Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leishmania development 1 protein

Species:

Leishmania mexicana

UniProt:

E9B208_LEIMU

TriTrypDb:

LmxM.30.2090

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B208

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B208

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.625
CLV_NRD_NRD_1	15	17	PF00675	0.680
CLV_NRD_NRD_1	176	178	PF00675	0.614
CLV_NRD_NRD_1	191	193	PF00675	0.555
CLV_NRD_NRD_1	203	205	PF00675	0.640
CLV_NRD_NRD_1	211	213	PF00675	0.532
CLV_NRD_NRD_1	28	30	PF00675	0.666
CLV_NRD_NRD_1	57	59	PF00675	0.732
CLV_PCSK_KEX2_1	15	17	PF00082	0.667
CLV_PCSK_KEX2_1	203	205	PF00082	0.633
CLV_PCSK_KEX2_1	211	213	PF00082	0.528
CLV_PCSK_KEX2_1	28	30	PF00082	0.670
CLV_PCSK_KEX2_1	57	59	PF00082	0.626
CLV_PCSK_SKI1_1	204	208	PF00082	0.574
CLV_PCSK_SKI1_1	212	216	PF00082	0.583
CLV_PCSK_SKI1_1	283	287	PF00082	0.573
CLV_PCSK_SKI1_1	290	294	PF00082	0.556
DEG_APCC_DBOX_1	191	199	PF00400	0.575
DEG_SCF_FBW7_1	227	234	PF00400	0.756
DOC_MAPK_gen_1	200	209	PF00069	0.684
DOC_PP4_FxxP_1	163	166	PF00568	0.711
DOC_USP7_MATH_1	125	129	PF00917	0.718
DOC_USP7_MATH_1	27	31	PF00917	0.765
DOC_USP7_MATH_1	272	276	PF00917	0.794
DOC_USP7_MATH_1	321	325	PF00917	0.698
DOC_USP7_MATH_1	377	381	PF00917	0.517
DOC_WW_Pin1_4	140	145	PF00397	0.815
DOC_WW_Pin1_4	146	151	PF00397	0.682
DOC_WW_Pin1_4	19	24	PF00397	0.760
DOC_WW_Pin1_4	227	232	PF00397	0.752
DOC_WW_Pin1_4	266	271	PF00397	0.675
LIG_14-3-3_CanoR_1	177	182	PF00244	0.630
LIG_14-3-3_CanoR_1	18	23	PF00244	0.746
LIG_14-3-3_CanoR_1	204	210	PF00244	0.715
LIG_14-3-3_CanoR_1	278	286	PF00244	0.559
LIG_14-3-3_CanoR_1	28	36	PF00244	0.812
LIG_14-3-3_CanoR_1	290	299	PF00244	0.601
LIG_14-3-3_CanoR_1	334	343	PF00244	0.710
LIG_14-3-3_CanoR_1	47	56	PF00244	0.495
LIG_Clathr_ClatBox_1	285	289	PF01394	0.561
LIG_CtBP_PxDLS_1	124	128	PF00389	0.711
LIG_DLG_GKlike_1	177	184	PF00625	0.505
LIG_FHA_1	127	133	PF00498	0.522
LIG_FHA_2	356	362	PF00498	0.541
LIG_LIR_Apic_2	161	166	PF02991	0.714
LIG_LIR_Gen_1	180	188	PF02991	0.685
LIG_LIR_Gen_1	241	249	PF02991	0.590
LIG_LIR_Gen_1	64	71	PF02991	0.660
LIG_LIR_Gen_1	96	103	PF02991	0.658
LIG_LIR_LC3C_4	308	312	PF02991	0.438
LIG_LIR_Nem_3	180	184	PF02991	0.718
LIG_LIR_Nem_3	241	246	PF02991	0.590
LIG_LIR_Nem_3	64	70	PF02991	0.680
LIG_LIR_Nem_3	96	102	PF02991	0.549
LIG_PCNA_PIPBox_1	183	192	PF02747	0.602
LIG_PDZ_Class_1	377	382	PF00595	0.736
LIG_Pex14_2	243	247	PF04695	0.665
LIG_Pex14_2	322	326	PF04695	0.589
LIG_SH2_CRK	67	71	PF00017	0.553
LIG_SH2_NCK_1	63	67	PF00017	0.584
LIG_SH2_SRC	63	66	PF00017	0.478
LIG_SH2_STAP1	67	71	PF00017	0.686
LIG_SH2_STAT5	162	165	PF00017	0.624
LIG_SH2_STAT5	233	236	PF00017	0.612
LIG_SH2_STAT5	284	287	PF00017	0.540
LIG_SH3_3	119	125	PF00018	0.616
LIG_SH3_3	138	144	PF00018	0.762
LIG_SH3_3	340	346	PF00018	0.675
LIG_SH3_3	360	366	PF00018	0.714
LIG_SH3_5	158	162	PF00018	0.719
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.439
LIG_SUMO_SIM_anti_2	72	81	PF11976	0.543
LIG_SUMO_SIM_par_1	205	210	PF11976	0.674
LIG_SUMO_SIM_par_1	308	314	PF11976	0.439
LIG_TRAF2_1	337	340	PF00917	0.487
LIG_TRAF2_1	95	98	PF00917	0.557
MOD_CK1_1	149	155	PF00069	0.804
MOD_CK1_1	21	27	PF00069	0.691
MOD_CK1_1	30	36	PF00069	0.793
MOD_CK1_1	50	56	PF00069	0.490
MOD_CK2_1	188	194	PF00069	0.588
MOD_CK2_1	31	37	PF00069	0.659
MOD_CK2_1	333	339	PF00069	0.693
MOD_CMANNOS	326	329	PF00535	0.593
MOD_GlcNHglycan	280	283	PF01048	0.669
MOD_GlcNHglycan	323	326	PF01048	0.731
MOD_GlcNHglycan	350	353	PF01048	0.680
MOD_GlcNHglycan	379	382	PF01048	0.660
MOD_GSK3_1	173	180	PF00069	0.690
MOD_GSK3_1	227	234	PF00069	0.756
MOD_GSK3_1	27	34	PF00069	0.761
MOD_GSK3_1	284	291	PF00069	0.647
MOD_GSK3_1	311	318	PF00069	0.728
MOD_LATS_1	26	32	PF00433	0.647
MOD_N-GLC_1	278	283	PF02516	0.512
MOD_NEK2_1	173	178	PF00069	0.630
MOD_NEK2_2	115	120	PF00069	0.593
MOD_PIKK_1	179	185	PF00454	0.707
MOD_PIKK_1	21	27	PF00454	0.548
MOD_PIKK_1	247	253	PF00454	0.673
MOD_PIKK_1	50	56	PF00454	0.640
MOD_PKA_1	177	183	PF00069	0.600
MOD_PKA_1	28	34	PF00069	0.620
MOD_PKA_2	27	33	PF00069	0.673
MOD_PKA_2	277	283	PF00069	0.509
MOD_PKA_2	333	339	PF00069	0.617
MOD_PKA_2	48	54	PF00069	0.760
MOD_PKB_1	16	24	PF00069	0.566
MOD_Plk_1	125	131	PF00069	0.619
MOD_Plk_1	288	294	PF00069	0.663
MOD_Plk_1	97	103	PF00069	0.444
MOD_Plk_4	75	81	PF00069	0.525
MOD_ProDKin_1	140	146	PF00069	0.817
MOD_ProDKin_1	19	25	PF00069	0.761
MOD_ProDKin_1	227	233	PF00069	0.754
MOD_ProDKin_1	266	272	PF00069	0.673
MOD_SUMO_rev_2	336	344	PF00179	0.712
TRG_DiLeu_BaEn_3	339	345	PF01217	0.504
TRG_ENDOCYTIC_2	67	70	PF00928	0.558
TRG_ER_diArg_1	15	18	PF00400	0.620
TRG_ER_diArg_1	184	187	PF00400	0.723
TRG_ER_diArg_1	27	29	PF00400	0.567
TRG_ER_diArg_1	46	49	PF00400	0.799
TRG_ER_diArg_1	56	58	PF00400	0.611
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I674	Leptomonas seymouri	44%	75%
A0A3Q8IGG7	Leishmania donovani	86%	100%
A4I6Y7	Leishmania infantum	86%	100%
Q4Q653	Leishmania major	87%	100%