tRNA_lig_CPD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B213_LEIMU

TriTrypDb:

LmxM.30.2130

Length:

928

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B213

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B213

Function

Biological processes
Term	Name	Level	Count
GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	8	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	9	10
GO:0006396	RNA processing	6	10
GO:0006399	tRNA metabolic process	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008033	tRNA processing	8	10
GO:0008152	metabolic process	1	10
GO:0008380	RNA splicing	7	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0016310	phosphorylation	5	1
GO:0033554	cellular response to stress	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046939	obsolete nucleotide phosphorylation	6	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0003972	RNA ligase (ATP) activity	5	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0008452	RNA ligase activity	4	10
GO:0016874	ligase activity	2	10
GO:0016886	ligase activity, forming phosphoric ester bonds	3	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0019205	nucleobase-containing compound kinase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0046403	polynucleotide 3'-phosphatase activity	6	1
GO:0046404	polydeoxyribonucleotide 5'-hydroxyl-kinase activity	7	1
GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	5	1
GO:0051733	polydeoxyribonucleotide kinase activity	6	1
GO:0051734	polynucleotide kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	371	375	PF00656	0.667
CLV_C14_Caspase3-7	383	387	PF00656	0.345
CLV_C14_Caspase3-7	546	550	PF00656	0.469
CLV_NRD_NRD_1	151	153	PF00675	0.333
CLV_NRD_NRD_1	16	18	PF00675	0.768
CLV_NRD_NRD_1	21	23	PF00675	0.765
CLV_NRD_NRD_1	214	216	PF00675	0.386
CLV_NRD_NRD_1	245	247	PF00675	0.297
CLV_NRD_NRD_1	429	431	PF00675	0.466
CLV_NRD_NRD_1	533	535	PF00675	0.347
CLV_NRD_NRD_1	6	8	PF00675	0.789
CLV_NRD_NRD_1	712	714	PF00675	0.460
CLV_NRD_NRD_1	866	868	PF00675	0.496
CLV_NRD_NRD_1	909	911	PF00675	0.535
CLV_PCSK_FUR_1	14	18	PF00082	0.820
CLV_PCSK_KEX2_1	16	18	PF00082	0.749
CLV_PCSK_KEX2_1	21	23	PF00082	0.723
CLV_PCSK_KEX2_1	214	216	PF00082	0.386
CLV_PCSK_KEX2_1	245	247	PF00082	0.297
CLV_PCSK_KEX2_1	342	344	PF00082	0.488
CLV_PCSK_KEX2_1	429	431	PF00082	0.464
CLV_PCSK_KEX2_1	6	8	PF00082	0.783
CLV_PCSK_KEX2_1	616	618	PF00082	0.532
CLV_PCSK_KEX2_1	866	868	PF00082	0.379
CLV_PCSK_KEX2_1	909	911	PF00082	0.489
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.466
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.590
CLV_PCSK_PC1ET2_1	909	911	PF00082	0.551
CLV_PCSK_PC7_1	17	23	PF00082	0.538
CLV_PCSK_PC7_1	2	8	PF00082	0.523
CLV_PCSK_PC7_1	425	431	PF00082	0.399
CLV_PCSK_SKI1_1	258	262	PF00082	0.452
CLV_PCSK_SKI1_1	291	295	PF00082	0.503
CLV_PCSK_SKI1_1	342	346	PF00082	0.510
CLV_PCSK_SKI1_1	625	629	PF00082	0.428
CLV_PCSK_SKI1_1	80	84	PF00082	0.471
CLV_PCSK_SKI1_1	801	805	PF00082	0.493
CLV_PCSK_SKI1_1	910	914	PF00082	0.574
DEG_APCC_DBOX_1	526	534	PF00400	0.427
DEG_APCC_DBOX_1	79	87	PF00400	0.347
DEG_Nend_UBRbox_1	1	4	PF02207	0.721
DEG_SCF_FBW7_1	136	143	PF00400	0.431
DOC_ANK_TNKS_1	214	221	PF00023	0.413
DOC_CKS1_1	37	42	PF01111	0.530
DOC_CKS1_1	409	414	PF01111	0.285
DOC_CYCLIN_RxL_1	533	543	PF00134	0.308
DOC_CYCLIN_RxL_1	798	809	PF00134	0.470
DOC_CYCLIN_yClb1_LxF_4	330	336	PF00134	0.457
DOC_CYCLIN_yCln2_LP_2	805	808	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.515
DOC_MAPK_gen_1	121	131	PF00069	0.428
DOC_MAPK_gen_1	245	253	PF00069	0.271
DOC_MAPK_gen_1	534	540	PF00069	0.354
DOC_MAPK_gen_1	688	698	PF00069	0.330
DOC_MAPK_gen_1	74	83	PF00069	0.536
DOC_MAPK_gen_1	909	915	PF00069	0.474
DOC_MAPK_MEF2A_6	691	698	PF00069	0.335
DOC_PP2B_LxvP_1	388	391	PF13499	0.411
DOC_PP2B_LxvP_1	696	699	PF13499	0.329
DOC_PP2B_LxvP_1	805	808	PF13499	0.464
DOC_PP2B_LxvP_1	84	87	PF13499	0.478
DOC_PP2B_LxvP_1	913	916	PF13499	0.419
DOC_PP2B_PxIxI_1	878	884	PF00149	0.308
DOC_PP4_FxxP_1	186	189	PF00568	0.499
DOC_PP4_FxxP_1	580	583	PF00568	0.468
DOC_PP4_FxxP_1	82	85	PF00568	0.476
DOC_SPAK_OSR1_1	215	219	PF12202	0.338
DOC_USP7_MATH_1	287	291	PF00917	0.584
DOC_USP7_MATH_1	38	42	PF00917	0.743
DOC_USP7_MATH_1	441	445	PF00917	0.394
DOC_USP7_MATH_1	547	551	PF00917	0.532
DOC_USP7_MATH_1	583	587	PF00917	0.435
DOC_USP7_MATH_1	686	690	PF00917	0.344
DOC_USP7_MATH_1	787	791	PF00917	0.395
DOC_USP7_UBL2_3	153	157	PF12436	0.426
DOC_WW_Pin1_4	132	137	PF00397	0.501
DOC_WW_Pin1_4	291	296	PF00397	0.465
DOC_WW_Pin1_4	36	41	PF00397	0.757
DOC_WW_Pin1_4	408	413	PF00397	0.494
DOC_WW_Pin1_4	414	419	PF00397	0.550
DOC_WW_Pin1_4	49	54	PF00397	0.699
DOC_WW_Pin1_4	519	524	PF00397	0.564
DOC_WW_Pin1_4	718	723	PF00397	0.560
DOC_WW_Pin1_4	733	738	PF00397	0.529
DOC_WW_Pin1_4	896	901	PF00397	0.360
LIG_14-3-3_CanoR_1	180	190	PF00244	0.349
LIG_14-3-3_CanoR_1	245	253	PF00244	0.441
LIG_14-3-3_CanoR_1	29	38	PF00244	0.812
LIG_14-3-3_CanoR_1	408	412	PF00244	0.405
LIG_14-3-3_CanoR_1	625	634	PF00244	0.566
LIG_APCC_ABBA_1	315	320	PF00400	0.366
LIG_BIR_III_4	442	446	PF00653	0.489
LIG_BIR_III_4	857	861	PF00653	0.320
LIG_BRCT_BRCA1_1	212	216	PF00533	0.467
LIG_BRCT_BRCA1_1	527	531	PF00533	0.307
LIG_BRCT_BRCA1_1	61	65	PF00533	0.317
LIG_CtBP_PxDLS_1	725	729	PF00389	0.431
LIG_deltaCOP1_diTrp_1	499	507	PF00928	0.377
LIG_EH1_1	53	61	PF00400	0.443
LIG_FHA_1	139	145	PF00498	0.591
LIG_FHA_1	409	415	PF00498	0.324
LIG_FHA_1	516	522	PF00498	0.444
LIG_FHA_1	570	576	PF00498	0.542
LIG_FHA_1	633	639	PF00498	0.423
LIG_FHA_1	656	662	PF00498	0.317
LIG_FHA_1	693	699	PF00498	0.416
LIG_FHA_1	733	739	PF00498	0.419
LIG_FHA_1	752	758	PF00498	0.324
LIG_FHA_1	846	852	PF00498	0.465
LIG_FHA_1	860	866	PF00498	0.216
LIG_FHA_2	194	200	PF00498	0.508
LIG_FHA_2	50	56	PF00498	0.669
LIG_FHA_2	544	550	PF00498	0.457
LIG_FHA_2	626	632	PF00498	0.536
LIG_FHA_2	719	725	PF00498	0.517
LIG_FHA_2	759	765	PF00498	0.475
LIG_LIR_Apic_2	158	164	PF02991	0.438
LIG_LIR_Apic_2	184	189	PF02991	0.470
LIG_LIR_Apic_2	407	412	PF02991	0.473
LIG_LIR_Apic_2	660	666	PF02991	0.370
LIG_LIR_Gen_1	117	127	PF02991	0.437
LIG_LIR_Gen_1	139	148	PF02991	0.451
LIG_LIR_Gen_1	311	318	PF02991	0.306
LIG_LIR_Gen_1	650	659	PF02991	0.406
LIG_LIR_Gen_1	96	104	PF02991	0.372
LIG_LIR_Nem_3	117	122	PF02991	0.441
LIG_LIR_Nem_3	139	145	PF02991	0.477
LIG_LIR_Nem_3	213	219	PF02991	0.379
LIG_LIR_Nem_3	311	317	PF02991	0.297
LIG_LIR_Nem_3	332	338	PF02991	0.382
LIG_LIR_Nem_3	650	655	PF02991	0.399
LIG_LIR_Nem_3	96	100	PF02991	0.370
LIG_NRBOX	594	600	PF00104	0.347
LIG_NRBOX	838	844	PF00104	0.470
LIG_PCNA_yPIPBox_3	794	803	PF02747	0.391
LIG_Pex14_1	310	314	PF04695	0.414
LIG_Pex14_1	507	511	PF04695	0.429
LIG_Pex14_2	314	318	PF04695	0.426
LIG_SH2_CRK	142	146	PF00017	0.601
LIG_SH2_CRK	240	244	PF00017	0.476
LIG_SH2_CRK	409	413	PF00017	0.482
LIG_SH2_CRK	652	656	PF00017	0.515
LIG_SH2_CRK	788	792	PF00017	0.341
LIG_SH2_GRB2like	652	655	PF00017	0.518
LIG_SH2_GRB2like	893	896	PF00017	0.284
LIG_SH2_NCK_1	142	146	PF00017	0.599
LIG_SH2_NCK_1	788	792	PF00017	0.365
LIG_SH2_PTP2	596	599	PF00017	0.343
LIG_SH2_STAP1	247	251	PF00017	0.418
LIG_SH2_STAP1	336	340	PF00017	0.522
LIG_SH2_STAP1	555	559	PF00017	0.305
LIG_SH2_STAP1	673	677	PF00017	0.439
LIG_SH2_STAP1	775	779	PF00017	0.366
LIG_SH2_STAP1	788	792	PF00017	0.341
LIG_SH2_STAP1	893	897	PF00017	0.284
LIG_SH2_STAT5	130	133	PF00017	0.544
LIG_SH2_STAT5	420	423	PF00017	0.522
LIG_SH2_STAT5	596	599	PF00017	0.411
LIG_SH2_STAT5	826	829	PF00017	0.480
LIG_SH3_2	904	909	PF14604	0.512
LIG_SH3_3	184	190	PF00018	0.506
LIG_SH3_3	34	40	PF00018	0.584
LIG_SH3_3	719	725	PF00018	0.567
LIG_SH3_3	780	786	PF00018	0.539
LIG_SH3_3	901	907	PF00018	0.358
LIG_SUMO_SIM_anti_2	574	579	PF11976	0.443
LIG_SUMO_SIM_par_1	655	660	PF11976	0.470
LIG_SUMO_SIM_par_1	693	700	PF11976	0.340
LIG_SUMO_SIM_par_1	727	733	PF11976	0.464
LIG_SUMO_SIM_par_1	846	853	PF11976	0.416
LIG_TRAF2_1	172	175	PF00917	0.534
LIG_TRFH_1	186	190	PF08558	0.320
LIG_UBA3_1	530	536	PF00899	0.401
LIG_UBA3_1	638	647	PF00899	0.397
LIG_WRC_WIRS_1	775	780	PF05994	0.403
LIG_WW_1	890	893	PF00397	0.400
MOD_CK1_1	197	203	PF00069	0.650
MOD_CK1_1	276	282	PF00069	0.595
MOD_CK1_1	32	38	PF00069	0.770
MOD_CK1_1	407	413	PF00069	0.496
MOD_CK1_1	49	55	PF00069	0.579
MOD_CK1_1	586	592	PF00069	0.357
MOD_CK1_1	632	638	PF00069	0.504
MOD_CK2_1	193	199	PF00069	0.458
MOD_CK2_1	625	631	PF00069	0.525
MOD_CK2_1	881	887	PF00069	0.179
MOD_Cter_Amidation	14	17	PF01082	0.785
MOD_Cter_Amidation	243	246	PF01082	0.332
MOD_Cter_Amidation	614	617	PF01082	0.535
MOD_DYRK1A_RPxSP_1	36	40	PF00069	0.535
MOD_GlcNHglycan	104	107	PF01048	0.487
MOD_GlcNHglycan	174	179	PF01048	0.480
MOD_GlcNHglycan	183	186	PF01048	0.438
MOD_GlcNHglycan	267	270	PF01048	0.568
MOD_GlcNHglycan	275	278	PF01048	0.596
MOD_GlcNHglycan	279	282	PF01048	0.580
MOD_GlcNHglycan	326	330	PF01048	0.509
MOD_GlcNHglycan	354	358	PF01048	0.632
MOD_GlcNHglycan	442	446	PF01048	0.409
MOD_GlcNHglycan	569	572	PF01048	0.607
MOD_GlcNHglycan	585	588	PF01048	0.319
MOD_GlcNHglycan	8	11	PF01048	0.665
MOD_GSK3_1	132	139	PF00069	0.507
MOD_GSK3_1	193	200	PF00069	0.506
MOD_GSK3_1	2	9	PF00069	0.684
MOD_GSK3_1	273	280	PF00069	0.658
MOD_GSK3_1	287	294	PF00069	0.623
MOD_GSK3_1	32	39	PF00069	0.784
MOD_GSK3_1	404	411	PF00069	0.338
MOD_GSK3_1	42	49	PF00069	0.740
MOD_GSK3_1	515	522	PF00069	0.399
MOD_GSK3_1	543	550	PF00069	0.516
MOD_GSK3_1	55	62	PF00069	0.497
MOD_GSK3_1	583	590	PF00069	0.414
MOD_GSK3_1	625	632	PF00069	0.527
MOD_GSK3_1	655	662	PF00069	0.501
MOD_GSK3_1	763	770	PF00069	0.434
MOD_GSK3_1	843	850	PF00069	0.312
MOD_N-GLC_1	136	141	PF02516	0.543
MOD_N-GLC_1	2	7	PF02516	0.522
MOD_N-GLC_1	30	35	PF02516	0.585
MOD_N-GLC_1	42	47	PF02516	0.648
MOD_N-GLC_1	751	756	PF02516	0.507
MOD_N-GLC_1	917	922	PF02516	0.442
MOD_NEK2_1	1	6	PF00069	0.750
MOD_NEK2_1	301	306	PF00069	0.375
MOD_NEK2_1	309	314	PF00069	0.323
MOD_NEK2_1	318	323	PF00069	0.311
MOD_NEK2_1	325	330	PF00069	0.395
MOD_NEK2_1	404	409	PF00069	0.439
MOD_NEK2_1	515	520	PF00069	0.400
MOD_NEK2_1	598	603	PF00069	0.505
MOD_NEK2_1	620	625	PF00069	0.512
MOD_NEK2_1	65	70	PF00069	0.560
MOD_NEK2_1	657	662	PF00069	0.451
MOD_NEK2_1	705	710	PF00069	0.386
MOD_NEK2_1	732	737	PF00069	0.477
MOD_NEK2_1	820	825	PF00069	0.348
MOD_NEK2_1	843	848	PF00069	0.404
MOD_NEK2_2	686	691	PF00069	0.468
MOD_OFUCOSY	306	313	PF10250	0.223
MOD_PIKK_1	110	116	PF00454	0.343
MOD_PIKK_1	197	203	PF00454	0.614
MOD_PIKK_1	245	251	PF00454	0.383
MOD_PIKK_1	318	324	PF00454	0.401
MOD_PIKK_1	38	44	PF00454	0.689
MOD_PIKK_1	515	521	PF00454	0.315
MOD_PIKK_1	599	605	PF00454	0.262
MOD_PIKK_1	625	631	PF00454	0.463
MOD_PKA_1	21	27	PF00069	0.661
MOD_PKA_1	245	251	PF00069	0.302
MOD_PKA_1	6	12	PF00069	0.706
MOD_PKA_2	1	7	PF00069	0.814
MOD_PKA_2	21	27	PF00069	0.704
MOD_PKA_2	245	251	PF00069	0.410
MOD_PKA_2	407	413	PF00069	0.548
MOD_PKA_2	461	467	PF00069	0.432
MOD_Plk_1	100	106	PF00069	0.377
MOD_Plk_1	157	163	PF00069	0.443
MOD_Plk_1	452	458	PF00069	0.366
MOD_Plk_1	630	636	PF00069	0.552
MOD_Plk_1	917	923	PF00069	0.474
MOD_Plk_4	140	146	PF00069	0.465
MOD_Plk_4	166	172	PF00069	0.418
MOD_Plk_4	55	61	PF00069	0.466
MOD_Plk_4	659	665	PF00069	0.408
MOD_Plk_4	774	780	PF00069	0.319
MOD_Plk_4	850	856	PF00069	0.350
MOD_Plk_4	917	923	PF00069	0.385
MOD_ProDKin_1	132	138	PF00069	0.504
MOD_ProDKin_1	291	297	PF00069	0.459
MOD_ProDKin_1	36	42	PF00069	0.757
MOD_ProDKin_1	408	414	PF00069	0.496
MOD_ProDKin_1	49	55	PF00069	0.690
MOD_ProDKin_1	519	525	PF00069	0.561
MOD_ProDKin_1	718	724	PF00069	0.554
MOD_ProDKin_1	733	739	PF00069	0.526
MOD_ProDKin_1	896	902	PF00069	0.360
MOD_SUMO_rev_2	549	554	PF00179	0.539
MOD_SUMO_rev_2	640	648	PF00179	0.409
TRG_ENDOCYTIC_2	142	145	PF00928	0.452
TRG_ENDOCYTIC_2	240	243	PF00928	0.469
TRG_ENDOCYTIC_2	596	599	PF00928	0.375
TRG_ENDOCYTIC_2	652	655	PF00928	0.453
TRG_ENDOCYTIC_2	775	778	PF00928	0.324
TRG_ENDOCYTIC_2	788	791	PF00928	0.423
TRG_ER_diArg_1	14	17	PF00400	0.715
TRG_ER_diArg_1	214	216	PF00400	0.386
TRG_ER_diArg_1	245	247	PF00400	0.296
TRG_ER_diArg_1	429	431	PF00400	0.499
TRG_ER_diArg_1	865	867	PF00400	0.312
TRG_NES_CRM1_1	733	747	PF08389	0.397
TRG_NLS_MonoExtN_4	907	913	PF00514	0.496
TRG_Pf-PMV_PEXEL_1	743	747	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S2	Leptomonas seymouri	61%	100%
A0A0S4J4W5	Bodo saltans	35%	100%
A0A1X0NHZ8	Trypanosomatidae	33%	100%
A0A3R7M5Z2	Trypanosoma rangeli	37%	100%
A0A3S7X4Q3	Leishmania donovani	87%	100%
A4HJJ5	Leishmania braziliensis	73%	100%
A4I6Z2	Leishmania infantum	87%	100%
Q4Q648	Leishmania major	88%	100%