Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B203_LEIMU

TriTrypDb:

LmxM.30.2040

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B203

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B203

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.600
CLV_NRD_NRD_1	301	303	PF00675	0.679
CLV_NRD_NRD_1	41	43	PF00675	0.601
CLV_PCSK_KEX2_1	106	108	PF00082	0.600
CLV_PCSK_KEX2_1	301	303	PF00082	0.679
CLV_PCSK_KEX2_1	41	43	PF00082	0.601
CLV_PCSK_SKI1_1	164	168	PF00082	0.522
CLV_PCSK_SKI1_1	260	264	PF00082	0.555
CLV_PCSK_SKI1_1	295	299	PF00082	0.526
CLV_PCSK_SKI1_1	369	373	PF00082	0.597
CLV_PCSK_SKI1_1	375	379	PF00082	0.557
CLV_PCSK_SKI1_1	42	46	PF00082	0.601
DEG_SPOP_SBC_1	261	265	PF00917	0.554
DEG_SPOP_SBC_1	399	403	PF00917	0.473
DOC_CKS1_1	354	359	PF01111	0.615
DOC_CYCLIN_RxL_1	289	300	PF00134	0.514
DOC_CYCLIN_RxL_1	42	54	PF00134	0.627
DOC_MAPK_gen_1	20	29	PF00069	0.405
DOC_MAPK_gen_1	318	328	PF00069	0.639
DOC_MAPK_gen_1	335	345	PF00069	0.680
DOC_MAPK_gen_1	7	15	PF00069	0.462
DOC_PP1_RVXF_1	367	373	PF00149	0.600
DOC_PP1_SILK_1	30	35	PF00149	0.489
DOC_PP2B_LxvP_1	343	346	PF13499	0.686
DOC_PP2B_LxvP_1	50	53	PF13499	0.627
DOC_PP2B_LxvP_1	67	70	PF13499	0.526
DOC_PP2B_PxIxI_1	273	279	PF00149	0.572
DOC_PP4_FxxP_1	192	195	PF00568	0.502
DOC_PP4_FxxP_1	244	247	PF00568	0.602
DOC_SPAK_OSR1_1	10	14	PF12202	0.461
DOC_USP7_MATH_1	109	113	PF00917	0.550
DOC_USP7_MATH_1	124	128	PF00917	0.550
DOC_USP7_MATH_1	181	185	PF00917	0.621
DOC_USP7_MATH_1	198	202	PF00917	0.545
DOC_USP7_MATH_1	236	240	PF00917	0.551
DOC_USP7_MATH_1	304	308	PF00917	0.646
DOC_USP7_MATH_1	446	450	PF00917	0.633
DOC_USP7_MATH_1	73	77	PF00917	0.623
DOC_WW_Pin1_4	159	164	PF00397	0.635
DOC_WW_Pin1_4	231	236	PF00397	0.600
DOC_WW_Pin1_4	270	275	PF00397	0.561
DOC_WW_Pin1_4	300	305	PF00397	0.653
DOC_WW_Pin1_4	330	335	PF00397	0.520
DOC_WW_Pin1_4	353	358	PF00397	0.619
DOC_WW_Pin1_4	403	408	PF00397	0.626
DOC_WW_Pin1_4	415	420	PF00397	0.607
LIG_14-3-3_CanoR_1	10	14	PF00244	0.461
LIG_14-3-3_CanoR_1	170	180	PF00244	0.622
LIG_14-3-3_CanoR_1	260	267	PF00244	0.553
LIG_14-3-3_CanoR_1	293	298	PF00244	0.668
LIG_14-3-3_CanoR_1	318	324	PF00244	0.778
LIG_14-3-3_CanoR_1	335	345	PF00244	0.568
LIG_14-3-3_CanoR_1	369	377	PF00244	0.601
LIG_Actin_WH2_2	325	340	PF00022	0.670
LIG_AP2alpha_1	372	376	PF02296	0.604
LIG_BRCT_BRCA1_1	198	202	PF00533	0.616
LIG_BRCT_BRCA1_1	486	490	PF00533	0.583
LIG_BRCT_BRCA1_2	486	492	PF00533	0.587
LIG_FHA_1	203	209	PF00498	0.630
LIG_FHA_1	246	252	PF00498	0.765
LIG_FHA_1	262	268	PF00498	0.617
LIG_FHA_1	271	277	PF00498	0.574
LIG_FHA_1	327	333	PF00498	0.737
LIG_FHA_1	409	415	PF00498	0.684
LIG_FHA_1	62	68	PF00498	0.666
LIG_FHA_2	205	211	PF00498	0.642
LIG_FHA_2	263	269	PF00498	0.657
LIG_FHA_2	270	276	PF00498	0.574
LIG_FHA_2	416	422	PF00498	0.669
LIG_FHA_2	450	456	PF00498	0.592
LIG_LIR_Apic_2	190	195	PF02991	0.503
LIG_LIR_Apic_2	241	247	PF02991	0.601
LIG_LIR_Gen_1	112	122	PF02991	0.605
LIG_LIR_Gen_1	487	496	PF02991	0.517
LIG_LIR_Nem_3	112	118	PF02991	0.611
LIG_LIR_Nem_3	291	297	PF02991	0.640
LIG_LIR_Nem_3	390	395	PF02991	0.594
LIG_LIR_Nem_3	420	426	PF02991	0.766
LIG_LIR_Nem_3	487	493	PF02991	0.572
LIG_PDZ_Class_1	495	500	PF00595	0.595
LIG_Pex14_2	372	376	PF04695	0.604
LIG_SH2_GRB2like	221	224	PF00017	0.521
LIG_SH2_SRC	221	224	PF00017	0.671
LIG_SH2_STAP1	115	119	PF00017	0.622
LIG_SH2_STAT5	221	224	PF00017	0.671
LIG_SH2_STAT5	417	420	PF00017	0.630
LIG_SH2_STAT5	485	488	PF00017	0.632
LIG_SH2_STAT5	96	99	PF00017	0.475
LIG_SH3_3	118	124	PF00018	0.579
LIG_SH3_3	131	137	PF00018	0.543
LIG_SH3_3	192	198	PF00018	0.497
LIG_SH3_3	219	225	PF00018	0.668
LIG_SH3_3	232	238	PF00018	0.659
LIG_SH3_3	248	254	PF00018	0.735
LIG_SH3_3	490	496	PF00018	0.521
LIG_SH3_3	50	56	PF00018	0.726
LIG_SH3_3	82	88	PF00018	0.643
LIG_SUMO_SIM_par_1	224	230	PF11976	0.621
LIG_SUMO_SIM_par_1	356	362	PF11976	0.508
MOD_CDK_SPK_2	159	164	PF00069	0.615
MOD_CDK_SPK_2	330	335	PF00069	0.520
MOD_CK1_1	148	154	PF00069	0.627
MOD_CK1_1	206	212	PF00069	0.773
MOD_CK1_1	256	262	PF00069	0.558
MOD_CK1_1	279	285	PF00069	0.625
MOD_CK1_1	288	294	PF00069	0.577
MOD_CK1_1	296	302	PF00069	0.565
MOD_CK1_1	305	311	PF00069	0.568
MOD_CK1_1	333	339	PF00069	0.561
MOD_CK1_1	341	347	PF00069	0.669
MOD_CK1_1	348	354	PF00069	0.609
MOD_CK1_1	398	404	PF00069	0.625
MOD_CK1_1	406	412	PF00069	0.609
MOD_CK1_1	449	455	PF00069	0.605
MOD_CK2_1	125	131	PF00069	0.580
MOD_CK2_1	144	150	PF00069	0.525
MOD_CK2_1	151	157	PF00069	0.602
MOD_CK2_1	204	210	PF00069	0.630
MOD_CK2_1	336	342	PF00069	0.638
MOD_CK2_1	415	421	PF00069	0.671
MOD_CK2_1	449	455	PF00069	0.605
MOD_DYRK1A_RPxSP_1	330	334	PF00069	0.519
MOD_GlcNHglycan	189	192	PF01048	0.574
MOD_GlcNHglycan	198	201	PF01048	0.650
MOD_GlcNHglycan	214	217	PF01048	0.715
MOD_GlcNHglycan	229	232	PF01048	0.600
MOD_GlcNHglycan	238	241	PF01048	0.627
MOD_GlcNHglycan	278	281	PF01048	0.663
MOD_GlcNHglycan	304	307	PF01048	0.643
MOD_GlcNHglycan	314	317	PF01048	0.586
MOD_GlcNHglycan	347	350	PF01048	0.669
MOD_GlcNHglycan	351	354	PF01048	0.637
MOD_GlcNHglycan	389	392	PF01048	0.578
MOD_GlcNHglycan	397	400	PF01048	0.544
MOD_GlcNHglycan	448	451	PF01048	0.470
MOD_GlcNHglycan	486	489	PF01048	0.579
MOD_GSK3_1	109	116	PF00069	0.540
MOD_GSK3_1	125	132	PF00069	0.557
MOD_GSK3_1	144	151	PF00069	0.546
MOD_GSK3_1	166	173	PF00069	0.697
MOD_GSK3_1	183	190	PF00069	0.651
MOD_GSK3_1	198	205	PF00069	0.694
MOD_GSK3_1	227	234	PF00069	0.813
MOD_GSK3_1	256	263	PF00069	0.581
MOD_GSK3_1	281	288	PF00069	0.691
MOD_GSK3_1	289	296	PF00069	0.727
MOD_GSK3_1	300	307	PF00069	0.646
MOD_GSK3_1	308	315	PF00069	0.587
MOD_GSK3_1	324	331	PF00069	0.686
MOD_GSK3_1	333	340	PF00069	0.638
MOD_GSK3_1	341	348	PF00069	0.638
MOD_GSK3_1	349	356	PF00069	0.569
MOD_GSK3_1	380	387	PF00069	0.560
MOD_GSK3_1	395	402	PF00069	0.516
MOD_GSK3_1	406	413	PF00069	0.600
MOD_GSK3_1	480	487	PF00069	0.574
MOD_LATS_1	143	149	PF00433	0.600
MOD_LATS_1	168	174	PF00433	0.566
MOD_N-GLC_1	124	129	PF02516	0.556
MOD_N-GLC_1	203	208	PF02516	0.670
MOD_N-GLC_1	324	329	PF02516	0.584
MOD_N-GLC_1	415	420	PF02516	0.550
MOD_NEK2_1	129	134	PF00069	0.594
MOD_NEK2_1	187	192	PF00069	0.582
MOD_NEK2_1	202	207	PF00069	0.758
MOD_NEK2_1	285	290	PF00069	0.601
MOD_NEK2_1	297	302	PF00069	0.712
MOD_NEK2_1	326	331	PF00069	0.676
MOD_NEK2_1	397	402	PF00069	0.676
MOD_NEK2_1	408	413	PF00069	0.651
MOD_NEK2_1	479	484	PF00069	0.611
MOD_PIKK_1	151	157	PF00454	0.686
MOD_PIKK_1	408	414	PF00454	0.644
MOD_PK_1	28	34	PF00069	0.487
MOD_PKA_2	337	343	PF00069	0.531
MOD_PKA_2	467	473	PF00069	0.623
MOD_PKA_2	6	12	PF00069	0.569
MOD_Plk_1	113	119	PF00069	0.620
MOD_Plk_1	181	187	PF00069	0.650
MOD_Plk_1	203	209	PF00069	0.642
MOD_Plk_1	217	223	PF00069	0.576
MOD_Plk_1	324	330	PF00069	0.585
MOD_Plk_1	341	347	PF00069	0.685
MOD_Plk_1	73	79	PF00069	0.615
MOD_Plk_4	113	119	PF00069	0.618
MOD_Plk_4	125	131	PF00069	0.502
MOD_Plk_4	198	204	PF00069	0.660
MOD_Plk_4	217	223	PF00069	0.506
MOD_Plk_4	28	34	PF00069	0.487
MOD_Plk_4	384	390	PF00069	0.541
MOD_ProDKin_1	159	165	PF00069	0.635
MOD_ProDKin_1	231	237	PF00069	0.599
MOD_ProDKin_1	270	276	PF00069	0.561
MOD_ProDKin_1	300	306	PF00069	0.655
MOD_ProDKin_1	330	336	PF00069	0.519
MOD_ProDKin_1	353	359	PF00069	0.615
MOD_ProDKin_1	403	409	PF00069	0.628
MOD_ProDKin_1	415	421	PF00069	0.608
MOD_SUMO_rev_2	147	154	PF00179	0.586
TRG_ENDOCYTIC_2	115	118	PF00928	0.622
TRG_ER_diArg_1	23	26	PF00400	0.541
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	375	380	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4R8	Leishmania donovani	84%	100%
A4HJI6	Leishmania braziliensis	61%	100%
A4I6Y1	Leishmania infantum	85%	100%
Q4Q658	Leishmania major	82%	100%