561	566	PF02991	0.542
LIG_LIR_Gen_1	216	227	PF02991	0.555
LIG_LIR_Gen_1	465	474	PF02991	0.649
LIG_LIR_Gen_1	644	653	PF02991	0.533
LIG_LIR_Nem_3	132	138	PF02991	0.619
LIG_LIR_Nem_3	216	222	PF02991	0.557
LIG_LIR_Nem_3	243	248	PF02991	0.721
LIG_LIR_Nem_3	465	471	PF02991	0.641
LIG_LIR_Nem_3	644	649	PF02991	0.537
LIG_LIR_Nem_3	706	712	PF02991	0.647
LIG_LIR_Nem_3	77	82	PF02991	0.555
LIG_MLH1_MIPbox_1	162	166	PF16413	0.665
LIG_MYND_1	123	127	PF01753	0.657
LIG_MYND_1	447	451	PF01753	0.551
LIG_RPA_C_Fungi	738	750	PF08784	0.663
LIG_SH2_CRK	709	713	PF00017	0.643
LIG_SH2_SRC	511	514	PF00017	0.611
LIG_SH2_STAP1	131	135	PF00017	0.653
LIG_SH2_STAT5	131	134	PF00017	0.597
LIG_SH2_STAT5	165	168	PF00017	0.769
LIG_SH2_STAT5	245	248	PF00017	0.520
LIG_SH2_STAT5	372	375	PF00017	0.793
LIG_SH3_2	538	543	PF14604	0.546
LIG_SH3_3	117	123	PF00018	0.664
LIG_SH3_3	185	191	PF00018	0.665
LIG_SH3_3	200	206	PF00018	0.540
LIG_SH3_3	219	225	PF00018	0.520
LIG_SH3_3	230	236	PF00018	0.671
LIG_SH3_3	241	247	PF00018	0.616
LIG_SH3_3	286	292	PF00018	0.806
LIG_SH3_3	384	390	PF00018	0.682
LIG_SH3_3	444	450	PF00018	0.728
LIG_SH3_3	535	541	PF00018	0.637
LIG_SH3_3	637	643	PF00018	0.680
LIG_SH3_3	92	98	PF00018	0.567
LIG_SUMO_SIM_anti_2	737	742	PF11976	0.459
LIG_SUMO_SIM_par_1	83	89	PF11976	0.520
LIG_TRAF2_1	310	313	PF00917	0.539
LIG_TRAF2_2	756	761	PF00917	0.666
LIG_WRC_WIRS_1	76	81	PF05994	0.562
MOD_CDC14_SPxK_1	540	543	PF00782	0.712
MOD_CDK_SPK_2	420	425	PF00069	0.853
MOD_CDK_SPxK_1	537	543	PF00069	0.708
MOD_CDK_SPxxK_3	187	194	PF00069	0.674
MOD_CDK_SPxxK_3	712	719	PF00069	0.641
MOD_CK1_1	156	162	PF00069	0.719
MOD_CK1_1	164	170	PF00069	0.697
MOD_CK1_1	253	259	PF00069	0.668
MOD_CK1_1	265	271	PF00069	0.701
MOD_CK1_1	346	352	PF00069	0.650
MOD_CK1_1	381	387	PF00069	0.683
MOD_CK1_1	420	426	PF00069	0.698
MOD_CK1_1	561	567	PF00069	0.616
MOD_CK1_1	633	639	PF00069	0.770
MOD_CK1_1	641	647	PF00069	0.656
MOD_CK1_1	708	714	PF00069	0.692
MOD_CK1_1	77	83	PF00069	0.628
MOD_CK1_1	88	94	PF00069	0.580
MOD_CK2_1	168	174	PF00069	0.693
MOD_CK2_1	209	215	PF00069	0.686
MOD_CK2_1	277	283	PF00069	0.704
MOD_CK2_1	307	313	PF00069	0.541
MOD_CK2_1	515	521	PF00069	0.605
MOD_CK2_1	584	590	PF00069	0.716
MOD_CK2_1	662	668	PF00069	0.744
MOD_CK2_1	712	718	PF00069	0.690
MOD_CK2_1	80	86	PF00069	0.640
MOD_DYRK1A_RPxSP_1	187	191	PF00069	0.666
MOD_GlcNHglycan	103	106	PF01048	0.653
MOD_GlcNHglycan	170	173	PF01048	0.735
MOD_GlcNHglycan	209	212	PF01048	0.552
MOD_GlcNHglycan	269	272	PF01048	0.674
MOD_GlcNHglycan	322	325	PF01048	0.779
MOD_GlcNHglycan	344	348	PF01048	0.771
MOD_GlcNHglycan	357	360	PF01048	0.555
MOD_GlcNHglycan	434	439	PF01048	0.724
MOD_GlcNHglycan	443	446	PF01048	0.670
MOD_GlcNHglycan	497	500	PF01048	0.575
MOD_GlcNHglycan	507	510	PF01048	0.628
MOD_GlcNHglycan	563	566	PF01048	0.655
MOD_GlcNHglycan	574	577	PF01048	0.805
MOD_GlcNHglycan	605	608	PF01048	0.733
MOD_GlcNHglycan	635	638	PF01048	0.772
MOD_GlcNHglycan	673	676	PF01048	0.613
MOD_GSK3_1	112	119	PF00069	0.730
MOD_GSK3_1	153	160	PF00069	0.681
MOD_GSK3_1	16	23	PF00069	0.729
MOD_GSK3_1	164	171	PF00069	0.587
MOD_GSK3_1	195	202	PF00069	0.774
MOD_GSK3_1	209	216	PF00069	0.568
MOD_GSK3_1	253	260	PF00069	0.615
MOD_GSK3_1	263	270	PF00069	0.680
MOD_GSK3_1	277	284	PF00069	0.622
MOD_GSK3_1	314	321	PF00069	0.705
MOD_GSK3_1	434	441	PF00069	0.743
MOD_GSK3_1	484	491	PF00069	0.688
MOD_GSK3_1	493	500	PF00069	0.617
MOD_GSK3_1	507	514	PF00069	0.634
MOD_GSK3_1	537	544	PF00069	0.740
MOD_GSK3_1	547	554	PF00069	0.683
MOD_GSK3_1	561	568	PF00069	0.693
MOD_GSK3_1	582	589	PF00069	0.756
MOD_GSK3_1	652	659	PF00069	0.646
MOD_GSK3_1	660	667	PF00069	0.610
MOD_GSK3_1	704	711	PF00069	0.698
MOD_GSK3_1	85	92	PF00069	0.669
MOD_N-GLC_1	250	255	PF02516	0.658
MOD_N-GLC_1	455	460	PF02516	0.572
MOD_N-GLC_1	505	510	PF02516	0.574
MOD_N-GLC_1	712	717	PF02516	0.688
MOD_N-GLC_2	262	264	PF02516	0.664
MOD_N-GLC_2	685	687	PF02516	0.514
MOD_NEK2_1	112	117	PF00069	0.687
MOD_NEK2_1	474	479	PF00069	0.581
MOD_NEK2_1	528	533	PF00069	0.692
MOD_NEK2_1	577	582	PF00069	0.685
MOD_NEK2_1	603	608	PF00069	0.678
MOD_NEK2_1	693	698	PF00069	0.678
MOD_NEK2_1	703	708	PF00069	0.571
MOD_NEK2_1	90	95	PF00069	0.537
MOD_PIKK_1	21	27	PF00454	0.615
MOD_PIKK_1	277	283	PF00454	0.590
MOD_PIKK_1	290	296	PF00454	0.704
MOD_PIKK_1	381	387	PF00454	0.787
MOD_PIKK_1	484	490	PF00454	0.668
MOD_PIKK_1	493	499	PF00454	0.671
MOD_PIKK_1	627	633	PF00454	0.526
MOD_PK_1	698	704	PF00069	0.575
MOD_PKA_1	257	263	PF00069	0.667
MOD_PKA_1	340	346	PF00069	0.630
MOD_PKA_1	704	710	PF00069	0.701
MOD_PKA_2	101	107	PF00069	0.579
MOD_PKA_2	161	167	PF00069	0.611
MOD_PKA_2	20	26	PF00069	0.593
MOD_PKA_2	340	346	PF00069	0.630
MOD_PKA_2	477	483	PF00069	0.560
MOD_PKA_2	492	498	PF00069	0.592
MOD_PKA_2	515	521	PF00069	0.565
MOD_PKA_2	558	564	PF00069	0.585
MOD_PKA_2	577	583	PF00069	0.676
MOD_PKA_2	624	630	PF00069	0.664
MOD_PKA_2	671	677	PF00069	0.729
MOD_PKB_1	273	281	PF00069	0.544
MOD_Plk_1	129	135	PF00069	0.666
MOD_Plk_1	455	461	PF00069	0.631
MOD_Plk_1	521	527	PF00069	0.534
MOD_Plk_1	734	740	PF00069	0.484
MOD_Plk_1	85	91	PF00069	0.560
MOD_Plk_2-3	584	590	PF00069	0.551
MOD_Plk_2-3	664	670	PF00069	0.594
MOD_Plk_4	134	140	PF00069	0.496
MOD_Plk_4	161	167	PF00069	0.663
MOD_Plk_4	229	235	PF00069	0.542
MOD_Plk_4	630	636	PF00069	0.726
MOD_Plk_4	641	647	PF00069	0.602
MOD_Plk_4	698	704	PF00069	0.686
MOD_Plk_4	725	731	PF00069	0.639
MOD_ProDKin_1	103	109	PF00069	0.625
MOD_ProDKin_1	164	170	PF00069	0.599
MOD_ProDKin_1	187	193	PF00069	0.680
MOD_ProDKin_1	197	203	PF00069	0.597
MOD_ProDKin_1	209	215	PF00069	0.600
MOD_ProDKin_1	240	246	PF00069	0.616
MOD_ProDKin_1	285	291	PF00069	0.651
MOD_ProDKin_1	373	379	PF00069	0.636
MOD_ProDKin_1	420	426	PF00069	0.855
MOD_ProDKin_1	438	444	PF00069	0.565
MOD_ProDKin_1	51	57	PF00069	0.735
MOD_ProDKin_1	537	543	PF00069	0.708
MOD_ProDKin_1	62	68	PF00069	0.734
MOD_ProDKin_1	639	645	PF00069	0.701
MOD_ProDKin_1	662	668	PF00069	0.759
MOD_ProDKin_1	687	693	PF00069	0.575
MOD_ProDKin_1	712	718	PF00069	0.659
MOD_ProDKin_1	80	86	PF00069	0.427
MOD_SUMO_for_1	581	584	PF00179	0.540
MOD_SUMO_rev_2	265	271	PF00179	0.568
MOD_SUMO_rev_2	310	317	PF00179	0.536
MOD_SUMO_rev_2	45	50	PF00179	0.674
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.676
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.677
TRG_DiLeu_BaLyEn_6	384	389	PF01217	0.545
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.527
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.492
TRG_ENDOCYTIC_2	245	248	PF00928	0.657
TRG_ENDOCYTIC_2	709	712	PF00928	0.647
TRG_ER_diArg_1	273	275	PF00400	0.684
TRG_ER_diArg_1	299	301	PF00400	0.696
TRG_ER_diArg_1	338	341	PF00400	0.708
TRG_ER_diArg_1	756	759	PF00400	0.528
TRG_ER_FFAT_2	159	171	PF00635	0.581
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFQ0	Leishmania donovani	77%	100%
A4HJK1	Leishmania braziliensis	46%	98%
A4I6Z8	Leishmania infantum	77%	100%
Q4Q642	Leishmania major	75%	100%