Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B216_LEIMU

TriTrypDb:

LmxM.30.2160

Length:

823

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B216

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B216

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	419	423	PF00656	0.625
CLV_C14_Caspase3-7	561	565	PF00656	0.654
CLV_C14_Caspase3-7	594	598	PF00656	0.763
CLV_C14_Caspase3-7	613	617	PF00656	0.584
CLV_MEL_PAP_1	682	688	PF00089	0.629
CLV_NRD_NRD_1	179	181	PF00675	0.683
CLV_NRD_NRD_1	268	270	PF00675	0.808
CLV_NRD_NRD_1	4	6	PF00675	0.571
CLV_NRD_NRD_1	442	444	PF00675	0.728
CLV_NRD_NRD_1	480	482	PF00675	0.637
CLV_NRD_NRD_1	531	533	PF00675	0.765
CLV_NRD_NRD_1	572	574	PF00675	0.811
CLV_NRD_NRD_1	583	585	PF00675	0.618
CLV_NRD_NRD_1	694	696	PF00675	0.685
CLV_NRD_NRD_1	94	96	PF00675	0.671
CLV_PCSK_KEX2_1	179	181	PF00082	0.683
CLV_PCSK_KEX2_1	229	231	PF00082	0.555
CLV_PCSK_KEX2_1	268	270	PF00082	0.595
CLV_PCSK_KEX2_1	327	329	PF00082	0.812
CLV_PCSK_KEX2_1	33	35	PF00082	0.874
CLV_PCSK_KEX2_1	442	444	PF00082	0.728
CLV_PCSK_KEX2_1	47	49	PF00082	0.636
CLV_PCSK_KEX2_1	480	482	PF00082	0.637
CLV_PCSK_KEX2_1	533	535	PF00082	0.777
CLV_PCSK_KEX2_1	553	555	PF00082	0.575
CLV_PCSK_KEX2_1	572	574	PF00082	0.772
CLV_PCSK_KEX2_1	583	585	PF00082	0.832
CLV_PCSK_KEX2_1	694	696	PF00082	0.783
CLV_PCSK_KEX2_1	819	821	PF00082	0.479
CLV_PCSK_KEX2_1	83	85	PF00082	0.619
CLV_PCSK_KEX2_1	94	96	PF00082	0.689
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.555
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.812
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.874
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.636
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.777
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.575
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.790
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.479
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.586
CLV_PCSK_PC7_1	549	555	PF00082	0.567
CLV_PCSK_SKI1_1	216	220	PF00082	0.736
DEG_Nend_UBRbox_1	1	4	PF02207	0.677
DEG_SPOP_SBC_1	120	124	PF00917	0.728
DEG_SPOP_SBC_1	185	189	PF00917	0.763
DEG_SPOP_SBC_1	322	326	PF00917	0.525
DEG_SPOP_SBC_1	399	403	PF00917	0.525
DEG_SPOP_SBC_1	499	503	PF00917	0.744
DEG_SPOP_SBC_1	578	582	PF00917	0.566
DOC_CYCLIN_yCln2_LP_2	127	133	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	259	265	PF00134	0.529
DOC_MAPK_gen_1	327	334	PF00069	0.609
DOC_MAPK_gen_1	94	102	PF00069	0.564
DOC_MAPK_MEF2A_6	95	104	PF00069	0.561
DOC_PP2B_LxvP_1	259	262	PF13499	0.525
DOC_PP4_FxxP_1	136	139	PF00568	0.543
DOC_PP4_FxxP_1	284	287	PF00568	0.788
DOC_PP4_FxxP_1	387	390	PF00568	0.756
DOC_PP4_FxxP_1	758	761	PF00568	0.692
DOC_PP4_MxPP_1	290	293	PF00568	0.763
DOC_PP4_MxPP_1	709	712	PF00568	0.730
DOC_USP7_MATH_1	139	143	PF00917	0.743
DOC_USP7_MATH_1	185	189	PF00917	0.810
DOC_USP7_MATH_1	211	215	PF00917	0.517
DOC_USP7_MATH_1	23	27	PF00917	0.699
DOC_USP7_MATH_1	231	235	PF00917	0.611
DOC_USP7_MATH_1	236	240	PF00917	0.595
DOC_USP7_MATH_1	32	36	PF00917	0.682
DOC_USP7_MATH_1	322	326	PF00917	0.622
DOC_USP7_MATH_1	382	386	PF00917	0.589
DOC_USP7_MATH_1	591	595	PF00917	0.773
DOC_USP7_MATH_1	644	648	PF00917	0.552
DOC_USP7_MATH_1	670	674	PF00917	0.770
DOC_USP7_UBL2_3	2	6	PF12436	0.670
DOC_USP7_UBL2_3	225	229	PF12436	0.757
DOC_USP7_UBL2_3	585	589	PF12436	0.573
DOC_USP7_UBL2_3	61	65	PF12436	0.771
DOC_WW_Pin1_4	122	127	PF00397	0.673
DOC_WW_Pin1_4	131	136	PF00397	0.739
DOC_WW_Pin1_4	220	225	PF00397	0.764
DOC_WW_Pin1_4	348	353	PF00397	0.840
DOC_WW_Pin1_4	378	383	PF00397	0.679
DOC_WW_Pin1_4	39	44	PF00397	0.858
DOC_WW_Pin1_4	391	396	PF00397	0.717
DOC_WW_Pin1_4	519	524	PF00397	0.626
DOC_WW_Pin1_4	574	579	PF00397	0.780
DOC_WW_Pin1_4	623	628	PF00397	0.656
DOC_WW_Pin1_4	663	668	PF00397	0.641
DOC_WW_Pin1_4	684	689	PF00397	0.693
DOC_WW_Pin1_4	739	744	PF00397	0.738
DOC_WW_Pin1_4	757	762	PF00397	0.573
DOC_WW_Pin1_4	769	774	PF00397	0.687
DOC_WW_Pin1_4	782	787	PF00397	0.611
DOC_WW_Pin1_4	812	817	PF00397	0.752
DOC_WW_Pin1_4	88	93	PF00397	0.741
LIG_14-3-3_CanoR_1	141	151	PF00244	0.692
LIG_14-3-3_CanoR_1	179	184	PF00244	0.743
LIG_14-3-3_CanoR_1	242	249	PF00244	0.806
LIG_14-3-3_CanoR_1	368	375	PF00244	0.636
LIG_14-3-3_CanoR_1	388	394	PF00244	0.591
LIG_14-3-3_CanoR_1	448	454	PF00244	0.629
LIG_14-3-3_CanoR_1	48	56	PF00244	0.709
LIG_14-3-3_CanoR_1	517	523	PF00244	0.720
LIG_14-3-3_CanoR_1	532	537	PF00244	0.648
LIG_14-3-3_CanoR_1	572	577	PF00244	0.712
LIG_14-3-3_CanoR_1	587	596	PF00244	0.590
LIG_14-3-3_CanoR_1	630	638	PF00244	0.745
LIG_14-3-3_CanoR_1	694	700	PF00244	0.732
LIG_14-3-3_CanoR_1	790	794	PF00244	0.762
LIG_BIR_III_4	616	620	PF00653	0.659
LIG_BRCT_BRCA1_1	124	128	PF00533	0.543
LIG_BRCT_BRCA1_1	370	374	PF00533	0.734
LIG_Clathr_ClatBox_1	801	805	PF01394	0.725
LIG_CtBP_PxDLS_1	390	394	PF00389	0.742
LIG_CtBP_PxDLS_1	738	742	PF00389	0.641
LIG_deltaCOP1_diTrp_1	748	758	PF00928	0.694
LIG_FHA_1	122	128	PF00498	0.724
LIG_FHA_1	17	23	PF00498	0.610
LIG_FHA_1	455	461	PF00498	0.641
LIG_FHA_1	660	666	PF00498	0.777
LIG_FHA_1	793	799	PF00498	0.466
LIG_FHA_2	112	118	PF00498	0.563
LIG_FHA_2	197	203	PF00498	0.744
LIG_FHA_2	417	423	PF00498	0.706
LIG_FHA_2	607	613	PF00498	0.647
LIG_HCF-1_HBM_1	513	516	PF13415	0.771
LIG_IRF3_LxIS_1	661	666	PF10401	0.564
LIG_LIR_Apic_2	134	139	PF02991	0.658
LIG_LIR_Apic_2	146	152	PF02991	0.798
LIG_LIR_Apic_2	282	287	PF02991	0.785
LIG_LIR_Apic_2	385	390	PF02991	0.756
LIG_LIR_Apic_2	698	704	PF02991	0.526
LIG_LIR_Apic_2	757	761	PF02991	0.693
LIG_LIR_Gen_1	202	211	PF02991	0.634
LIG_LIR_Gen_1	329	339	PF02991	0.734
LIG_LIR_Nem_3	125	131	PF02991	0.538
LIG_LIR_Nem_3	282	288	PF02991	0.745
LIG_LIR_Nem_3	329	334	PF02991	0.724
LIG_LIR_Nem_3	394	399	PF02991	0.586
LIG_LIR_Nem_3	486	492	PF02991	0.527
LIG_LIR_Nem_3	714	718	PF02991	0.525
LIG_LIR_Nem_3	815	821	PF02991	0.762
LIG_LYPXL_S_1	284	288	PF13949	0.748
LIG_MAD2	636	644	PF02301	0.777
LIG_MLH1_MIPbox_1	371	375	PF16413	0.733
LIG_PDZ_Class_2	818	823	PF00595	0.481
LIG_Pex14_1	413	417	PF04695	0.828
LIG_Pex14_2	150	154	PF04695	0.824
LIG_Pex14_2	284	288	PF04695	0.612
LIG_SH2_CRK	396	400	PF00017	0.529
LIG_SH2_CRK	489	493	PF00017	0.525
LIG_SH2_CRK	702	706	PF00017	0.638
LIG_SH2_CRK	715	719	PF00017	0.533
LIG_SH2_CRK	736	740	PF00017	0.813
LIG_SH2_CRK	770	774	PF00017	0.729
LIG_SH2_NCK_1	770	774	PF00017	0.744
LIG_SH2_SRC	729	732	PF00017	0.568
LIG_SH2_STAT3	263	266	PF00017	0.823
LIG_SH2_STAT5	149	152	PF00017	0.823
LIG_SH2_STAT5	16	19	PF00017	0.777
LIG_SH2_STAT5	729	732	PF00017	0.763
LIG_SH2_STAT5	770	773	PF00017	0.712
LIG_SH3_1	225	231	PF00018	0.643
LIG_SH3_1	664	670	PF00018	0.773
LIG_SH3_2	667	672	PF14604	0.772
LIG_SH3_3	225	231	PF00018	0.682
LIG_SH3_3	37	43	PF00018	0.874
LIG_SH3_3	664	670	PF00018	0.851
LIG_SH3_3	810	816	PF00018	0.736
LIG_SUMO_SIM_par_1	737	742	PF11976	0.641
LIG_SUMO_SIM_par_1	794	800	PF11976	0.442
LIG_TRAF2_1	26	29	PF00917	0.574
LIG_TRAF2_1	655	658	PF00917	0.772
LIG_TRAF2_1	8	11	PF00917	0.862
LIG_UBA3_1	637	643	PF00899	0.781
LIG_WW_3	91	95	PF00397	0.560
MOD_CDC14_SPxK_1	91	94	PF00782	0.677
MOD_CDK_SPK_2	220	225	PF00069	0.745
MOD_CDK_SPxK_1	88	94	PF00069	0.673
MOD_CDK_SPxxK_3	39	46	PF00069	0.874
MOD_CDK_SPxxK_3	623	630	PF00069	0.566
MOD_CDK_SPxxK_3	812	819	PF00069	0.678
MOD_CDK_SPxxK_3	88	95	PF00069	0.637
MOD_CK1_1	122	128	PF00069	0.592
MOD_CK1_1	142	148	PF00069	0.739
MOD_CK1_1	155	161	PF00069	0.606
MOD_CK1_1	252	258	PF00069	0.600
MOD_CK1_1	35	41	PF00069	0.716
MOD_CK1_1	366	372	PF00069	0.734
MOD_CK1_1	376	382	PF00069	0.611
MOD_CK1_1	452	458	PF00069	0.752
MOD_CK1_1	50	56	PF00069	0.759
MOD_CK1_1	501	507	PF00069	0.831
MOD_CK1_1	519	525	PF00069	0.852
MOD_CK1_1	577	583	PF00069	0.854
MOD_CK1_1	621	627	PF00069	0.736
MOD_CK1_1	629	635	PF00069	0.756
MOD_CK1_1	668	674	PF00069	0.654
MOD_CK1_1	760	766	PF00069	0.692
MOD_CK2_1	142	148	PF00069	0.743
MOD_CK2_1	196	202	PF00069	0.747
MOD_CK2_1	23	29	PF00069	0.569
MOD_CK2_1	323	329	PF00069	0.521
MOD_CK2_1	5	11	PF00069	0.861
MOD_CK2_1	562	568	PF00069	0.684
MOD_CK2_1	636	642	PF00069	0.620
MOD_Cter_Amidation	551	554	PF01082	0.573
MOD_Cter_Amidation	81	84	PF01082	0.583
MOD_GlcNHglycan	10	14	PF01048	0.697
MOD_GlcNHglycan	205	209	PF01048	0.521
MOD_GlcNHglycan	234	237	PF01048	0.796
MOD_GlcNHglycan	259	262	PF01048	0.525
MOD_GlcNHglycan	313	316	PF01048	0.638
MOD_GlcNHglycan	371	374	PF01048	0.804
MOD_GlcNHglycan	462	465	PF01048	0.646
MOD_GlcNHglycan	638	641	PF01048	0.782
MOD_GlcNHglycan	672	675	PF01048	0.772
MOD_GlcNHglycan	80	83	PF01048	0.832
MOD_GlcNHglycan	96	99	PF01048	0.595
MOD_GSK3_1	192	199	PF00069	0.749
MOD_GSK3_1	232	239	PF00069	0.762
MOD_GSK3_1	249	256	PF00069	0.605
MOD_GSK3_1	300	307	PF00069	0.769
MOD_GSK3_1	333	340	PF00069	0.659
MOD_GSK3_1	348	355	PF00069	0.575
MOD_GSK3_1	35	42	PF00069	0.822
MOD_GSK3_1	369	376	PF00069	0.734
MOD_GSK3_1	378	385	PF00069	0.715
MOD_GSK3_1	391	398	PF00069	0.602
MOD_GSK3_1	412	419	PF00069	0.815
MOD_GSK3_1	448	455	PF00069	0.746
MOD_GSK3_1	46	53	PF00069	0.677
MOD_GSK3_1	5	12	PF00069	0.837
MOD_GSK3_1	515	522	PF00069	0.749
MOD_GSK3_1	554	561	PF00069	0.716
MOD_GSK3_1	572	579	PF00069	0.621
MOD_GSK3_1	587	594	PF00069	0.809
MOD_GSK3_1	61	68	PF00069	0.569
MOD_GSK3_1	618	625	PF00069	0.599
MOD_GSK3_1	659	666	PF00069	0.565
MOD_GSK3_1	684	691	PF00069	0.565
MOD_GSK3_1	737	744	PF00069	0.753
MOD_GSK3_1	756	763	PF00069	0.556
MOD_LATS_1	7	13	PF00433	0.782
MOD_N-GLC_1	185	190	PF02516	0.764
MOD_N-GLC_1	304	309	PF02516	0.645
MOD_N-GLC_1	342	347	PF02516	0.661
MOD_N-GLC_1	483	488	PF02516	0.632
MOD_N-GLC_1	606	611	PF02516	0.652
MOD_N-GLC_1	746	751	PF02516	0.524
MOD_N-GLC_1	763	768	PF02516	0.567
MOD_NEK2_1	104	109	PF00069	0.660
MOD_NEK2_1	17	22	PF00069	0.778
MOD_NEK2_1	204	209	PF00069	0.731
MOD_NEK2_1	219	224	PF00069	0.548
MOD_NEK2_1	257	262	PF00069	0.697
MOD_NEK2_1	342	347	PF00069	0.732
MOD_NEK2_1	374	379	PF00069	0.775
MOD_NEK2_1	453	458	PF00069	0.585
MOD_NEK2_1	542	547	PF00069	0.771
MOD_NEK2_1	789	794	PF00069	0.748
MOD_NEK2_2	382	387	PF00069	0.578
MOD_PIKK_1	139	145	PF00454	0.749
MOD_PIKK_1	211	217	PF00454	0.791
MOD_PIKK_1	242	248	PF00454	0.806
MOD_PIKK_1	352	358	PF00454	0.542
MOD_PIKK_1	380	386	PF00454	0.565
MOD_PK_1	695	701	PF00069	0.738
MOD_PKA_1	179	185	PF00069	0.688
MOD_PKA_1	442	448	PF00069	0.643
MOD_PKA_1	46	52	PF00069	0.681
MOD_PKA_1	5	11	PF00069	0.569
MOD_PKA_1	532	538	PF00069	0.756
MOD_PKA_1	572	578	PF00069	0.708
MOD_PKA_1	94	100	PF00069	0.683
MOD_PKA_2	104	110	PF00069	0.592
MOD_PKA_2	172	178	PF00069	0.715
MOD_PKA_2	179	185	PF00069	0.631
MOD_PKA_2	356	362	PF00069	0.759
MOD_PKA_2	442	448	PF00069	0.682
MOD_PKA_2	47	53	PF00069	0.773
MOD_PKA_2	516	522	PF00069	0.724
MOD_PKA_2	572	578	PF00069	0.708
MOD_PKA_2	629	635	PF00069	0.796
MOD_PKA_2	659	665	PF00069	0.698
MOD_PKA_2	676	682	PF00069	0.652
MOD_PKA_2	789	795	PF00069	0.763
MOD_PKA_2	94	100	PF00069	0.695
MOD_Plk_1	152	158	PF00069	0.820
MOD_Plk_1	252	258	PF00069	0.582
MOD_Plk_1	425	431	PF00069	0.560
MOD_Plk_1	483	489	PF00069	0.798
MOD_Plk_1	746	752	PF00069	0.577
MOD_Plk_2-3	562	568	PF00069	0.709
MOD_Plk_2-3	608	614	PF00069	0.763
MOD_Plk_4	253	259	PF00069	0.718
MOD_Plk_4	382	388	PF00069	0.752
MOD_Plk_4	407	413	PF00069	0.750
MOD_Plk_4	426	432	PF00069	0.571
MOD_Plk_4	484	490	PF00069	0.826
MOD_Plk_4	746	752	PF00069	0.519
MOD_ProDKin_1	122	128	PF00069	0.674
MOD_ProDKin_1	131	137	PF00069	0.740
MOD_ProDKin_1	220	226	PF00069	0.766
MOD_ProDKin_1	348	354	PF00069	0.834
MOD_ProDKin_1	378	384	PF00069	0.682
MOD_ProDKin_1	39	45	PF00069	0.859
MOD_ProDKin_1	391	397	PF00069	0.715
MOD_ProDKin_1	519	525	PF00069	0.627
MOD_ProDKin_1	574	580	PF00069	0.782
MOD_ProDKin_1	623	629	PF00069	0.656
MOD_ProDKin_1	663	669	PF00069	0.639
MOD_ProDKin_1	684	690	PF00069	0.693
MOD_ProDKin_1	739	745	PF00069	0.738
MOD_ProDKin_1	757	763	PF00069	0.572
MOD_ProDKin_1	769	775	PF00069	0.686
MOD_ProDKin_1	782	788	PF00069	0.609
MOD_ProDKin_1	812	818	PF00069	0.753
MOD_ProDKin_1	88	94	PF00069	0.743
MOD_SUMO_rev_2	53	63	PF00179	0.777
TRG_DiLeu_BaEn_4	658	664	PF01217	0.565
TRG_ENDOCYTIC_2	203	206	PF00928	0.636
TRG_ENDOCYTIC_2	285	288	PF00928	0.748
TRG_ENDOCYTIC_2	396	399	PF00928	0.530
TRG_ENDOCYTIC_2	489	492	PF00928	0.653
TRG_ENDOCYTIC_2	702	705	PF00928	0.541
TRG_ENDOCYTIC_2	715	718	PF00928	0.501
TRG_ENDOCYTIC_2	736	739	PF00928	0.810
TRG_ER_diArg_1	178	180	PF00400	0.680
TRG_ER_diArg_1	267	269	PF00400	0.586
TRG_ER_diArg_1	310	313	PF00400	0.833
TRG_ER_diArg_1	694	696	PF00400	0.681
TRG_ER_diArg_1	93	95	PF00400	0.657
TRG_NLS_Bipartite_1	33	50	PF00514	0.580
TRG_NLS_Bipartite_1	572	588	PF00514	0.570
TRG_NLS_MonoCore_2	228	233	PF00514	0.552
TRG_NLS_MonoExtC_3	582	587	PF00514	0.572
TRG_NLS_MonoExtN_4	228	233	PF00514	0.552
TRG_NLS_MonoExtN_4	31	37	PF00514	0.868
TRG_NLS_MonoExtN_4	43	50	PF00514	0.673
TRG_NLS_MonoExtN_4	583	588	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	733	737	PF00026	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4Q4	Leishmania donovani	76%	100%
A4HJJ8	Leishmania braziliensis	38%	90%
A4I6Z5	Leishmania infantum	75%	100%
Q4Q645	Leishmania major	75%	100%