CRAL-TRIO domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B205_LEIMU

TriTrypDb:

LmxM.30.2060

Length:

491

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B205

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B205

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.150
CLV_C14_Caspase3-7	316	320	PF00656	0.364
CLV_C14_Caspase3-7	348	352	PF00656	0.598
CLV_C14_Caspase3-7	56	60	PF00656	0.540
CLV_C14_Caspase3-7	8	12	PF00656	0.432
CLV_NRD_NRD_1	299	301	PF00675	0.298
CLV_NRD_NRD_1	33	35	PF00675	0.474
CLV_NRD_NRD_1	344	346	PF00675	0.390
CLV_PCSK_KEX2_1	33	35	PF00082	0.427
CLV_PCSK_KEX2_1	387	389	PF00082	0.344
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.415
CLV_PCSK_SKI1_1	125	129	PF00082	0.523
CLV_PCSK_SKI1_1	179	183	PF00082	0.312
CLV_PCSK_SKI1_1	23	27	PF00082	0.450
CLV_PCSK_SKI1_1	232	236	PF00082	0.335
CLV_PCSK_SKI1_1	250	254	PF00082	0.339
CLV_PCSK_SKI1_1	261	265	PF00082	0.337
CLV_PCSK_SKI1_1	291	295	PF00082	0.384
CLV_PCSK_SKI1_1	387	391	PF00082	0.384
CLV_PCSK_SKI1_1	53	57	PF00082	0.563
CLV_Separin_Metazoa	30	34	PF03568	0.314
DEG_COP1_1	316	326	PF00400	0.246
DOC_MAPK_gen_1	300	307	PF00069	0.362
DOC_MAPK_gen_1	85	94	PF00069	0.469
DOC_MAPK_HePTP_8	243	255	PF00069	0.299
DOC_MAPK_MEF2A_6	232	240	PF00069	0.361
DOC_MAPK_MEF2A_6	246	255	PF00069	0.442
DOC_MAPK_MEF2A_6	87	96	PF00069	0.449
DOC_PP4_FxxP_1	66	69	PF00568	0.271
DOC_USP7_MATH_1	3	7	PF00917	0.533
DOC_USP7_MATH_1	443	447	PF00917	0.514
DOC_USP7_UBL2_3	246	250	PF12436	0.479
DOC_USP7_UBL2_3	346	350	PF12436	0.425
DOC_WW_Pin1_4	187	192	PF00397	0.298
DOC_WW_Pin1_4	276	281	PF00397	0.294
DOC_WW_Pin1_4	307	312	PF00397	0.360
DOC_WW_Pin1_4	65	70	PF00397	0.280
LIG_14-3-3_CanoR_1	141	149	PF00244	0.444
LIG_14-3-3_CanoR_1	33	37	PF00244	0.538
LIG_14-3-3_CanoR_1	388	393	PF00244	0.382
LIG_14-3-3_CanoR_1	85	90	PF00244	0.421
LIG_Actin_WH2_2	371	389	PF00022	0.319
LIG_deltaCOP1_diTrp_1	82	89	PF00928	0.496
LIG_eIF4E_1	73	79	PF01652	0.453
LIG_FHA_1	149	155	PF00498	0.485
LIG_FHA_1	188	194	PF00498	0.449
LIG_FHA_1	233	239	PF00498	0.308
LIG_FHA_1	357	363	PF00498	0.655
LIG_FHA_1	373	379	PF00498	0.406
LIG_FHA_1	412	418	PF00498	0.402
LIG_FHA_1	425	431	PF00498	0.320
LIG_FHA_2	311	317	PF00498	0.410
LIG_FHA_2	346	352	PF00498	0.677
LIG_FHA_2	451	457	PF00498	0.401
LIG_FHA_2	54	60	PF00498	0.607
LIG_LIR_Apic_2	413	418	PF02991	0.433
LIG_LIR_Apic_2	63	69	PF02991	0.238
LIG_LIR_Gen_1	397	405	PF02991	0.371
LIG_LIR_Gen_1	88	96	PF02991	0.527
LIG_LIR_Nem_3	11	17	PF02991	0.636
LIG_LIR_Nem_3	147	152	PF02991	0.397
LIG_LIR_Nem_3	244	248	PF02991	0.356
LIG_LIR_Nem_3	262	267	PF02991	0.366
LIG_LIR_Nem_3	35	39	PF02991	0.503
LIG_LIR_Nem_3	397	403	PF02991	0.335
LIG_LIR_Nem_3	409	415	PF02991	0.371
LIG_LIR_Nem_3	64	70	PF02991	0.446
LIG_LYPXL_SIV_4	286	294	PF13949	0.321
LIG_LYPXL_yS_3	14	17	PF13949	0.374
LIG_MAD2	288	296	PF02301	0.390
LIG_OCRL_FandH_1	470	482	PF00620	0.295
LIG_PCNA_PIPBox_1	195	204	PF02747	0.270
LIG_PCNA_PIPBox_1	257	266	PF02747	0.198
LIG_PDZ_Class_3	486	491	PF00595	0.412
LIG_Pex14_2	412	416	PF04695	0.325
LIG_Pex14_2	460	464	PF04695	0.224
LIG_PTB_Apo_2	69	76	PF02174	0.243
LIG_PTB_Phospho_1	69	75	PF10480	0.241
LIG_SH2_CRK	287	291	PF00017	0.369
LIG_SH2_CRK	36	40	PF00017	0.479
LIG_SH2_GRB2like	166	169	PF00017	0.447
LIG_SH2_SRC	341	344	PF00017	0.451
LIG_SH2_STAT5	149	152	PF00017	0.343
LIG_SH2_STAT5	166	169	PF00017	0.280
LIG_SH2_STAT5	322	325	PF00017	0.384
LIG_SH2_STAT5	326	329	PF00017	0.380
LIG_SH2_STAT5	415	418	PF00017	0.389
LIG_SH2_STAT5	438	441	PF00017	0.488
LIG_SH2_STAT5	452	455	PF00017	0.341
LIG_SH2_STAT5	73	76	PF00017	0.356
LIG_SH3_3	128	134	PF00018	0.471
LIG_SH3_3	169	175	PF00018	0.226
LIG_SH3_3	274	280	PF00018	0.363
LIG_SUMO_SIM_par_1	233	239	PF11976	0.354
LIG_SUMO_SIM_par_1	273	279	PF11976	0.212
LIG_TRAF2_1	19	22	PF00917	0.403
LIG_TRAF2_1	382	385	PF00917	0.472
LIG_TYR_ITIM	164	169	PF00017	0.371
LIG_TYR_ITIM	243	248	PF00017	0.402
LIG_UBA3_1	177	182	PF00899	0.405
LIG_UBA3_1	459	467	PF00899	0.237
LIG_WRC_WIRS_1	149	154	PF05994	0.198
MOD_CDC14_SPxK_1	68	71	PF00782	0.252
MOD_CDK_SPxK_1	65	71	PF00069	0.265
MOD_CK1_1	357	363	PF00069	0.651
MOD_CK1_1	446	452	PF00069	0.482
MOD_CK1_1	469	475	PF00069	0.391
MOD_CK2_1	103	109	PF00069	0.534
MOD_CK2_1	168	174	PF00069	0.435
MOD_CK2_1	430	436	PF00069	0.451
MOD_CK2_1	94	100	PF00069	0.303
MOD_GlcNHglycan	111	114	PF01048	0.458
MOD_GlcNHglycan	142	145	PF01048	0.368
MOD_GlcNHglycan	232	235	PF01048	0.198
MOD_GlcNHglycan	363	366	PF01048	0.680
MOD_GlcNHglycan	403	406	PF01048	0.454
MOD_GSK3_1	357	364	PF00069	0.610
MOD_GSK3_1	372	379	PF00069	0.462
MOD_GSK3_1	425	432	PF00069	0.353
MOD_GSK3_1	434	441	PF00069	0.472
MOD_GSK3_1	446	453	PF00069	0.371
MOD_N-GLC_2	72	74	PF02516	0.237
MOD_NEK2_1	230	235	PF00069	0.352
MOD_NEK2_1	256	261	PF00069	0.341
MOD_NEK2_1	430	435	PF00069	0.384
MOD_NEK2_1	92	97	PF00069	0.358
MOD_NEK2_2	218	223	PF00069	0.174
MOD_NEK2_2	62	67	PF00069	0.291
MOD_PK_1	394	400	PF00069	0.257
MOD_PKA_1	345	351	PF00069	0.378
MOD_PKA_2	132	138	PF00069	0.497
MOD_PKA_2	140	146	PF00069	0.374
MOD_PKA_2	32	38	PF00069	0.532
MOD_PKA_2	443	449	PF00069	0.417
MOD_Plk_1	376	382	PF00069	0.480
MOD_Plk_1	408	414	PF00069	0.315
MOD_Plk_4	232	238	PF00069	0.335
MOD_Plk_4	394	400	PF00069	0.381
MOD_Plk_4	411	417	PF00069	0.414
MOD_Plk_4	430	436	PF00069	0.477
MOD_Plk_4	466	472	PF00069	0.321
MOD_Plk_4	62	68	PF00069	0.507
MOD_ProDKin_1	187	193	PF00069	0.298
MOD_ProDKin_1	276	282	PF00069	0.294
MOD_ProDKin_1	307	313	PF00069	0.360
MOD_ProDKin_1	65	71	PF00069	0.278
MOD_SUMO_for_1	222	225	PF00179	0.198
TRG_DiLeu_BaEn_1	24	29	PF01217	0.386
TRG_ENDOCYTIC_2	14	17	PF00928	0.598
TRG_ENDOCYTIC_2	149	152	PF00928	0.382
TRG_ENDOCYTIC_2	166	169	PF00928	0.343
TRG_ENDOCYTIC_2	212	215	PF00928	0.374
TRG_ENDOCYTIC_2	245	248	PF00928	0.374
TRG_ENDOCYTIC_2	287	290	PF00928	0.378
TRG_ENDOCYTIC_2	36	39	PF00928	0.488
TRG_ENDOCYTIC_2	75	78	PF00928	0.336
TRG_ER_diArg_1	32	34	PF00400	0.396
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D4	Leptomonas seymouri	37%	94%
A0A0N0P991	Leptomonas seymouri	29%	100%
A0A0N0P9K9	Leptomonas seymouri	27%	100%
A0A0N1I2J8	Leptomonas seymouri	41%	100%
A0A0N1PCS4	Leptomonas seymouri	51%	100%
A0A0S4J7N0	Bodo saltans	24%	100%
A0A0S4KJL3	Bodo saltans	28%	100%
A0A1X0NUH5	Trypanosomatidae	26%	84%
A0A1X0NUJ5	Trypanosomatidae	26%	100%
A0A3Q8ICN0	Leishmania donovani	54%	99%
A0A3Q8IGQ2	Leishmania donovani	32%	100%
A0A3R7MUL5	Trypanosoma rangeli	25%	89%
A0A3S7X4P4	Leishmania donovani	41%	94%
A0A3S7X4R1	Leishmania donovani	91%	100%
A0A422P1E3	Trypanosoma rangeli	26%	100%
A4HJI7	Leishmania braziliensis	41%	100%
A4HJI8	Leishmania braziliensis	77%	100%
A4HJI9	Leishmania braziliensis	53%	100%
A4HKB3	Leishmania braziliensis	30%	99%
A4HKB4	Leishmania braziliensis	24%	100%
A4I6Y2	Leishmania infantum	41%	94%
A4I6Y3	Leishmania infantum	91%	100%
A4I6Y4	Leishmania infantum	52%	100%
A4I7U3	Leishmania infantum	32%	100%
E9B204	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B206	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9B2Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O17907	Caenorhabditis elegans	22%	100%
O43304	Homo sapiens	23%	71%
O76054	Homo sapiens	23%	100%
P58875	Bos taurus	21%	100%
Q03606	Caenorhabditis elegans	22%	68%
Q0V9N0	Xenopus tropicalis	23%	69%
Q16KN5	Aedes aegypti	22%	76%
Q4Q5F6	Leishmania major	32%	98%
Q4Q655	Leishmania major	49%	100%
Q4Q656	Leishmania major	89%	100%
Q4Q657	Leishmania major	41%	100%
Q7PWB1	Anopheles gambiae	22%	72%
Q99J08	Mus musculus	23%	100%
Q99MS0	Rattus norvegicus	22%	100%
Q9UDX3	Homo sapiens	23%	100%
Q9VMD6	Drosophila melanogaster	23%	75%
V5BL84	Trypanosoma cruzi	26%	100%
V5BQT0	Trypanosoma cruzi	25%	89%