Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B207_LEIMU

TriTrypDb:

LmxM.30.2080

Length:

807

Annotations

LeishMANIAdb annotations

A bacterial-type Mg2+ transporter found in kinetoplastids.. Expanded extensively on multiple lineages, especially T cruzi

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B207

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B207

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.464
CLV_C14_Caspase3-7	330	334	PF00656	0.394
CLV_C14_Caspase3-7	43	47	PF00656	0.441
CLV_C14_Caspase3-7	519	523	PF00656	0.604
CLV_C14_Caspase3-7	535	539	PF00656	0.497
CLV_C14_Caspase3-7	588	592	PF00656	0.707
CLV_C14_Caspase3-7	657	661	PF00656	0.704
CLV_NRD_NRD_1	10	12	PF00675	0.716
CLV_NRD_NRD_1	118	120	PF00675	0.641
CLV_NRD_NRD_1	23	25	PF00675	0.667
CLV_NRD_NRD_1	424	426	PF00675	0.684
CLV_NRD_NRD_1	51	53	PF00675	0.716
CLV_NRD_NRD_1	541	543	PF00675	0.450
CLV_NRD_NRD_1	548	550	PF00675	0.415
CLV_NRD_NRD_1	554	556	PF00675	0.368
CLV_NRD_NRD_1	800	802	PF00675	0.427
CLV_NRD_NRD_1	98	100	PF00675	0.740
CLV_PCSK_FUR_1	421	425	PF00082	0.727
CLV_PCSK_KEX2_1	118	120	PF00082	0.641
CLV_PCSK_KEX2_1	23	25	PF00082	0.649
CLV_PCSK_KEX2_1	271	273	PF00082	0.751
CLV_PCSK_KEX2_1	423	425	PF00082	0.690
CLV_PCSK_KEX2_1	51	53	PF00082	0.716
CLV_PCSK_KEX2_1	541	543	PF00082	0.455
CLV_PCSK_KEX2_1	547	549	PF00082	0.457
CLV_PCSK_KEX2_1	554	556	PF00082	0.374
CLV_PCSK_KEX2_1	98	100	PF00082	0.740
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.751
CLV_PCSK_SKI1_1	136	140	PF00082	0.702
CLV_PCSK_SKI1_1	362	366	PF00082	0.747
CLV_PCSK_SKI1_1	452	456	PF00082	0.581
CLV_PCSK_SKI1_1	541	545	PF00082	0.415
CLV_PCSK_SKI1_1	554	558	PF00082	0.306
CLV_PCSK_SKI1_1	580	584	PF00082	0.467
DEG_APCC_DBOX_1	237	245	PF00400	0.513
DEG_SPOP_SBC_1	109	113	PF00917	0.520
DOC_CKS1_1	686	691	PF01111	0.588
DOC_MAPK_gen_1	23	31	PF00069	0.449
DOC_PP1_RVXF_1	552	559	PF00149	0.677
DOC_PP1_RVXF_1	721	727	PF00149	0.616
DOC_PP2B_LxvP_1	477	480	PF13499	0.533
DOC_USP7_MATH_1	109	113	PF00917	0.520
DOC_USP7_MATH_1	237	241	PF00917	0.510
DOC_USP7_MATH_1	300	304	PF00917	0.481
DOC_USP7_MATH_1	310	314	PF00917	0.474
DOC_USP7_MATH_1	410	414	PF00917	0.500
DOC_USP7_MATH_1	471	475	PF00917	0.480
DOC_USP7_MATH_1	663	667	PF00917	0.703
DOC_USP7_MATH_1	766	770	PF00917	0.314
DOC_WW_Pin1_4	251	256	PF00397	0.505
DOC_WW_Pin1_4	374	379	PF00397	0.517
DOC_WW_Pin1_4	460	465	PF00397	0.518
DOC_WW_Pin1_4	617	622	PF00397	0.646
DOC_WW_Pin1_4	679	684	PF00397	0.684
DOC_WW_Pin1_4	685	690	PF00397	0.619
DOC_WW_Pin1_4	771	776	PF00397	0.411
LIG_14-3-3_CanoR_1	101	107	PF00244	0.480
LIG_14-3-3_CanoR_1	11	17	PF00244	0.473
LIG_14-3-3_CanoR_1	238	242	PF00244	0.508
LIG_14-3-3_CanoR_1	314	321	PF00244	0.511
LIG_14-3-3_CanoR_1	351	357	PF00244	0.521
LIG_14-3-3_CanoR_1	362	369	PF00244	0.496
LIG_14-3-3_CanoR_1	39	45	PF00244	0.528
LIG_14-3-3_CanoR_1	51	56	PF00244	0.477
LIG_14-3-3_CanoR_1	577	583	PF00244	0.641
LIG_14-3-3_CanoR_1	587	594	PF00244	0.636
LIG_14-3-3_CanoR_1	730	738	PF00244	0.617
LIG_Actin_WH2_2	156	174	PF00022	0.513
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_BIR_III_2	660	664	PF00653	0.651
LIG_BRCT_BRCA1_1	129	133	PF00533	0.522
LIG_BRCT_BRCA1_1	589	593	PF00533	0.624
LIG_Clathr_ClatBox_1	527	531	PF01394	0.615
LIG_deltaCOP1_diTrp_1	328	335	PF00928	0.486
LIG_eIF4E_1	744	750	PF01652	0.348
LIG_FHA_1	160	166	PF00498	0.531
LIG_FHA_1	24	30	PF00498	0.447
LIG_FHA_1	280	286	PF00498	0.493
LIG_FHA_1	375	381	PF00498	0.502
LIG_FHA_1	388	394	PF00498	0.371
LIG_FHA_1	398	404	PF00498	0.424
LIG_FHA_1	484	490	PF00498	0.318
LIG_FHA_1	714	720	PF00498	0.525
LIG_FHA_1	798	804	PF00498	0.497
LIG_FHA_2	156	162	PF00498	0.488
LIG_FHA_2	220	226	PF00498	0.377
LIG_FHA_2	328	334	PF00498	0.486
LIG_FHA_2	402	408	PF00498	0.510
LIG_FHA_2	586	592	PF00498	0.703
LIG_FHA_2	674	680	PF00498	0.653
LIG_GBD_Chelix_1	285	293	PF00786	0.684
LIG_Integrin_RGD_1	677	679	PF01839	0.452
LIG_LIR_Apic_2	465	470	PF02991	0.455
LIG_LIR_Gen_1	207	217	PF02991	0.464
LIG_LIR_Gen_1	282	292	PF02991	0.490
LIG_LIR_Gen_1	439	448	PF02991	0.409
LIG_LIR_Gen_1	492	503	PF02991	0.442
LIG_LIR_Gen_1	736	746	PF02991	0.534
LIG_LIR_Gen_1	774	785	PF02991	0.305
LIG_LIR_Nem_3	180	185	PF02991	0.441
LIG_LIR_Nem_3	207	213	PF02991	0.464
LIG_LIR_Nem_3	282	287	PF02991	0.501
LIG_LIR_Nem_3	439	443	PF02991	0.417
LIG_LIR_Nem_3	446	451	PF02991	0.402
LIG_LIR_Nem_3	492	498	PF02991	0.442
LIG_LIR_Nem_3	502	508	PF02991	0.341
LIG_LIR_Nem_3	734	740	PF02991	0.605
LIG_LIR_Nem_3	773	779	PF02991	0.397
LIG_LIR_Nem_3	791	796	PF02991	0.218
LIG_NRBOX	288	294	PF00104	0.480
LIG_PAM2_1	750	762	PF00658	0.334
LIG_PDZ_Class_2	802	807	PF00595	0.661
LIG_Pex14_1	331	335	PF04695	0.483
LIG_PTB_Apo_2	16	23	PF02174	0.478
LIG_PTB_Phospho_1	16	22	PF10480	0.447
LIG_RPA_C_Fungi	543	555	PF08784	0.492
LIG_SH2_CRK	467	471	PF00017	0.565
LIG_SH2_CRK	505	509	PF00017	0.515
LIG_SH2_CRK	796	800	PF00017	0.348
LIG_SH2_NCK_1	106	110	PF00017	0.563
LIG_SH2_NCK_1	467	471	PF00017	0.565
LIG_SH2_PTP2	284	287	PF00017	0.615
LIG_SH2_PTP2	744	747	PF00017	0.388
LIG_SH2_SRC	804	807	PF00017	0.587
LIG_SH2_STAP1	131	135	PF00017	0.639
LIG_SH2_STAP1	245	249	PF00017	0.634
LIG_SH2_STAP1	720	724	PF00017	0.416
LIG_SH2_STAT3	453	456	PF00017	0.570
LIG_SH2_STAT5	106	109	PF00017	0.566
LIG_SH2_STAT5	284	287	PF00017	0.628
LIG_SH2_STAT5	384	387	PF00017	0.684
LIG_SH2_STAT5	436	439	PF00017	0.550
LIG_SH2_STAT5	507	510	PF00017	0.508
LIG_SH2_STAT5	720	723	PF00017	0.416
LIG_SH2_STAT5	744	747	PF00017	0.374
LIG_SH2_STAT5	798	801	PF00017	0.495
LIG_SH2_STAT5	804	807	PF00017	0.543
LIG_SH3_1	424	430	PF00018	0.644
LIG_SH3_3	187	193	PF00018	0.637
LIG_SH3_3	275	281	PF00018	0.645
LIG_SH3_3	383	389	PF00018	0.556
LIG_SH3_3	424	430	PF00018	0.671
LIG_SH3_3	677	683	PF00018	0.541
LIG_SH3_3	745	751	PF00018	0.388
LIG_SUMO_SIM_par_1	526	531	PF11976	0.498
LIG_TRAF2_1	430	433	PF00917	0.538
LIG_TRAF2_1	634	637	PF00917	0.517
LIG_TYR_ITIM	503	508	PF00017	0.348
MOD_CDK_SPxxK_3	251	258	PF00069	0.629
MOD_CDK_SPxxK_3	462	469	PF00069	0.655
MOD_CK1_1	110	116	PF00069	0.678
MOD_CK1_1	117	123	PF00069	0.633
MOD_CK1_1	15	21	PF00069	0.596
MOD_CK1_1	313	319	PF00069	0.571
MOD_CK1_1	354	360	PF00069	0.665
MOD_CK1_1	446	452	PF00069	0.515
MOD_CK1_1	458	464	PF00069	0.510
MOD_CK1_1	483	489	PF00069	0.359
MOD_CK1_1	581	587	PF00069	0.637
MOD_CK1_1	620	626	PF00069	0.596
MOD_CK1_1	70	76	PF00069	0.690
MOD_CK1_1	729	735	PF00069	0.489
MOD_CK2_1	219	225	PF00069	0.441
MOD_CK2_1	314	320	PF00069	0.757
MOD_GlcNHglycan	142	145	PF01048	0.640
MOD_GlcNHglycan	148	151	PF01048	0.597
MOD_GlcNHglycan	25	29	PF01048	0.579
MOD_GlcNHglycan	298	301	PF01048	0.599
MOD_GlcNHglycan	316	319	PF01048	0.558
MOD_GlcNHglycan	357	360	PF01048	0.612
MOD_GlcNHglycan	40	43	PF01048	0.635
MOD_GlcNHglycan	412	415	PF01048	0.604
MOD_GlcNHglycan	473	476	PF01048	0.734
MOD_GlcNHglycan	477	480	PF01048	0.687
MOD_GlcNHglycan	482	485	PF01048	0.610
MOD_GlcNHglycan	602	605	PF01048	0.620
MOD_GlcNHglycan	670	673	PF01048	0.572
MOD_GSK3_1	104	111	PF00069	0.677
MOD_GSK3_1	113	120	PF00069	0.608
MOD_GSK3_1	146	153	PF00069	0.774
MOD_GSK3_1	155	162	PF00069	0.643
MOD_GSK3_1	215	222	PF00069	0.578
MOD_GSK3_1	266	273	PF00069	0.678
MOD_GSK3_1	288	295	PF00069	0.657
MOD_GSK3_1	296	303	PF00069	0.685
MOD_GSK3_1	306	313	PF00069	0.552
MOD_GSK3_1	327	334	PF00069	0.554
MOD_GSK3_1	351	358	PF00069	0.634
MOD_GSK3_1	374	381	PF00069	0.664
MOD_GSK3_1	387	394	PF00069	0.437
MOD_GSK3_1	397	404	PF00069	0.541
MOD_GSK3_1	40	47	PF00069	0.535
MOD_GSK3_1	455	462	PF00069	0.651
MOD_GSK3_1	471	478	PF00069	0.574
MOD_GSK3_1	490	497	PF00069	0.246
MOD_GSK3_1	578	585	PF00069	0.572
MOD_GSK3_1	616	623	PF00069	0.547
MOD_GSK3_1	664	671	PF00069	0.638
MOD_GSK3_1	67	74	PF00069	0.684
MOD_GSK3_1	714	721	PF00069	0.448
MOD_GSK3_1	724	731	PF00069	0.448
MOD_GSK3_1	766	773	PF00069	0.418
MOD_GSK3_1	784	791	PF00069	0.244
MOD_LATS_1	312	318	PF00433	0.510
MOD_LATS_1	69	75	PF00433	0.691
MOD_N-GLC_1	12	17	PF02516	0.583
MOD_N-GLC_1	18	23	PF02516	0.582
MOD_N-GLC_1	31	36	PF02516	0.513
MOD_N-GLC_1	663	668	PF02516	0.588
MOD_N-GLC_1	714	719	PF02516	0.480
MOD_N-GLC_1	724	729	PF02516	0.418
MOD_N-GLC_1	74	79	PF02516	0.683
MOD_NEK2_1	196	201	PF00069	0.655
MOD_NEK2_1	215	220	PF00069	0.551
MOD_NEK2_1	292	297	PF00069	0.596
MOD_NEK2_1	335	340	PF00069	0.560
MOD_NEK2_1	379	384	PF00069	0.581
MOD_NEK2_1	40	45	PF00069	0.561
MOD_NEK2_1	401	406	PF00069	0.630
MOD_NEK2_1	443	448	PF00069	0.503
MOD_NEK2_1	490	495	PF00069	0.335
MOD_NEK2_1	498	503	PF00069	0.265
MOD_NEK2_1	578	583	PF00069	0.629
MOD_NEK2_1	593	598	PF00069	0.537
MOD_NEK2_1	718	723	PF00069	0.454
MOD_NEK2_1	726	731	PF00069	0.460
MOD_NEK2_2	155	160	PF00069	0.638
MOD_PIKK_1	300	306	PF00454	0.488
MOD_PIKK_1	362	368	PF00454	0.692
MOD_PIKK_1	452	458	PF00454	0.524
MOD_PK_1	12	18	PF00069	0.531
MOD_PKA_1	118	124	PF00069	0.561
MOD_PKA_1	23	29	PF00069	0.549
MOD_PKA_1	271	277	PF00069	0.659
MOD_PKA_1	51	57	PF00069	0.624
MOD_PKA_2	107	113	PF00069	0.608
MOD_PKA_2	117	123	PF00069	0.537
MOD_PKA_2	159	165	PF00069	0.622
MOD_PKA_2	171	177	PF00069	0.547
MOD_PKA_2	23	29	PF00069	0.580
MOD_PKA_2	237	243	PF00069	0.651
MOD_PKA_2	271	277	PF00069	0.659
MOD_PKA_2	313	319	PF00069	0.631
MOD_PKA_2	38	44	PF00069	0.637
MOD_PKA_2	51	57	PF00069	0.582
MOD_PKA_2	568	574	PF00069	0.555
MOD_PKA_2	654	660	PF00069	0.640
MOD_PKA_2	673	679	PF00069	0.579
MOD_PKA_2	70	76	PF00069	0.549
MOD_PKA_2	729	735	PF00069	0.512
MOD_PKA_2	97	103	PF00069	0.665
MOD_PKB_1	450	458	PF00069	0.516
MOD_Plk_1	12	18	PF00069	0.589
MOD_Plk_1	127	133	PF00069	0.654
MOD_Plk_1	24	30	PF00069	0.595
MOD_Plk_1	31	37	PF00069	0.580
MOD_Plk_1	327	333	PF00069	0.602
MOD_Plk_1	714	720	PF00069	0.474
MOD_Plk_2-3	517	523	PF00069	0.434
MOD_Plk_4	12	18	PF00069	0.589
MOD_Plk_4	205	211	PF00069	0.522
MOD_Plk_4	288	294	PF00069	0.592
MOD_Plk_4	31	37	PF00069	0.580
MOD_Plk_4	379	385	PF00069	0.682
MOD_Plk_4	443	449	PF00069	0.506
MOD_Plk_4	490	496	PF00069	0.376
MOD_Plk_4	508	514	PF00069	0.425
MOD_Plk_4	520	526	PF00069	0.535
MOD_Plk_4	695	701	PF00069	0.497
MOD_Plk_4	714	720	PF00069	0.301
MOD_Plk_4	736	742	PF00069	0.348
MOD_Plk_4	788	794	PF00069	0.348
MOD_ProDKin_1	251	257	PF00069	0.628
MOD_ProDKin_1	374	380	PF00069	0.636
MOD_ProDKin_1	460	466	PF00069	0.646
MOD_ProDKin_1	617	623	PF00069	0.546
MOD_ProDKin_1	679	685	PF00069	0.596
MOD_ProDKin_1	771	777	PF00069	0.494
TRG_DiLeu_BaEn_1	288	293	PF01217	0.589
TRG_DiLeu_BaEn_4	247	253	PF01217	0.635
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.645
TRG_DiLeu_BaLyEn_6	523	528	PF01217	0.499
TRG_DiLeu_BaLyEn_6	552	557	PF01217	0.500
TRG_ENDOCYTIC_2	284	287	PF00928	0.749
TRG_ENDOCYTIC_2	505	508	PF00928	0.523
TRG_ENDOCYTIC_2	737	740	PF00928	0.476
TRG_ENDOCYTIC_2	744	747	PF00928	0.322
TRG_ENDOCYTIC_2	796	799	PF00928	0.348
TRG_ER_diArg_1	22	24	PF00400	0.552
TRG_ER_diArg_1	421	424	PF00400	0.683
TRG_ER_diArg_1	450	453	PF00400	0.684
TRG_ER_diArg_1	50	52	PF00400	0.645
TRG_ER_diArg_1	540	542	PF00400	0.542
TRG_ER_diArg_1	546	549	PF00400	0.494
TRG_ER_diArg_1	554	556	PF00400	0.381
TRG_ER_diArg_1	98	101	PF00400	0.680
TRG_Pf-PMV_PEXEL_1	554	559	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4P2	Leishmania donovani	85%	100%
A4HJX2	Leishmania braziliensis	60%	98%
A4I6Y6	Leishmania infantum	85%	100%
Q4Q654	Leishmania major	81%	100%