Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B218_LEIMU

TriTrypDb:

LmxM.30.2180

Length:

861

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B218

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B218

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	528	532	PF00656	0.747
CLV_C14_Caspase3-7	818	822	PF00656	0.521
CLV_NRD_NRD_1	133	135	PF00675	0.837
CLV_NRD_NRD_1	172	174	PF00675	0.826
CLV_NRD_NRD_1	177	179	PF00675	0.828
CLV_NRD_NRD_1	41	43	PF00675	0.559
CLV_NRD_NRD_1	427	429	PF00675	0.631
CLV_NRD_NRD_1	461	463	PF00675	0.727
CLV_NRD_NRD_1	490	492	PF00675	0.545
CLV_NRD_NRD_1	496	498	PF00675	0.534
CLV_NRD_NRD_1	581	583	PF00675	0.767
CLV_NRD_NRD_1	609	611	PF00675	0.650
CLV_NRD_NRD_1	61	63	PF00675	0.835
CLV_PCSK_FUR_1	578	582	PF00082	0.770
CLV_PCSK_KEX2_1	11	13	PF00082	0.837
CLV_PCSK_KEX2_1	133	135	PF00082	0.678
CLV_PCSK_KEX2_1	172	174	PF00082	0.725
CLV_PCSK_KEX2_1	177	179	PF00082	0.692
CLV_PCSK_KEX2_1	225	227	PF00082	0.701
CLV_PCSK_KEX2_1	41	43	PF00082	0.645
CLV_PCSK_KEX2_1	490	492	PF00082	0.545
CLV_PCSK_KEX2_1	580	582	PF00082	0.682
CLV_PCSK_KEX2_1	61	63	PF00082	0.632
CLV_PCSK_KEX2_1	611	613	PF00082	0.645
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.837
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.701
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.682
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.645
CLV_PCSK_PC7_1	173	179	PF00082	0.667
CLV_PCSK_SKI1_1	21	25	PF00082	0.604
CLV_PCSK_SKI1_1	325	329	PF00082	0.622
CLV_PCSK_SKI1_1	57	61	PF00082	0.739
DEG_APCC_DBOX_1	792	800	PF00400	0.538
DEG_SCF_FBW7_1	356	362	PF00400	0.659
DEG_SCF_FBW7_2	667	674	PF00400	0.814
DEG_SPOP_SBC_1	360	364	PF00917	0.558
DEG_SPOP_SBC_1	534	538	PF00917	0.754
DOC_CKS1_1	356	361	PF01111	0.546
DOC_CKS1_1	668	673	PF01111	0.826
DOC_CKS1_1	851	856	PF01111	0.694
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.540
DOC_MAPK_gen_1	426	435	PF00069	0.510
DOC_MAPK_gen_1	772	780	PF00069	0.764
DOC_MAPK_MEF2A_6	193	201	PF00069	0.623
DOC_PP1_RVXF_1	496	503	PF00149	0.508
DOC_PP2B_LxvP_1	77	80	PF13499	0.842
DOC_PP2B_PxIxI_1	641	647	PF00149	0.544
DOC_PP4_FxxP_1	16	19	PF00568	0.782
DOC_PP4_FxxP_1	851	854	PF00568	0.575
DOC_USP7_MATH_1	120	124	PF00917	0.542
DOC_USP7_MATH_1	150	154	PF00917	0.800
DOC_USP7_MATH_1	183	187	PF00917	0.630
DOC_USP7_MATH_1	216	220	PF00917	0.657
DOC_USP7_MATH_1	327	331	PF00917	0.674
DOC_USP7_MATH_1	360	364	PF00917	0.558
DOC_USP7_MATH_1	413	417	PF00917	0.660
DOC_USP7_MATH_1	422	426	PF00917	0.658
DOC_USP7_MATH_1	512	516	PF00917	0.524
DOC_USP7_MATH_1	517	521	PF00917	0.547
DOC_USP7_MATH_1	535	539	PF00917	0.724
DOC_USP7_MATH_1	545	549	PF00917	0.640
DOC_USP7_MATH_1	569	573	PF00917	0.752
DOC_USP7_MATH_1	586	590	PF00917	0.544
DOC_USP7_MATH_1	682	686	PF00917	0.723
DOC_USP7_MATH_1	7	11	PF00917	0.531
DOC_USP7_MATH_1	707	711	PF00917	0.716
DOC_USP7_MATH_1	72	76	PF00917	0.730
DOC_USP7_MATH_1	733	737	PF00917	0.532
DOC_USP7_UBL2_3	53	57	PF12436	0.739
DOC_USP7_UBL2_3	607	611	PF12436	0.695
DOC_WW_Pin1_4	172	177	PF00397	0.770
DOC_WW_Pin1_4	187	192	PF00397	0.533
DOC_WW_Pin1_4	355	360	PF00397	0.811
DOC_WW_Pin1_4	361	366	PF00397	0.771
DOC_WW_Pin1_4	372	377	PF00397	0.605
DOC_WW_Pin1_4	451	456	PF00397	0.557
DOC_WW_Pin1_4	536	541	PF00397	0.750
DOC_WW_Pin1_4	567	572	PF00397	0.770
DOC_WW_Pin1_4	590	595	PF00397	0.632
DOC_WW_Pin1_4	614	619	PF00397	0.687
DOC_WW_Pin1_4	634	639	PF00397	0.698
DOC_WW_Pin1_4	64	69	PF00397	0.822
DOC_WW_Pin1_4	653	658	PF00397	0.502
DOC_WW_Pin1_4	667	672	PF00397	0.825
DOC_WW_Pin1_4	784	789	PF00397	0.760
DOC_WW_Pin1_4	79	84	PF00397	0.742
DOC_WW_Pin1_4	840	845	PF00397	0.727
DOC_WW_Pin1_4	850	855	PF00397	0.767
LIG_14-3-3_CanoR_1	347	351	PF00244	0.642
LIG_14-3-3_CanoR_1	361	365	PF00244	0.520
LIG_14-3-3_CanoR_1	554	561	PF00244	0.674
LIG_14-3-3_CanoR_1	681	690	PF00244	0.560
LIG_14-3-3_CanoR_1	715	720	PF00244	0.808
LIG_14-3-3_CanoR_1	774	779	PF00244	0.766
LIG_BRCT_BRCA1_1	679	683	PF00533	0.772
LIG_BRCT_BRCA1_1	9	13	PF00533	0.541
LIG_eIF4E_1	830	836	PF01652	0.698
LIG_FHA_1	290	296	PF00498	0.654
LIG_FHA_1	351	357	PF00498	0.548
LIG_FHA_1	379	385	PF00498	0.577
LIG_FHA_1	452	458	PF00498	0.571
LIG_FHA_1	539	545	PF00498	0.733
LIG_FHA_1	662	668	PF00498	0.530
LIG_FHA_1	695	701	PF00498	0.648
LIG_FHA_1	749	755	PF00498	0.551
LIG_FHA_1	99	105	PF00498	0.675
LIG_FHA_2	13	19	PF00498	0.801
LIG_FHA_2	22	28	PF00498	0.525
LIG_FHA_2	474	480	PF00498	0.704
LIG_FHA_2	524	530	PF00498	0.738
LIG_FHA_2	739	745	PF00498	0.631
LIG_FHA_2	816	822	PF00498	0.621
LIG_FHA_2	823	829	PF00498	0.694
LIG_LIR_Apic_2	15	19	PF02991	0.791
LIG_LIR_Apic_2	827	833	PF02991	0.614
LIG_LIR_Gen_1	29	37	PF02991	0.668
LIG_LIR_Nem_3	10	16	PF02991	0.548
LIG_LIR_Nem_3	29	34	PF02991	0.510
LIG_LIR_Nem_3	341	345	PF02991	0.631
LIG_LYPXL_yS_3	622	625	PF13949	0.749
LIG_MYND_3	290	294	PF01753	0.536
LIG_NRP_CendR_1	859	861	PF00754	0.689
LIG_SH2_CRK	31	35	PF00017	0.546
LIG_SH2_NCK_1	749	753	PF00017	0.602
LIG_SH2_PTP2	830	833	PF00017	0.613
LIG_SH2_STAP1	31	35	PF00017	0.662
LIG_SH2_STAT3	485	488	PF00017	0.647
LIG_SH2_STAT5	274	277	PF00017	0.689
LIG_SH2_STAT5	466	469	PF00017	0.760
LIG_SH2_STAT5	485	488	PF00017	0.330
LIG_SH2_STAT5	830	833	PF00017	0.788
LIG_SH3_1	177	183	PF00018	0.658
LIG_SH3_1	373	379	PF00018	0.564
LIG_SH3_2	767	772	PF14604	0.541
LIG_SH3_2	80	85	PF14604	0.813
LIG_SH3_3	102	108	PF00018	0.668
LIG_SH3_3	177	183	PF00018	0.687
LIG_SH3_3	192	198	PF00018	0.651
LIG_SH3_3	337	343	PF00018	0.534
LIG_SH3_3	353	359	PF00018	0.564
LIG_SH3_3	373	379	PF00018	0.834
LIG_SH3_3	764	770	PF00018	0.561
LIG_SH3_3	77	83	PF00018	0.703
LIG_SH3_3	92	98	PF00018	0.704
LIG_SUMO_SIM_anti_2	292	297	PF11976	0.652
LIG_SUMO_SIM_anti_2	664	670	PF11976	0.531
LIG_SUMO_SIM_par_1	664	670	PF11976	0.531
LIG_SUMO_SIM_par_1	718	725	PF11976	0.737
LIG_TRAF2_1	219	222	PF00917	0.686
LIG_TRAF2_1	320	323	PF00917	0.752
LIG_TRAF2_1	564	567	PF00917	0.767
LIG_TRAF2_1	706	709	PF00917	0.721
LIG_TRAF2_1	741	744	PF00917	0.627
LIG_TYR_ITIM	700	705	PF00017	0.519
LIG_UBA3_1	203	211	PF00899	0.578
LIG_WRC_WIRS_1	13	18	PF05994	0.808
LIG_WW_3	82	86	PF00397	0.812
MOD_CDC14_SPxK_1	175	178	PF00782	0.590
MOD_CDC14_SPxK_1	190	193	PF00782	0.621
MOD_CDC14_SPxK_1	539	542	PF00782	0.743
MOD_CDC14_SPxK_1	82	85	PF00782	0.732
MOD_CDK_SPK_2	172	177	PF00069	0.735
MOD_CDK_SPxK_1	172	178	PF00069	0.646
MOD_CDK_SPxK_1	187	193	PF00069	0.533
MOD_CDK_SPxK_1	355	361	PF00069	0.760
MOD_CDK_SPxK_1	536	542	PF00069	0.751
MOD_CDK_SPxK_1	79	85	PF00069	0.739
MOD_CDK_SPxK_1	850	856	PF00069	0.578
MOD_CDK_SPxxK_3	361	368	PF00069	0.559
MOD_CDK_SPxxK_3	536	543	PF00069	0.753
MOD_CDK_SPxxK_3	784	791	PF00069	0.547
MOD_CK1_1	123	129	PF00069	0.703
MOD_CK1_1	162	168	PF00069	0.840
MOD_CK1_1	229	235	PF00069	0.797
MOD_CK1_1	247	253	PF00069	0.536
MOD_CK1_1	276	282	PF00069	0.798
MOD_CK1_1	341	347	PF00069	0.744
MOD_CK1_1	364	370	PF00069	0.638
MOD_CK1_1	400	406	PF00069	0.780
MOD_CK1_1	416	422	PF00069	0.657
MOD_CK1_1	424	430	PF00069	0.631
MOD_CK1_1	47	53	PF00069	0.742
MOD_CK1_1	473	479	PF00069	0.719
MOD_CK1_1	538	544	PF00069	0.673
MOD_CK1_1	548	554	PF00069	0.626
MOD_CK1_1	572	578	PF00069	0.636
MOD_CK1_1	633	639	PF00069	0.669
MOD_CK1_1	710	716	PF00069	0.808
MOD_CK1_1	724	730	PF00069	0.575
MOD_CK1_1	768	774	PF00069	0.669
MOD_CK1_1	786	792	PF00069	0.617
MOD_CK2_1	162	168	PF00069	0.777
MOD_CK2_1	21	27	PF00069	0.633
MOD_CK2_1	216	222	PF00069	0.661
MOD_CK2_1	364	370	PF00069	0.852
MOD_CK2_1	523	529	PF00069	0.536
MOD_CK2_1	561	567	PF00069	0.653
MOD_CK2_1	703	709	PF00069	0.660
MOD_CK2_1	733	739	PF00069	0.821
MOD_CK2_1	822	828	PF00069	0.651
MOD_GlcNHglycan	118	121	PF01048	0.520
MOD_GlcNHglycan	161	164	PF01048	0.843
MOD_GlcNHglycan	168	171	PF01048	0.743
MOD_GlcNHglycan	185	188	PF01048	0.753
MOD_GlcNHglycan	213	216	PF01048	0.693
MOD_GlcNHglycan	218	221	PF01048	0.710
MOD_GlcNHglycan	232	235	PF01048	0.676
MOD_GlcNHglycan	275	278	PF01048	0.741
MOD_GlcNHglycan	329	332	PF01048	0.703
MOD_GlcNHglycan	472	475	PF01048	0.760
MOD_GlcNHglycan	514	517	PF01048	0.738
MOD_GlcNHglycan	519	522	PF01048	0.822
MOD_GlcNHglycan	52	56	PF01048	0.606
MOD_GlcNHglycan	523	526	PF01048	0.711
MOD_GlcNHglycan	531	534	PF01048	0.565
MOD_GlcNHglycan	547	550	PF01048	0.585
MOD_GlcNHglycan	556	559	PF01048	0.783
MOD_GlcNHglycan	571	574	PF01048	0.589
MOD_GlcNHglycan	588	591	PF01048	0.544
MOD_GlcNHglycan	612	615	PF01048	0.688
MOD_GlcNHglycan	638	641	PF01048	0.748
MOD_GlcNHglycan	705	708	PF01048	0.780
MOD_GlcNHglycan	72	75	PF01048	0.642
MOD_GlcNHglycan	731	734	PF01048	0.531
MOD_GlcNHglycan	788	791	PF01048	0.700
MOD_GlcNHglycan	800	803	PF01048	0.603
MOD_GlcNHglycan	92	95	PF01048	0.832
MOD_GSK3_1	116	123	PF00069	0.654
MOD_GSK3_1	155	162	PF00069	0.736
MOD_GSK3_1	183	190	PF00069	0.805
MOD_GSK3_1	211	218	PF00069	0.711
MOD_GSK3_1	226	233	PF00069	0.615
MOD_GSK3_1	306	313	PF00069	0.696
MOD_GSK3_1	321	328	PF00069	0.677
MOD_GSK3_1	341	348	PF00069	0.719
MOD_GSK3_1	355	362	PF00069	0.689
MOD_GSK3_1	374	381	PF00069	0.598
MOD_GSK3_1	398	405	PF00069	0.730
MOD_GSK3_1	416	423	PF00069	0.633
MOD_GSK3_1	466	473	PF00069	0.785
MOD_GSK3_1	47	54	PF00069	0.642
MOD_GSK3_1	512	519	PF00069	0.710
MOD_GSK3_1	521	528	PF00069	0.664
MOD_GSK3_1	529	536	PF00069	0.663
MOD_GSK3_1	567	574	PF00069	0.628
MOD_GSK3_1	586	593	PF00069	0.633
MOD_GSK3_1	610	617	PF00069	0.664
MOD_GSK3_1	630	637	PF00069	0.602
MOD_GSK3_1	703	710	PF00069	0.692
MOD_GSK3_1	711	718	PF00069	0.648
MOD_GSK3_1	720	727	PF00069	0.613
MOD_GSK3_1	729	736	PF00069	0.534
MOD_GSK3_1	779	786	PF00069	0.789
MOD_GSK3_1	806	813	PF00069	0.724
MOD_LATS_1	552	558	PF00433	0.749
MOD_N-GLC_1	306	311	PF02516	0.470
MOD_N-GLC_1	397	402	PF02516	0.610
MOD_N-GLC_1	441	446	PF02516	0.526
MOD_N-GLC_1	605	610	PF02516	0.750
MOD_NEK2_1	210	215	PF00069	0.617
MOD_NEK2_1	30	35	PF00069	0.450
MOD_NEK2_1	345	350	PF00069	0.738
MOD_NEK2_1	436	441	PF00069	0.601
MOD_NEK2_1	523	528	PF00069	0.748
MOD_NEK2_1	747	752	PF00069	0.531
MOD_NEK2_1	810	815	PF00069	0.745
MOD_PIKK_1	123	129	PF00454	0.640
MOD_PIKK_1	21	27	PF00454	0.677
MOD_PIKK_1	332	338	PF00454	0.771
MOD_PIKK_1	378	384	PF00454	0.639
MOD_PIKK_1	402	408	PF00454	0.554
MOD_PIKK_1	441	447	PF00454	0.519
MOD_PIKK_1	464	470	PF00454	0.838
MOD_PIKK_1	62	68	PF00454	0.566
MOD_PIKK_1	707	713	PF00454	0.604
MOD_PK_1	715	721	PF00069	0.745
MOD_PK_1	774	780	PF00069	0.768
MOD_PKA_1	610	616	PF00069	0.645
MOD_PKA_1	62	68	PF00069	0.663
MOD_PKA_2	346	352	PF00069	0.587
MOD_PKA_2	360	366	PF00069	0.523
MOD_PKA_2	792	798	PF00069	0.754
MOD_PKB_1	114	122	PF00069	0.732
MOD_PKB_1	304	312	PF00069	0.467
MOD_PKB_1	418	426	PF00069	0.541
MOD_PKB_1	504	512	PF00069	0.674
MOD_PKB_1	610	618	PF00069	0.657
MOD_PKB_1	772	780	PF00069	0.764
MOD_Plk_1	244	250	PF00069	0.807
MOD_Plk_1	605	611	PF00069	0.555
MOD_Plk_1	707	713	PF00069	0.748
MOD_Plk_1	738	744	PF00069	0.737
MOD_Plk_4	150	156	PF00069	0.803
MOD_Plk_4	341	347	PF00069	0.755
MOD_Plk_4	44	50	PF00069	0.504
MOD_Plk_4	556	562	PF00069	0.657
MOD_ProDKin_1	172	178	PF00069	0.769
MOD_ProDKin_1	187	193	PF00069	0.533
MOD_ProDKin_1	355	361	PF00069	0.814
MOD_ProDKin_1	372	378	PF00069	0.601
MOD_ProDKin_1	451	457	PF00069	0.555
MOD_ProDKin_1	536	542	PF00069	0.751
MOD_ProDKin_1	567	573	PF00069	0.771
MOD_ProDKin_1	590	596	PF00069	0.632
MOD_ProDKin_1	614	620	PF00069	0.690
MOD_ProDKin_1	634	640	PF00069	0.699
MOD_ProDKin_1	64	70	PF00069	0.824
MOD_ProDKin_1	653	659	PF00069	0.504
MOD_ProDKin_1	667	673	PF00069	0.825
MOD_ProDKin_1	784	790	PF00069	0.759
MOD_ProDKin_1	79	85	PF00069	0.746
MOD_ProDKin_1	840	846	PF00069	0.732
MOD_ProDKin_1	850	856	PF00069	0.768
MOD_SUMO_rev_2	317	327	PF00179	0.569
TRG_DiLeu_BaEn_1	495	500	PF01217	0.502
TRG_ENDOCYTIC_2	31	34	PF00928	0.660
TRG_ENDOCYTIC_2	622	625	PF00928	0.749
TRG_ENDOCYTIC_2	702	705	PF00928	0.519
TRG_ER_diArg_1	132	134	PF00400	0.825
TRG_ER_diArg_1	171	173	PF00400	0.827
TRG_ER_diArg_1	176	178	PF00400	0.815
TRG_ER_diArg_1	303	306	PF00400	0.438
TRG_ER_diArg_1	60	62	PF00400	0.773
TRG_ER_diArg_1	609	612	PF00400	0.553
TRG_ER_diArg_1	679	682	PF00400	0.770
TRG_NLS_MonoExtN_4	607	614	PF00514	0.645
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIP7	Leishmania donovani	73%	95%
A4HJK0	Leishmania braziliensis	46%	100%
A4I6Z7	Leishmania infantum	73%	95%
Q4Q643	Leishmania major	71%	100%