CRAL-TRIO domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B204_LEIMU

TriTrypDb:

LmxM.30.2050

Length:

519

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 37
NetGPI	no	yes: 0, no: 37

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B204

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B204

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.520
CLV_C14_Caspase3-7	473	477	PF00656	0.498
CLV_C14_Caspase3-7	66	70	PF00656	0.684
CLV_NRD_NRD_1	144	146	PF00675	0.488
CLV_NRD_NRD_1	343	345	PF00675	0.401
CLV_NRD_NRD_1	373	375	PF00675	0.498
CLV_PCSK_KEX2_1	343	345	PF00082	0.304
CLV_PCSK_KEX2_1	373	375	PF00082	0.492
CLV_PCSK_KEX2_1	493	495	PF00082	0.462
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.508
CLV_PCSK_SKI1_1	174	178	PF00082	0.360
CLV_PCSK_SKI1_1	191	195	PF00082	0.288
CLV_PCSK_SKI1_1	264	268	PF00082	0.352
CLV_PCSK_SKI1_1	284	288	PF00082	0.326
CLV_PCSK_SKI1_1	307	311	PF00082	0.395
CLV_PCSK_SKI1_1	314	318	PF00082	0.385
CLV_Separin_Metazoa	188	192	PF03568	0.221
DEG_APCC_DBOX_1	330	338	PF00400	0.261
DOC_CKS1_1	237	242	PF01111	0.153
DOC_CKS1_1	512	517	PF01111	0.461
DOC_MAPK_gen_1	29	36	PF00069	0.426
DOC_MAPK_HePTP_8	266	278	PF00069	0.264
DOC_MAPK_MEF2A_6	269	278	PF00069	0.450
DOC_MAPK_MEF2A_6	314	321	PF00069	0.225
DOC_PP1_RVXF_1	321	328	PF00149	0.311
DOC_PP1_RVXF_1	498	505	PF00149	0.342
DOC_PP2B_PxIxI_1	273	279	PF00149	0.153
DOC_PP4_FxxP_1	327	330	PF00568	0.339
DOC_PP4_FxxP_1	441	444	PF00568	0.372
DOC_USP7_MATH_1	21	25	PF00917	0.366
DOC_USP7_MATH_1	330	334	PF00917	0.337
DOC_USP7_MATH_1	472	476	PF00917	0.491
DOC_USP7_UBL2_3	284	288	PF12436	0.212
DOC_USP7_UBL2_3	489	493	PF12436	0.207
DOC_WW_Pin1_4	140	145	PF00397	0.405
DOC_WW_Pin1_4	236	241	PF00397	0.228
DOC_WW_Pin1_4	299	304	PF00397	0.261
DOC_WW_Pin1_4	508	513	PF00397	0.407
LIG_14-3-3_CanoR_1	129	136	PF00244	0.383
LIG_14-3-3_CanoR_1	238	248	PF00244	0.158
LIG_14-3-3_CanoR_1	452	458	PF00244	0.494
LIG_APCC_ABBA_1	276	281	PF00400	0.378
LIG_BIR_II_1	1	5	PF00653	0.705
LIG_BRCT_BRCA1_1	282	286	PF00533	0.186
LIG_BRCT_BRCA1_1	474	478	PF00533	0.597
LIG_BRCT_BRCA1_2	282	288	PF00533	0.168
LIG_deltaCOP1_diTrp_1	94	101	PF00928	0.477
LIG_eIF4E_1	85	91	PF01652	0.434
LIG_FHA_1	131	137	PF00498	0.400
LIG_FHA_1	161	167	PF00498	0.492
LIG_FHA_1	17	23	PF00498	0.653
LIG_FHA_1	216	222	PF00498	0.427
LIG_FHA_1	398	404	PF00498	0.402
LIG_FHA_1	438	444	PF00498	0.361
LIG_FHA_1	466	472	PF00498	0.352
LIG_FHA_2	1	7	PF00498	0.648
LIG_FHA_2	13	19	PF00498	0.607
LIG_FHA_2	240	246	PF00498	0.434
LIG_FHA_2	337	343	PF00498	0.428
LIG_FHA_2	452	458	PF00498	0.318
LIG_FHA_2	471	477	PF00498	0.407
LIG_Integrin_isoDGR_2	172	174	PF01839	0.193
LIG_LIR_Apic_2	326	330	PF02991	0.355
LIG_LIR_Apic_2	439	444	PF02991	0.410
LIG_LIR_Gen_1	205	215	PF02991	0.406
LIG_LIR_Gen_1	400	407	PF02991	0.412
LIG_LIR_Gen_1	435	444	PF02991	0.430
LIG_LIR_Gen_1	49	59	PF02991	0.355
LIG_LIR_Nem_3	283	289	PF02991	0.391
LIG_LIR_Nem_3	39	44	PF02991	0.504
LIG_LIR_Nem_3	400	405	PF02991	0.407
LIG_LIR_Nem_3	435	441	PF02991	0.394
LIG_LIR_Nem_3	49	54	PF02991	0.491
LIG_OCRL_FandH_1	496	508	PF00620	0.297
LIG_Pex14_2	438	442	PF04695	0.331
LIG_REV1ctd_RIR_1	284	290	PF16727	0.485
LIG_SH2_CRK	178	182	PF00017	0.327
LIG_SH2_CRK	224	228	PF00017	0.355
LIG_SH2_CRK	308	312	PF00017	0.348
LIG_SH2_CRK	41	45	PF00017	0.462
LIG_SH2_NCK_1	178	182	PF00017	0.319
LIG_SH2_PTP2	402	405	PF00017	0.489
LIG_SH2_SRC	345	348	PF00017	0.383
LIG_SH2_STAP1	308	312	PF00017	0.480
LIG_SH2_STAT5	178	181	PF00017	0.342
LIG_SH2_STAT5	345	348	PF00017	0.361
LIG_SH2_STAT5	402	405	PF00017	0.423
LIG_SH2_STAT5	464	467	PF00017	0.492
LIG_SH2_STAT5	51	54	PF00017	0.512
LIG_SH2_STAT5	85	88	PF00017	0.353
LIG_SH3_1	40	46	PF00018	0.295
LIG_SH3_3	234	240	PF00018	0.153
LIG_SH3_3	40	46	PF00018	0.494
LIG_SH3_3	509	515	PF00018	0.497
LIG_SUMO_SIM_anti_2	202	209	PF11976	0.334
LIG_SUMO_SIM_anti_2	482	489	PF11976	0.392
LIG_SUMO_SIM_par_1	213	220	PF11976	0.259
LIG_TRAF2_1	63	66	PF00917	0.775
LIG_TYR_ITIM	176	181	PF00017	0.376
LIG_TYR_ITIM	222	227	PF00017	0.267
LIG_TYR_ITIM	306	311	PF00017	0.435
LIG_UBA3_1	189	194	PF00899	0.385
LIG_UBA3_1	33	38	PF00899	0.513
LIG_WRC_WIRS_1	438	443	PF05994	0.405
MOD_CDC14_SPxK_1	143	146	PF00782	0.327
MOD_CDK_SPK_2	140	145	PF00069	0.363
MOD_CDK_SPK_2	236	241	PF00069	0.153
MOD_CDK_SPxK_1	140	146	PF00069	0.320
MOD_CK1_1	253	259	PF00069	0.161
MOD_CK1_1	333	339	PF00069	0.388
MOD_CK1_1	446	452	PF00069	0.413
MOD_CK2_1	213	219	PF00069	0.472
MOD_CK2_1	239	245	PF00069	0.447
MOD_CK2_1	451	457	PF00069	0.513
MOD_CK2_1	60	66	PF00069	0.684
MOD_GlcNHglycan	233	236	PF01048	0.400
MOD_GlcNHglycan	314	317	PF01048	0.323
MOD_GlcNHglycan	364	367	PF01048	0.497
MOD_GlcNHglycan	389	393	PF01048	0.730
MOD_GlcNHglycan	429	432	PF01048	0.468
MOD_GlcNHglycan	445	448	PF01048	0.400
MOD_GlcNHglycan	62	65	PF01048	0.696
MOD_GSK3_1	12	19	PF00069	0.716
MOD_GSK3_1	140	147	PF00069	0.473
MOD_GSK3_1	195	202	PF00069	0.415
MOD_GSK3_1	213	220	PF00069	0.431
MOD_GSK3_1	362	369	PF00069	0.514
MOD_GSK3_1	381	388	PF00069	0.689
MOD_GSK3_1	397	404	PF00069	0.478
MOD_GSK3_1	460	467	PF00069	0.421
MOD_GSK3_1	85	92	PF00069	0.372
MOD_N-GLC_1	417	422	PF02516	0.281
MOD_NEK2_1	177	182	PF00069	0.188
MOD_NEK2_1	312	317	PF00069	0.292
MOD_NEK2_1	427	432	PF00069	0.331
MOD_NEK2_1	451	456	PF00069	0.534
MOD_NEK2_2	124	129	PF00069	0.357
MOD_PIKK_1	451	457	PF00454	0.451
MOD_PKA_1	323	329	PF00069	0.361
MOD_PKA_2	144	150	PF00069	0.497
MOD_PKA_2	330	336	PF00069	0.176
MOD_PKA_2	372	378	PF00069	0.689
MOD_PKA_2	451	457	PF00069	0.616
MOD_Plk_1	117	123	PF00069	0.466
MOD_Plk_1	409	415	PF00069	0.382
MOD_Plk_4	217	223	PF00069	0.388
MOD_Plk_4	255	261	PF00069	0.333
MOD_Plk_4	301	307	PF00069	0.283
MOD_Plk_4	336	342	PF00069	0.331
MOD_Plk_4	437	443	PF00069	0.410
MOD_Plk_4	47	53	PF00069	0.390
MOD_ProDKin_1	140	146	PF00069	0.410
MOD_ProDKin_1	236	242	PF00069	0.228
MOD_ProDKin_1	299	305	PF00069	0.261
MOD_ProDKin_1	508	514	PF00069	0.419
MOD_SUMO_rev_2	63	72	PF00179	0.491
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.535
TRG_ENDOCYTIC_2	178	181	PF00928	0.340
TRG_ENDOCYTIC_2	224	227	PF00928	0.359
TRG_ENDOCYTIC_2	308	311	PF00928	0.367
TRG_ENDOCYTIC_2	402	405	PF00928	0.410
TRG_ENDOCYTIC_2	41	44	PF00928	0.472
TRG_ENDOCYTIC_2	51	54	PF00928	0.466
TRG_ER_diArg_1	343	345	PF00400	0.237
TRG_ER_diArg_1	372	374	PF00400	0.498
TRG_NES_CRM1_1	205	219	PF08389	0.207
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D4	Leptomonas seymouri	44%	99%
A0A0N0P991	Leptomonas seymouri	27%	100%
A0A0N0P992	Leptomonas seymouri	22%	68%
A0A0N0P9K9	Leptomonas seymouri	28%	100%
A0A0N1I2J8	Leptomonas seymouri	34%	100%
A0A0N1PCS4	Leptomonas seymouri	38%	100%
A0A0S4J7N0	Bodo saltans	24%	100%
A0A0S4KJL3	Bodo saltans	28%	100%
A0A1X0NUH5	Trypanosomatidae	22%	89%
A0A1X0NUJ5	Trypanosomatidae	27%	100%
A0A3Q8ICN0	Leishmania donovani	39%	100%
A0A3Q8IGQ2	Leishmania donovani	29%	100%
A0A3R7MUL5	Trypanosoma rangeli	26%	94%
A0A3S5H7R8	Leishmania donovani	24%	68%
A0A3S7X4P4	Leishmania donovani	83%	100%
A0A3S7X4R1	Leishmania donovani	41%	100%
A0A422P1E3	Trypanosoma rangeli	27%	100%
A4HJI7	Leishmania braziliensis	64%	98%
A4HJI8	Leishmania braziliensis	40%	100%
A4HJI9	Leishmania braziliensis	38%	91%
A4HKB3	Leishmania braziliensis	29%	100%
A4HKB4	Leishmania braziliensis	27%	100%
A4HKB5	Leishmania braziliensis	21%	68%
A4I6Y2	Leishmania infantum	83%	100%
A4I6Y3	Leishmania infantum	41%	100%
A4I6Y4	Leishmania infantum	38%	100%
A4I7U3	Leishmania infantum	29%	100%
A4I7U4	Leishmania infantum	24%	68%
A8Y5H7	Mus musculus	21%	73%
B5MCN3	Homo sapiens	21%	100%
E9B205	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B206	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B2Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B2Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	68%
O43304	Homo sapiens	22%	75%
O76054	Homo sapiens	22%	100%
P58875	Bos taurus	22%	100%
Q0V9N0	Xenopus tropicalis	21%	73%
Q4Q5F5	Leishmania major	24%	68%
Q4Q5F6	Leishmania major	29%	100%
Q4Q655	Leishmania major	39%	100%
Q4Q656	Leishmania major	40%	99%
Q4Q657	Leishmania major	80%	100%
Q8R0F9	Mus musculus	21%	100%
Q92503	Homo sapiens	22%	73%
Q99J08	Mus musculus	22%	100%
Q99MS0	Rattus norvegicus	22%	100%
Q9UDX3	Homo sapiens	21%	100%
V5BL84	Trypanosoma cruzi	27%	100%
V5BQT0	Trypanosoma cruzi	24%	94%