RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubercidin resistance protein, putative

Species:

Leishmania mexicana

UniProt:

E9B200_LEIMU

TriTrypDb:

LmxM.30.2010

Length:

606

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B200

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B200

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.732
CLV_C14_Caspase3-7	19	23	PF00656	0.629
CLV_C14_Caspase3-7	412	416	PF00656	0.764
CLV_NRD_NRD_1	149	151	PF00675	0.521
CLV_NRD_NRD_1	277	279	PF00675	0.588
CLV_NRD_NRD_1	476	478	PF00675	0.593
CLV_PCSK_KEX2_1	148	150	PF00082	0.523
CLV_PCSK_KEX2_1	476	478	PF00082	0.593
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.466
CLV_PCSK_SKI1_1	481	485	PF00082	0.556
CLV_PCSK_SKI1_1	534	538	PF00082	0.434
DEG_Nend_UBRbox_2	1	3	PF02207	0.764
DEG_SCF_FBW7_1	319	324	PF00400	0.734
DEG_SPOP_SBC_1	171	175	PF00917	0.662
DEG_SPOP_SBC_1	308	312	PF00917	0.817
DEG_SPOP_SBC_1	81	85	PF00917	0.751
DOC_CKS1_1	144	149	PF01111	0.827
DOC_CKS1_1	488	493	PF01111	0.625
DOC_CKS1_1	540	545	PF01111	0.841
DOC_CYCLIN_yCln2_LP_2	484	487	PF00134	0.625
DOC_PP2B_LxvP_1	484	487	PF13499	0.670
DOC_PP4_FxxP_1	468	471	PF00568	0.629
DOC_PP4_FxxP_1	575	578	PF00568	0.759
DOC_USP7_MATH_1	178	182	PF00917	0.812
DOC_USP7_MATH_1	213	217	PF00917	0.688
DOC_USP7_MATH_1	308	312	PF00917	0.810
DOC_USP7_MATH_1	321	325	PF00917	0.690
DOC_USP7_MATH_1	367	371	PF00917	0.803
DOC_USP7_MATH_1	589	593	PF00917	0.470
DOC_USP7_MATH_1	80	84	PF00917	0.796
DOC_WW_Pin1_4	119	124	PF00397	0.729
DOC_WW_Pin1_4	134	139	PF00397	0.813
DOC_WW_Pin1_4	143	148	PF00397	0.829
DOC_WW_Pin1_4	216	221	PF00397	0.771
DOC_WW_Pin1_4	287	292	PF00397	0.639
DOC_WW_Pin1_4	29	34	PF00397	0.821
DOC_WW_Pin1_4	310	315	PF00397	0.794
DOC_WW_Pin1_4	317	322	PF00397	0.721
DOC_WW_Pin1_4	371	376	PF00397	0.806
DOC_WW_Pin1_4	433	438	PF00397	0.748
DOC_WW_Pin1_4	452	457	PF00397	0.668
DOC_WW_Pin1_4	460	465	PF00397	0.788
DOC_WW_Pin1_4	487	492	PF00397	0.761
DOC_WW_Pin1_4	494	499	PF00397	0.766
DOC_WW_Pin1_4	539	544	PF00397	0.837
LIG_14-3-3_CanoR_1	234	244	PF00244	0.770
LIG_14-3-3_CanoR_1	339	345	PF00244	0.661
LIG_14-3-3_CanoR_1	476	480	PF00244	0.703
LIG_APCC_ABBA_1	387	392	PF00400	0.660
LIG_BIR_III_2	69	73	PF00653	0.636
LIG_deltaCOP1_diTrp_1	232	240	PF00928	0.757
LIG_EVH1_1	485	489	PF00568	0.622
LIG_FHA_1	314	320	PF00498	0.867
LIG_FHA_1	329	335	PF00498	0.686
LIG_FHA_1	351	357	PF00498	0.772
LIG_FHA_1	406	412	PF00498	0.773
LIG_FHA_1	488	494	PF00498	0.689
LIG_FHA_1	523	529	PF00498	0.636
LIG_FHA_1	543	549	PF00498	0.620
LIG_FHA_2	167	173	PF00498	0.663
LIG_FHA_2	224	230	PF00498	0.710
LIG_FHA_2	318	324	PF00498	0.827
LIG_FHA_2	410	416	PF00498	0.814
LIG_FHA_2	446	452	PF00498	0.751
LIG_Integrin_isoDGR_2	428	430	PF01839	0.464
LIG_LIR_Apic_2	466	471	PF02991	0.688
LIG_LIR_Apic_2	509	514	PF02991	0.741
LIG_LIR_Gen_1	462	471	PF02991	0.637
LIG_LIR_Gen_1	592	602	PF02991	0.327
LIG_LIR_Gen_1	93	103	PF02991	0.721
LIG_LIR_Nem_3	462	468	PF02991	0.643
LIG_LIR_Nem_3	569	575	PF02991	0.768
LIG_LIR_Nem_3	592	597	PF02991	0.327
LIG_LIR_Nem_3	93	98	PF02991	0.800
LIG_NRBOX	226	232	PF00104	0.800
LIG_Pex14_2	590	594	PF04695	0.327
LIG_PTB_Apo_2	354	361	PF02174	0.643
LIG_Rb_LxCxE_1	438	459	PF01857	0.641
LIG_REV1ctd_RIR_1	357	366	PF16727	0.813
LIG_SH2_CRK	95	99	PF00017	0.771
LIG_SH2_STAP1	465	469	PF00017	0.697
LIG_SH2_STAP1	95	99	PF00017	0.669
LIG_SH3_3	18	24	PF00018	0.790
LIG_SH3_3	27	33	PF00018	0.710
LIG_SH3_3	369	375	PF00018	0.828
LIG_SH3_3	483	489	PF00018	0.681
LIG_SH3_3	540	546	PF00018	0.795
LIG_SUMO_SIM_anti_2	330	336	PF11976	0.658
LIG_TRAF2_1	567	570	PF00917	0.722
LIG_WRC_WIRS_1	356	361	PF05994	0.710
MOD_CDK_SPK_2	143	148	PF00069	0.778
MOD_CDK_SPK_2	287	292	PF00069	0.639
MOD_CDK_SPK_2	539	544	PF00069	0.800
MOD_CDK_SPxK_1	143	149	PF00069	0.717
MOD_CDK_SPxxK_3	143	150	PF00069	0.782
MOD_CK1_1	111	117	PF00069	0.798
MOD_CK1_1	122	128	PF00069	0.703
MOD_CK1_1	155	161	PF00069	0.822
MOD_CK1_1	216	222	PF00069	0.642
MOD_CK1_1	235	241	PF00069	0.696
MOD_CK1_1	243	249	PF00069	0.716
MOD_CK1_1	265	271	PF00069	0.670
MOD_CK1_1	284	290	PF00069	0.774
MOD_CK1_1	310	316	PF00069	0.817
MOD_CK1_1	340	346	PF00069	0.775
MOD_CK1_1	365	371	PF00069	0.788
MOD_CK1_1	455	461	PF00069	0.734
MOD_CK1_1	463	469	PF00069	0.814
MOD_CK1_1	518	524	PF00069	0.786
MOD_CK1_1	539	545	PF00069	0.796
MOD_CK1_1	55	61	PF00069	0.831
MOD_CK1_1	8	14	PF00069	0.766
MOD_CK1_1	85	91	PF00069	0.824
MOD_CK1_1	93	99	PF00069	0.718
MOD_CK2_1	166	172	PF00069	0.664
MOD_CK2_1	317	323	PF00069	0.830
MOD_CK2_1	348	354	PF00069	0.824
MOD_CK2_1	393	399	PF00069	0.725
MOD_CK2_1	44	50	PF00069	0.754
MOD_CK2_1	445	451	PF00069	0.790
MOD_CK2_1	98	104	PF00069	0.739
MOD_GlcNHglycan	12	15	PF01048	0.566
MOD_GlcNHglycan	154	157	PF01048	0.585
MOD_GlcNHglycan	18	21	PF01048	0.518
MOD_GlcNHglycan	180	183	PF01048	0.636
MOD_GlcNHglycan	189	192	PF01048	0.572
MOD_GlcNHglycan	237	240	PF01048	0.565
MOD_GlcNHglycan	346	349	PF01048	0.586
MOD_GlcNHglycan	365	368	PF01048	0.449
MOD_GlcNHglycan	591	594	PF01048	0.470
MOD_GlcNHglycan	7	10	PF01048	0.573
MOD_GSK3_1	121	128	PF00069	0.676
MOD_GSK3_1	166	173	PF00069	0.711
MOD_GSK3_1	192	199	PF00069	0.768
MOD_GSK3_1	303	310	PF00069	0.820
MOD_GSK3_1	313	320	PF00069	0.758
MOD_GSK3_1	340	347	PF00069	0.782
MOD_GSK3_1	358	365	PF00069	0.675
MOD_GSK3_1	367	374	PF00069	0.746
MOD_GSK3_1	405	412	PF00069	0.795
MOD_GSK3_1	433	440	PF00069	0.786
MOD_GSK3_1	451	458	PF00069	0.694
MOD_GSK3_1	459	466	PF00069	0.796
MOD_GSK3_1	509	516	PF00069	0.630
MOD_GSK3_1	518	525	PF00069	0.781
MOD_GSK3_1	8	15	PF00069	0.728
MOD_GSK3_1	81	88	PF00069	0.815
MOD_GSK3_1	90	97	PF00069	0.679
MOD_N-GLC_1	254	259	PF02516	0.498
MOD_N-GLC_1	456	461	PF02516	0.503
MOD_N-GLC_1	509	514	PF02516	0.427
MOD_N-GLC_1	518	523	PF02516	0.565
MOD_N-GLC_1	65	70	PF02516	0.560
MOD_NEK2_1	262	267	PF00069	0.694
MOD_NEK2_1	382	387	PF00069	0.663
MOD_NEK2_1	44	49	PF00069	0.776
MOD_NEK2_1	445	450	PF00069	0.752
MOD_NEK2_1	54	59	PF00069	0.679
MOD_NEK2_1	94	99	PF00069	0.770
MOD_PIKK_1	155	161	PF00454	0.716
MOD_PIKK_1	206	212	PF00454	0.786
MOD_PIKK_1	262	268	PF00454	0.658
MOD_PIKK_1	284	290	PF00454	0.819
MOD_PIKK_1	337	343	PF00454	0.769
MOD_PIKK_1	348	354	PF00454	0.774
MOD_PIKK_1	382	388	PF00454	0.762
MOD_PIKK_1	400	406	PF00454	0.643
MOD_PIKK_1	52	58	PF00454	0.754
MOD_PIKK_1	536	542	PF00454	0.758
MOD_PK_1	82	88	PF00069	0.689
MOD_PKA_2	304	310	PF00069	0.641
MOD_PKA_2	475	481	PF00069	0.736
MOD_PKA_2	81	87	PF00069	0.692
MOD_Plk_1	254	260	PF00069	0.765
MOD_Plk_1	445	451	PF00069	0.638
MOD_Plk_1	518	524	PF00069	0.780
MOD_Plk_1	90	96	PF00069	0.762
MOD_Plk_4	355	361	PF00069	0.710
MOD_Plk_4	409	415	PF00069	0.770
MOD_Plk_4	82	88	PF00069	0.789
MOD_Plk_4	90	96	PF00069	0.683
MOD_ProDKin_1	119	125	PF00069	0.729
MOD_ProDKin_1	134	140	PF00069	0.812
MOD_ProDKin_1	143	149	PF00069	0.830
MOD_ProDKin_1	216	222	PF00069	0.767
MOD_ProDKin_1	287	293	PF00069	0.639
MOD_ProDKin_1	29	35	PF00069	0.822
MOD_ProDKin_1	310	316	PF00069	0.796
MOD_ProDKin_1	317	323	PF00069	0.721
MOD_ProDKin_1	371	377	PF00069	0.807
MOD_ProDKin_1	433	439	PF00069	0.748
MOD_ProDKin_1	452	458	PF00069	0.669
MOD_ProDKin_1	460	466	PF00069	0.789
MOD_ProDKin_1	487	493	PF00069	0.760
MOD_ProDKin_1	494	500	PF00069	0.765
MOD_ProDKin_1	539	545	PF00069	0.835
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.763
TRG_ENDOCYTIC_2	465	468	PF00928	0.644
TRG_ENDOCYTIC_2	572	575	PF00928	0.766
TRG_ENDOCYTIC_2	95	98	PF00928	0.770
TRG_ER_diArg_1	149	151	PF00400	0.736
TRG_NES_CRM1_1	42	56	PF08389	0.623
TRG_NLS_MonoExtN_4	147	152	PF00514	0.661
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4Q2	Leishmania donovani	85%	100%
A4HJI3	Leishmania braziliensis	54%	98%
A4I732	Leishmania infantum	84%	85%
Q4Q661	Leishmania major	82%	100%