LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Tryparedoxin-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Tryparedoxin-like protein
Gene product:
tryparedoxin 4, putative
Species:
Leishmania mexicana
UniProt:
E9B1Z6_LEIMU
TriTrypDb:
LmxM.30.1970
Length:
180

Annotations

LeishMANIAdb annotations

A large family of kinetoplastid-specific oxidoreductases. Only expanded in the Leptomonas genus. Localization: ER (by feature) / Mitochondial outer membrane (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 30
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 28
NetGPI no yes: 0, no: 28
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 11
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0005634 nucleus 5 2
GO:0032473 cytoplasmic side of mitochondrial outer membrane 4 1
GO:0098552 side of membrane 2 1
GO:0098562 cytoplasmic side of membrane 3 1
GO:0005829 cytosol 2 1

Expansion

Sequence features

E9B1Z6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1Z6

PDB structure(s): 3s9f_A

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 2
GO:0009056 catabolic process 2 2
GO:0009987 cellular process 1 2
GO:0042743 hydrogen peroxide metabolic process 4 2
GO:0042744 hydrogen peroxide catabolic process 4 2
GO:0044237 cellular metabolic process 2 2
GO:0044248 cellular catabolic process 3 2
GO:0072593 reactive oxygen species metabolic process 3 2
GO:0009892 negative regulation of metabolic process 4 2
GO:0009966 regulation of signal transduction 4 2
GO:0009968 negative regulation of signal transduction 5 2
GO:0010605 negative regulation of macromolecule metabolic process 5 2
GO:0010646 regulation of cell communication 4 2
GO:0010648 negative regulation of cell communication 5 2
GO:0019222 regulation of metabolic process 3 2
GO:0023051 regulation of signaling 3 2
GO:0023057 negative regulation of signaling 4 2
GO:0030111 regulation of Wnt signaling pathway 5 2
GO:0030178 negative regulation of Wnt signaling pathway 6 2
GO:0031396 regulation of protein ubiquitination 8 2
GO:0031397 negative regulation of protein ubiquitination 9 2
GO:0031399 regulation of protein modification process 6 2
GO:0031400 negative regulation of protein modification process 7 2
GO:0048519 negative regulation of biological process 3 2
GO:0048523 negative regulation of cellular process 4 2
GO:0048583 regulation of response to stimulus 3 2
GO:0048585 negative regulation of response to stimulus 4 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051172 negative regulation of nitrogen compound metabolic process 5 2
GO:0051246 regulation of protein metabolic process 5 2
GO:0051248 negative regulation of protein metabolic process 6 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0065007 biological regulation 1 2
GO:0080090 regulation of primary metabolic process 4 2
GO:1903320 regulation of protein modification by small protein conjugation or removal 7 2
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 8 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 18
GO:0004791 thioredoxin-disulfide reductase activity 2 18
GO:0015035 protein-disulfide reductase activity 3 18
GO:0015036 disulfide oxidoreductase activity 4 18
GO:0016209 antioxidant activity 1 18
GO:0016491 oxidoreductase activity 2 18
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 18
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4 18
GO:0047134 protein-disulfide reductase (NAD(P)) activity 4 18
GO:0140096 catalytic activity, acting on a protein 2 18

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 124 126 PF00675 0.462
CLV_NRD_NRD_1 13 15 PF00675 0.447
CLV_NRD_NRD_1 157 159 PF00675 0.508
CLV_PCSK_KEX2_1 124 126 PF00082 0.450
CLV_PCSK_KEX2_1 157 159 PF00082 0.450
CLV_PCSK_SKI1_1 125 129 PF00082 0.466
CLV_PCSK_SKI1_1 44 48 PF00082 0.271
CLV_Separin_Metazoa 11 15 PF03568 0.391
DOC_CDC14_PxL_1 109 117 PF14671 0.502
DOC_MAPK_MEF2A_6 163 172 PF00069 0.445
DOC_MAPK_MEF2A_6 28 35 PF00069 0.239
DOC_USP7_MATH_1 156 160 PF00917 0.518
DOC_USP7_MATH_1 42 46 PF00917 0.428
DOC_WW_Pin1_4 44 49 PF00397 0.461
DOC_WW_Pin1_4 70 75 PF00397 0.431
LIG_14-3-3_CanoR_1 124 134 PF00244 0.356
LIG_14-3-3_CanoR_1 157 161 PF00244 0.480
LIG_BIR_II_1 1 5 PF00653 0.470
LIG_BRCT_BRCA1_1 1 5 PF00533 0.356
LIG_Clathr_ClatBox_1 115 119 PF01394 0.479
LIG_FHA_1 162 168 PF00498 0.292
LIG_FHA_1 174 180 PF00498 0.271
LIG_FHA_1 27 33 PF00498 0.244
LIG_FHA_1 45 51 PF00498 0.465
LIG_GBD_Chelix_1 170 178 PF00786 0.322
LIG_IRF3_LxIS_1 63 69 PF10401 0.341
LIG_LIR_Apic_2 36 42 PF02991 0.455
LIG_LIR_Gen_1 29 37 PF02991 0.478
LIG_LIR_Gen_1 60 68 PF02991 0.450
LIG_LIR_Gen_1 87 96 PF02991 0.406
LIG_LIR_Nem_3 29 33 PF02991 0.467
LIG_LIR_Nem_3 60 66 PF02991 0.441
LIG_LIR_Nem_3 87 91 PF02991 0.462
LIG_NRBOX 169 175 PF00104 0.430
LIG_Pex14_2 35 39 PF04695 0.457
LIG_Pex14_2 63 67 PF04695 0.441
LIG_SH2_GRB2like 80 83 PF00017 0.341
LIG_SH2_PTP2 30 33 PF00017 0.369
LIG_SH2_STAT5 30 33 PF00017 0.457
LIG_SH2_STAT5 34 37 PF00017 0.453
LIG_SH2_STAT5 80 83 PF00017 0.436
LIG_SH3_3 107 113 PF00018 0.420
LIG_SUMO_SIM_anti_2 114 119 PF11976 0.361
LIG_SUMO_SIM_par_1 108 114 PF11976 0.498
LIG_SUMO_SIM_par_1 171 176 PF11976 0.465
MOD_CDK_SPK_2 44 49 PF00069 0.408
MOD_CDK_SPxxK_3 44 51 PF00069 0.535
MOD_CK1_1 111 117 PF00069 0.474
MOD_CK1_1 69 75 PF00069 0.498
MOD_CK2_1 70 76 PF00069 0.484
MOD_DYRK1A_RPxSP_1 44 48 PF00069 0.464
MOD_GlcNHglycan 35 38 PF01048 0.229
MOD_GSK3_1 66 73 PF00069 0.443
MOD_NEK2_1 126 131 PF00069 0.323
MOD_NEK2_1 161 166 PF00069 0.485
MOD_NEK2_1 173 178 PF00069 0.361
MOD_PKA_2 156 162 PF00069 0.267
MOD_Plk_4 111 117 PF00069 0.477
MOD_Plk_4 173 179 PF00069 0.397
MOD_Plk_4 26 32 PF00069 0.270
MOD_Plk_4 76 82 PF00069 0.507
MOD_ProDKin_1 44 50 PF00069 0.461
MOD_ProDKin_1 70 76 PF00069 0.431
MOD_SUMO_rev_2 70 79 PF00179 0.467
TRG_ENDOCYTIC_2 30 33 PF00928 0.479
TRG_ER_diArg_1 124 126 PF00400 0.412

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HT51 Leptomonas seymouri 49% 98%
A0A0N1HZM3 Leptomonas seymouri 42% 100%
A0A0N1I697 Leptomonas seymouri 37% 100%
A0A1X0P005 Trypanosomatidae 41% 100%
A0A1X0P190 Trypanosomatidae 34% 91%
A0A3Q8IED6 Leishmania donovani 37% 100%
A0A3Q8IG90 Leishmania donovani 45% 97%
A0A3S7X2H1 Leishmania donovani 41% 100%
A0A422MZX1 Trypanosoma rangeli 39% 93%
A0A422MZX8 Trypanosoma rangeli 41% 100%
A0A6L0XIW2 Leishmania infantum 40% 100%
A0A6L0XKX4 Leishmania infantum 37% 100%
A4HHC6 Leishmania braziliensis 41% 100%
A4HHC7 Leishmania braziliensis 34% 100%
A4HHC8 Leishmania braziliensis 33% 100%
A4HJH8 Leishmania braziliensis 51% 100%
A4I6X1 Leishmania infantum 45% 97%
B6DTG3 Bodo saltans 46% 100%
B6DTG4 Bodo saltans 37% 100%
C9ZKL4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 91%
C9ZL57 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9ADX3 Leishmania major 40% 100%
E9ADX4 Leishmania major 39% 100%
E9ALV7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9ALV8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9B1Z5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
O77404 Trypanosoma brucei brucei 41% 100%
Q4Q665 Leishmania major 88% 100%
Q4Q666 Leishmania major 50% 100%
Q5VZ03 Homo sapiens 33% 100%
Q8VC33 Mus musculus 27% 83%
Q96CM4 Homo sapiens 27% 85%
Q9D531 Mus musculus 34% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS