Prostaglandin f2-alpha synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prostaglandin f2-alpha synthase

Species:

Leishmania mexicana

UniProt:

E9B215_LEIMU

TriTrypDb:

LmxM.30.2150

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B215

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B215

PDB structure(s): 4f40_A , 4f40_B , 4g5d_A , 4g5d_B

Function

Biological processes
Term	Name	Level	Count
GO:0001516	prostaglandin biosynthetic process	8	4
GO:0006082	organic acid metabolic process	3	4
GO:0006629	lipid metabolic process	3	4
GO:0006631	fatty acid metabolic process	4	4
GO:0006633	fatty acid biosynthetic process	5	4
GO:0006636	unsaturated fatty acid biosynthetic process	6	4
GO:0006690	icosanoid metabolic process	6	4
GO:0006692	prostanoid metabolic process	6	4
GO:0006693	prostaglandin metabolic process	7	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0009058	biosynthetic process	2	4
GO:0009987	cellular process	1	4
GO:0016053	organic acid biosynthetic process	4	4
GO:0019752	carboxylic acid metabolic process	5	4
GO:0032787	monocarboxylic acid metabolic process	6	4
GO:0033559	unsaturated fatty acid metabolic process	5	4
GO:0043436	oxoacid metabolic process	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0044281	small molecule metabolic process	2	4
GO:0044283	small molecule biosynthetic process	3	4
GO:0046394	carboxylic acid biosynthetic process	5	4
GO:0046456	icosanoid biosynthetic process	6	4
GO:0046457	prostanoid biosynthetic process	7	4
GO:0071704	organic substance metabolic process	2	4
GO:0072330	monocarboxylic acid biosynthetic process	6	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016491	oxidoreductase activity	2	9
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	5
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	5
GO:0036094	small molecule binding	2	1
GO:0036130	prostaglandin H2 endoperoxidase reductase activity	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1
GO:0036131	prostaglandin D2 11-ketoreductase activity	5	4
GO:0047017	prostaglandin-F synthase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	117	121	PF00082	0.401
CLV_PCSK_SKI1_1	190	194	PF00082	0.344
CLV_PCSK_SKI1_1	38	42	PF00082	0.344
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.458
DOC_MAPK_gen_1	139	148	PF00069	0.490
DOC_MAPK_gen_1	217	227	PF00069	0.485
DOC_USP7_UBL2_3	122	126	PF12436	0.586
DOC_USP7_UBL2_3	240	244	PF12436	0.558
DOC_WW_Pin1_4	163	168	PF00397	0.510
DOC_WW_Pin1_4	195	200	PF00397	0.485
DOC_WW_Pin1_4	24	29	PF00397	0.530
LIG_BIR_II_1	1	5	PF00653	0.464
LIG_CAP-Gly_1	278	284	PF01302	0.519
LIG_CSL_BTD_1	196	199	PF09270	0.485
LIG_deltaCOP1_diTrp_1	129	134	PF00928	0.510
LIG_eIF4E_1	105	111	PF01652	0.485
LIG_FHA_1	164	170	PF00498	0.510
LIG_FHA_1	48	54	PF00498	0.485
LIG_FHA_1	6	12	PF00498	0.420
LIG_FHA_1	75	81	PF00498	0.485
LIG_HCF-1_HBM_1	135	138	PF13415	0.406
LIG_LIR_Gen_1	104	111	PF02991	0.494
LIG_LIR_Nem_3	104	108	PF02991	0.494
LIG_LIR_Nem_3	129	134	PF02991	0.485
LIG_LIR_Nem_3	195	200	PF02991	0.485
LIG_SH2_PTP2	105	108	PF00017	0.485
LIG_SH2_SRC	109	112	PF00017	0.485
LIG_SH2_SRC	127	130	PF00017	0.485
LIG_SH2_STAP1	87	91	PF00017	0.485
LIG_SH2_STAT5	105	108	PF00017	0.485
LIG_SH2_STAT5	109	112	PF00017	0.485
LIG_SH2_STAT5	127	130	PF00017	0.485
LIG_SH3_3	12	18	PF00018	0.416
LIG_SUMO_SIM_par_1	7	12	PF11976	0.521
LIG_TRAF2_1	93	96	PF00917	0.544
LIG_TYR_ITIM	103	108	PF00017	0.485
LIG_UBA3_1	210	219	PF00899	0.544
LIG_UBA3_1	235	240	PF00899	0.552
MOD_Cter_Amidation	123	126	PF01082	0.344
MOD_GlcNHglycan	257	261	PF01048	0.392
MOD_GlcNHglycan	66	69	PF01048	0.385
MOD_GSK3_1	234	241	PF00069	0.502
MOD_GSK3_1	5	12	PF00069	0.326
MOD_NEK2_1	64	69	PF00069	0.564
MOD_NEK2_1	75	80	PF00069	0.497
MOD_NEK2_1	94	99	PF00069	0.510
MOD_PKA_2	64	70	PF00069	0.544
MOD_Plk_1	56	62	PF00069	0.510
MOD_Plk_1	87	93	PF00069	0.492
MOD_Plk_2-3	262	268	PF00069	0.527
MOD_ProDKin_1	163	169	PF00069	0.510
MOD_ProDKin_1	195	201	PF00069	0.485
MOD_ProDKin_1	24	30	PF00069	0.527
MOD_SUMO_for_1	192	195	PF00179	0.544
MOD_SUMO_rev_2	135	143	PF00179	0.485
MOD_SUMO_rev_2	182	192	PF00179	0.510
TRG_ENDOCYTIC_2	105	108	PF00928	0.485
TRG_ENDOCYTIC_2	45	48	PF00928	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R8	Leptomonas seymouri	29%	75%
A0A0N0P8F4	Leptomonas seymouri	34%	78%
A0A0N1I3R2	Leptomonas seymouri	29%	99%
A0A0N1I9Z1	Leptomonas seymouri	58%	100%
A0A0N1PCR7	Leptomonas seymouri	48%	100%
A0A0S4J2H7	Bodo saltans	33%	100%
A0A0S4J7K9	Bodo saltans	31%	80%
A0A1D5XGW0	Triticum aestivum	34%	90%
A0A1X0NFW0	Trypanosomatidae	35%	84%
A0A1X0NIH1	Trypanosomatidae	33%	90%
A0A1X0NNX8	Trypanosomatidae	67%	100%
A0A1X0P7C2	Trypanosomatidae	56%	100%
A0A1X9QHJ0	Triticum aestivum	34%	90%
A0A2P1GIY9	Catharanthus roseus	36%	88%
A0A3Q8IFG1	Leishmania donovani	93%	100%
A0A3Q8IJ05	Leishmania donovani	58%	100%
A0A3R7NJY8	Trypanosoma rangeli	34%	84%
A0A3S7X124	Leishmania donovani	32%	76%
A0A3S7X518	Leishmania donovani	29%	99%
A0A422N1G0	Trypanosoma rangeli	54%	100%
A0A422N9R4	Trypanosoma rangeli	35%	87%
A0A422NBS6	Trypanosoma rangeli	65%	100%
A0PQ11	Mycobacterium ulcerans (strain Agy99)	41%	100%
A0QJ99	Mycobacterium avium (strain 104)	42%	100%
A0QL30	Mycobacterium avium (strain 104)	43%	99%
A0QV09	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	45%	100%
A0QV10	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	54%	100%
A1CRI1	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	34%	86%
A1D4E3	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	31%	88%
A1KMW6	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	44%	100%
A1T726	Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1)	47%	100%
A1UEC5	Mycobacterium sp. (strain KMS)	43%	100%
A1UEC6	Mycobacterium sp. (strain KMS)	51%	100%
A2Q8B5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	28%	89%
A3PXS9	Mycobacterium sp. (strain JLS)	43%	100%
A3PXT0	Mycobacterium sp. (strain JLS)	51%	100%
A4HG21	Leishmania braziliensis	32%	100%
A4HJJ7	Leishmania braziliensis	87%	100%
A4HJS6	Leishmania braziliensis	30%	100%
A4HK26	Leishmania braziliensis	56%	100%
A4I342	Leishmania infantum	32%	76%
A4I6Z4	Leishmania infantum	93%	100%
A4I792	Leishmania infantum	29%	99%
A4I7L0	Leishmania infantum	58%	100%
A4TE41	Mycolicibacterium gilvum (strain PYR-GCK)	48%	100%
A5U6Y1	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	43%	100%
B0XNR0	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	31%	90%
B2HIJ9	Mycobacterium marinum (strain ATCC BAA-535 / M)	40%	100%
B4F9A4	Zea mays	35%	90%
B8ASB2	Oryza sativa subsp. indica	25%	81%
B8N195	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	31%	89%
B8ZS00	Mycobacterium leprae (strain Br4923)	41%	100%
B9VRJ2	Papaver somniferum	35%	88%
C5FFQ7	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	31%	87%
C6TBN2	Glycine max	23%	82%
C9JRZ8	Homo sapiens	40%	90%
C9ZJL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	84%
D0A6W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
D0A735	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	91%
D3ZF77	Rattus norvegicus	40%	88%
E7C196	Erythroxylum coca	34%	87%
E9ACW1	Leishmania major	30%	100%
E9AYA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AZF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B287	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	99%
E9B2G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
F4HPY8	Arabidopsis thaliana	27%	86%
G4MZI3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	33%	87%
G4N708	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	33%	88%
H9JTG9	Bombyx mori	39%	92%
O08782	Cricetulus griseus	42%	90%
O13283	Candida tropicalis	33%	88%
O13848	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
O14088	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
O32210	Bacillus subtilis (strain 168)	59%	100%
O34678	Bacillus subtilis (strain 168)	58%	100%
O42888	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	87%
O49133	Fragaria ananassa	36%	89%
O59826	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	83%
O60218	Homo sapiens	43%	90%
O69462	Mycobacterium leprae (strain TN)	41%	100%
O70473	Cricetulus griseus	40%	88%
O74237	Candida tenuis	35%	88%
O80944	Arabidopsis thaliana	40%	91%
O94315	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	93%
O94735	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	32%	90%
P02532	Rana temporaria	36%	88%
P05980	Bos taurus	39%	88%
P06632	Corynebacterium sp. (strain ATCC 31090)	44%	100%
P07943	Rattus norvegicus	42%	90%
P14065	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	91%
P14550	Homo sapiens	40%	87%
P15121	Homo sapiens	42%	90%
P15122	Oryctolagus cuniculus	42%	90%
P15339	Corynebacterium sp. (strain SHS752001)	38%	100%
P16116	Bos taurus	43%	90%
P17264	Lithobates catesbeianus	35%	88%
P17516	Homo sapiens	38%	88%
P21300	Mus musculus	41%	90%
P22045	Leishmania major	94%	100%
P23457	Rattus norvegicus	34%	88%
P23901	Hordeum vulgare	36%	89%
P26690	Glycine max	36%	90%
P27800	Sporidiobolus salmonicolor	40%	88%
P28475	Malus domestica	37%	92%
P30863	Escherichia coli (strain K12)	36%	100%
P31210	Rattus norvegicus	38%	87%
P31867	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	35%	89%
P38115	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	83%
P38715	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	87%
P42330	Homo sapiens	37%	88%
P42972	Bacillus subtilis (strain 168)	27%	95%
P45376	Mus musculus	42%	90%
P45377	Mus musculus	41%	90%
P46336	Bacillus subtilis (strain 168)	28%	92%
P46905	Bacillus subtilis (strain 168)	26%	92%
P47137	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P49378	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	34%	86%
P50578	Sus scrofa	41%	87%
P51635	Rattus norvegicus	40%	87%
P51652	Rattus norvegicus	35%	88%
P51857	Homo sapiens	39%	87%
P52895	Homo sapiens	38%	88%
P52897	Bos taurus	39%	88%
P52898	Bos taurus	39%	88%
P58744	Salmonella typhi	44%	100%
P70694	Mus musculus	37%	88%
P74308	Synechocystis sp. (strain PCC 6803 / Kazusa)	40%	87%
P76187	Escherichia coli (strain K12)	26%	95%
P76234	Escherichia coli (strain K12)	28%	100%
P77256	Escherichia coli (strain K12)	28%	87%
P77735	Escherichia coli (strain K12)	25%	88%
P78736	Pachysolen tannophilus	32%	89%
P80276	Sus scrofa	43%	90%
P80508	Oryctolagus cuniculus	38%	88%
P82125	Sus scrofa	42%	94%
P82809	Mesocricetus auratus	34%	88%
P87039	Candida tropicalis	32%	88%
P9WQA4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	43%	100%
P9WQA5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	43%	100%
Q01213	Mucor mucedo	32%	88%
Q02198	Pseudomonas putida	44%	96%
Q04828	Homo sapiens	38%	88%
Q07551	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	91%
Q09632	Caenorhabditis elegans	42%	88%
Q0CUL0	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	30%	89%
Q0GYU4	Hypocrea jecorina	37%	89%
Q0GYU5	Hypocrea jecorina	38%	86%
Q0JE32	Oryza sativa subsp. japonica	25%	81%
Q0PCF4	Hordeum vulgare	34%	90%
Q0PGJ6	Arabidopsis thaliana	42%	90%
Q10494	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	88%
Q10PE7	Oryza sativa subsp. japonica	34%	89%
Q12458	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	91%
Q1BAN7	Mycobacterium sp. (strain MCS)	43%	100%
Q1XAA8	Equus caballus	37%	88%
Q28FD1	Xenopus tropicalis	41%	87%
Q2UKD0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	31%	89%
Q3L181	Rauvolfia serpentina	24%	84%
Q3ZCJ2	Bos taurus	40%	87%
Q3ZFI7	Hypocrea jecorina	38%	92%
Q46857	Escherichia coli (strain K12)	44%	100%
Q4DJ07	Trypanosoma cruzi (strain CL Brener)	58%	100%
Q4Q5N9	Leishmania major	58%	100%
Q4Q5X1	Leishmania major	30%	100%
Q4Q973	Leishmania major	29%	69%
Q4R802	Macaca fascicularis	35%	89%
Q4WJT9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	90%
Q54NZ7	Dictyostelium discoideum	41%	91%
Q55FL3	Dictyostelium discoideum	40%	88%
Q568L5	Danio rerio	40%	88%
Q56Y42	Arabidopsis thaliana	24%	78%
Q5BGA7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	32%	89%
Q5R5D5	Pongo abelii	40%	87%
Q5R7C9	Pongo abelii	38%	88%
Q5REQ0	Pongo abelii	38%	88%
Q5RJP0	Rattus norvegicus	42%	90%
Q5U1Y4	Rattus norvegicus	39%	94%
Q5ZK84	Gallus gallus	41%	87%
Q6AYQ2	Rattus norvegicus	35%	89%
Q6AZW2	Danio rerio	42%	88%
Q6GMC7	Xenopus laevis	41%	87%
Q6IMN8	Dictyostelium discoideum	40%	96%
Q6W8P9	Equus caballus	36%	88%
Q6Y0Z3	Candida parapsilosis	31%	88%
Q73SC5	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	42%	99%
Q73VK6	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	42%	100%
Q76L36	Candida parapsilosis	39%	93%
Q76L37	Candida parapsilosis	35%	93%
Q7G764	Oryza sativa subsp. japonica	34%	88%
Q7G765	Oryza sativa subsp. japonica	34%	88%
Q7TXI6	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	44%	100%
Q84TF0	Arabidopsis thaliana	41%	90%
Q876L8	Hypocrea jecorina	29%	88%
Q8K023	Mus musculus	34%	88%
Q8SSK6	Encephalitozoon cuniculi (strain GB-M1)	39%	94%
Q8VC28	Mus musculus	35%	88%
Q8VCX1	Mus musculus	41%	87%
Q8X195	Candida boidinii	32%	88%
Q8X7Z7	Escherichia coli O157:H7	37%	100%
Q8XBT6	Escherichia coli O157:H7	44%	100%
Q8Z988	Salmonella typhi	35%	100%
Q8ZH36	Yersinia pestis	35%	100%
Q8ZI40	Yersinia pestis	47%	100%
Q8ZM06	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	45%	100%
Q8ZRM7	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	35%	100%
Q91WR5	Mus musculus	36%	88%
Q94A68	Arabidopsis thaliana	26%	75%
Q95JH4	Macaca fuscata fuscata	38%	88%
Q95JH5	Macaca fascicularis	38%	88%
Q95JH6	Macaca fuscata fuscata	38%	88%
Q95JH7	Macaca fascicularis	38%	88%
Q96JD6	Homo sapiens	36%	89%
Q9C1X5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q9DCT1	Mus musculus	40%	94%
Q9GV41	Trypanosoma brucei brucei	61%	100%
Q9JII6	Mus musculus	41%	87%
Q9M338	Arabidopsis thaliana	37%	90%
Q9P430	Scheffersomyces shehatae	36%	88%
Q9P8R5	Aspergillus niger	28%	89%
Q9SQ64	Papaver somniferum	35%	88%
Q9SQ67	Papaver somniferum	34%	88%
Q9SQ68	Papaver somniferum	34%	88%
Q9SQ69	Papaver somniferum	35%	88%
Q9SQ70	Papaver somniferum	34%	88%
Q9TV64	Oryctolagus cuniculus	39%	87%
Q9USV2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
V5B6J8	Trypanosoma cruzi	34%	84%
V5BBS9	Trypanosoma cruzi	57%	100%
V5BR74	Trypanosoma cruzi	34%	88%
W5DYE3	Triticum aestivum	34%	90%