Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B212_LEIMU

TriTrypDb:

LmxM.30.2120

Length:

767

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B212

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B212

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.684
CLV_C14_Caspase3-7	66	70	PF00656	0.686
CLV_C14_Caspase3-7	745	749	PF00656	0.518
CLV_NRD_NRD_1	127	129	PF00675	0.635
CLV_NRD_NRD_1	40	42	PF00675	0.644
CLV_NRD_NRD_1	408	410	PF00675	0.648
CLV_NRD_NRD_1	88	90	PF00675	0.518
CLV_PCSK_FUR_1	40	44	PF00082	0.700
CLV_PCSK_KEX2_1	40	42	PF00082	0.688
CLV_PCSK_KEX2_1	408	410	PF00082	0.616
CLV_PCSK_KEX2_1	88	90	PF00082	0.518
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.707
CLV_PCSK_SKI1_1	200	204	PF00082	0.686
CLV_PCSK_SKI1_1	689	693	PF00082	0.726
DEG_APCC_DBOX_1	57	65	PF00400	0.690
DEG_APCC_DBOX_1	749	757	PF00400	0.505
DEG_Nend_UBRbox_2	1	3	PF02207	0.635
DEG_SCF_FBW7_1	148	154	PF00400	0.718
DEG_SPOP_SBC_1	72	76	PF00917	0.612
DOC_CDC14_PxL_1	134	142	PF14671	0.675
DOC_CDC14_PxL_1	395	403	PF14671	0.515
DOC_CKS1_1	148	153	PF01111	0.719
DOC_CKS1_1	526	531	PF01111	0.691
DOC_CYCLIN_RxL_1	197	205	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	706	712	PF00134	0.627
DOC_MAPK_DCC_7	750	758	PF00069	0.501
DOC_MAPK_gen_1	15	22	PF00069	0.577
DOC_MAPK_gen_1	56	63	PF00069	0.553
DOC_MAPK_gen_1	705	713	PF00069	0.626
DOC_MAPK_gen_1	88	95	PF00069	0.681
DOC_MAPK_JIP1_4	4	10	PF00069	0.492
DOC_MAPK_MEF2A_6	4	12	PF00069	0.487
DOC_MAPK_MEF2A_6	56	63	PF00069	0.553
DOC_MAPK_MEF2A_6	705	713	PF00069	0.626
DOC_PP1_SILK_1	124	129	PF00149	0.682
DOC_PP2B_LxvP_1	119	122	PF13499	0.631
DOC_PP2B_LxvP_1	241	244	PF13499	0.638
DOC_PP4_FxxP_1	535	538	PF00568	0.598
DOC_USP7_MATH_1	122	126	PF00917	0.646
DOC_USP7_MATH_1	166	170	PF00917	0.703
DOC_USP7_MATH_1	189	193	PF00917	0.657
DOC_USP7_MATH_1	347	351	PF00917	0.550
DOC_USP7_MATH_1	435	439	PF00917	0.571
DOC_USP7_MATH_1	567	571	PF00917	0.685
DOC_USP7_MATH_1	600	604	PF00917	0.691
DOC_USP7_MATH_1	617	621	PF00917	0.548
DOC_USP7_MATH_1	628	632	PF00917	0.621
DOC_USP7_MATH_1	685	689	PF00917	0.782
DOC_USP7_MATH_1	712	716	PF00917	0.663
DOC_USP7_UBL2_3	732	736	PF12436	0.579
DOC_USP7_UBL2_3	763	767	PF12436	0.561
DOC_WW_Pin1_4	144	149	PF00397	0.703
DOC_WW_Pin1_4	151	156	PF00397	0.652
DOC_WW_Pin1_4	185	190	PF00397	0.547
DOC_WW_Pin1_4	202	207	PF00397	0.659
DOC_WW_Pin1_4	268	273	PF00397	0.657
DOC_WW_Pin1_4	338	343	PF00397	0.695
DOC_WW_Pin1_4	402	407	PF00397	0.663
DOC_WW_Pin1_4	462	467	PF00397	0.736
DOC_WW_Pin1_4	489	494	PF00397	0.802
DOC_WW_Pin1_4	502	507	PF00397	0.662
DOC_WW_Pin1_4	509	514	PF00397	0.530
DOC_WW_Pin1_4	522	527	PF00397	0.673
DOC_WW_Pin1_4	536	541	PF00397	0.633
DOC_WW_Pin1_4	674	679	PF00397	0.806
DOC_WW_Pin1_4	680	685	PF00397	0.787
LIG_14-3-3_CanoR_1	128	134	PF00244	0.624
LIG_14-3-3_CanoR_1	190	198	PF00244	0.665
LIG_14-3-3_CanoR_1	200	206	PF00244	0.601
LIG_14-3-3_CanoR_1	58	64	PF00244	0.602
LIG_14-3-3_CanoR_1	623	632	PF00244	0.592
LIG_14-3-3_CanoR_1	649	654	PF00244	0.704
LIG_14-3-3_CanoR_1	696	706	PF00244	0.637
LIG_14-3-3_CanoR_1	750	754	PF00244	0.611
LIG_Actin_WH2_2	114	130	PF00022	0.677
LIG_APCC_ABBAyCdc20_2	428	434	PF00400	0.677
LIG_BRCT_BRCA1_1	91	95	PF00533	0.698
LIG_Clathr_ClatBox_1	140	144	PF01394	0.678
LIG_FHA_1	229	235	PF00498	0.587
LIG_FHA_1	529	535	PF00498	0.708
LIG_FHA_1	587	593	PF00498	0.590
LIG_FHA_1	624	630	PF00498	0.720
LIG_FHA_2	405	411	PF00498	0.667
LIG_FHA_2	597	603	PF00498	0.599
LIG_FXI_DFP_1	140	144	PF00024	0.628
LIG_LIR_Apic_2	142	148	PF02991	0.695
LIG_LIR_Apic_2	520	526	PF02991	0.695
LIG_LIR_Apic_2	533	538	PF02991	0.578
LIG_LIR_Gen_1	520	529	PF02991	0.690
LIG_LIR_Gen_1	544	552	PF02991	0.519
LIG_LIR_Gen_1	575	583	PF02991	0.478
LIG_LIR_Nem_3	310	315	PF02991	0.654
LIG_LIR_Nem_3	392	396	PF02991	0.645
LIG_LIR_Nem_3	515	521	PF02991	0.705
LIG_LIR_Nem_3	544	549	PF02991	0.519
LIG_LIR_Nem_3	575	580	PF02991	0.480
LIG_MYND_1	32	36	PF01753	0.603
LIG_PAM2_1	109	121	PF00658	0.632
LIG_Pex14_2	582	586	PF04695	0.534
LIG_PTAP_UEV_1	264	269	PF05743	0.542
LIG_Rb_pABgroove_1	135	143	PF01858	0.674
LIG_Rb_pABgroove_1	416	424	PF01858	0.522
LIG_SH2_CRK	145	149	PF00017	0.654
LIG_SH2_CRK	18	22	PF00017	0.593
LIG_SH2_CRK	315	319	PF00017	0.681
LIG_SH2_CRK	396	400	PF00017	0.651
LIG_SH2_CRK	422	426	PF00017	0.526
LIG_SH2_CRK	577	581	PF00017	0.659
LIG_SH2_CRK	759	763	PF00017	0.566
LIG_SH2_NCK_1	396	400	PF00017	0.513
LIG_SH2_NCK_1	422	426	PF00017	0.526
LIG_SH2_PTP2	523	526	PF00017	0.693
LIG_SH2_SRC	18	21	PF00017	0.598
LIG_SH2_SRC	521	524	PF00017	0.707
LIG_SH2_STAP1	422	426	PF00017	0.526
LIG_SH2_STAP1	470	474	PF00017	0.579
LIG_SH2_STAP1	588	592	PF00017	0.504
LIG_SH2_STAT3	450	453	PF00017	0.690
LIG_SH2_STAT3	552	555	PF00017	0.593
LIG_SH2_STAT5	447	450	PF00017	0.685
LIG_SH2_STAT5	523	526	PF00017	0.693
LIG_SH2_STAT5	577	580	PF00017	0.479
LIG_SH2_STAT5	588	591	PF00017	0.487
LIG_SH2_STAT5	757	760	PF00017	0.620
LIG_SH3_1	145	151	PF00018	0.707
LIG_SH3_1	152	158	PF00018	0.654
LIG_SH3_1	262	268	PF00018	0.686
LIG_SH3_1	523	529	PF00018	0.688
LIG_SH3_3	145	151	PF00018	0.707
LIG_SH3_3	152	158	PF00018	0.654
LIG_SH3_3	26	32	PF00018	0.568
LIG_SH3_3	262	268	PF00018	0.691
LIG_SH3_3	284	290	PF00018	0.698
LIG_SH3_3	363	369	PF00018	0.550
LIG_SH3_3	479	485	PF00018	0.680
LIG_SH3_3	48	54	PF00018	0.624
LIG_SH3_3	507	513	PF00018	0.679
LIG_SH3_3	523	529	PF00018	0.677
LIG_SH3_3	679	685	PF00018	0.847
LIG_SH3_3	706	712	PF00018	0.677
LIG_SH3_3	717	723	PF00018	0.541
LIG_SUMO_SIM_par_1	527	533	PF11976	0.646
LIG_SUMO_SIM_par_1	59	66	PF11976	0.553
LIG_TRAF2_1	179	182	PF00917	0.665
LIG_TRAF2_1	599	602	PF00917	0.626
LIG_WRC_WIRS_1	579	584	PF05994	0.482
LIG_WW_1	419	422	PF00397	0.510
LIG_WW_3	562	566	PF00397	0.606
MOD_CDC14_SPxK_1	677	680	PF00782	0.697
MOD_CDK_SPK_2	147	152	PF00069	0.714
MOD_CDK_SPK_2	185	190	PF00069	0.523
MOD_CDK_SPK_2	489	494	PF00069	0.554
MOD_CDK_SPK_2	509	514	PF00069	0.524
MOD_CDK_SPK_2	536	541	PF00069	0.538
MOD_CDK_SPxK_1	402	408	PF00069	0.591
MOD_CDK_SPxK_1	674	680	PF00069	0.709
MOD_CDK_SPxxK_3	402	409	PF00069	0.667
MOD_CK1_1	147	153	PF00069	0.716
MOD_CK1_1	165	171	PF00069	0.526
MOD_CK1_1	175	181	PF00069	0.624
MOD_CK1_1	185	191	PF00069	0.509
MOD_CK1_1	213	219	PF00069	0.705
MOD_CK1_1	254	260	PF00069	0.645
MOD_CK1_1	263	269	PF00069	0.581
MOD_CK1_1	276	282	PF00069	0.545
MOD_CK1_1	359	365	PF00069	0.585
MOD_CK1_1	386	392	PF00069	0.682
MOD_CK1_1	397	403	PF00069	0.579
MOD_CK1_1	495	501	PF00069	0.834
MOD_CK1_1	525	531	PF00069	0.558
MOD_CK1_1	539	545	PF00069	0.658
MOD_CK1_1	547	553	PF00069	0.644
MOD_CK1_1	603	609	PF00069	0.767
MOD_CK1_1	62	68	PF00069	0.676
MOD_CK1_1	622	628	PF00069	0.745
MOD_CK1_1	631	637	PF00069	0.670
MOD_CK1_1	647	653	PF00069	0.623
MOD_CK1_1	669	675	PF00069	0.691
MOD_CK1_1	73	79	PF00069	0.577
MOD_CK1_1	84	90	PF00069	0.551
MOD_CK2_1	151	157	PF00069	0.727
MOD_CK2_1	404	410	PF00069	0.667
MOD_CK2_1	435	441	PF00069	0.644
MOD_CK2_1	567	573	PF00069	0.656
MOD_CK2_1	596	602	PF00069	0.595
MOD_CK2_1	604	610	PF00069	0.589
MOD_CK2_1	621	627	PF00069	0.699
MOD_CK2_1	638	644	PF00069	0.581
MOD_CK2_1	651	657	PF00069	0.590
MOD_CK2_1	673	679	PF00069	0.694
MOD_CK2_1	698	704	PF00069	0.701
MOD_CK2_1	71	77	PF00069	0.615
MOD_CK2_1	712	718	PF00069	0.552
MOD_DYRK1A_RPxSP_1	462	466	PF00069	0.674
MOD_GlcNHglycan	130	133	PF01048	0.634
MOD_GlcNHglycan	164	167	PF01048	0.660
MOD_GlcNHglycan	172	177	PF01048	0.666
MOD_GlcNHglycan	192	195	PF01048	0.538
MOD_GlcNHglycan	262	265	PF01048	0.602
MOD_GlcNHglycan	291	294	PF01048	0.706
MOD_GlcNHglycan	331	334	PF01048	0.563
MOD_GlcNHglycan	455	458	PF01048	0.673
MOD_GlcNHglycan	475	479	PF01048	0.727
MOD_GlcNHglycan	668	671	PF01048	0.642
MOD_GlcNHglycan	742	745	PF01048	0.698
MOD_GlcNHglycan	83	86	PF01048	0.519
MOD_GSK3_1	147	154	PF00069	0.716
MOD_GSK3_1	162	169	PF00069	0.563
MOD_GSK3_1	185	192	PF00069	0.529
MOD_GSK3_1	209	216	PF00069	0.550
MOD_GSK3_1	228	235	PF00069	0.562
MOD_GSK3_1	256	263	PF00069	0.603
MOD_GSK3_1	307	314	PF00069	0.606
MOD_GSK3_1	334	341	PF00069	0.580
MOD_GSK3_1	343	350	PF00069	0.587
MOD_GSK3_1	355	362	PF00069	0.537
MOD_GSK3_1	410	417	PF00069	0.727
MOD_GSK3_1	492	499	PF00069	0.833
MOD_GSK3_1	524	531	PF00069	0.666
MOD_GSK3_1	596	603	PF00069	0.619
MOD_GSK3_1	604	611	PF00069	0.723
MOD_GSK3_1	617	624	PF00069	0.749
MOD_GSK3_1	627	634	PF00069	0.624
MOD_GSK3_1	640	647	PF00069	0.607
MOD_GSK3_1	669	676	PF00069	0.798
MOD_GSK3_1	680	687	PF00069	0.620
MOD_GSK3_1	72	79	PF00069	0.629
MOD_GSK3_1	740	747	PF00069	0.653
MOD_GSK3_1	89	96	PF00069	0.514
MOD_N-GLC_1	213	218	PF02516	0.684
MOD_N-GLC_1	334	339	PF02516	0.565
MOD_N-GLC_1	414	419	PF02516	0.535
MOD_N-GLC_1	644	649	PF02516	0.685
MOD_NEK2_1	127	132	PF00069	0.621
MOD_NEK2_1	234	239	PF00069	0.542
MOD_NEK2_1	311	316	PF00069	0.522
MOD_NEK2_1	474	479	PF00069	0.710
MOD_NEK2_1	648	653	PF00069	0.724
MOD_NEK2_1	81	86	PF00069	0.665
MOD_NEK2_2	307	312	PF00069	0.510
MOD_NEK2_2	347	352	PF00069	0.551
MOD_NEK2_2	427	432	PF00069	0.535
MOD_NEK2_2	567	572	PF00069	0.658
MOD_PIKK_1	166	172	PF00454	0.716
MOD_PIKK_1	492	498	PF00454	0.794
MOD_PIKK_1	669	675	PF00454	0.691
MOD_PK_1	649	655	PF00069	0.613
MOD_PK_1	698	704	PF00069	0.651
MOD_PK_1	89	95	PF00069	0.511
MOD_PKA_1	128	134	PF00069	0.637
MOD_PKA_2	127	133	PF00069	0.622
MOD_PKA_2	189	195	PF00069	0.661
MOD_PKA_2	209	215	PF00069	0.522
MOD_PKA_2	622	628	PF00069	0.604
MOD_PKA_2	648	654	PF00069	0.633
MOD_PKA_2	697	703	PF00069	0.654
MOD_PKA_2	749	755	PF00069	0.610
MOD_PKB_1	696	704	PF00069	0.469
MOD_Plk_1	414	420	PF00069	0.664
MOD_Plk_1	474	480	PF00069	0.758
MOD_Plk_1	600	606	PF00069	0.738
MOD_Plk_1	644	650	PF00069	0.670
MOD_Plk_1	89	95	PF00069	0.559
MOD_Plk_2-3	334	340	PF00069	0.563
MOD_Plk_4	122	128	PF00069	0.682
MOD_Plk_4	307	313	PF00069	0.509
MOD_Plk_4	530	536	PF00069	0.761
MOD_Plk_4	575	581	PF00069	0.707
MOD_Plk_4	59	65	PF00069	0.563
MOD_ProDKin_1	144	150	PF00069	0.705
MOD_ProDKin_1	151	157	PF00069	0.652
MOD_ProDKin_1	185	191	PF00069	0.547
MOD_ProDKin_1	202	208	PF00069	0.658
MOD_ProDKin_1	268	274	PF00069	0.659
MOD_ProDKin_1	338	344	PF00069	0.695
MOD_ProDKin_1	402	408	PF00069	0.666
MOD_ProDKin_1	462	468	PF00069	0.735
MOD_ProDKin_1	489	495	PF00069	0.803
MOD_ProDKin_1	502	508	PF00069	0.661
MOD_ProDKin_1	509	515	PF00069	0.530
MOD_ProDKin_1	522	528	PF00069	0.671
MOD_ProDKin_1	536	542	PF00069	0.630
MOD_ProDKin_1	674	680	PF00069	0.808
MOD_SUMO_for_1	179	182	PF00179	0.665
MOD_SUMO_rev_2	142	148	PF00179	0.645
MOD_SUMO_rev_2	168	176	PF00179	0.622
MOD_SUMO_rev_2	377	381	PF00179	0.713
TRG_DiLeu_BaEn_1	439	444	PF01217	0.625
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.530
TRG_DiLeu_BaLyEn_6	706	711	PF01217	0.635
TRG_ENDOCYTIC_2	308	311	PF00928	0.654
TRG_ENDOCYTIC_2	315	318	PF00928	0.674
TRG_ENDOCYTIC_2	422	425	PF00928	0.524
TRG_ENDOCYTIC_2	521	524	PF00928	0.707
TRG_ENDOCYTIC_2	577	580	PF00928	0.616
TRG_ER_diArg_1	40	43	PF00400	0.648
TRG_ER_diArg_1	56	59	PF00400	0.557
TRG_ER_diLys_1	763	767	PF00400	0.611
TRG_NLS_MonoExtN_4	38	45	PF00514	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEZ8	Leishmania donovani	81%	100%
A4HJJ4	Leishmania braziliensis	52%	100%
A4I6Z1	Leishmania infantum	81%	100%
Q4Q649	Leishmania major	78%	99%